Dominik Linz

Summary

Country: Germany

Publications

  1. doi Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am J Hypertens 27:1293-300. 2014
  2. doi Renal denervation: effects on atrial electrophysiology and arrhythmias
    Dominik Linz
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, 66421, Homburg Saar, Germany
    Clin Res Cardiol 103:765-74. 2014
  3. doi Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am J Hypertens 28:256-65. 2015
  4. pmc Obstructive sleep apnea and atrial arrhythmogenesis
    Mathias Hohl
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, D 66421 Homburg Saar, Germany
    Curr Cardiol Rev 10:362-8. 2014
  5. doi Atrial autonomic innervation: a target for interventional antiarrhythmic therapy?
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saarland, Germany Electronic address
    J Am Coll Cardiol 63:215-24. 2014
  6. doi Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    Heart Rhythm 10:1525-30. 2013
  7. doi Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Hypertension 62:767-74. 2013
  8. doi Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Hypertension 61:225-31. 2013
  9. pmc Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar 66421, Germany
    J Transl Med 10:187. 2012
  10. doi Antihypertensive and laxative effects by pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:1560-7. 2012

Detail Information

Publications32

  1. doi Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am J Hypertens 27:1293-300. 2014
    ..Obstructive sleep apnea (OSA) is associated with hypertension and the progression of chronic kidney disease (CKD). Renal sympathetic innervation contributes to either condition...
  2. doi Renal denervation: effects on atrial electrophysiology and arrhythmias
    Dominik Linz
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, 66421, Homburg Saar, Germany
    Clin Res Cardiol 103:765-74. 2014
    ..This review focuses on the potential atrial antiarrhythmic and antiremodeling effects of RDN in AF patients with hypertension, heart failure, and sleep apnea and discusses the possible role of RDN in the treatment of AF...
  3. doi Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Am J Hypertens 28:256-65. 2015
    ..Renal sympathetic denervation (RDN) decreases sympathetic renal efferent and afferent nerve activity...
  4. pmc Obstructive sleep apnea and atrial arrhythmogenesis
    Mathias Hohl
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, D 66421 Homburg Saar, Germany
    Curr Cardiol Rev 10:362-8. 2014
    ....
  5. doi Atrial autonomic innervation: a target for interventional antiarrhythmic therapy?
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saarland, Germany Electronic address
    J Am Coll Cardiol 63:215-24. 2014
    ....
  6. doi Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    Heart Rhythm 10:1525-30. 2013
    ..Increased sympathetic activation during acute ventricular ischemia is involved in the occurrence of life-threatening arrhythmias...
  7. doi Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Hypertension 62:767-74. 2013
    ..However, the generation of atrial oxidative stress was not modulated. ..
  8. doi Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Hypertension 61:225-31. 2013
    ..Modulation of the autonomic nervous system by RDN might provide rate control and reduce susceptibility to AF. Whether RDN may provide rate control in a larger number of patients with AF deserves further clinical studies...
  9. pmc Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats
    Dominik Linz
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar 66421, Germany
    J Transl Med 10:187. 2012
    ..The additive effects of obesity and metabolic syndrome on left ventricular (LV) maladaptive remodeling and function in hypertension are not characterized...
  10. doi Antihypertensive and laxative effects by pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:1560-7. 2012
    ..Intestinal NHE3 blockade could be a new treatment strategy for elderly patients suffering from high blood pressure and constipation...
  11. doi Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea
    Dominik Linz
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Hypertension 60:172-8. 2012
    ..Renal denervation displays antiarrhythmic effects by reducing NTP-induced AERP shortening and inhibits postapneic BP rises associated with obstructive events...
  12. doi Combined blockade of early and late activated atrial potassium currents suppresses atrial fibrillation in a pig model of obstructive apnea
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Heart Rhythm 8:1933-9. 2011
    ..The role of different atrial potassium channels under those conditions has not been investigated...
  13. doi Effects of renal sympathetic denervation on exercise blood pressure, heart rate, and capacity in patients with resistant hypertension
    Sebastian Ewen
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 63:839-45. 2014
    ..No changes were observed in the control group. In conclusion, renal denervation reduced blood pressure and heart rate during exercise, improved mean workload, and increased exercise time without impairing chronotropic competence. ..
  14. doi Expanding the indication spectrum: renal denervation in diabetes
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 9:R117-21. 2013
    ..This review highlights the background of approaching the renal sympathetic nerves as a potential new therapeutic option to improve glycaemic control in patients with resistant hypertension...
  15. doi Orthostatic function after renal sympathetic denervation in patients with resistant hypertension
    Matthias Lenski
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Int J Cardiol 169:418-24. 2013
    ..However, safety concerns exist concerning the development of orthostatic dysfunction after RDN...
  16. doi Improvements in left ventricular hypertrophy and diastolic function following renal denervation: effects beyond blood pressure and heart rate reduction
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    J Am Coll Cardiol 63:1916-23. 2014
    ..This study sought to investigate the interaction between blood pressure (BP) and heart rate (HR) reduction and changes in left ventricular (LV) structure and function following renal sympathetic denervation (RDN)...
  17. doi Effects of electrical stimulation of carotid baroreflex and renal denervation on atrial electrophysiology
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    J Cardiovasc Electrophysiol 24:1028-33. 2013
    ..Increased vagal tone potentially shortens atrial refractoriness resulting in a stabilization of reentry circuits perpetuating atrial fibrillation (AF)...
  18. doi Renal sympathetic denervation: applications in hypertension and beyond
    Michael Bohm
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Straße 1, DE 66421 Homburg Saar, Germany
    Nat Rev Cardiol 10:465-76. 2013
    ....
  19. doi Therapeutic potential of renal sympathetic denervation in patients with chronic heart failure
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    EuroIntervention 9:R122-6. 2013
    ....
  20. doi Effects of renal sympathetic denervation on heart rate and atrioventricular conduction in patients with resistant hypertension
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Int J Cardiol 167:2846-51. 2013
    ..Renal sympathetic denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. The present study aimed to investigate the effects of RDN on HR and other electrocardiographic parameters...
  21. doi Reduced effect of percutaneous renal denervation on blood pressure in patients with isolated systolic hypertension
    Sebastian Ewen
    From the Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin S E, C U, D L, I K, B C, U L, M B, F M and Institut für Medizinische Biometrie, Epidemiologie und Medizinische Informatik S W, Universitatsklinikum des Saarlandes, Homburg Saar, Germany and Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universitatsklinikum Erlangen, Erlangen, Germany R E S
    Hypertension 65:193-9. 2015
    ..In conclusion, renal denervation reduces office and ambulatory blood pressure in patients with ISH. However, this reduction is less pronounced compared with patients with CH. ..
  22. doi Potential role of renal sympathetic denervation for the treatment of cardiac arrhythmias
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 9:R110-6. 2013
    ..Furthermore, RDN may have a beneficial impact on ventricular arrhythmia, in particular in patients with coronary artery disease or heart failure...
  23. doi Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation
    Dominik Linz
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Heart Rhythm 8:1436-43. 2011
    ..Obstructive sleep apnea (OSA) causes negative tracheal pressure (NTP) and is associated with atrial fibrillation (AF)...
  24. doi The sympathetic nervous system in chronic kidney disease
    Sebastian Ewen
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse Geb 40, Homburg Saar, Germany
    Curr Hypertens Rep 15:370-6. 2013
    ..In this review current knowledge of the role of the sympathetic nervous system in the development and progression of CKD will be summarized, and novel treatment options targeting sympathetic nervous system activity will be discussed. ..
  25. doi Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension
    Felix Mahfoud
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 60:419-24. 2012
    ....
  26. doi Effects of renal denervation on atrial arrhythmogenesis
    Dominik Linz
    Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Germany
    Future Cardiol 10:813-22. 2014
    ....
  27. doi Renal denervation: a novel non-pharmacological approach in heart failure
    Michael Bohm
    Universitatsklinikum des Saarlandes, Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Str 1, DE 66424, Homburg Saar, Germany
    J Cardiovasc Transl Res 7:330-7. 2014
    ..Altogether, renal denervation is a promising novel technique that may improve the outcome of patients with sympathetic hyperactivity and cardiovascular diseases. ..
  28. doi Renal denervation and heart failure
    Michael Bohm
    Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Eur J Heart Fail 16:608-13. 2014
    ..The first proof-of-concept studies are planned to evaluate the clinical effect of this pathophysiologically plausible method, which might be able to change clinical practice. ..
  29. doi Novel and nonpharmacologic approaches to cardio-protection in hypertension
    Luca Donazzan
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str 1, Geb 40, 66421, Homburg, Saar, Germany
    Curr Hypertens Rep 16:430. 2014
    ..Their pleiotropic effects appear promising in cardiovascular remodeling, heart failure and arrhythmias and could potentially affect cardiovascular morbidity and mortality. ..
  30. doi Renal denervation for the treatment of cardiovascular high risk-hypertension or beyond?
    Michael Bohm
    From the Klinik für Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany M B, D L, C U, F M and Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia M E
    Circ Res 115:400-9. 2014
    ....
  31. doi Efficacy and safety of catheter-based radiofrequency renal denervation in stented renal arteries
    Felix Mahfoud
    From the Klinik für Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany F M, B C, D L, M B Medtronic Cardiovascular, Santa Rosa, CA S T, J R, D S J, R J M Klinik für Kardiologie and Angiologie II, Universitäts Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany T Z Brigham and Women s Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA D L B and Prairie Heart Institute at St John s Hospital, Springfield, IL K R S
    Circ Cardiovasc Interv 7:813-20. 2014
    ..Although catheter-based renal denervation (RDN) can reduce blood pressure in certain patients with resistant hypertension, there are no data on the feasibility and safety of RDN in stented RA...
  32. doi Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial
    Felix Mahfoud
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Eur Heart J 35:2224-31b. 2014
    ..The present multi-centre study aimed to investigate the effect of RDN on anatomic and functional myocardial parameters, assessed by cardiac magnetic resonance (CMR), in patients with resistant hypertension...