K P Lesch

Summary

Country: Germany

Publications

  1. ncbi request reprint Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    K P Lesch
    Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Science 274:1527-31. 1996
  2. ncbi request reprint Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder
    J Deckert
    Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany, Istituto di Ricovero e Cura a Carattere Scientifico H San Raffaele, DSNP, Via Prinetti 29, 20127 Milan, Italy
    Hum Mol Genet 8:621-4. 1999
  3. pmc Splitting schizophrenia: periodic catatonia-susceptibility locus on chromosome 15q15
    G Stober
    1Department of Psychiatry and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Am J Hum Genet 67:1201-7. 2000
  4. ncbi request reprint Functional characterization of the murine serotonin transporter gene promoter in serotonergic raphe neurons
    A Heils
    Department of Psychiatry, University of Wurzburg, Germany
    J Neurochem 70:932-9. 1998
  5. ncbi request reprint Polymorphic MAO-A and 5-HT-transporter genes: analysis of interactions in panic disorder
    P Sand
    Department of Psychiatry, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    World J Biol Psychiatry 1:147-50. 2000
  6. ncbi request reprint Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene
    G Stober
    Department of Psychiatry, University of Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 248:82-6. 1998
  7. ncbi request reprint Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene
    A Heils
    Department of Psychiatry, University of Wurzburg, Germany
    J Neural Transm Gen Sect 102:247-54. 1995
  8. ncbi request reprint Linkage and family-based association study of schizophrenia and the synapsin III locus that maps to chromosome 22q13
    G Stober
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    Am J Med Genet 96:392-7. 2000
  9. doi request reprint No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample
    T J Renner
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Germany
    Atten Defic Hyperact Disord 3:285-9. 2011
  10. ncbi request reprint Allelic variation of human serotonin transporter gene expression
    A Heils
    Department of Psychiatry, University of Wurzburg, Germany
    J Neurochem 66:2621-4. 1996

Detail Information

Publications91

  1. ncbi request reprint Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    K P Lesch
    Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Science 274:1527-31. 1996
    ....
  2. ncbi request reprint Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder
    J Deckert
    Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany, Istituto di Ricovero e Cura a Carattere Scientifico H San Raffaele, DSNP, Via Prinetti 29, 20127 Milan, Italy
    Hum Mol Genet 8:621-4. 1999
    ....
  3. pmc Splitting schizophrenia: periodic catatonia-susceptibility locus on chromosome 15q15
    G Stober
    1Department of Psychiatry and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Am J Hum Genet 67:1201-7. 2000
    ..Our findings provide evidence that periodic catatonia is associated with a major disease locus, which maps to chromosome 15q15...
  4. ncbi request reprint Functional characterization of the murine serotonin transporter gene promoter in serotonergic raphe neurons
    A Heils
    Department of Psychiatry, University of Wurzburg, Germany
    J Neurochem 70:932-9. 1998
    ..Fusion of the 5-HTT gene promoter unit to a gene of choice may aid its cell-selective expression in transgenic strategies...
  5. ncbi request reprint Polymorphic MAO-A and 5-HT-transporter genes: analysis of interactions in panic disorder
    P Sand
    Department of Psychiatry, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    World J Biol Psychiatry 1:147-50. 2000
    ..There was no significant difference in odds ratios, suggesting that the observed increase of genetic liability by the long MAO-A gene promoter allele is not modified by the 5-HTT gene promoter polymorphism...
  6. ncbi request reprint Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene
    G Stober
    Department of Psychiatry, University of Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 248:82-6. 1998
    ..00004. Our findings indicate that both polymorphisms are unlikely to play a substantial role in the genetic predisposition to schizophrenic disorders...
  7. ncbi request reprint Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene
    A Heils
    Department of Psychiatry, University of Wurzburg, Germany
    J Neural Transm Gen Sect 102:247-54. 1995
    ....
  8. ncbi request reprint Linkage and family-based association study of schizophrenia and the synapsin III locus that maps to chromosome 22q13
    G Stober
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    Am J Med Genet 96:392-7. 2000
    ..In addition, no evidence for gender differences or parent-of-origin effects were found. Thus, the synapsin III locus at chromosome 22q13 is not likely to contain a schizophrenia susceptibility gene...
  9. doi request reprint No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample
    T J Renner
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Germany
    Atten Defic Hyperact Disord 3:285-9. 2011
    ..5%, P = 0.55). We conclude that A-3081T is not a major risk variant in our ADHD sample, though SLC6A2 remains an interesting candidate gene in ADHD, especially for the inattentive subtype...
  10. ncbi request reprint Allelic variation of human serotonin transporter gene expression
    A Heils
    Department of Psychiatry, University of Wurzburg, Germany
    J Neurochem 66:2621-4. 1996
    ..Allelic variation in 5-HTT-related functions may play a role in the expression and modulation of complex traits and behavior...
  11. ncbi request reprint Gene structure and 5'-flanking regulatory region of the murine serotonin transporter
    D Bengel
    Department of Psychiatry, University of Wurzburg, Germany
    Brain Res Mol Brain Res 44:286-92. 1997
    ....
  12. ncbi request reprint Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease
    R Mossner
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Mol Psychiatry 6:350-2. 2001
    ..Thus, the 5HTTLPR but not the MAOA gene promoter-associated polymorphism may be a risk factor for depression in PD patients, while neither polymorphism increases the risk for development of Parkinson's disease itself...
  13. ncbi request reprint Moclobemide response in depressed patients: association study with a functional polymorphism in the monoamine oxidase A promoter
    Daniel J Muller
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Pharmacopsychiatry 35:157-8. 2002
  14. ncbi request reprint Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region
    K Glatz
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    J Neurochem 86:1072-8. 2003
    ..Our findings may contribute to explain the vulnerability to stress-related disorders in susceptible individuals, in whom further clinical studies should follow up on these in vitro findings...
  15. ncbi request reprint The genomic organization of the murine Mlc1 (Wkl1, KIAA0027) gene
    V Steinke
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Neural Transm 110:333-43. 2003
    ..The characterization of the genomic structure of the murine gene will facilitate studies of gene function and physiological properties of the encoded protein in transgenic mouse models...
  16. doi request reprint Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals
    C G Baehne
    Department of Psychiatry, University of Wuerzburg, Wuerzburg, Bavaria, Germany
    Mol Psychiatry 14:1032-9. 2009
    ..This mechanism might also be relevant in the pathophysiology of ADHD...
  17. ncbi request reprint hKCNN3 which maps to chromosome 1q21 is not the causative gene in periodic catatonia, a familial subtype of schizophrenia
    G Stober
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 250:163-8. 2000
    ..Linkage mapping showed segregation with marker D1S498 (theta = 0.05) and placed hKCNN3 in the genetic linkage map in a cluster of genes near the centromeric region of chromosome 1...
  18. ncbi request reprint Isolation of a cDNA encoding the human brain serotonin transporter
    K P Lesch
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    J Neural Transm Gen Sect 91:67-72. 1993
    ..Hydropathicity analysis revealed twelve membrane spanning segments, a topology proposed for other cloned sodium-dependent transporters...
  19. ncbi request reprint Association analysis of the functional monoamine oxidase A gene promotor polymorphism in migraine
    M Marziniak
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 111:603-9. 2004
    ..These findings thus indicate that there is no association between the functional MAO-A-LPR and susceptibility to migraine...
  20. ncbi request reprint Functional characterization of the human PAX3 gene regulatory region
    O Okladnova
    Clinical Neurochemistry, Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, Wurzburg, 97080, Germany
    Genomics 57:110-9. 1999
    ....
  21. ncbi request reprint Modulation of serotonin transporter function by interleukin-4
    R Mossner
    Department of Psychiatry, University of Wurzburg, Germany
    Life Sci 68:873-80. 2001
    ....
  22. ncbi request reprint Distribution of the B33 CTG repeat polymorphism in a subtype of schizophrenia
    D Bengel
    Department of Psychiatry, , Germany
    Eur Arch Psychiatry Clin Neurosci 248:78-81. 1998
    ..Nevertheless, that periodic catatonia displays dominant inheritance and anticipation, characteristic of genetic disorders involving trinucleotide repeats, justifies further screening for triplet repeat expansions in this illness...
  23. ncbi request reprint Norepinephrine transporter gene (NET) variants in patients with panic disorder
    P G Sand
    Department of Psychiatry, University of Wurzburg, Füchsleinstrazze 15, D 97080, Wurzburg, Germany
    Neurosci Lett 333:41-4. 2002
    ..Except for a silent substitution (G1287A), overall frequencies of variant alleles were low (< or =0.016). None of the variants under study was found to be associated with PD regardless of an additional diagnosis of agoraphobia...
  24. doi request reprint Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
    K P Lesch
    ADHD Clinical Research Network, Unit for Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 16:491-503. 2011
    ..These findings implicate CNVs of behaviour-related genes in the pathogenesis of ADHD and are consistent with the notion that both frequent and rare variants influence the development of this common multifactorial syndrome...
  25. ncbi request reprint Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice
    A Schmitt
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neurosci Res 71:701-9. 2003
    ....
  26. ncbi request reprint A functional serotonin transporter gene polymorphism is associated with migraine with aura
    M Marziniak
    Department of Neurology, University of Wurzburg, Germany
    Neurology 64:157-9. 2005
    ..001). This indicates that the 5-HTT may be involved in the polygenic etiology of migraine with aura...
  27. ncbi request reprint Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and beta-adrenoceptor antagonists
    K P Lesch
    Department of Psychiatry, University of Wurzburg, West Germany
    J Clin Endocrinol Metab 70:670-4. 1990
    ..3 +/- 6.5 x 10(3) nmol.min/L (P less than 0.05). The selective beta 1-adrenoceptor antagonist betaxolol did not significantly alter the IPS-induced HPA response.(ABSTRACT TRUNCATED AT 250 WORDS)..
  28. ncbi request reprint Organization of the human serotonin transporter gene
    K P Lesch
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    J Neural Transm Gen Sect 95:157-62. 1994
    ..The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders...
  29. ncbi request reprint Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the susceptibility to MPP+
    K P Lesch
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    J Neural Transm Gen Sect 93:75-82. 1993
    ..They are also likely to facilitate molecular pharmacologic and genetic investigations of the human VMT in neurodegenerative disorders...
  30. ncbi request reprint Exonic variants of the GABA(B) receptor gene and panic disorder
    P G Sand
    Department of Psychiatry, University of Wurzburg, Germany
    Psychiatr Genet 10:191-4. 2000
    ..There was no indication of an increased vulnerability to panic disorder or agoraphobia with respect to the allelic variants under study...
  31. ncbi request reprint Functional PAX-6 gene-linked polymorphic region: potential association with paranoid schizophrenia
    G Stober
    Department of Psychiatry, University of Wurzburg, Germany
    Biol Psychiatry 45:1585-91. 1999
    ....
  32. doi request reprint Dances with black widow spiders: dysregulation of glutamate signalling enters centre stage in ADHD
    K P Lesch
    Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, ADHD Clinical Research Network, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Neuropsychopharmacol 23:479-91. 2013
    ....
  33. ncbi request reprint Structural variation of the monoamine oxidase A gene promoter repeat polymorphism in nonhuman primates
    J R Wendland
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Genes Brain Behav 5:40-5. 2006
    ....
  34. doi request reprint Allelic variants of SNAP25 in a family-based sample of ADHD
    T J Renner
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 115:317-21. 2008
    ..In our German ADHD sample no preferential transmission of either variant could be observed. Further investigation considering sub-sample analysis regarding response to D-amphetamine could enlight the role of SNAP25 in ADHD...
  35. doi request reprint Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity
    N Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Int J Obes (Lond) 34:701-11. 2010
    ....
  36. ncbi request reprint Impulsivity, aggression, and serotonin: a molecular psychobiological perspective
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Behav Sci Law 18:581-604. 2000
    ....
  37. ncbi request reprint NO synthase-positive striatal interneurons are decreased in schizophrenia
    S Fritzen
    Department of Psychiatry, Julius Maximilians University Würzburg, Germany
    Eur Neuropsychopharmacol 17:595-9. 2007
    ..Our results suggest that striatal nitrinergic interneurons are involved in the pathophysiology of at least some forms of schizophrenia, such as e.g. catatonic schizophrenia...
  38. ncbi request reprint D4 receptor gene variation modulates activation of prefrontal cortex during working memory
    M J Herrmann
    University Hospital of Psychiatry and Psychotherapy, Department of Psychology, University of Wurzburg, Germany
    Eur J Neurosci 26:2713-8. 2007
    ..Therefore, we interpret the effects of the 7-repeat allele group of DRD4 as a sign of ineffective brain activity, perhaps even as a sign of prefrontal noise...
  39. ncbi request reprint Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs
    M Marziniak
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 114:1227-32. 2007
    ..For the first time, our results indicate a role of allelic variation of the 5-HT1A receptor in motion related discomfort in migraineurs and a role of the 5-HT1B receptor polymorphism in headache intensity...
  40. doi request reprint [Neurobiology of attention-deficit hyperactivity disorder]
    T J Renner
    Klinik und Poliklinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Universitat Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg
    Nervenarzt 79:771-81. 2008
    ....
  41. ncbi request reprint Effect of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on human serotonergic cells
    G Bringmann
    Institute of Organic Chemistry, University of Wurzburg, Germany
    Neurochem Res 25:837-43. 2000
    ....
  42. doi request reprint The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia
    A Reif
    Department of Psychiatry and Psychotherapy, Section of Clinical and Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Eur J Neurol 15:637-9. 2008
    ..However, no significant differences were observed between patients and controls. Bearing in mind the caveat of the small patient sample size, our data nevertheless argue against a major genetic role of MAO-A polymorphism in FTD...
  43. pmc Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease and neuroantigen-specific interferon-gamma production in mouse EAE
    H H Hofstetter
    Clinical Research Group for Multiple Sclerosis, Department of Neurology, University of Wurzburg, Germany
    Clin Exp Immunol 142:39-44. 2005
    ..These findings suggest a potential role of extracellular 5-HT homeostasis in the fine-tuning of neuroantigen-specific immune responses...
  44. ncbi request reprint Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter
    K P Lesch
    Department of Psychiatry, University of Wurzburg, F R G
    J Neurochem 60:2319-22. 1993
    ..Our findings are likely to facilitate molecular pharmacologic and genetic investigations of the 5-HT transporter in psychiatric disorders...
  45. ncbi request reprint Serotonergic gene expression and depression: implications for developing novel antidepressants
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    J Affect Disord 62:57-76. 2001
    ....
  46. ncbi request reprint Periodic catatonia: a schizophrenic subtype with major gene effect and anticipation
    G Stober
    Department of Psychiatry, University of Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 245:135-41. 1995
    ..Thus, periodic catatonia as a specific clinical subtype of schizophrenia is a promising candidate for molecular genetic evaluation...
  47. ncbi request reprint Adult neurogenesis in serotonin transporter deficient mice
    A Schmitt
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 114:1107-19. 2007
    ....
  48. doi request reprint Serotonin transporter knockout and repeated social defeat stress: impact on neuronal morphology and plasticity in limbic brain areas
    S L Nietzer
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Behav Brain Res 220:42-54. 2011
    ..Social stress leads to similar but less pronounced changes in the WT, and neuroplasticity upon stress is reduced in 5-Htt KO mice...
  49. ncbi request reprint Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:801-3. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801-803, 2000...
  50. ncbi request reprint Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans
    K P Lesch
    Department of Psychiatry, University of Wurzburg, FRG
    Eur J Clin Pharmacol 39:17-9. 1990
    ..Therefore, the hypothermic response to IPS may provide a convenient in vivo paradigma to assess the function of the presynaptic 5-HT receptor in affective disorders and its involvement in the effects of psychotropic drugs...
  51. ncbi request reprint Mouse anxiety: the power of knockout
    K P Lesch
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Pharmacogenomics J 1:187-92. 2001
    ....
  52. ncbi request reprint A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree
    J Meyer
    Department of Psychiatry and Psychotherapy, University of Wurzburg, D 97080 Wurzburg, Germany
    Mol Psychiatry 6:302-6. 2001
    ....
  53. ncbi request reprint Antidepressants and gene expression profiling: how to SNARE novel drug targets
    K P Lesch
    Department of Psychiatry and Psychotherapy, Section of Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Pharmacogenomics J 2:346-8. 2002
  54. doi request reprint Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12
    M Romanos
    ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 13:522-30. 2008
    ..Our study provides further evidence for common gene effects throughout different populations despite the complex multifactorial etiology of ADHD...
  55. ncbi request reprint Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    Am J Psychiatry 161:569-72. 2004
    ..The authors analyzed the influence of 5-HTTLPR variants on personality disorders...
  56. ncbi request reprint No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families
    D P McKeane
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Schizophr Res 75:1-3. 2005
    ..It is unlikely that mutations in DLL4 are causative in this collection of families with linkage to 15q15...
  57. ncbi request reprint Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation
    T Canli
    Department of Psychology, Stony Brook University, Stony Brook, NY, USA
    J Neural Transm 112:1479-85. 2005
    ..Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence...
  58. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder
    S Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 10:1126-32. 2005
    ..064). Our results link potentially functional TPH2 variations to the pathophysiology of ADHD, and further support the relevance of 5-HT in disorders related to altered motor activity and cognitive processes...
  59. ncbi request reprint Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study
    C Altamura
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
    Cereb Cortex 17:1394-401. 2007
    ..These results provide evidence of 5-HTT gene effects on neocortical morphology in epistatic interaction with genetic variants at other loci and may model the effect of functional 5-HTT gene variants on neocortical development in autism...
  60. ncbi request reprint No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD
    B G Schimmelmann
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Essen, Germany
    J Neural Transm 114:523-6. 2007
    ..We did not find support for an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD in our sample...
  61. ncbi request reprint An adenosine A2A receptor gene haplotype is associated with migraine with aura
    C Hohoff
    Department of Psychiatry and Psychotherapy, University of Munster, Munster, Germany
    Cephalalgia 27:177-81. 2007
    ..01) but not in patients without aura, compared with the control group. This indicates that A2AR gene variation may contribute to the pathogenesis of migraine with aura...
  62. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
    ..Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p...
  63. ncbi request reprint Quantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    J Neural Transm 111:27-35. 2004
    ..The adaptive changes of 5HT3 receptor expression constitute a part of the complex regulatory pattern of 5HT receptors in 5HTT knockout mice...
  64. ncbi request reprint Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders
    D L Murphy
    Laboratory of Clinical Science, Building 10, Room 3D41, 10 Center Drive, NIMH, NIH DHHS, Bethesda, MD 20892 1264, USA
    Genes Brain Behav 2:350-64. 2003
    ....
  65. ncbi request reprint The utility of the non-human primate; model for studying gene by environment interactions in behavioral research
    C S Barr
    NIAAA DICBR, NIH, Clinical Studies, Primate Unit, Bldg 112, Poolesville, MD 20837, USA
    Genes Brain Behav 2:336-40. 2003
    ....
  66. ncbi request reprint Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein
    A Ravary
    INSERM U106, CHU Pitie Salpetriere, 47 bd de l Hopital, 75651 Paris Cedex 13, France
    Eur J Neurosci 13:1349-62. 2001
    ..This study therefore validates the 5-HTT KO model despite the occurrence of an incomplete translation, and brings novel information on the in vivo 5-HT uptake and cellular processing of an abnormal 5-HTT protein...
  67. ncbi request reprint Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity
    C Mannoury la Cour
    Institut National de la Sante et de la Recherche Medicale U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, 75634 Paris Cedex 13, France
    J Neurosci 21:2178-85. 2001
    ..Similarities between these changes and those evoked by chronic treatment with 5-HT reuptake inhibitors emphasize the existence of regional differences in 5-HT(1A) receptor regulatory mechanisms...
  68. ncbi request reprint Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice
    Y Pan
    Department of Molecular Genetics, Weizmann Institute of Science, 76100, Rehovot, Israel
    Brain Res Dev Brain Res 126:125-9. 2001
    ..The results imply that midbrain-hindbrain neuronal cultures of knockout mice, that do not express serotonin transporters, acquire the capacity to take up serotonin, apparently via dopamine transporters...
  69. ncbi request reprint Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice
    N Salichon
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 146, Institut Curie, 91405 Orsay, France
    J Neurosci 21:884-96. 2001
    ..Finally, because the 5-HT1B receptor inhibits glutamate release, our results suggest that visual and somatosensory projections must release glutamate for proper segregation...
  70. ncbi request reprint Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences
    Q Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20892 1264, USA
    J Neurosci 20:7888-95. 2000
    ..Finally, alterations in G-protein coupling to 5-HT(1A) receptors are unlikely to be involved in the desensitization of 5-HT(1A) receptors in 5-HTT -/- mice...
  71. ncbi request reprint Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter
    V Fabre
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Eur J Neurosci 12:2299-310. 2000
    ..Such effects were not detected in 5-HTT-/- mice, further confirming the occurrence of marked alterations of 5-HT1A and 5-HT1B autoreceptors in these animals...
  72. pmc Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
    S Eddahibi
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 492, Departement de Physiologie, CHU Henri Mondor Assistance Publique Hopitaux de Paris, Creteil, France
    J Clin Invest 105:1555-62. 2000
    ..This occurred despite potentiation of acute hypoxic pulmonary vasoconstriction in the 5-HTT(-/-) mice. These data further support a key role of 5-HTT in hypoxia-induced pulmonary vascular SMC proliferation and pulmonary hypertension...
  73. ncbi request reprint Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice
    Q Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20892 1264, USA
    J Pharmacol Exp Ther 291:999-1007. 1999
    ....
  74. ncbi request reprint Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter
    A Rioux
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Neurosci Lett 262:113-6. 1999
    ....
  75. pmc Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
    I Sora
    Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 95:7699-704. 1998
    ..These results have substantial implications for understanding cocaine actions and for strategies to produce anticocaine medications...
  76. ncbi request reprint Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice
    D Bengel
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892 1264, USA
    Mol Pharmacol 53:649-55. 1998
    ..Together, these data suggest that the presence of a functional 5-HTT is essential for brain 5-HT homeostasis and for 3,4-methylenedioxymethamphetamine-induced hyperactivity...
  77. ncbi request reprint Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders
    Y V Syagailo
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Am J Med Genet 105:168-71. 2001
    ..Our results suggest that there is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in our population...
  78. pmc Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference
    I Sora
    Molecular Neurobiology, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 98:5300-5. 2001
    ..These results provide insights into the brain molecular targets necessary for cocaine reward in knockout mice that develop in their absence and suggest novel strategies for anticocaine medication development...
  79. ncbi request reprint Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release
    A M Persico
    Laboratory of Neuroscience, Università Campus Bio Medico, 00155 Rome, Italy
    J Neurosci 21:6862-73. 2001
    ..Transient 5-HTT expression is thus required for barrel pattern formation, whereas activity-dependent vesicular 5-HT release is not...
  80. ncbi request reprint Further evidence for a modulation of Novelty Seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants
    A Strobel
    Mol Psychiatry 8:371-2. 2003
  81. ncbi request reprint Altered rapid eye movement sleep timing in serotonin transporter knockout mice
    J P Wisor
    Sleep and Circadian Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94304, USA
    Neuroreport 14:233-8. 2003
    ..Genetic differences in serotonin systems and developmental exposure to SERT blockers are likely to exert effects on REMS...
  82. ncbi request reprint Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates
    M Champoux
    Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH Animal Center, Poolesville, MD 20837, USA
    Mol Psychiatry 7:1058-63. 2002
    ..These results demonstrate the contributions of rearing environment and genetic background, and their interaction, in a nonhuman primate model of behavioral development...
  83. ncbi request reprint Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions
    F S Hall
    Molecular Neurobiology Branch, NIDA IRP, NIH, Box 5180, Baltimore, MD 21224, USA
    Neuroscience 115:153-61. 2002
    ....
  84. ncbi request reprint No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking
    A Strobel
    Mol Psychiatry 7:537-8. 2002
  85. ncbi request reprint Evolutionary conserved microsatellites in the promoter region of the 5-hydroxytryptamine receptor 2C gene (HTR2C) are not associated with bipolar disorder in females
    J Meyer
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 109:939-46. 2002
    ..Furthermore, no association of specific alleles with bipolar disorder was found. These results indicate that the HTR2C promoter polymorphism does not contribute significantly to the etiopathogenesis of bipolar disorder in females...
  86. ncbi request reprint Increased hippocampal DNA oxidation in serotonin transporter deficient mice
    R Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 109:557-65. 2002
    ..Given the importance of the hippocampus in learning and memory, this may be the most important neurochemical consequence of the absence of the 5HTT...
  87. ncbi request reprint No missense mutation of WKL1 in a subgroup of probands with schizophrenia
    J M Devaney
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Mol Psychiatry 7:419-23. 2002
    ..No missense mutations were detected in any of the other 42 probands studied. These data exclude the role of WKL1 in schizophrenia susceptibility in the subjects studied...
  88. ncbi request reprint Exclusion of the neuronal nicotinic acetylcholine receptor alpha7 subunit gene as a candidate for catatonic schizophrenia in a large family supporting the chromosome 15q13-22 locus
    J Meyer
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 7:220-3. 2002
    ..This result provides strong evidence that a gene located telomeric to CHRNA7 is causative for the pathogenesis of catatonic schizophrenia in this family...
  89. ncbi request reprint Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family
    J Gross
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Psychiatr Genet 11:197-200. 2001
    ..No variant exclusively co-segregates with the disease in the large pedigree, providing evidence that CELSR1 is not causative for the pathogenesis of catatonic schizophrenia in this family...
  90. ncbi request reprint Early experience and serotonin transporter gene variation interact to influence primate CNS function
    A J Bennett
    National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies Primate Unit, Poolesville, MD 20837, USA
    Mol Psychiatry 7:118-22. 2002
    ....
  91. ncbi request reprint Cellular localization and expression of the serotonin transporter in mouse brain
    D Bengel
    Section on Clinical Neuropharmacology, Laboratory of Clinical Science, NIMH, NIH Clinical Center, Bethesda, MD 20892, USA
    Brain Res 778:338-45. 1997
    ..In contrast to previous findings in rat brain, the highest densities of 5-HTT sites were found in areas outside the raphe complex, particularly in the substantia nigra, globus pallidus, and superior colliculi...