Klaus Lieb

Summary

Country: Germany

Publications

  1. doi request reprint Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    Br J Psychiatry 196:4-12. 2010
  2. pmc A survey of german physicians in private practice about contacts with pharmaceutical sales representatives
    Klaus Lieb
    Klinik fur Psychiatrie und Psychotherapie, Universitätsmedizin Mainz, Mainz, Germany
    Dtsch Arztebl Int 107:392-8. 2010
  3. pmc Emotional modulation of motor response inhibition in women with borderline personality disorder: an fMRI study
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    J Psychiatry Neurosci 38:164-72. 2013
  4. doi request reprint Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Germany
    World J Biol Psychiatry 11:45-58. 2010
  5. doi request reprint Extraction of prefronto-amygdalar pathways by combining probability maps
    Tobias Bracht
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Psychiatry Res 174:217-22. 2009
  6. doi request reprint Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University of Mainz, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:487-95. 2009
  7. doi request reprint Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression
    Nadine Dreimüller
    Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, Germany
    Neuropharmacology 62:264-9. 2012
  8. doi request reprint Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHD
    Alexandra Sebastian
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University Freiburg, Germany
    Psychiatry Res 202:132-41. 2012
  9. doi request reprint Predictors of dropout from inpatient dialectical behavior therapy among women with borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    J Behav Ther Exp Psychiatry 39:497-503. 2008
  10. doi request reprint Borderline typical symptoms in adult patients with attention deficit/hyperactivity disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Atten Defic Hyperact Disord 1:11-8. 2009

Detail Information

Publications59

  1. doi request reprint Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    Br J Psychiatry 196:4-12. 2010
    ..Many patients with borderline personality disorder receive pharmacological treatment, but there is uncertainty about the usefulness of such therapies...
  2. pmc A survey of german physicians in private practice about contacts with pharmaceutical sales representatives
    Klaus Lieb
    Klinik fur Psychiatrie und Psychotherapie, Universitätsmedizin Mainz, Mainz, Germany
    Dtsch Arztebl Int 107:392-8. 2010
    ..A further goal is to determine whether alternatives to current practices can be envisioned...
  3. pmc Emotional modulation of motor response inhibition in women with borderline personality disorder: an fMRI study
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    J Psychiatry Neurosci 38:164-72. 2013
    ..Although both problems may be combined specifically in BPD, few studies to date have investigated the emotional modulation of impulsivity in BPD...
  4. doi request reprint Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Germany
    World J Biol Psychiatry 11:45-58. 2010
    ....
  5. doi request reprint Extraction of prefronto-amygdalar pathways by combining probability maps
    Tobias Bracht
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Psychiatry Res 174:217-22. 2009
    ..We believe that our approach provides a promising tool to assess the integrity of specific structural connections in patients with neuropsychiatric disorders...
  6. doi request reprint Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University of Mainz, Germany
    Am J Med Genet B Neuropsychiatr Genet 150:487-95. 2009
    ....
  7. doi request reprint Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression
    Nadine Dreimüller
    Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Untere Zahlbacher Str 8, Germany
    Neuropharmacology 62:264-9. 2012
    ..This has to be confirmed in further investigations. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  8. doi request reprint Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHD
    Alexandra Sebastian
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University Freiburg, Germany
    Psychiatry Res 202:132-41. 2012
    ....
  9. doi request reprint Predictors of dropout from inpatient dialectical behavior therapy among women with borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    J Behav Ther Exp Psychiatry 39:497-503. 2008
    ..Experiential avoidance and anxiety may be associated with dropout in inpatient DBT. Low life-time suicidality and high anger could reflect a subtype at risk for discontinuation of inpatient treatment...
  10. doi request reprint Borderline typical symptoms in adult patients with attention deficit/hyperactivity disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Atten Defic Hyperact Disord 1:11-8. 2009
    ..Females with ADHD and BPD share more clinical features than males. However, symptoms of self-destruction and affect dysregulation appear to be more severe in BPD patients...
  11. doi request reprint Small amygdala-high aggression? The role of the amygdala in modulating aggression in healthy subjects
    Swantje Matthies
    Department of Psychiatry and Psychotherapy, University Medical Centre Freiburg, Freiburg, Germany
    World J Biol Psychiatry 13:75-81. 2012
    ..In order to better understand the physiological role of the amygdala in modulating aggressive behaviour we investigated the relationship between amygdala volumes and lifetime aggression in healthy subjects...
  12. pmc Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    BMC Psychiatry 11:16. 2011
    ..Peripheral blood markers and executive functions are particularly promising candidates as markers for the onset of action and thus the prediction of final treatment outcome in MDD...
  13. doi request reprint The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 35:415-20. 2011
    ..If replicated, this combined marker could be considered useful for prospective confirmatory trials in patients with MDD...
  14. pmc Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons
    Andreas G Franke
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Str 8, Mainz 55131, Germany
    BMC Med 11:102. 2013
    ..The prevalence of surgeons taking pharmacological cognitive enhancement (CE) or mood enhancement (ME) drugs has not been systematically assessed so far...
  15. pmc What users think about the differences between caffeine and illicit/prescription stimulants for cognitive enhancement
    Andreas G Franke
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    PLoS ONE 7:e40047. 2012
    ..This result shows the need for well-directed and differentiated information to prevent the potentially harmful use of illicit or prescription stimulants for CE...
  16. doi request reprint Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    J Neural Transm 116:1185-8. 2009
    ..Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients...
  17. doi request reprint Emotional reactions to standardized stimuli in women with borderline personality disorder: stronger negative affect, but no differences in reactivity
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, D 79104 Freiburg, Germany
    J Nerv Ment Dis 197:808-15. 2009
    ..Extreme negative affectivity may be a more appropriate description of BPD-related emotional problems than emotional hyperreactivity...
  18. doi request reprint Evaluation of the efficacy and effectiveness of a structured disorder tailored psychotherapy in ADHD in adults: study protocol of a randomized controlled multicentre trial
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Atten Defic Hyperact Disord 2:203-12. 2010
    ..The trial is funded by the German Federal Ministry of Research and Education (01GV0606) and is part of the German network for the treatment of ADHD in children and adults (ADHD-NET)...
  19. doi request reprint Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    Psychiatry Res 181:151-4. 2010
    ..Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD...
  20. doi request reprint Psychological therapies for people with borderline personality disorder
    Jutta M Stoffers
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
    Cochrane Database Syst Rev 8:CD005652. 2012
    ..In recent years, several disorder-specific interventions have been developed. This is an update of a review published in the Cochrane Database of Systematic Reviews in 2006...
  21. pmc Rationale and design of the randomised clinical trial comparing early medication change (EMC) strategy with treatment as usual (TAU) in patients with major depressive disorder--the EMC trial
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany
    Trials 11:21. 2010
    ..Even more important, non-improvement (HAMD decrease <20%) after 14 days of treatment was found to be highly predictive for a poor final treatment outcome...
  22. doi request reprint Impulsivity in borderline personality disorder: impairment in self-report measures, but not behavioral inhibition
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Psychopathology 43:180-8. 2010
    ..However, previous clinical and experimental studies investigating impulsivity in BPD rendered mixed results. In this study, impulsivity was assessed by self-report scales and behavioral inhibition tasks to compare different data levels...
  23. doi request reprint Comparison of different strategies to decrease negative affect and increase positive affect in women with borderline personality disorder
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Behav Res Ther 49:68-73. 2011
    ..In this study we compared the effect of different emotion regulation strategies on positive and negative emotions in patients with borderline personality disorder...
  24. doi request reprint Reliability of three alternate forms of the trail making tests a and B
    Stefanie Wagner
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    Arch Clin Neuropsychol 26:314-21. 2011
    ..76 and 0.89 and between 0.86 and 0.94, respectively. Because of their identical difficulty and high reliability, the herein described versions of the TMT A and B are suitable for sequential testing of executive functioning...
  25. pmc Associations between Physical and Cognitive Doping - A Cross-Sectional Study in 2.997 Triathletes
    Pavel Dietz
    Department of Sports Medicine, Rehabilitation and Disease Prevention, Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 8:e78702. 2013
    ....
  26. ncbi request reprint Impulsivity in borderline personality disorder: a matter of disturbed impulse control or a facet of emotional dysregulation?
    Alexandra Sebastian
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    Curr Psychiatry Rep 15:339. 2013
    ..In sum, although basic mechanisms of impulse control seem not to be disturbed in BPD, clinically well observed impulsive behaviors may be explained by comorbid ADHD or may be the consequence of dysregulation of BPD salient emotions...
  27. doi request reprint [Characteristics of university students using stimulants for cognitive enhancement: a pilot study]
    Andreas G Franke
    Klinik fur Psychiatrie und Psychotherapie, Universitätsmedizin Mainz, Untere Zahlbacher Strasse 8, Mainz
    Psychiatr Prax 39:174-80. 2012
    ..Aim of this pilot study was to characterize students in Germany who use methylphenidate (MPH) and/or amphetamines (AMPH) for PN...
  28. doi request reprint Group therapy module to enhance self-esteem in patients with borderline personality disorder: a pilot study
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical Centre, Germany
    Int J Group Psychother 60:373-87. 2010
    ..Results showed a greater improvement in self-esteem in the intervention group. The findings suggest that the therapy module is an effective adjunctive treatment in increasing self-esteem in BPD...
  29. doi request reprint [Treatment satisfaction of patients with borderline personality disorder in inpatient schema therapy]
    Neele Reiss
    Klinik fur Psychiatrie und Psychotherapie, Universitätsmedizin Mainz
    Psychother Psychosom Med Psychol 63:93-100. 2013
    ..The results of the present study demonstrate treatment satisfaction of BPD patients in inpatient ST and give directions for the future development of these programs...
  30. doi request reprint Randomized response estimates for the 12-month prevalence of cognitive-enhancing drug use in university students
    Pavel Dietz
    Department of Sports Medicine, Rehabilitation and Disease Prevention, Johannes Gutenberg University, Mainz, Germany
    Pharmacotherapy 33:44-50. 2013
    ..To estimate the 12-month prevalence of cognitive-enhancing drug use...
  31. doi request reprint Impulsiveness and venturesomeness in German smokers
    Nina Bernow
    Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Untere Zahlbacher Strasse 8, Mainz, Germany
    Nicotine Tob Res 13:714-21. 2011
    ..Furthermore, it was intended to further the knowledge about associations between different self-reported impulsivity components and different smoking variables...
  32. doi request reprint Time course of response to antidepressants: predictive value of early improvement and effect of additional psychotherapy
    Dietrich van Calker
    Department of Psychiatry and Psychotherapy, University Medical Centre Freiburg, Germany
    J Affect Disord 114:243-53. 2009
    ..We have analysed in more severely depressed inpatients treated with antidepressants i) the predictive value of early improvement for later response and ii) the impact of additional psychotherapy on the time course of response...
  33. doi request reprint Dopamine D2/D3 receptor availability and venturesomeness
    Nina Bernow
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    Psychiatry Res 193:80-4. 2011
    ..Our results suggest the involvement of extrastriatal dopaminergic neurotransmission in venturesomeness, a component of impulsivity...
  34. doi request reprint Effects of sleep deprivation on nocturnal cytokine concentrations in depressed patients and healthy control subjects
    Ulrich Voderholzer
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
    J Neuropsychiatry Clin Neurosci 24:354-66. 2012
    ..The interaction between antidepressant effects of TSD and alterations of cytokines warrants further investigation...
  35. doi request reprint Neurochemical alterations in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    World J Biol Psychiatry 11:372-81. 2010
    ..Borderline personality disorder (BPD) is associated with structural and functional brain changes. Recent models and findings refer to alterations of glutamate and total N-acetylaspartate (tNAA) in this condition...
  36. doi request reprint The use of Ginkgo biloba in healthy elderly
    Andreas G Franke
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Str 8, 55131, Mainz, Germany
    Age (Dordr) 36:435-44. 2014
    ..Thus, there is a need to establish reliable and independent sources of scientific information for healthcare professionals and the general public. ..
  37. doi request reprint Impulsivity in borderline personality disorder: a matter of disturbed impulse control or a facet of emotional dysregulation?
    Alexandra Sebastian
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Strasse 8, 55131, Mainz, Germany
    Curr Psychiatry Rep 15:339. 2013
    ..In sum, although basic mechanisms of impulse control seem not to be disturbed in BPD, clinically well observed impulsive behaviors may be explained by comorbid ADHD or may be the consequence of dysregulation of BPD salient emotions...
  38. doi request reprint State dependent posterior hippocampal volume increases in patients with major depressive disorder
    Ingrid Schermuly
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Germany
    J Affect Disord 135:405-9. 2011
    ..However, prospective longitudinal studies investigating volumes in hippocampal subregions and their association with clinical findings are still lacking...
  39. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of personality disorders
    Sabine C Herpertz
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    World J Biol Psychiatry 8:212-44. 2007
    ....
  40. doi request reprint Attitudes towards prescribing cognitive enhancers among primary care physicians in Germany
    Andreas G Franke
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Str, 17, D 55128 Mainz, Germany
    BMC Fam Pract 15:3. 2014
    ..Therefore, we studied the knowledge of primary care physicians about CE and their attitudes toward prescribing CE drugs to healthy subjects...
  41. pmc Early life stress differentially modulates distinct forms of brain plasticity in young and adult mice
    Inga Herpfer
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    PLoS ONE 7:e46004. 2012
    ..As a growing body of evidence suggests that brain plasticity is disturbed in affective disorders, we examined the short-term and remote effects of early life stress on different forms of brain plasticity...
  42. doi request reprint The 5-HTTLPR polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with Borderline Personality Disorder
    Stefanie Wagner
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    J Psychiatr Res 43:1067-72. 2009
    ..On the other hand, serious life events (SLE) are of major importance in the development of BPD. However, the inter-relations between SLEs, impulsivity, and 5-HTTLPR are not understood...
  43. doi request reprint Attention-deficit hyperactivity disorder as a potentially aggravating factor in borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Br J Psychiatry 192:118-23. 2008
    ..Clinical experience suggests that people with borderline personality disorder often meet criteria for attention-deficit hyperactivity disorder (ADHD). However, empirical data are sparse...
  44. doi request reprint Time course of anger and other emotions in women with borderline personality disorder: a preliminary study
    Gitta A Jacob
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Behav Ther Exp Psychiatry 39:391-402. 2008
    ..The BPD group showed also stronger negative emotions over the whole experiment. The study is the first to demonstrate prolonged anger reactions in BPD patients in an experimental setting...
  45. ncbi request reprint Inferior frontal white matter microstructure and patterns of psychopathology in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    Neuroimage 35:738-47. 2007
    ....
  46. ncbi request reprint Substance P and Substance P receptor antagonists in the pathogenesis and treatment of affective disorders
    Inga Herpfer
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    World J Biol Psychiatry 4:56-63. 2003
    ..Key words: substance P, neurokinin1-receptor, affective disorders, depression, review...
  47. ncbi request reprint Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study
    Ludger Tebartz van Elst
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    Biol Psychiatry 54:163-71. 2003
    ..We measured limbic and prefrontal brain volumes to test the hypothesis that frontolimbic brain pathology might be associated with borderline personality disorder...
  48. ncbi request reprint Borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Lancet 364:453-61. 2004
    ..Current strategies are focusing on the neurobiological underpinnings of the disorder and the development and dissemination of better and more cost-effective treatments to clinicians...
  49. ncbi request reprint Increased diurnal salivary cortisol in women with borderline personality disorder
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    J Psychiatr Res 38:559-65. 2004
    ..Increased adrenal activity and lowered feedback sensitivity of the HPA-axis may characterise BPD. Further studies have to reveal reasons of heightened adrenal activity in these patients...
  50. ncbi request reprint Increased delta power and discrepancies in objective and subjective sleep measurements in borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Haupt strasse 5, 79104 Freiburg, Germany
    J Psychiatr Res 39:489-98. 2005
    ..Earlier findings in sleep EEG abnormalities in BPD may have been confounded by concomitant depressive symptoms...
  51. ncbi request reprint The impact of posttraumatic stress disorder on dysfunctional implicit and explicit emotions among women with borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    J Nerv Ment Dis 195:537-9. 2007
    ..Self-reported guilt proneness and implicit anxiety may mediate the negative impact of comorbid PTSD on women with BPD...
  52. ncbi request reprint Clonidine in acute aversive inner tension and self-injurious behavior in female patients with borderline personality disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    J Clin Psychiatry 65:1414-9. 2004
    ....
  53. ncbi request reprint Shame and implicit self-concept in women with borderline personality disorder
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Am J Psychiatry 164:500-8. 2007
    ....
  54. ncbi request reprint Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential
    Inga Herpfer
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    CNS Drugs 19:275-93. 2005
    ..These compounds may be more efficacious in antagonising the effects of SP than compounds that only block the NK1R...
  55. ncbi request reprint No modulatory effect of neurokinin-1 receptor antagonists on serotonin uptake in human and rat brain synaptosomes
    Klaus Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
    Eur Neuropsychopharmacol 15:641-6. 2005
    ..These results show that in humans, as in rodents, inhibition of the 5-HT transporter is probably not the underlying mechanism of the assumed antidepressant activity of NK-1-RA...
  56. ncbi request reprint Self-stigma, empowerment, and perceived legitimacy of discrimination among women with mental illness
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    Psychiatr Serv 57:399-402. 2006
    ..The authors hypothesized that a high level of perceived discrimination, little sense of identification with the group of people with mental illness, and a high level of perceived legitimacy of discrimination lead to self-stigma...
  57. ncbi request reprint Measuring shame and guilt by self-report questionnaires: a validation study
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Psychiatry Res 150:313-25. 2007
    ..The discriminant validity of the TOSCA-3 to distinguish between shame- and guilt-proneness may be diminished in clinical samples. The measure of state shame (ESS) showed a large overlap with state anxiety...
  58. ncbi request reprint Elevated pain thresholds correlate with dissociation and aversive arousal in patients with borderline personality disorder
    Petra Ludäscher
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Psychiatry Res 149:291-6. 2007
    ..Measuring electric pain thresholds is a valid and reasonable method for larger studies...
  59. ncbi request reprint Self-stigma in women with borderline personality disorder and women with social phobia
    NICOLAS RUSCH
    Department of Psychiatry and Psychotherapy, University of Freiburg, Germany
    J Nerv Ment Dis 194:766-73. 2006
    ..This may reflect intense labeling processes as being mentally ill due to repeated hospitalizations, frequent interpersonal difficulties, and visible scars...