Karin Loser

Summary

Country: Germany

Publications

  1. pmc Bacteria tracking by in vivo magnetic resonance imaging
    Verena Hoerr
    Department of Clinical Radiology, University Hospital Munster, Munster 48149, Germany
    BMC Biol 11:63. 2013
  2. doi request reprint Regulatory T cells: banned cells for decades
    Karin Loser
    Department of Dermatology, Interdisciplinary Center of Clinical Research, University of Munster, Munster, Germany
    J Invest Dermatol 132:864-71. 2012
  3. ncbi request reprint Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin D
    Karin Loser
    Department of Dermatology and Interdisciplinary Center of Clinical Research IZKF, University of Munster, Munster, Germany
    Int Immunopharmacol 9:587-9. 2009
  4. doi request reprint Galectin-2 suppresses contact allergy by inducing apoptosis in activated CD8+ T cells
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 182:5419-29. 2009
  5. ncbi request reprint The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    Nat Med 16:713-7. 2010
  6. pmc The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    PLoS ONE 5:e8958. 2010
  7. ncbi request reprint FK506 controls CD40L-induced systemic autoimmunity in mice
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 126:1307-15. 2006
  8. pmc The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis
    Beatrix Petersen
    Institute of Immunology, University of Munster, Munster, Germany
    EMBO J 32:100-11. 2013
  9. ncbi request reprint An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 174:5298-305. 2005
  10. ncbi request reprint IL-10 controls ultraviolet-induced carcinogenesis in mice
    Karin Loser
    Department of Dermatology and Interdisciplinary Center of Clinical Research, Interdisziplinäres Zentrum für Klinische Forschung, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    J Immunol 179:365-71. 2007

Collaborators

Detail Information

Publications31

  1. pmc Bacteria tracking by in vivo magnetic resonance imaging
    Verena Hoerr
    Department of Clinical Radiology, University Hospital Munster, Munster 48149, Germany
    BMC Biol 11:63. 2013
    ..In this study we established an in vivo imaging platform by magnetic resonance imaging (MRI) for tracking bacteria in mouse models of infection to study infection biology of clinically relevant bacteria...
  2. doi request reprint Regulatory T cells: banned cells for decades
    Karin Loser
    Department of Dermatology, Interdisciplinary Center of Clinical Research, University of Munster, Munster, Germany
    J Invest Dermatol 132:864-71. 2012
    ..Furthermore, we discuss the role of Tregs in cutaneous inflammatory and autoimmune disorders...
  3. ncbi request reprint Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin D
    Karin Loser
    Department of Dermatology and Interdisciplinary Center of Clinical Research IZKF, University of Munster, Munster, Germany
    Int Immunopharmacol 9:587-9. 2009
    ....
  4. doi request reprint Galectin-2 suppresses contact allergy by inducing apoptosis in activated CD8+ T cells
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 182:5419-29. 2009
    ..Taken together, these data indicate that galectin-2 may represent a novel therapeutic alternative for the treatment of CD8-mediated inflammatory disorders such as contact allergy...
  5. ncbi request reprint The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    Nat Med 16:713-7. 2010
    ..These results demonstrate a link between local expression of DAMP molecules and the development of systemic autoimmunity...
  6. pmc The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    PLoS ONE 5:e8958. 2010
    ....
  7. ncbi request reprint FK506 controls CD40L-induced systemic autoimmunity in mice
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 126:1307-15. 2006
    ..Together, these findings show the beneficial therapeutic effects of FK506 for the treatment of CD40L-induced autoimmunity. Additionally, these results demonstrate that FK506 is able to suppress ongoing severe autoimmune responses...
  8. pmc The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis
    Beatrix Petersen
    Institute of Immunology, University of Munster, Munster, Germany
    EMBO J 32:100-11. 2013
    ....
  9. ncbi request reprint An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 174:5298-305. 2005
    ..Furthermore, CD86-mediated costimulation appears to play a more critical role in the protection against photocarcinogenesis than CD80...
  10. ncbi request reprint IL-10 controls ultraviolet-induced carcinogenesis in mice
    Karin Loser
    Department of Dermatology and Interdisciplinary Center of Clinical Research, Interdisziplinäres Zentrum für Klinische Forschung, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    J Immunol 179:365-71. 2007
    ..Moreover, these results point out the crucial role of Th1 responses and UV-induced regulatory T cell function in the protection against UV-induced tumor development...
  11. ncbi request reprint Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
    Karin Loser
    Department of Dermatology, University of Munster, D 48149 Munster, Germany
    Nat Med 12:1372-9. 2006
    ..Therefore, environmental stimuli at the skin can rewire the local and systemic immune system by means of RANKL...
  12. doi request reprint Dendritic cell activation by combined exposure to anti-CD40 plus interleukin (IL)-12 and IL-18 efficiently stimulates anti-tumor immunity
    Sandra Balkow
    Department of Dermatology, University of Mainz, Mainz, Germany
    Exp Dermatol 18:78-87. 2009
    ..These data indicate that maturation of DC with anti-CD40 plus IL-12 and IL-18 potently stimulates the generation of an anti-tumor immune response and may lead to improved immunotherapeutic capacity of DC vaccination...
  13. doi request reprint α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation
    Matteo Auriemma
    Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 132:1814-24. 2012
    ....
  14. ncbi request reprint Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells
    Sandra Balkow
    Department of Dermatology, University of Muenster, Muenster, Germany
    Blood 110:3949-58. 2007
    ..Thus, retroviral infection of DCs leads to an expansion of regulatory T cells, which might serve as an immune escape mechanism of the virus...
  15. ncbi request reprint Enhanced contact hypersensitivity and antiviral immune responses in vivo by keratinocyte-targeted overexpression of IL-15
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    Eur J Immunol 34:2022-31. 2004
    ..Together, our results show that overexpression of IL-15 in the epidermis enhances both innate and adaptive cutaneous immunity...
  16. doi request reprint RANK is expressed in metastatic melanoma and highly upregulated on melanoma-initiating cells
    Verena Kupas
    Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 131:944-55. 2011
    ....
  17. ncbi request reprint Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologues
    Klaus Wethmar
    Max Planck Institute for Molecular Biomedicine, Munster, Germany, and Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    Eur J Immunol 36:2781-94. 2006
    ..Taken together, this study shows that ICAM-2 strongly supports transmigration of immature DC across resting endothelium by interacting with ligands that are distinct from beta2-integrins and DC-SIGN homologues...
  18. ncbi request reprint Dendritic cells and T cells in the regulation of cutaneous immunity
    Karin Loser
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Adv Dermatol 23:307-33. 2007
    ..In the future, a better understanding of Treg function in vivo and the interactions of Tregs and pathogenic effector T cells in autoimmune disorders may help to improve the design of Treg-based therapies...
  19. doi request reprint Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells
    Nina Weis
    Laboratory for Neuroendocrinology of the Skin and Interdisciplinary Endocrinology, Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 134:168-75. 2014
    ..Our findings encourage further studies on SKI-1 as a potential target for melanoma therapy. ..
  20. ncbi request reprint Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major
    Jan Ehrchen
    Institute for Experimental Dermatology, University of Munster, Munster, Germany
    FASEB J 21:3208-18. 2007
    ..Therefore, we propose that the absence of 1alpha,25(OH)2D3-mediated inhibition of macrophage microbicidal activity in Vdr-KO mice results in increased resistance to Leishmania infection...
  21. doi request reprint Molecular and cellular mechanisms of photocarcinogenesis
    Stefan Beissert
    Department of Dermatology, University of Munster, Munster, Germany
    Photochem Photobiol 84:29-34. 2008
    ..In the following, new molecular and cellular mechanisms of UV-induced skin tumor development will be described and discussed...
  22. doi request reprint Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore
    Thomas Brzoska
    Department of Dermatology, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
    Adv Exp Med Biol 681:107-16. 2010
    ....
  23. doi request reprint Tissue microarray analysis of RANKL in cutaneous lupus erythematosus and psoriasis
    Ferdinand Toberer
    Exp Dermatol 20:600-2. 2011
    ..These data show a different expression of RANKL in the epidermis of skin lesions from patients with CLE compared to those with psoriasis suggesting that RANKL might play an important role in the pathogenesis of the disease...
  24. ncbi request reprint CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis
    Daniel Kess
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 171:5697-706. 2003
    ..This murine inflammatory skin model may also have relevance for human polygenic inflammatory diseases...
  25. ncbi request reprint Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity
    Johanna Breuer
    Department of Neurology, University of Munster, Munster
    Ann Neurol 75:739-58. 2014
    ..Here, we investigated the mechanisms underlying the beneficial effects of immune regulatory processes induced in the skin by moderate ultraviolet B (UVB) radiation on central nervous system (CNS) autoimmunity...
  26. ncbi request reprint Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice
    Frank U Müller
    Institute of Pharmacology and Toxicology, University of Munster, Domagkstrasse 12, D 48149 Munster, Germany
    J Biol Chem 280:6906-14. 2005
    ..Our results indicate that heart-directed expression of CREM-IbDeltaC-X leads to complex cardiac alterations, suggesting CREM as a central regulator of cardiac morphology, function, and gene expression...
  27. pmc Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells
    Stefanie Loeser
    Institute of Molecular Biotechnology, Austrian Academy of Science, 1030 Vienna, Austria
    J Exp Med 204:879-91. 2007
    ..Inhibition of Cbl-b is a novel approach to stimulate long-lasting immunity against cancer...
  28. ncbi request reprint Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse
    Peter Reichardt
    Helmholtz Centre for Infection Research HZI, Junior Research Group Immunodynamics, Braunschweig, Germany
    Blood 110:1519-29. 2007
    ....
  29. ncbi request reprint Structure and duration of contact between dendritic cells and T cells are controlled by T cell activation state
    Tobias Rothoeft
    Children s Hospital of the Ruhr University Bochum, Germany
    Eur J Immunol 36:3105-17. 2006
    ..These results demonstrate that T cells control the mode of interaction based on information gathered from DC...
  30. ncbi request reprint G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo
    Wiebke Hansen
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Immunol 177:209-15. 2006
    ..Our results suggest that GPR83 might be critically involved in the peripheral generation of Foxp3+ Treg cells in vivo...
  31. ncbi request reprint Neuropilin-1: a surface marker of regulatory T cells
    Dunja Bruder
    Eur J Immunol 34:623-30. 2004
    ..Thus, Nrp1 constitutes a useful surface marker to distinguish Treg cells from both naive and recently activated CD4+CD25+ non-regulatory T cells...