Carsten Lukas

Summary

Country: Germany

Publications

  1. pmc Primary angiitis of the central nervous system presenting with subacute and fatal course of disease: a case report
    Carsten Lukas
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    BMC Neurol 5:16. 2005
  2. doi request reprint Early central atrophy rate predicts 5 year clinical outcome in multiple sclerosis
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Neurol Neurosurg Psychiatry 81:1351-6. 2010
  3. doi request reprint Spinal cord atrophy in spinocerebellar ataxia type 3 and 6 : impact on clinical disability
    Carsten Lukas
    Dept of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital Ruhr University Bochum, Gudrunstr 56, 44791, Bochum, Germany
    J Neurol 255:1244-9. 2008
  4. ncbi request reprint Efficacy of mitoxantrone and intrathecal triamcinolone acetonide treatment in chronic progressive multiple sclerosis patients
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Clin Neuropharmacol 29:286-91. 2006
  5. ncbi request reprint Progressive hepatic mitochondrial dysfunction in premanifest Huntington's disease
    Rainer Hoffmann
    Department of Neurology, Huntington Center NRW, Ruhr University Bochum, St Josef Hospital, Bochum, Germany
    Mov Disord 29:831-4. 2014
  6. doi request reprint A new sulcus-corrected approach for assessing cerebellar volume in spinocerebellar ataxia
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Psychiatry Res 193:123-30. 2011
  7. ncbi request reprint Repeat intrathecal triamcinolone acetonide application reduces acute occurring painful dysesthesia in patients with relapsing remitting multiple sclerosis
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    ScientificWorldJournal 6:460-5. 2006
  8. pmc Disease course and outcome of 15 monocentrically treated natalizumab-associated progressive multifocal leukoencephalopathy patients
    Stefanie Dahlhaus
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Neurol Neurosurg Psychiatry 84:1068-74. 2013
  9. doi request reprint Relevance of spinal cord abnormalities to clinical disability in multiple sclerosis: MR imaging findings in a large cohort of patients
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany Departments of Neurology, Radiology, Epidemiology and Biostatistics, Anatomy and Neurosciences, Section of Clinical Neuroscience, and Physics and Medical Technology, MS Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany
    Radiology 269:542-52. 2013
  10. ncbi request reprint Dissociation of grey and white matter reduction in spinocerebellar ataxia type 3 and 6: a voxel-based morphometry study
    Carsten Lukas
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Neurosci Lett 408:230-5. 2006

Collaborators

Detail Information

Publications19

  1. pmc Primary angiitis of the central nervous system presenting with subacute and fatal course of disease: a case report
    Carsten Lukas
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    BMC Neurol 5:16. 2005
    ..This rare but treatable disease provides a diagnostic challenge owing to the lack of pathognomonic tests and the necessity of a histological confirmation...
  2. doi request reprint Early central atrophy rate predicts 5 year clinical outcome in multiple sclerosis
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Neurol Neurosurg Psychiatry 81:1351-6. 2010
    ..To examine the predictive value of central atrophy in early multiple sclerosis (MS) patients, for medium term clinical outcome...
  3. doi request reprint Spinal cord atrophy in spinocerebellar ataxia type 3 and 6 : impact on clinical disability
    Carsten Lukas
    Dept of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital Ruhr University Bochum, Gudrunstr 56, 44791, Bochum, Germany
    J Neurol 255:1244-9. 2008
    ..To quantify spinal cord atrophy and its impact on clinical disability in spinocerebellar ataxia (SCA) type 3 and 6...
  4. ncbi request reprint Efficacy of mitoxantrone and intrathecal triamcinolone acetonide treatment in chronic progressive multiple sclerosis patients
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Clin Neuropharmacol 29:286-91. 2006
    ..Future trials will show the efficacy of combination of both treatment approaches in chronic progressive patients with MS...
  5. ncbi request reprint Progressive hepatic mitochondrial dysfunction in premanifest Huntington's disease
    Rainer Hoffmann
    Department of Neurology, Huntington Center NRW, Ruhr University Bochum, St Josef Hospital, Bochum, Germany
    Mov Disord 29:831-4. 2014
    ..In this longitudinal pilot study, we investigated whether there is evidence for progressive hepatic mitochondrial dysfunction in premanifest HD...
  6. doi request reprint A new sulcus-corrected approach for assessing cerebellar volume in spinocerebellar ataxia
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Psychiatry Res 193:123-30. 2011
    ..In contrast to currently used methods, this new approach may be more sensitive even to small atrophic changes affecting sulcal widening...
  7. ncbi request reprint Repeat intrathecal triamcinolone acetonide application reduces acute occurring painful dysesthesia in patients with relapsing remitting multiple sclerosis
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    ScientificWorldJournal 6:460-5. 2006
    ..Repeated intrathecal TCA injection may provide a substantial benefit in RRMS patients with acute onset of pain due to an inflammatory lesion within the spinal cord...
  8. pmc Disease course and outcome of 15 monocentrically treated natalizumab-associated progressive multifocal leukoencephalopathy patients
    Stefanie Dahlhaus
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Neurol Neurosurg Psychiatry 84:1068-74. 2013
    ..We evaluated retrospectively 15 patients with natalizumab-associated PML treated at our centre...
  9. doi request reprint Relevance of spinal cord abnormalities to clinical disability in multiple sclerosis: MR imaging findings in a large cohort of patients
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany Departments of Neurology, Radiology, Epidemiology and Biostatistics, Anatomy and Neurosciences, Section of Clinical Neuroscience, and Physics and Medical Technology, MS Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany
    Radiology 269:542-52. 2013
    ..To determine whether spinal cord atrophy differs among disease subtypes in multiple sclerosis (MS) and whether it offers diagnostic and clinical correlative information beyond that provided by other magnetic resonance (MR) imaging markers...
  10. ncbi request reprint Dissociation of grey and white matter reduction in spinocerebellar ataxia type 3 and 6: a voxel-based morphometry study
    Carsten Lukas
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Neurosci Lett 408:230-5. 2006
    ..In contrast, SCA3 represents a form of ponto-cerebellar atrophy with predominant affection of pontine nuclei and fibre tracts...
  11. pmc Benefit of repetitive intrathecal triamcinolone acetonide therapy in predominantly spinal multiple sclerosis: prediction by upper spinal cord atrophy
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University of Bochum, Bochum, Germany
    Ther Adv Neurol Disord 2:42-9. 2009
    ..Absence of USC atrophy as measured on MRI is a predictive marker for intrathecal TCA therapy outcome in progressive MS. Patients with initial poor walking abilities, but only little or no atrophy, benefited most from TCA therapy...
  12. pmc A novel cognitive-neurophysiological state biomarker in premanifest Huntington's disease validated on longitudinal data
    Christian Beste
    Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Germany
    Sci Rep 3:1797. 2013
    ..The study provides a biomarker, which could change practice of progression diagnostics in a major basal ganglia disease and which may help to evaluate potential neuroprotective treatments in future clinical trials...
  13. doi request reprint Natalizumab-associated reversible encephalopathy syndrome mimicking progressive multifocal leukoencephalopathy
    Bernhard F Décard
    Department of Neurology at St Josef Hospital, Ruhr University Bochum, Germany
    Mult Scler 19:249-51. 2013
    ..To our knowledge, this is the first case of its kind. Our case suggests that awareness ought to be sharpened for reversible leukoencephalopathy syndrome in the follow-up of natalizumab treated multiple sclerosis patients...
  14. doi request reprint 1H-magnetic resonance spectroscopy in diffuse and focal cervical cord lesions in multiple sclerosis
    Barbara Bellenberg
    Department of Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University of Bochum, Gudrunstr 56, 44791, Bochum, Germany
    Eur Radiol 23:3379-92. 2013
    ..5 T in comparison to quantitative MR imaging of the upper cervical cord area and T2 relaxometry at baseline and follow-up...
  15. ncbi request reprint Sensitivity and reproducibility of a new fast 3D segmentation technique for clinical MR-based brain volumetry in multiple sclerosis
    Carsten Lukas
    Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr 56, 44791, Bochum, Germany
    Neuroradiology 46:906-15. 2004
    ..Analysis times were 6 min for processing of 128 slices. The proposed technique is reliable and highly suitable for quantitative studies of brain atrophy, e.g., in multiple sclerosis...
  16. doi request reprint Successful treatment of cerebellar ataxia and tremor in multiple sclerosis with topiramate: a case report
    Alexandra Schroeder
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Clin Neuropharmacol 33:317-8. 2010
    ..Multiple sclerosis immunotherapy was not changed in this period. In conclusion, topiramate may be a new therapeutic option to treat cerebellar tremor and ataxia in patients with multiple sclerosis...
  17. doi request reprint Successful management of natalizumab-associated progressive multifocal leukoencephalopathy and immune reconstitution syndrome in a patient with multiple sclerosis
    Alexandra Schröder
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Arch Neurol 67:1391-4. 2010
    ..To describe a case of successful clinical management of natalizumab-associated progressive multifocal leukoencephalopathy (PML) and immune reconstitution syndrome (IRIS) in a patient with multiple sclerosis...
  18. ncbi request reprint Hepatic mitochondrial dysfunction in manifest and premanifest Huntington disease
    Sven H Stüwe
    Department of Neurology, Huntington Centre NRW, Ruhr University Bochum, Bochum, Germany
    Neurology 80:743-6. 2013
    ..In this cross-sectional study, we investigated whether there is evidence for hepatic mitochondrial dysfunction in manifest and/or premanifest Huntington disease (HD) by using the ¹³C-methionine breath test...
  19. ncbi request reprint Efficacy and safety of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients
    Volker Hoffmann
    Department of Neurology, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Neurol Sci 211:81-4. 2003
    ..No serious side effects occurred. We conclude that repeated intrathecal TCA injection provides substantial benefit for progressive MS patients with predominantly spinal symptoms...