R P Linke

Summary

Country: Germany

Publications

  1. ncbi request reprint Senile seminal vesicle amyloid is derived from semenogelin I
    Reinhold P Linke
    Department of Structural Research, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Lab Clin Med 145:187-93. 2005
  2. ncbi request reprint Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide abeta1-42 by mirror image phage display
    Katja Wiesehan
    Forschungszentrum Julich, IBI 2, 52425 Julich, Germany
    Chembiochem 4:748-53. 2003
  3. ncbi request reprint Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosis
    Stefan O Schonland
    Department of Internal Medicine V Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S160-3. 2005
  4. ncbi request reprint Severe problems in diagnosing amyloid diseases
    Reinhold P Linke
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Acta Histochem 105:373-5. 2003
  5. ncbi request reprint Production of recombinant human beta2-microglobulin for scintigraphic diagnosis of amyloidosis in uremia and hemodialysis
    R P Linke
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 267:627-33. 2000
  6. ncbi request reprint Highly sensitive diagnosis of amyloid and various amyloid syndromes using Congo red fluorescence
    R P Linke
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Virchows Arch 436:439-48. 2000
  7. ncbi request reprint High-sensitivity diagnosis of AA amyloidosis using Congo red and immunohistochemistry detects missed amyloid deposits
    R P Linke
    Max Planck Institute of Biochemistry, Martinsried, Germany
    J Histochem Cytochem 43:863-9. 1995
  8. ncbi request reprint Classification of amyloidosis: misdiagnosing by way of incomplete immunohistochemistry and how to prevent it
    Reinhold P Linke
    Department of Structural Studies, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Acta Histochem 108:197-208. 2006
  9. pmc A new isoleucine substitution of Val-20 in transthyretin tetramers selectively impairs dimer-dimer contacts and causes systemic amyloidosis
    D E Jenne
    Max Planck Institut fur Psychiatrie, Abteilung Neuroimmunologie, Martinsried, Germany
    Proc Natl Acad Sci U S A 93:6302-7. 1996
  10. ncbi request reprint [Interdisciplinary guidelines for the diagnosis and therapy of extracerebral amyloidosis]
    Reinhold P Linke
    Dtsch Med Wochenschr 131:2795-6; author reply 2796. 2006

Collaborators

  • Per Westermark
  • K Altland
  • A Solomon
  • Anthony D Ho
  • Arnt V Kristen
  • M Zeier
  • G Merlini
  • Thomas R Appel
  • J Makovitzky
  • Christoph Rocken
  • Marcus Fändrich
  • S Dithmar
  • Bouke P C Hazenberg
  • Stefan O Schonland
  • Jolanta B Perz
  • Gerald P Gellermann
  • Hartmut Goldschmidt
  • Thomas J Dengler
  • Michael Hundemer
  • Martin Laimer
  • Katja Wiesehan
  • Max Puille
  • Ernst Hund
  • Ute Hegenbart
  • Volker Schroeckh
  • Anja Radestock
  • Mordechai Pras
  • Stephan Diekmann
  • Tim Lütkepohl
  • Astrid Tannert
  • Christian Leisner
  • Reinhard Singer
  • Peter Hortschansky
  • Jorg Beimler
  • Shmuel Shtrasburg
  • Thomas Hawranek
  • Karin Kaindl
  • Michael Emberger
  • Johann W Bauer
  • Helmut Hintner
  • Brigitte Mlineritsch
  • Christoph M Lanschützer
  • Eberhard Unger
  • Stephan Patt
  • Dieter Willbold
  • Bettina Schmitt
  • Matthias Stoldt
  • Enrico Bucci
  • Katrin Buder
  • Mary K Steen-Müller
  • Richard Bauer
  • D E Jenne
  • Dagmar Steiner
  • Rigobert Kiett
  • B Obermaier
  • K Denzel
  • P Blätzinger
  • P Winter

Detail Information

Publications19

  1. ncbi request reprint Senile seminal vesicle amyloid is derived from semenogelin I
    Reinhold P Linke
    Department of Structural Research, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Lab Clin Med 145:187-93. 2005
    ..The results of our research provide unequivocal evidence that SSVA is derived from SgI, and we provisionally designate this form of amyloidosis as ASgI...
  2. ncbi request reprint Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide abeta1-42 by mirror image phage display
    Katja Wiesehan
    Forschungszentrum Julich, IBI 2, 52425 Julich, Germany
    Chembiochem 4:748-53. 2003
    ..Fibrillar deposits derived from other amyloidosis were not labeled by D-pep. Possible applications of this novel and highly specific Abeta ligand in diagnosis and therapy of Alzheimer's disease are discussed...
  3. ncbi request reprint Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosis
    Stefan O Schonland
    Department of Internal Medicine V Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S160-3. 2005
    ..Here we review recent results of ASCT, eligibility criteria for HDM and report our own treatment results in 41 patients...
  4. ncbi request reprint Severe problems in diagnosing amyloid diseases
    Reinhold P Linke
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Acta Histochem 105:373-5. 2003
  5. ncbi request reprint Production of recombinant human beta2-microglobulin for scintigraphic diagnosis of amyloidosis in uremia and hemodialysis
    R P Linke
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 267:627-33. 2000
    ..Finally, the use of indium-111 instead of iodine-131 has reduced the radioactive load and resulted in higher resolution...
  6. ncbi request reprint Highly sensitive diagnosis of amyloid and various amyloid syndromes using Congo red fluorescence
    R P Linke
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Virchows Arch 436:439-48. 2000
    ..This method can, therefore, allow the earliest diagnosis and classification of amyloid, which is a good basis for an amyloid class-specific therapy while organ damage is still minimal...
  7. ncbi request reprint High-sensitivity diagnosis of AA amyloidosis using Congo red and immunohistochemistry detects missed amyloid deposits
    R P Linke
    Max Planck Institute of Biochemistry, Martinsried, Germany
    J Histochem Cytochem 43:863-9. 1995
    ..Had our technique (Lab 3) been available at the time of biopsy, amyloid could have been diagnosed years earlier, thereby sparing the patient further biopsies and allowing initiation of earlier treatment before organ damage could occur...
  8. ncbi request reprint Classification of amyloidosis: misdiagnosing by way of incomplete immunohistochemistry and how to prevent it
    Reinhold P Linke
    Department of Structural Studies, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Acta Histochem 108:197-208. 2006
    ..It is the purpose of this report to analyze such cases and to document some of the typical mistakes. Here, we show how to avoid common pitfalls and how one can arrive at a correct diagnosis using immunohistochemistry appropriately...
  9. pmc A new isoleucine substitution of Val-20 in transthyretin tetramers selectively impairs dimer-dimer contacts and causes systemic amyloidosis
    D E Jenne
    Max Planck Institut fur Psychiatrie, Abteilung Neuroimmunologie, Martinsried, Germany
    Proc Natl Acad Sci U S A 93:6302-7. 1996
    ....
  10. ncbi request reprint [Interdisciplinary guidelines for the diagnosis and therapy of extracerebral amyloidosis]
    Reinhold P Linke
    Dtsch Med Wochenschr 131:2795-6; author reply 2796. 2006
  11. ncbi request reprint Genetic microheterogeneity of human transthyretin detected by IEF
    Klaus Altland
    Institut fur Humangenetik, Justus Liebig Universitat, Giessen, Germany
    Electrophoresis 28:2053-64. 2007
    ..All types of amyloidogenic mutations affected the stability of TTR tetramers...
  12. ncbi request reprint [Systemic ALlambda amyloidosis associated with vascular fragility]
    Martin Laimer
    Universitätsklinik für Dermatologie, Paracelsus Medizinische Privatuniversität Salzburg, Osterreich
    J Dtsch Dermatol Ges 2:934-9. 2004
    ..This approach led to a significant improvement in relevant parameters. Recent advances in diagnosis, monitoring and therapy have made it easier to manage patients with amyloidosis with their poor prognosis...
  13. ncbi request reprint Histochemical and topo-optical investigations on tissue-isolated and in vitro amyloid fibrils
    Thomas R Appel
    Leibniz Institute of Molecular Biotechnology, Jena, Germany
    Amyloid 12:174-83. 2005
    ....
  14. pmc Raft lipids as common components of human extracellular amyloid fibrils
    Gerald P Gellermann
    Institut fur Molekulare Biotechnologie, Beutenbergstrasse 11, 07745 Jena, Germany
    Proc Natl Acad Sci U S A 102:6297-302. 2005
    ..These data suggest the existence of common cellular mechanisms in the generation of different types of clinical amyloid deposits...
  15. ncbi request reprint High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study
    Jolanta B Perz
    Department of Haematology Oncology, Clinic of Internal Medicine, University of Heidelberg, 69120 Heidelberg, Germany
    Br J Haematol 127:543-51. 2004
    ..We could not show an additional benefit of VAD induction in terms of increasing haematological response rate; however the 13% mortality rate after HDM and ASCT in our series was lower than the previous report...
  16. ncbi request reprint Ptosis from localized A-lambda-amyloid deposits in the levator palpebrae muscle
    Stefan Dithmar
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    Ophthalmology 111:1043-7. 2004
    ..To describe a patient with unilateral ptosis caused by localized amyloid deposits of immunoglobulin lambda-light chains (A-lambda-amyloid) in the levator palpebrae muscle...
  17. ncbi request reprint No regression of renal AL amyloid in monoclonal gammopathy after successful autologous blood stem cell transplantation and significant clinical improvement
    Martin Zeier
    Department of Medicine Nephrology, University of Heidelberg, Bergheimerstrasse 56a, D 69115 Heidelberg, Germany
    Nephrol Dial Transplant 18:2644-7. 2003
    ..High-dose chemotherapy followed by autologous blood stem cell transplantation induces remission of plasma cell dyscrasia in patients with AL amyloidosis. The impact of this treatment on the glomerular amyloid mass is still unknown...
  18. ncbi request reprint 99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy
    Max Puille
    Department of Nuclear Medicine, Justus Liebig University, Giessen, Germany
    Eur J Nucl Med Mol Imaging 29:376-9. 2002
    ..99mTc-DPD scintigraphy is proposed as a simple and valuable diagnostic aid to evaluate the severity of the disease and the risk of concomitant heart problems...
  19. ncbi request reprint Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvement
    Arnt V Kristen
    Department of Cardiology, Medical University of Heidelberg, Heidelberg, Germany
    Amyloid 14:283-7. 2007
    ..Final clinical assessment of severity of cardiac involvement in the present patient is rendered complex by possible concomitant or preceding idiopathic dilated cardiomyopathy...