Klaus Peter Lesch

Summary

Country: Germany

Publications

  1. doi request reprint Dances with black widow spiders: dysregulation of glutamate signalling enters centre stage in ADHD
    K P Lesch
    Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, ADHD Clinical Research Network, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Neuropsychopharmacol 23:479-91. 2013
  2. doi request reprint Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders
    Klaus Peter Lesch
    Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, ADHD Clinical Research Network, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Neuron 76:175-91. 2012
  3. pmc Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour
    Klaus Peter Lesch
    Division of Molecular Psychiatry MP, Laboratory of Translational Neuroscience LTN, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Philos Trans R Soc Lond B Biol Sci 367:2426-43. 2012
  4. pmc Gene-environment interaction and the genetics of depression
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychiatry Neurosci 29:174-84. 2004
  5. ncbi request reprint Pharmacogenetics of the serotonin transporter
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1062-73. 2005
  6. doi request reprint Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
    K P Lesch
    ADHD Clinical Research Network, Unit for Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 16:491-503. 2011
  7. ncbi request reprint Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics
    Klaus Peter Lesch
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 7:381-5. 2004
  8. ncbi request reprint Anxiety-related traits in mice with modified genes of the serotonergic pathway
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Eur J Pharmacol 480:185-204. 2003
  9. doi request reprint Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
  10. ncbi request reprint Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 106:1223-30. 1999

Collaborators

Detail Information

Publications122 found, 100 shown here

  1. doi request reprint Dances with black widow spiders: dysregulation of glutamate signalling enters centre stage in ADHD
    K P Lesch
    Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, ADHD Clinical Research Network, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Neuropsychopharmacol 23:479-91. 2013
    ....
  2. doi request reprint Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders
    Klaus Peter Lesch
    Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, ADHD Clinical Research Network, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Neuron 76:175-91. 2012
    ....
  3. pmc Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour
    Klaus Peter Lesch
    Division of Molecular Psychiatry MP, Laboratory of Translational Neuroscience LTN, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Philos Trans R Soc Lond B Biol Sci 367:2426-43. 2012
    ..Mouse models in conjunction with approaches focusing on TPH2 variants in humans provide unexpected views of 5-HT's role in brain development and in disorders related to negative emotionality, aggression and antisocial behaviour...
  4. pmc Gene-environment interaction and the genetics of depression
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychiatry Neurosci 29:174-84. 2004
    ..Given the etiologic and psychobiologic complexity of mood disorders, it is not surprising that the identification of specific genetic factors is extremely difficult and continues to be among the last frontiers of gene hunting...
  5. ncbi request reprint Pharmacogenetics of the serotonin transporter
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1062-73. 2005
    ....
  6. doi request reprint Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
    K P Lesch
    ADHD Clinical Research Network, Unit for Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 16:491-503. 2011
    ..These findings implicate CNVs of behaviour-related genes in the pathogenesis of ADHD and are consistent with the notion that both frequent and rare variants influence the development of this common multifactorial syndrome...
  7. ncbi request reprint Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics
    Klaus Peter Lesch
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 7:381-5. 2004
    ....
  8. ncbi request reprint Anxiety-related traits in mice with modified genes of the serotonergic pathway
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Eur J Pharmacol 480:185-204. 2003
    ..Finally, we attempt to identify future directions of genetic manipulation in animal models to advance our understanding of brain dysregulation characteristic of anxiety disorders...
  9. doi request reprint Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
    ..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability...
  10. ncbi request reprint Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 106:1223-30. 1999
    ..The findings confirm that the pericentric region of human chromosome 17 is highly unstable and furnishs additional evidence for intricate complexity of 5HTT regulation under physiological condition and in disease...
  11. ncbi request reprint Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link?
    Klaus Peter Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, Germany
    Eur J Pharmacol 526:113-24. 2005
    ..These new developments have broad implications for our understanding how genetic vulnerability to alcohol dependence is manifested in the brain's response to emotional stimuli...
  12. ncbi request reprint Antidepressants and gene expression profiling: how to SNARE novel drug targets
    K P Lesch
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Pharmacogenomics J 2:346-8. 2002
  13. ncbi request reprint Impulsivity, aggression, and serotonin: a molecular psychobiological perspective
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Behav Sci Law 18:581-604. 2000
    ....
  14. ncbi request reprint Serotonergic gene expression and depression: implications for developing novel antidepressants
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    J Affect Disord 62:57-76. 2001
    ....
  15. ncbi request reprint Molecular foundation of anxiety disorders
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 108:717-46. 2001
    ..Integration of these emerging tools and technologies for genetic analysis will provide the groundwork for an advanced stage of gene identification and functional studies in anxiety and related disorders...
  16. ncbi request reprint Variation of serotonergic gene expression: neurodevelopment and the complexity of response to psychopharmacologic drugs
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Germany
    Eur Neuropsychopharmacol 11:457-74. 2001
    ....
  17. ncbi request reprint Mouse anxiety: the power of knockout
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Pharmacogenomics J 1:187-92. 2001
    ....
  18. doi request reprint When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience
    Klaus Peter Lesch
    Molecular Psychiatry, ADHD Clinical Research Network, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Curr Top Behav Neurosci 7:251-80. 2011
    ....
  19. pmc Linking emotion to the social brain. The role of the serotonin transporter in human social behaviour
    Klaus Peter Lesch
    Department of Psychiatry and Psychotherapy, Molecular and Clinical Psychobiology, University of Wurzburg, Germany
    EMBO Rep 8:S24-9. 2007
  20. doi request reprint COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control
    Sebastian Heinzel
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Cereb Cortex 23:1453-62. 2013
    ..Our findings might help to disentangle the genetic basis of dopaminergic mechanisms underlying prefrontal (dys)function...
  21. ncbi request reprint Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 10:309-20. 2007
    ..These findings implicate alterations of 5-HT synthesis in emotion regulation and confirm TPH2 as a susceptibility and/or modifier gene of affective spectrum disorders...
  22. doi request reprint A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:317-26. 2010
    ..Further replication studies, however, are necessary to validate the apparent complexity of G x E interactions in disorders of human personality...
  23. doi request reprint Affect-modulated startle reflex and dopamine D4 receptor gene variation
    Paul Pauli
    Department of Psychology, Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Psychophysiology 47:25-33. 2010
    ..Results speak for the importance of the DRD4 polymorphism in modulating emotional responses and also for the usefulness of the affect-modulated ASR as an endophenotype...
  24. doi request reprint Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Arch Gen Psychiatry 66:41-50. 2009
    ..Although rodent data suggest that the neuronal isoform of nitric oxide synthase (NOS-I) modifies diverse behaviors including aggression, this has not been translated to human studies...
  25. doi request reprint Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD)
    Andreas J Fallgatter
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany
    Eur Neuropsychopharmacol 23:458-68. 2013
    ..The results of our study further strengthen the concept of an LPHN3 risk haplotype for ADHD and support the usefulness of the endophenotype approach in psychiatric and psychological research...
  26. doi request reprint Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
    Tim Hahn
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Hum Brain Mapp 32:1557-65. 2011
    ....
  27. ncbi request reprint Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disorders
    Ann Christine Ehlis
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 32:162-70. 2007
    ..These results indicate that COMT genotype exerts a strong impact on prefrontal functioning and executive control in schizophrenia spectrum disorders...
  28. ncbi request reprint Absence of thermal hyperalgesia in serotonin transporter-deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 23:708-15. 2003
    ..In contrast, bilateral mechanical allodynia, a centrally mediated phenomenon, was associated with decreased spinal 5-HT concentrations in 5-HTT-/- mice and may possibly be caused by a lack of spinal inhibition...
  29. pmc Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD
    Thomas Dresler
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 35:2193-202. 2010
    ....
  30. doi request reprint Reduced NoGo-anteriorisation during continuous performance test in deletion syndrome 22q11.2
    Marcel Romanos
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinic of Wuerzburg, Fuechsleinstrasse 15, 97074 Wuerzburg, Germany
    J Psychiatr Res 44:768-74. 2010
    ..Despite recent reports of structural alterations of the ACC in DS22q11.2 our findings suggest that response-inhibition mediated by the ACC is not impaired in DS22q11.2...
  31. ncbi request reprint Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1127-32. 2008
    ..The findings confirm the exclusive specificity of Tph2 in brain 5-HT synthesis and suggest that Tph2-synthesized 5-HT is not required for serotonergic neuron formation...
  32. ncbi request reprint Allelic variation of serotonin transporter function modulates the brain electrical response for error processing
    Andreas J Fallgatter
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    Neuropsychopharmacology 29:1506-11. 2004
    ....
  33. doi request reprint A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophrenia
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University Würzburg, Germany
    Int J Neuropsychopharmacol 14:887-97. 2011
    ..Our fNIRS data extend previous studies suggesting disturbed prefrontal functioning in schizophrenia and suggest that genetic variation of NOS1 has a role in cognitive dysfunction, probably by mediating glutamatergic tone...
  34. doi request reprint Early attentional deficits in an attention-to-prepulse paradigm in ADHD adults
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology and Psychotherapy, University of Wurzburg, Marcusstr 9 11, 97070 Wurzburg, Germany
    J Abnorm Psychol 119:594-603. 2010
    ..Attention deficits in ADHD patients may reflect not general derangements in information processing or ability to attend but, rather, selective disturbances of controlled attention during early information processing...
  35. ncbi request reprint Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women
    Katharina Domschke
    Department of Psychiatry, University of Munster, Germany
    Int J Neuropsychopharmacol 7:183-8. 2004
    ..Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women...
  36. pmc Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions
    Daniel Louis Albert van den Hove
    Institute of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 6:e22715. 2011
    ..Moreover, hippocampal gene expression profiles suggest that distinct molecular mechanisms mediate the behavioral effects of the 5-Htt genotype, PS exposure, and their interaction...
  37. pmc DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders
    Andreas Reif
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2318-27. 2011
    ..031). Additional SNPs showed association with personality scores (p=0.008-0.048). Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders...
  38. ncbi request reprint A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 9:13-20. 2006
    ..Our results thus suggest that the NOS-III genotype may convey a modest genetic risk to develop bipolar disorder. This finding should be further clarified by the use of within-family designs and in samples of other ethnicity...
  39. doi request reprint Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
    Claudia Kriegebaum
    Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University of Wurzburg, Wurzburg, Germany
    Neurochem Int 57:512-7. 2010
    ..The formation of the serotonergic system thus seems to be a preserved expressional pattern due to intrinsic cellular programs which occurs also in the absence of its key molecule, namely 5-HT...
  40. doi request reprint KCNIP4 as a candidate gene for personality disorders and adult ADHD
    Lena Weißflog
    Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Eur Neuropsychopharmacol 23:436-47. 2013
    ..0079 to 0.049). Seven markers within the KCNIP4 gene showed an association with PD (p values from 0.0043 to 0.0437). The results of these studies suggest a role of KCNIP4 in the etiology of ADHD, PD and other co-morbid disorders...
  41. doi request reprint Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: an event-related potential study
    Ann Christine Ehlis
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:291-302. 2011
    ....
  42. doi request reprint The expression of the transcription factor FEV in adult human brain and its association with affective disorders
    Claudia B Kriegebaum
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    J Neural Transm 117:831-6. 2010
    ..FEV therefore might not account for the genetic risk towards depression or bipolar disorder. Furthermore, the specificity of FEV for the serotonergic system should be reconsidered...
  43. ncbi request reprint Rare variants of the gene encoding the potassium chloride co-transporter 3 are associated with bipolar disorder
    Jobst Meyer
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    Int J Neuropsychopharmacol 8:495-504. 2005
    ..Our data strongly suggest that rare variants of SLC12A6 may represent risk factors for bipolar disorder...
  44. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  45. doi request reprint Methylphenidate normalizes emotional processing in adult patients with attention-deficit/hyperactivity disorder: preliminary findings
    Annette Conzelmann
    Department of Psychology, Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Germany
    Brain Res 1381:159-66. 2011
    ..The data suggest that MPH as first choice treatment in ADHD has a positive impact on emotional processes in adult ADHD patients and points to the clinical relevance of emotional-dysfunctions in ADHD...
  46. doi request reprint The COGITAT holeboard system as a valuable tool to assess learning, memory and activity in mice
    Antonia M Post
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Behav Brain Res 220:152-8. 2011
    ..Overall, our data indicate that this spatial learning task will be useful to characterize spatial memory in various genetic or pharmacological mouse models...
  47. ncbi request reprint Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models
    Naozumi Araragi
    Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, Wurzburg, Germany
    Curr Drug Targets 14:549-70. 2013
    ..Finally, effects of therapeutic drugs and psychoactive drugs on KO mouse models as well as on synaptic plasticity will be discussed...
  48. ncbi request reprint Mutational analysis of the connexin 36 gene (CX36) and exclusion of the coding sequence as a candidate region for catatonic schizophrenia in a large pedigree
    Jobst Meyer
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, D 97080 Wurzburg, Germany
    Schizophr Res 58:87-91. 2002
    ..No variant exclusively cosegregates with the disease in a large pedigree that mainly supports the chromosome 15q14 locus, providing evidence that CX36 is not causative for the pathogenesis of catatonic schizophrenia in this family...
  49. ncbi request reprint MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophrenia
    Sandra Selch
    Department of Psychiatry and Psychotherapy Molecular and Clinical Psychobiology, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 61:1211-4. 2007
    ....
  50. pmc Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2076-85. 2011
    ..We demonstrate an association of DGKH with BPD, UPD, and aADHD by applying a two-stage design. These disorders share the feature of mood instability, so that this phenotype might be associated with genetic variation in DGKH...
  51. ncbi request reprint Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007
    ..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center...
  52. ncbi request reprint Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing
    Martin J Herrmann
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Cereb Cortex 17:1160-3. 2007
    ....
  53. pmc Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study
    Olga Rivero
    Unit of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 5:e12254. 2010
    ..To further investigate the contribution of AHI1 to the susceptibility of schizophrenia, we evaluated the effect of AHI1 variation on the vulnerability to psychosis in two samples from Spain and Germany...
  54. ncbi request reprint Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia
    Claus Jürgen Scholz
    IZKF Laboratory for Microarray Applications, University of Wurzburg, Wurzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:967-72. 2010
    ..Similar phenomena might also occur in other risk genes for both BPD and SCZ, providing a molecular basis for the genetic overlap of both entities...
  55. doi request reprint Autonomic hypoactivity in boys with attention-deficit/hyperactivity disorder and the influence of methylphenidate
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Germany
    World J Biol Psychiatry 15:56-65. 2014
    ..In addition, effects of methylphenidate (MPH) are examined. We further assessed whether this hypoarousal is a stable characteristic or ameliorated by arousing emotional stimuli...
  56. pmc Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification
    Lise Gutknecht
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 7:e43157. 2012
    ....
  57. ncbi request reprint Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF
    Sabrina Fritzen
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy Josef Schneider Str 11, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Mol Cell Neurosci 35:261-71. 2007
    ..Together, these results emphasize the important role of the different NOS isoforms with respect to adult neurogenesis...
  58. ncbi request reprint Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C
    Michael R Kraus
    Medizinische Klinik und Poliklinik II, Department of Gastroenterology and Hepatology, University of Wurzburg, Wurzburg, Germany
    Gastroenterology 132:1279-86. 2007
    ..Interferon-induced depression is a major complication in antiviral therapy of chronic hepatitis C. Little is known about underlying mechanisms and reliable predictive factors associated with cytokine-induced depressive symptoms...
  59. ncbi request reprint Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 32:2375-83. 2007
    ..These findings indicate complex interactions between genetic variation of the serotonergic circuitry and environmental factors arguing against simplistic, mono-causal explanations of violent behavior...
  60. ncbi request reprint Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  61. ncbi request reprint The brain-specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain
    Angelika Schmitt
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Glia 44:283-95. 2003
    ..Detailed information on Mlc1 expression in brain is likely to lead to a better understanding of Mlc1 involvement in the pathogenesis of both MLC and catatonic schizophrenia...
  62. ncbi request reprint Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia
    Claudia Rothe
    Department of Psychiatry, University of Munster, Germany
    Int J Neuropsychopharmacol 7:189-92. 2004
    ..03, n=101). In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia...
  63. pmc A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Marcusstr 9 11, 97070 Wurzburg, Germany
    Psychopharmacology (Berl) 224:573-9. 2012
    ..However, the association of eCB system with emotional-motivational reactivity is complex and bidirectional due to upcoming compensatory processes...
  64. doi request reprint Gene-environment interaction influences anxiety-like behavior in ethologically based mouse models
    Antonia M Post
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Behav Brain Res 218:99-105. 2011
    ..These results challenge the comparability of not sufficiently standardized tests of anxiety-like behavior and emphasize the need for controlling environmental variables in behavioral phenotyping...
  65. doi request reprint Integrating neurobiological markers of depression
    Tim Hahn
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Wuerzburg, Germany
    Arch Gen Psychiatry 68:361-8. 2011
    ..However, current classification approaches are mainly based on data from a single biomarker, making it difficult to predict disorders characterized by complex patterns of symptoms...
  66. doi request reprint Functional amygdala-hippocampus connectivity during anticipation of aversive events is associated with Gray's trait "sensitivity to punishment"
    Tim Hahn
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychophysiology and Functional Imaging, University Hospital Wuerzburg, Germany
    Biol Psychiatry 68:459-64. 2010
    ....
  67. ncbi request reprint Structural and functional characterization of the human PAX7 5'-flanking regulatory region
    Yana V Syagailo
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Gene 294:259-68. 2002
    ....
  68. pmc A novel approach to probabilistic biomarker-based classification using functional near-infrared spectroscopy
    Tim Hahn
    Department of Cognitive Psychology II, Johann Wolfgang Goethe University Frankfurt Main, Frankfurt am Main, Germany
    Hum Brain Mapp 34:1102-14. 2013
    ..In addition, our approach can easily compensate for variable class priors, which is highly advantageous in making predictions in a wide range of clinical neuroimaging applications...
  69. ncbi request reprint A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine
    Rainald Mossner
    Department of Psychiatry, University of Wurzburg, Germany
    Headache 45:132-6. 2005
    ..Objective: The present study is designed to further elucidate the molecular genetic basis of migraine with and without aura...
  70. doi request reprint Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective
    Jonas Waider
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Psychoneuroendocrinology 36:393-405. 2011
    ....
  71. doi request reprint A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Psychopharmacology (Berl) 214:239-48. 2011
    ..In line with this, we have previously shown that a functional promoter polymorphism of NOS1, termed NOS1 ex1f-VNTR, is associated with impulsivity-related traits and related disorders...
  72. ncbi request reprint Altered functioning of the cingulate gyrus in two cases of chromosome 22q11 deletion syndrome
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuechsleinstr 15, D 97080 Wuerzburg, Germany
    Psychiatry Res 132:273-8. 2004
    ..We conclude that more extensive study of NoGo anteriorisation as a potential endophenotype of 22q11-DS patients at risk for 22q11-associated psychiatric conditions is warranted...
  73. doi request reprint Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter
    Florian Palm
    Department of Neurology, University of Wurzburg, Neurologische Klinik der Universität, D 97080 Wurzburg, Germany
    Eur J Pain 12:790-7. 2008
    ..Human variants of the 5-HTT genotypes might be part of the factors determining the extent of nerve injury and hyperalgesia in inflammation...
  74. ncbi request reprint Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits
    Regina Hünnerkopf
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 32:2552-60. 2007
    ..Our results support the notion that allelic variation at the BDNF locus--in interaction with other gene variants--influences anxiety- and depression-related personality traits...
  75. pmc 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg 97080, Germany
    Mol Pain 7:21. 2011
    ..Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain thresholds...
  76. doi request reprint Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy
    Niels Hansen
    Department of Neurology, University of Wurzburg, Josef Schneider Straße 11, 97080 Wurzburg, Germany
    Neurosci Lett 495:93-7. 2011
    ..Conversely, attenuation of mechanical allodynia in 5-HTT-/- mice may indicate reduced 5-HT-mediated facilitation in the central nervous system...
  77. ncbi request reprint Toward a molecular architecture of personality
    Andreas Reif
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuchsleinstr 15, 97080, Wuerzburg, Germany
    Behav Brain Res 139:1-20. 2003
    ..The findings converge on the notion that a probabilistic rather than deterministic impact of genes on the expression of behavior will contribute to the demystification of behavioral disorders...
  78. ncbi request reprint Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1162-8. 2005
    ..In conclusion, we suggest that in females homocysteinemia is an unspecific risk factor for organic brain disorders like dementia, and possibly depression, but not for schizophrenia...
  79. ncbi request reprint Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity
    Christian P Jacob
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 30:1711-8. 2005
    ..Our findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits...
  80. doi request reprint Panic disorder and a possible treatment approach by means of high-frequency rTMS: a case report
    Thomas Dresler
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
    World J Biol Psychiatry 10:991-7. 2009
    ....
  81. doi request reprint Catechol-O-methyltransferase Val158Met genotype affects neural correlates of aversive stimuli processing
    Martin J Herrmann
    Department of Psychiatry, Psychosomatics, and PsychotherapyUniversity of Würzburg, Wurzburg, Germany
    Cogn Affect Behav Neurosci 9:168-72. 2009
    ..Specifically, Met/Met carriers respond more sensitively to unpleasant stimuli, as compared with Val/Val carriers. We did not find evidence that life stress moderates the effect of the COMT genotype on emotional stimuli processing...
  82. doi request reprint Neural response to reward anticipation is modulated by Gray's impulsivity
    Tim Hahn
    University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany
    Neuroimage 46:1148-53. 2009
    ....
  83. doi request reprint Decreased anxiety in mice lacking the organic cation transporter 3
    Thomas Wultsch
    Section of Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 116:689-97. 2009
    ....
  84. ncbi request reprint Toxicity and metabolism of the chloral-derived mammalian alkaloid 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) in PC12 cells
    Gerhard Bringmann
    Institut fur Organische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Z Naturforsch C 61:601-10. 2006
    ....
  85. ncbi request reprint Neurogenesis and schizophrenia: dividing neurons in a divided mind?
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:290-9. 2007
    ..In conclusion, several lines of evidence suggest that reduced AN may contribute to the etiopathogenesis of schizophrenic disorders, whereas it does not seem to be a critical risk factor for affective disorders...
  86. ncbi request reprint 22q11.2 deletion syndrome as a natural model for COMT haploinsufficiency-related dopaminergic dysfunction in ADHD
    Andreas J Fallgatter
    Laboratory for Psychophysiology and Functional Imaging, Department for Psychiatry and Psychotherapy, University of Wuerzburg, Fuchsleinstrasse 15, 97080 Wuerzburg, Germany
    Int J Neuropsychopharmacol 10:295-9. 2007
  87. doi request reprint Neural hyporesponsiveness and hyperresponsiveness during immediate and delayed reward processing in adult attention-deficit/hyperactivity disorder
    Michael M Plichta
    Department of Psychiatry, Psychosomatics and Psychotherapy, Laboratory for Psychophysiology and Functional Imaging, Institute of Psychology, Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 65:7-14. 2009
    ..Dysfunctional reward processing, accompanied by a limited ability to tolerate reward delays, has been proposed as an important feature in attention-deficit/hyperactivity disorder (ADHD)...
  88. ncbi request reprint Aberrant accumulation of serotonin in dopaminergic neurons
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Neurosci Lett 401:49-54. 2006
    ..This provides a molecular rationale for improving antidepressant efficacy by additional pharmacological inhibition of the DAT...
  89. doi request reprint Analysis of the stathmin rs182455 single nucleotide promoter polymorphism in patients with multiple sclerosis
    Mathias Buttmann
    Neurologische Klinik, Julius Maximilians Universitat, Wurzburg, Germany
    J Neurogenet 22:181-6. 2008
    ..We conclude that despite potential importance of stathmin in the pathogenesis of MS, the rs182455 polymorphism does not influence MS susceptibility or clinical disease course...
  90. ncbi request reprint Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Eur Neuropsychopharmacol 19:266-82. 2009
    ..In conclusion, our findings indicate that brain 5-HT synthesis across the lifespan is exclusively maintained by TPH2...
  91. ncbi request reprint Unaltered susceptibility to scrapie in serotonin transporter deficient mice
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Neurochem Int 49:454-8. 2006
    ..These findings argue against a major role of the 5-HTT in the pathogenesis of prion diseases in mice...
  92. ncbi request reprint The Wuerzburg Research Initiative on Adult Attention-Deficit/Hyperactivity Disorder (WURIN-AADHD): multi-layered evaluation of long-term course
    Christian Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 256:i12-20. 2006
    ....
  93. doi request reprint Abnormal affective responsiveness in attention-deficit/hyperactivity disorder: subtype differences
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Marcusstrasse 9 11, Wurzburg, Germany
    Biol Psychiatry 65:578-85. 2009
    ..This study examined the affective modulation of the startle reflex in a large sample of ADHD patients. The aim was to compare subtypes of ADHD...
  94. ncbi request reprint Differential functional variability of serotonin transporter and monoamine oxidase a genes in macaque species displaying contrasting levels of aggression-related behavior
    Jens R Wendland
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, 97080, Wurzburg, Germany
    Behav Genet 36:163-72. 2006
    ..Taken together, these findings suggest that genetic variation of serotonergic neurotransmission may play an important role in determining inter-species differences in aggression related behavior in macaques...
  95. ncbi request reprint Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 21:833-6. 2007
    ..51 (95% CI 0.36-0.65). This argues against an involvement of the 5-HT(3A) receptor in the polygenic aetiology of early-onset OCD...
  96. ncbi request reprint Serotonergic gene inactivation in mice: models for anxiety and aggression?
    Klaus Peter Lesch
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Novartis Found Symp 268:111-40; discussion 140-6, 167-70. 2005
    ....
  97. ncbi request reprint Encephalopathy and myoclonus triggered by valproic acid
    Andreas Reif
    Department of Psychiatry, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:1061-3. 2004
    ..On VPA discontinuation, all symptoms vanished and EEG normalized. We thus suggest that direct VPA-induced encephalopathy in the absence of ammonemia does exist, in this case probably facilitated by psychotropic polypharmacy...
  98. ncbi request reprint Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter
    Dong Kyu Kim
    Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropharmacology 49:798-810. 2005
    ....
  99. ncbi request reprint Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP
    Prakasham Rumajogee
    Laboratoire de Neurobiologie des Signaux Intercellulaires, CNRS UMR 7101, Universite Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France
    Eur J Neurosci 19:937-44. 2004
    ....
  100. ncbi request reprint Serotonin transporter gene polymorphism (5-HTTLPR) and emotional response to auditory hallucinations in schizophrenia
    Julio Sanjuan
    Int J Neuropsychopharmacol 9:131-3. 2006
  101. ncbi request reprint Gender-dependent regulation of G-protein-gated inwardly rectifying potassium current in dorsal raphe neurons in knock-out mice devoid of the 5-hydroxytryptamine transporter
    Alexandre Julien Châu Loucif
    UMR 677, Inserm UPMC, NeuroPsychoPharmacologie, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    J Neurobiol 66:1475-88. 2006
    ..Accordingly, gender differences in central 5-HT neurotransmission appear to depend-at least in part-on sex-related variations in corresponding receptor-G protein signaling mechanisms...