Klaus Lieb

..Many patients with borderline personality disorder receive pharmacological treatment, but there is uncertainty about the usefulness of such therapies...

..A further goal is to determine whether alternatives to current practices can be envisioned...

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..We believe that our approach provides a promising tool to assess the integrity of specific structural connections in patients with neuropsychiatric disorders...

..This has to be confirmed in further investigations. This article is part of a Special Issue entitled 'Anxiety and Depression'...

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..Experiential avoidance and anxiety may be associated with dropout in inpatient DBT. Low life-time suicidality and high anger could reflect a subtype at risk for discontinuation of inpatient treatment...

..Females with ADHD and BPD share more clinical features than males. However, symptoms of self-destruction and affect dysregulation appear to be more severe in BPD patients...

..In order to better understand the physiological role of the amygdala in modulating aggressive behaviour we investigated the relationship between amygdala volumes and lifetime aggression in healthy subjects...

..Peripheral blood markers and executive functions are particularly promising candidates as markers for the onset of action and thus the prediction of final treatment outcome in MDD...

..If replicated, this combined marker could be considered useful for prospective confirmatory trials in patients with MDD...

..This result shows the need for well-directed and differentiated information to prevent the potentially harmful use of illicit or prescription stimulants for CE...

..The trial is funded by the German Federal Ministry of Research and Education (01GV0606) and is part of the German network for the treatment of ADHD in children and adults (ADHD-NET)...

..Extreme negative affectivity may be a more appropriate description of BPD-related emotional problems than emotional hyperreactivity...

..Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients...

..Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD...

..In recent years, several disorder-specific interventions have been developed. This is an update of a review published in the Cochrane Database of Systematic Reviews in 2006...

..Even more important, non-improvement (HAMD decrease <20%) after 14 days of treatment was found to be highly predictive for a poor final treatment outcome...

..In this study we compared the effect of different emotion regulation strategies on positive and negative emotions in patients with borderline personality disorder...

..76 and 0.89 and between 0.86 and 0.94, respectively. Because of their identical difficulty and high reliability, the herein described versions of the TMT A and B are suitable for sequential testing of executive functioning...

..However, previous clinical and experimental studies investigating impulsivity in BPD rendered mixed results. In this study, impulsivity was assessed by self-report scales and behavioral inhibition tasks to compare different data levels...

..Aim of this pilot study was to characterize students in Germany who use methylphenidate (MPH) and/or amphetamines (AMPH) for PN...

..Results showed a greater improvement in self-esteem in the intervention group. The findings suggest that the therapy module is an effective adjunctive treatment in increasing self-esteem in BPD...

..Furthermore, it was intended to further the knowledge about associations between different self-reported impulsivity components and different smoking variables...

..We have analysed in more severely depressed inpatients treated with antidepressants i) the predictive value of early improvement for later response and ii) the impact of additional psychotherapy on the time course of response...

..Our results suggest the involvement of extrastriatal dopaminergic neurotransmission in venturesomeness, a component of impulsivity...

..In sum, although basic mechanisms of impulse control seem not to be disturbed in BPD, clinically well observed impulsive behaviors may be explained by comorbid ADHD or may be the consequence of dysregulation of BPD salient emotions...

..The interaction between antidepressant effects of TSD and alterations of cytokines warrants further investigation...

..Borderline personality disorder (BPD) is associated with structural and functional brain changes. Recent models and findings refer to alterations of glutamate and total N-acetylaspartate (tNAA) in this condition...

..In sum, although basic mechanisms of impulse control seem not to be disturbed in BPD, clinically well observed impulsive behaviors may be explained by comorbid ADHD or may be the consequence of dysregulation of BPD salient emotions...

..However, prospective longitudinal studies investigating volumes in hippocampal subregions and their association with clinical findings are still lacking...

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..As a growing body of evidence suggests that brain plasticity is disturbed in affective disorders, we examined the short-term and remote effects of early life stress on different forms of brain plasticity...

..To estimate the 12-month prevalence of cognitive-enhancing drug use...

..On the other hand, serious life events (SLE) are of major importance in the development of BPD. However, the inter-relations between SLEs, impulsivity, and 5-HTTLPR are not understood...

..Clinical experience suggests that people with borderline personality disorder often meet criteria for attention-deficit hyperactivity disorder (ADHD). However, empirical data are sparse...

..The BPD group showed also stronger negative emotions over the whole experiment. The study is the first to demonstrate prolonged anger reactions in BPD patients in an experimental setting...

..Measuring electric pain thresholds is a valid and reasonable method for larger studies...

..Self-reported guilt proneness and implicit anxiety may mediate the negative impact of comorbid PTSD on women with BPD...

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..Key words: substance P, neurokinin1-receptor, affective disorders, depression, review...

..These results show that in humans, as in rodents, inhibition of the 5-HT transporter is probably not the underlying mechanism of the assumed antidepressant activity of NK-1-RA...

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..Current strategies are focusing on the neurobiological underpinnings of the disorder and the development and dissemination of better and more cost-effective treatments to clinicians...

..Increased adrenal activity and lowered feedback sensitivity of the HPA-axis may characterise BPD. Further studies have to reveal reasons of heightened adrenal activity in these patients...

..The discriminant validity of the TOSCA-3 to distinguish between shame- and guilt-proneness may be diminished in clinical samples. The measure of state shame (ESS) showed a large overlap with state anxiety...

..Further placebo-controlled studies with larger populations are needed to confirm this finding...

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..Earlier findings in sleep EEG abnormalities in BPD may have been confounded by concomitant depressive symptoms...

..The authors hypothesized that a high level of perceived discrimination, little sense of identification with the group of people with mental illness, and a high level of perceived legitimacy of discrimination lead to self-stigma...

..This may reflect intense labeling processes as being mentally ill due to repeated hospitalizations, frequent interpersonal difficulties, and visible scars...

..These compounds may be more efficacious in antagonising the effects of SP than compounds that only block the NK1R...