Research Topics
Genomes and Genes
| Karin LoserSummaryCountry: Germany Publications
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Detail Information
Publications
Regulatory T cells: banned cells for decadesKarin Loser
Department of Dermatology, Interdisciplinary Center of Clinical Research, University of Munster, Munster, Germany
J Invest Dermatol 132:864-71. 2012..Furthermore, we discuss the role of Tregs in cutaneous inflammatory and autoimmune disorders...
The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humansKarin Loser
Department of Dermatology, University of Munster, Munster, Germany
PLoS ONE 5:e8958. 2010....- Galectin-2 suppresses contact allergy by inducing apoptosis in activated CD8+ T cellsKarin Loser
Department of Dermatology, University of Munster, Munster, Germany
J Immunol 182:5419-29. 2009..Taken together, these data indicate that galectin-2 may represent a novel therapeutic alternative for the treatment of CD8-mediated inflammatory disorders such as contact allergy... - The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cellsKarin Loser
Department of Dermatology, University of Munster, Munster, Germany
Nat Med 16:713-7. 2010..These results demonstrate a link between local expression of DAMP molecules and the development of systemic autoimmunity... - Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin DKarin Loser
Department of Dermatology and Interdisciplinary Center of Clinical Research IZKF, University of Munster, Munster, Germany
Int Immunopharmacol 9:587-9. 2009.... 
FK506 controls CD40L-induced systemic autoimmunity in miceKarin Loser
Department of Dermatology, University of Munster, Munster, Germany
J Invest Dermatol 126:1307-15. 2006..Together, these findings show the beneficial therapeutic effects of FK506 for the treatment of CD40L-induced autoimmunity. Additionally, these results demonstrate that FK506 is able to suppress ongoing severe autoimmune responses...- The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitisBeatrix Petersen
Institute of Immunology, University of Munster, Munster, Germany
EMBO J 32:100-11. 2013.... - Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cellsKarin Loser
Department of Dermatology, University of Munster, D 48149 Munster, Germany
Nat Med 12:1372-9. 2006..Therefore, environmental stimuli at the skin can rewire the local and systemic immune system by means of RANKL... - IL-10 controls ultraviolet-induced carcinogenesis in miceKarin Loser
Department of Dermatology and Interdisciplinary Center of Clinical Research, Interdisziplinäres Zentrum für Klinische Forschung, University of Munster, Von Esmarch Strasse 58, Munster, Germany
J Immunol 179:365-71. 2007..Moreover, these results point out the crucial role of Th1 responses and UV-induced regulatory T cell function in the protection against UV-induced tumor development... - An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in miceKarin Loser
Department of Dermatology, University of Munster, Munster, Germany
J Immunol 174:5298-305. 2005..Furthermore, CD86-mediated costimulation appears to play a more critical role in the protection against photocarcinogenesis than CD80... - Dendritic cell activation by combined exposure to anti-CD40 plus interleukin (IL)-12 and IL-18 efficiently stimulates anti-tumor immunitySandra Balkow
Department of Dermatology, University of Mainz, Mainz, Germany
Exp Dermatol 18:78-87. 2009..These data indicate that maturation of DC with anti-CD40 plus IL-12 and IL-18 potently stimulates the generation of an anti-tumor immune response and may lead to improved immunotherapeutic capacity of DC vaccination... - α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammationMatteo Auriemma
Department of Dermatology, University of Munster, Munster, Germany
J Invest Dermatol 132:1814-24. 2012.... - Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cellsSandra Balkow
Department of Dermatology, University of Muenster, Muenster, Germany
Blood 110:3949-58. 2007..Thus, retroviral infection of DCs leads to an expansion of regulatory T cells, which might serve as an immune escape mechanism of the virus... - Enhanced contact hypersensitivity and antiviral immune responses in vivo by keratinocyte-targeted overexpression of IL-15Karin Loser
Department of Dermatology, University of Munster, Munster, Germany
Eur J Immunol 34:2022-31. 2004..Together, our results show that overexpression of IL-15 in the epidermis enhances both innate and adaptive cutaneous immunity... - Dendritic cells and T cells in the regulation of cutaneous immunityKarin Loser
Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
Adv Dermatol 23:307-33. 2007..In the future, a better understanding of Treg function in vivo and the interactions of Tregs and pathogenic effector T cells in autoimmune disorders may help to improve the design of Treg-based therapies... - RANK is expressed in metastatic melanoma and highly upregulated on melanoma-initiating cellsVerena Kupas
Department of Dermatology, University of Munster, Munster, Germany
J Invest Dermatol 131:944-55. 2011.... - Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologuesKlaus Wethmar
Max Planck Institute for Molecular Biomedicine, Munster, Germany, and Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
Eur J Immunol 36:2781-94. 2006..Taken together, this study shows that ICAM-2 strongly supports transmigration of immature DC across resting endothelium by interacting with ligands that are distinct from beta2-integrins and DC-SIGN homologues... - Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania majorJan Ehrchen
Institute for Experimental Dermatology, University of Munster, Munster, Germany
FASEB J 21:3208-18. 2007..Therefore, we propose that the absence of 1alpha,25(OH)2D3-mediated inhibition of macrophage microbicidal activity in Vdr-KO mice results in increased resistance to Leishmania infection... - Molecular and cellular mechanisms of photocarcinogenesisStefan Beissert
Department of Dermatology, University of Munster, Munster, Germany
Photochem Photobiol 84:29-34. 2008..In the following, new molecular and cellular mechanisms of UV-induced skin tumor development will be described and discussed... - Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophoreThomas Brzoska
Department of Dermatology, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
Adv Exp Med Biol 681:107-16. 2010.... - Tissue microarray analysis of RANKL in cutaneous lupus erythematosus and psoriasisFerdinand Toberer
Exp Dermatol 20:600-2. 2011..These data show a different expression of RANKL in the epidermis of skin lesions from patients with CLE compared to those with psoriasis suggesting that RANKL might play an important role in the pathogenesis of the disease... - CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasisDaniel Kess
Department of Dermatology, University of Cologne, Cologne, Germany
J Immunol 171:5697-706. 2003..This murine inflammatory skin model may also have relevance for human polygenic inflammatory diseases... - Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic miceFrank U Müller
Institute of Pharmacology and Toxicology, University of Munster, Domagkstrasse 12, D 48149 Munster, Germany
J Biol Chem 280:6906-14. 2005..Our results indicate that heart-directed expression of CREM-IbDeltaC-X leads to complex cardiac alterations, suggesting CREM as a central regulator of cardiac morphology, function, and gene expression... - Structure and duration of contact between dendritic cells and T cells are controlled by T cell activation stateTobias Rothoeft
Children s Hospital of the Ruhr University Bochum, Germany
Eur J Immunol 36:3105-17. 2006..These results demonstrate that T cells control the mode of interaction based on information gathered from DC... - Naive B cells generate regulatory T cells in the presence of a mature immunologic synapsePeter Reichardt
Helmholtz Centre for Infection Research HZI, Junior Research Group Immunodynamics, Braunschweig, Germany
Blood 110:1519-29. 2007.... - Spontaneous tumor rejection by cbl-b-deficient CD8+ T cellsStefanie Loeser
Institute of Molecular Biotechnology, Austrian Academy of Science, 1030 Vienna, Austria
J Exp Med 204:879-91. 2007..Inhibition of Cbl-b is a novel approach to stimulate long-lasting immunity against cancer... - Neuropilin-1: a surface marker of regulatory T cellsDunja Bruder
Eur J Immunol 34:623-30. 2004..Thus, Nrp1 constitutes a useful surface marker to distinguish Treg cells from both naive and recently activated CD4+CD25+ non-regulatory T cells... - G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivoWiebke Hansen
Department of Mucosal Immunity, German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
J Immunol 177:209-15. 2006..Our results suggest that GPR83 might be critically involved in the peripheral generation of Foxp3+ Treg cells in vivo...