Klaus Peter Lesch

Summary

Country: Germany

Publications

  1. ncbi Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders
    Klaus Peter Lesch
    Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, ADHD Clinical Research Network, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Neuron 76:175-91. 2012
  2. ncbi Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour
    Klaus Peter Lesch
    Division of Molecular Psychiatry MP, Laboratory of Translational Neuroscience LTN, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Philos Trans R Soc Lond B Biol Sci 367:2426-43. 2012
  3. ncbi Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 106:1223-30. 1999
  4. ncbi Linking emotion to the social brain. The role of the serotonin transporter in human social behaviour
    Klaus-Peter Lesch
    Department of Psychiatry and Psychotherapy, Molecular and Clinical Psychobiology, , Germany
    EMBO Rep 8:S24-9. 2007
  5. ncbi Gene-environment interaction and the genetics of depression
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychiatry Neurosci 29:174-84. 2004
  6. ncbi Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
  7. ncbi Pharmacogenetics of the serotonin transporter
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1062-73. 2005
  8. ncbi Anxiety-related traits in mice with modified genes of the serotonergic pathway
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Eur J Pharmacol 480:185-204. 2003
  9. ncbi Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link?
    Klaus Peter Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, Germany
    Eur J Pharmacol 526:113-24. 2005
  10. ncbi Antidepressants and gene expression profiling: how to SNARE novel drug targets
    K P Lesch
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, , , Germany
    Pharmacogenomics J 2:346-8. 2002

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders
    Klaus Peter Lesch
    Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, ADHD Clinical Research Network, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Neuron 76:175-91. 2012
    ....
  2. ncbi Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour
    Klaus Peter Lesch
    Division of Molecular Psychiatry MP, Laboratory of Translational Neuroscience LTN, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Philos Trans R Soc Lond B Biol Sci 367:2426-43. 2012
    ..Mouse models in conjunction with approaches focusing on TPH2 variants in humans provide unexpected views of 5-HT's role in brain development and in disorders related to negative emotionality, aggression and antisocial behaviour...
  3. ncbi Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 106:1223-30. 1999
    ..The findings confirm that the pericentric region of human chromosome 17 is highly unstable and furnishs additional evidence for intricate complexity of 5HTT regulation under physiological condition and in disease...
  4. ncbi Linking emotion to the social brain. The role of the serotonin transporter in human social behaviour
    Klaus-Peter Lesch
    Department of Psychiatry and Psychotherapy, Molecular and Clinical Psychobiology, , Germany
    EMBO Rep 8:S24-9. 2007
  5. ncbi Gene-environment interaction and the genetics of depression
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychiatry Neurosci 29:174-84. 2004
    ..Given the etiologic and psychobiologic complexity of mood disorders, it is not surprising that the identification of specific genetic factors is extremely difficult and continues to be among the last frontiers of gene hunting...
  6. ncbi Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
    ..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability...
  7. ncbi Pharmacogenetics of the serotonin transporter
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1062-73. 2005
    ....
  8. ncbi Anxiety-related traits in mice with modified genes of the serotonergic pathway
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Eur J Pharmacol 480:185-204. 2003
    ..Finally, we attempt to identify future directions of genetic manipulation in animal models to advance our understanding of brain dysregulation characteristic of anxiety disorders...
  9. ncbi Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link?
    Klaus Peter Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, Germany
    Eur J Pharmacol 526:113-24. 2005
    ..These new developments have broad implications for our understanding how genetic vulnerability to alcohol dependence is manifested in the brain's response to emotional stimuli...
  10. ncbi Antidepressants and gene expression profiling: how to SNARE novel drug targets
    K P Lesch
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, , , Germany
    Pharmacogenomics J 2:346-8. 2002
  11. ncbi Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
    K P Lesch
    ADHD Clinical Research Network, Unit for Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 16:491-503. 2011
    ..These findings implicate CNVs of behaviour-related genes in the pathogenesis of ADHD and are consistent with the notion that both frequent and rare variants influence the development of this common multifactorial syndrome...
  12. ncbi Impulsivity, aggression, and serotonin: a molecular psychobiological perspective
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Behav Sci Law 18:581-604. 2000
    ....
  13. ncbi Serotonergic gene expression and depression: implications for developing novel antidepressants
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    J Affect Disord 62:57-76. 2001
    ....
  14. ncbi Molecular foundation of anxiety disorders
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 108:717-46. 2001
    ..Integration of these emerging tools and technologies for genetic analysis will provide the groundwork for an advanced stage of gene identification and functional studies in anxiety and related disorders...
  15. ncbi Variation of serotonergic gene expression: neurodevelopment and the complexity of response to psychopharmacologic drugs
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Germany
    Eur Neuropsychopharmacol 11:457-74. 2001
    ....
  16. ncbi Mouse anxiety: the power of knockout
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Pharmacogenomics J 1:187-92. 2001
    ....
  17. ncbi Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics
    Klaus Peter Lesch
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 7:381-5. 2004
    ....
  18. ncbi When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience
    Klaus Peter Lesch
    Molecular Psychiatry, ADHD Clinical Research Network, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Curr Top Behav Neurosci 7:251-80. 2011
    ....
  19. ncbi Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 10:309-20. 2007
    ..These findings implicate alterations of 5-HT synthesis in emotion regulation and confirm TPH2 as a susceptibility and/or modifier gene of affective spectrum disorders...
  20. ncbi Affect-modulated startle reflex and dopamine D4 receptor gene variation
    Paul Pauli
    Department of Psychology, Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Psychophysiology 47:25-33. 2010
    ..Results speak for the importance of the DRD4 polymorphism in modulating emotional responses and also for the usefulness of the affect-modulated ASR as an endophenotype...
  21. ncbi A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:317-26. 2010
    ..Further replication studies, however, are necessary to validate the apparent complexity of G x E interactions in disorders of human personality...
  22. ncbi Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Arch Gen Psychiatry 66:41-50. 2009
    ..Although rodent data suggest that the neuronal isoform of nitric oxide synthase (NOS-I) modifies diverse behaviors including aggression, this has not been translated to human studies...
  23. ncbi Absence of thermal hyperalgesia in serotonin transporter-deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 23:708-15. 2003
    ..In contrast, bilateral mechanical allodynia, a centrally mediated phenomenon, was associated with decreased spinal 5-HT concentrations in 5-HTT-/- mice and may possibly be caused by a lack of spinal inhibition...
  24. ncbi Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
    Tim Hahn
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Hum Brain Mapp 32:1557-65. 2011
    ....
  25. ncbi Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disorders
    Ann Christine Ehlis
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 32:162-70. 2007
    ..These results indicate that COMT genotype exerts a strong impact on prefrontal functioning and executive control in schizophrenia spectrum disorders...
  26. ncbi Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD
    Thomas Dresler
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 35:2193-202. 2010
    ....
  27. ncbi Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1127-32. 2008
    ..The findings confirm the exclusive specificity of Tph2 in brain 5-HT synthesis and suggest that Tph2-synthesized 5-HT is not required for serotonergic neuron formation...
  28. ncbi Allelic variation of serotonin transporter function modulates the brain electrical response for error processing
    Andreas J Fallgatter
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    Neuropsychopharmacology 29:1506-11. 2004
    ....
  29. ncbi Reduced NoGo-anteriorisation during continuous performance test in deletion syndrome 22q11.2
    Marcel Romanos
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinic of Wuerzburg, Fuechsleinstrasse 15, 97074 Wuerzburg, Germany
    J Psychiatr Res 44:768-74. 2010
    ..Despite recent reports of structural alterations of the ACC in DS22q11.2 our findings suggest that response-inhibition mediated by the ACC is not impaired in DS22q11.2...
  30. ncbi Early attentional deficits in an attention-to-prepulse paradigm in ADHD adults
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology and Psychotherapy, University of Wurzburg, Marcusstr 9 11, 97070 Wurzburg, Germany
    J Abnorm Psychol 119:594-603. 2010
    ..Attention deficits in ADHD patients may reflect not general derangements in information processing or ability to attend but, rather, selective disturbances of controlled attention during early information processing...
  31. ncbi A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophrenia
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University Würzburg, Germany
    Int J Neuropsychopharmacol 14:887-97. 2011
    ..Our fNIRS data extend previous studies suggesting disturbed prefrontal functioning in schizophrenia and suggest that genetic variation of NOS1 has a role in cognitive dysfunction, probably by mediating glutamatergic tone...
  32. ncbi Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women
    Katharina Domschke
    Department of Psychiatry, University of Munster, Germany
    Int J Neuropsychopharmacol 7:183-8. 2004
    ..Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women...
  33. ncbi Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions
    Daniel Louis Albert van den Hove
    Institute of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 6:e22715. 2011
    ..Moreover, hippocampal gene expression profiles suggest that distinct molecular mechanisms mediate the behavioral effects of the 5-Htt genotype, PS exposure, and their interaction...
  34. ncbi DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders
    Andreas Reif
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2318-27. 2011
    ..031). Additional SNPs showed association with personality scores (p=0.008-0.048). Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders...
  35. ncbi Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
    Claudia Kriegebaum
    Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University of Wurzburg, Wurzburg, Germany
    Neurochem Int 57:512-7. 2010
    ..The formation of the serotonergic system thus seems to be a preserved expressional pattern due to intrinsic cellular programs which occurs also in the absence of its key molecule, namely 5-HT...
  36. ncbi A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 9:13-20. 2006
    ..Our results thus suggest that the NOS-III genotype may convey a modest genetic risk to develop bipolar disorder. This finding should be further clarified by the use of within-family designs and in samples of other ethnicity...
  37. ncbi Rare variants of the gene encoding the potassium chloride co-transporter 3 are associated with bipolar disorder
    Jobst Meyer
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    Int J Neuropsychopharmacol 8:495-504. 2005
    ..Our data strongly suggest that rare variants of SLC12A6 may represent risk factors for bipolar disorder...
  38. ncbi The expression of the transcription factor FEV in adult human brain and its association with affective disorders
    Claudia B Kriegebaum
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    J Neural Transm 117:831-6. 2010
    ..FEV therefore might not account for the genetic risk towards depression or bipolar disorder. Furthermore, the specificity of FEV for the serotonergic system should be reconsidered...
  39. ncbi Methylphenidate normalizes emotional processing in adult patients with attention-deficit/hyperactivity disorder: preliminary findings
    Annette Conzelmann
    Department of Psychology, Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Germany
    Brain Res 1381:159-66. 2011
    ..The data suggest that MPH as first choice treatment in ADHD has a positive impact on emotional processes in adult ADHD patients and points to the clinical relevance of emotional-dysfunctions in ADHD...
  40. ncbi Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  41. ncbi Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: an event-related potential study
    Ann Christine Ehlis
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:291-302. 2011
    ....
  42. ncbi MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophrenia
    Sandra Selch
    Department of Psychiatry and Psychotherapy Molecular and Clinical Psychobiology, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 61:1211-4. 2007
    ....
  43. ncbi Mutational analysis of the connexin 36 gene (CX36) and exclusion of the coding sequence as a candidate region for catatonic schizophrenia in a large pedigree
    Jobst Meyer
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, D 97080 Wurzburg, Germany
    Schizophr Res 58:87-91. 2002
    ..No variant exclusively cosegregates with the disease in a large pedigree that mainly supports the chromosome 15q14 locus, providing evidence that CX36 is not causative for the pathogenesis of catatonic schizophrenia in this family...
  44. ncbi Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 32:2375-83. 2007
    ..These findings indicate complex interactions between genetic variation of the serotonergic circuitry and environmental factors arguing against simplistic, mono-causal explanations of violent behavior...
  45. ncbi Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2076-85. 2011
    ..We demonstrate an association of DGKH with BPD, UPD, and aADHD by applying a two-stage design. These disorders share the feature of mood instability, so that this phenotype might be associated with genetic variation in DGKH...
  46. ncbi Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007
    ..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center...
  47. ncbi Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF
    Sabrina Fritzen
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy Josef Schneider Str 11, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Mol Cell Neurosci 35:261-71. 2007
    ..Together, these results emphasize the important role of the different NOS isoforms with respect to adult neurogenesis...
  48. ncbi Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C
    Michael R Kraus
    Medizinische Klinik und Poliklinik II, Department of Gastroenterology and Hepatology, University of Wurzburg, Wurzburg, Germany
    Gastroenterology 132:1279-86. 2007
    ..Interferon-induced depression is a major complication in antiviral therapy of chronic hepatitis C. Little is known about underlying mechanisms and reliable predictive factors associated with cytokine-induced depressive symptoms...
  49. ncbi The brain-specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain
    Angelika Schmitt
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Glia 44:283-95. 2003
    ..Detailed information on Mlc1 expression in brain is likely to lead to a better understanding of Mlc1 involvement in the pathogenesis of both MLC and catatonic schizophrenia...
  50. ncbi Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia
    Claudia Rothe
    Department of Psychiatry, University of Munster, Germany
    Int J Neuropsychopharmacol 7:189-92. 2004
    ..03, n=101). In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia...
  51. ncbi Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia
    Claus Jürgen Scholz
    IZKF Laboratory for Microarray Applications, University of Wurzburg, Wurzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:967-72. 2010
    ..Similar phenomena might also occur in other risk genes for both BPD and SCZ, providing a molecular basis for the genetic overlap of both entities...
  52. ncbi Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  53. ncbi Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study
    Olga Rivero
    Unit of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 5:e12254. 2010
    ..To further investigate the contribution of AHI1 to the susceptibility of schizophrenia, we evaluated the effect of AHI1 variation on the vulnerability to psychosis in two samples from Spain and Germany...
  54. ncbi Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing
    Martin J Herrmann
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Cereb Cortex 17:1160-3. 2007
    ....
  55. ncbi The COGITAT holeboard system as a valuable tool to assess learning, memory and activity in mice
    Antonia M Post
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Behav Brain Res 220:152-8. 2011
    ..Overall, our data indicate that this spatial learning task will be useful to characterize spatial memory in various genetic or pharmacological mouse models...
  56. ncbi Integrating neurobiological markers of depression
    Tim Hahn
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Wuerzburg, Germany
    Arch Gen Psychiatry 68:361-8. 2011
    ..However, current classification approaches are mainly based on data from a single biomarker, making it difficult to predict disorders characterized by complex patterns of symptoms...
  57. ncbi Functional amygdala-hippocampus connectivity during anticipation of aversive events is associated with Gray's trait "sensitivity to punishment"
    Tim Hahn
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychophysiology and Functional Imaging, University Hospital Wuerzburg, Germany
    Biol Psychiatry 68:459-64. 2010
    ....
  58. ncbi Gene-environment interaction influences anxiety-like behavior in ethologically based mouse models
    Antonia M Post
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Behav Brain Res 218:99-105. 2011
    ..These results challenge the comparability of not sufficiently standardized tests of anxiety-like behavior and emphasize the need for controlling environmental variables in behavioral phenotyping...
  59. ncbi Structural and functional characterization of the human PAX7 5'-flanking regulatory region
    Yana V Syagailo
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Gene 294:259-68. 2002
    ....
  60. ncbi A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine
    Rainald Mossner
    Department of Psychiatry, University of Wurzburg, Germany
    Headache 45:132-6. 2005
    ..Objective: The present study is designed to further elucidate the molecular genetic basis of migraine with and without aura...
  61. ncbi Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective
    Jonas Waider
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Psychoneuroendocrinology 36:393-405. 2011
    ....
  62. ncbi Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter
    Florian Palm
    Department of Neurology, University of Wurzburg, Neurologische Klinik der Universität, D 97080 Wurzburg, Germany
    Eur J Pain 12:790-7. 2008
    ..Human variants of the 5-HTT genotypes might be part of the factors determining the extent of nerve injury and hyperalgesia in inflammation...
  63. ncbi Altered functioning of the cingulate gyrus in two cases of chromosome 22q11 deletion syndrome
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuechsleinstr 15, D 97080 Wuerzburg, Germany
    Psychiatry Res 132:273-8. 2004
    ..We conclude that more extensive study of NoGo anteriorisation as a potential endophenotype of 22q11-DS patients at risk for 22q11-associated psychiatric conditions is warranted...
  64. ncbi A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Psychopharmacology (Berl) 214:239-48. 2011
    ..In line with this, we have previously shown that a functional promoter polymorphism of NOS1, termed NOS1 ex1f-VNTR, is associated with impulsivity-related traits and related disorders...
  65. ncbi Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits
    Regina Hünnerkopf
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 32:2552-60. 2007
    ..Our results support the notion that allelic variation at the BDNF locus--in interaction with other gene variants--influences anxiety- and depression-related personality traits...
  66. ncbi 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg 97080, Germany
    Mol Pain 7:21. 2011
    ..Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain thresholds...
  67. ncbi Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy
    Niels Hansen
    Department of Neurology, University of Wurzburg, Josef Schneider Straße 11, 97080 Wurzburg, Germany
    Neurosci Lett 495:93-7. 2011
    ..Conversely, attenuation of mechanical allodynia in 5-HTT-/- mice may indicate reduced 5-HT-mediated facilitation in the central nervous system...
  68. ncbi Toward a molecular architecture of personality
    Andreas Reif
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuchsleinstr 15, 97080, Wuerzburg, Germany
    Behav Brain Res 139:1-20. 2003
    ..The findings converge on the notion that a probabilistic rather than deterministic impact of genes on the expression of behavior will contribute to the demystification of behavioral disorders...
  69. ncbi Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1162-8. 2005
    ..In conclusion, we suggest that in females homocysteinemia is an unspecific risk factor for organic brain disorders like dementia, and possibly depression, but not for schizophrenia...
  70. ncbi Panic disorder and a possible treatment approach by means of high-frequency rTMS: a case report
    Thomas Dresler
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
    World J Biol Psychiatry 10:991-7. 2009
    ....
  71. ncbi Analysis of the stathmin rs182455 single nucleotide promoter polymorphism in patients with multiple sclerosis
    Mathias Buttmann
    Neurologische Klinik, Julius Maximilians Universitat, Wurzburg, Germany
    J Neurogenet 22:181-6. 2008
    ..We conclude that despite potential importance of stathmin in the pathogenesis of MS, the rs182455 polymorphism does not influence MS susceptibility or clinical disease course...
  72. ncbi Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Eur Neuropsychopharmacol 19:266-82. 2009
    ..In conclusion, our findings indicate that brain 5-HT synthesis across the lifespan is exclusively maintained by TPH2...
  73. ncbi Aberrant accumulation of serotonin in dopaminergic neurons
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Neurosci Lett 401:49-54. 2006
    ..This provides a molecular rationale for improving antidepressant efficacy by additional pharmacological inhibition of the DAT...
  74. ncbi Decreased anxiety in mice lacking the organic cation transporter 3
    Thomas Wultsch
    Section of Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 116:689-97. 2009
    ....
  75. ncbi Neural hyporesponsiveness and hyperresponsiveness during immediate and delayed reward processing in adult attention-deficit/hyperactivity disorder
    Michael M Plichta
    Department of Psychiatry, Psychosomatics and Psychotherapy, Laboratory for Psychophysiology and Functional Imaging, Institute of Psychology, Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 65:7-14. 2009
    ..Dysfunctional reward processing, accompanied by a limited ability to tolerate reward delays, has been proposed as an important feature in attention-deficit/hyperactivity disorder (ADHD)...
  76. ncbi Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity
    Christian P Jacob
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 30:1711-8. 2005
    ..Our findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits...
  77. ncbi Unaltered susceptibility to scrapie in serotonin transporter deficient mice
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Neurochem Int 49:454-8. 2006
    ..These findings argue against a major role of the 5-HTT in the pathogenesis of prion diseases in mice...
  78. ncbi Neurogenesis and schizophrenia: dividing neurons in a divided mind?
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:290-9. 2007
    ..In conclusion, several lines of evidence suggest that reduced AN may contribute to the etiopathogenesis of schizophrenic disorders, whereas it does not seem to be a critical risk factor for affective disorders...
  79. ncbi 22q11.2 deletion syndrome as a natural model for COMT haploinsufficiency-related dopaminergic dysfunction in ADHD
    Andreas J Fallgatter
    Laboratory for Psychophysiology and Functional Imaging, Department for Psychiatry and Psychotherapy, University of Wuerzburg, , 97080 Wuerzburg, Germany
    Int J Neuropsychopharmacol 10:295-9. 2007
  80. ncbi Catechol-O-methyltransferase Val158Met genotype affects neural correlates of aversive stimuli processing
    Martin J Herrmann
    Department of Psychiatry, Psychosomatics, and PsychotherapyUniversity of Würzburg, Wurzburg, Germany
    Cogn Affect Behav Neurosci 9:168-72. 2009
    ..Specifically, Met/Met carriers respond more sensitively to unpleasant stimuli, as compared with Val/Val carriers. We did not find evidence that life stress moderates the effect of the COMT genotype on emotional stimuli processing...
  81. ncbi Toxicity and metabolism of the chloral-derived mammalian alkaloid 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) in PC12 cells
    Gerhard Bringmann
    Institut fur Organische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Z Naturforsch C 61:601-10. 2006
    ....
  82. ncbi Neural response to reward anticipation is modulated by Gray's impulsivity
    Tim Hahn
    University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany
    Neuroimage 46:1148-53. 2009
    ....
  83. ncbi The Wuerzburg Research Initiative on Adult Attention-Deficit/Hyperactivity Disorder (WURIN-AADHD): multi-layered evaluation of long-term course
    Christian Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 256:i12-20. 2006
    ....
  84. ncbi Abnormal affective responsiveness in attention-deficit/hyperactivity disorder: subtype differences
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Marcusstrasse 9 11, Wurzburg, Germany
    Biol Psychiatry 65:578-85. 2009
    ..This study examined the affective modulation of the startle reflex in a large sample of ADHD patients. The aim was to compare subtypes of ADHD...
  85. ncbi Differential functional variability of serotonin transporter and monoamine oxidase a genes in macaque species displaying contrasting levels of aggression-related behavior
    Jens R Wendland
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, , 97080, , Germany
    Behav Genet 36:163-72. 2006
    ..Taken together, these findings suggest that genetic variation of serotonergic neurotransmission may play an important role in determining inter-species differences in aggression related behavior in macaques...
  86. ncbi Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 21:833-6. 2007
    ..51 (95% CI 0.36-0.65). This argues against an involvement of the 5-HT(3A) receptor in the polygenic aetiology of early-onset OCD...
  87. ncbi Encephalopathy and myoclonus triggered by valproic acid
    Andreas Reif
    Department of Psychiatry, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:1061-3. 2004
    ..On VPA discontinuation, all symptoms vanished and EEG normalized. We thus suggest that direct VPA-induced encephalopathy in the absence of ammonemia does exist, in this case probably facilitated by psychotropic polypharmacy...
  88. ncbi Serotonergic gene inactivation in mice: models for anxiety and aggression?
    Klaus Peter Lesch
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Novartis Found Symp 268:111-40; discussion 140-6, 167-70. 2005
    ....
  89. ncbi Serotonin transporter: gene, genetic disorders, and pharmacogenetics
    Dennis L Murphy
    Laboratory of Clinical Science, Building 10, Room 3D41, 10 Center Drive, MSC 1264, NIMH, NIH, Bethesda, MD 20892, USA
    Mol Interv 4:109-23. 2004
    ....
  90. ncbi Gender-dependent regulation of G-protein-gated inwardly rectifying potassium current in dorsal raphe neurons in knock-out mice devoid of the 5-hydroxytryptamine transporter
    Alexandre Julien Châu Loucif
    UMR 677, Inserm UPMC, NeuroPsychoPharmacologie, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    J Neurobiol 66:1475-88. 2006
    ..Accordingly, gender differences in central 5-HT neurotransmission appear to depend-at least in part-on sex-related variations in corresponding receptor-G protein signaling mechanisms...
  91. ncbi Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP
    Prakasham Rumajogee
    Laboratoire de Neurobiologie des Signaux Intercellulaires, CNRS UMR 7101, Universite Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France
    Eur J Neurosci 19:937-44. 2004
    ....
  92. ncbi Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter
    Saoussen Bouali
    INSERM U288, NeuroPsychoPharmacologie Moléculaire Cellulaire et Fonctionalle, France
    Eur J Neurosci 18:2203-12. 2003
    ..The differential effects of testosterone and estradiol on 5-HT1A-mediated control of 5-HT neurotransmission might be related to the well-established gender differences in the vulnerability to depression...
  93. ncbi Interaction of serotonergic and noradrenergic gene variants in panic disorder
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany
    Psychiatr Genet 16:59-65. 2006
    ....
  94. ncbi Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior
    Andrew Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:2077-88. 2003
    ..5-HTT null mutant mice provide a model to investigate the role of the 5-HTT in mood and anxiety disorders...
  95. ncbi 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice
    Jose Manuel Trigo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Biol Psychiatry 62:669-79. 2007
    ..The aim of the present study was to determine the contribution of the serotonin transporter (SERT) in MDMA self-administration behavior by using knockout (KO) mice deficient in SERT...
  96. ncbi Reduced programmed cell death in brains of serotonin transporter knockout mice
    Antonio M Persico
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Italy
    Neuroreport 14:341-4. 2003
    ....
  97. ncbi Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies
    Renee F Ren-Patterson
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892-1264, USA
    Cell Mol Neurobiol 26:755-80. 2006
    ....
  98. ncbi Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res 942:109-19. 2002
    ..This study also demonstrates that DA neurons can store 5-HT for possible "false neurotransmitter" or other usage...
  99. ncbi GABA(B) receptors in 5-HT transporter- and 5-HT1A receptor-knock-out mice: further evidence of a transduction pathway shared with 5-HT1A receptors
    Clotilde Mannoury La Cour
    INSERM U288, , Cellulaire et Fonctionnelle, , Paris, France
    J Neurochem 89:886-96. 2004
    ....
  100. ncbi Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters
    Hao-Wei Shen
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Neuropsychopharmacology 29:1790-9. 2004
    ..Cocaine-induced alterations in CPu DA levels in DAT-, SERT-, and DAT/SERT double-KO mice appear to provide better correlations with cocaine CPP than cocaine-induced DA level alterations in NAc or PFc...
  101. ncbi A pharmacological analysis of mice with a targeted disruption of the serotonin transporter
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3D41, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 195:147-66. 2007
    ..Partial or complete ablation of serotonin transporter (SERT) expression in mice leads to altered responses to serotonin receptor agonists and other classes of drugs...