Claudia Lengerke

Summary

Country: Germany

Publications

  1. pmc Autologous blood cell therapies from pluripotent stem cells
    Claudia Lengerke
    Division of Hematology and Oncology, University of Tuebingen Medical Center II, 72076 Tuebingen, Germany
    Blood Rev 24:27-37. 2010
  2. pmc Caudal genes in blood development and leukemia
    Claudia Lengerke
    University of Tübingen Medical Center Hematology and Oncology, Tubingen, Germany
    Ann N Y Acad Sci 1266:47-54. 2012
  3. pmc Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma
    Claudia Lengerke
    University of Tuebingen Medical Center II, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    BMC Cancer 11:42. 2011
  4. pmc Interactions between Cdx genes and retinoic acid modulate early cardiogenesis
    Claudia Lengerke
    Department of Hematology and Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany
    Dev Biol 354:134-42. 2011
  5. doi request reprint Disease models from pluripotent stem cells
    Claudia Lengerke
    Division of Hematology and Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany
    Ann N Y Acad Sci 1176:191-6. 2009
  6. pmc Hematopoietic development from human induced pluripotent stem cells
    Claudia Lengerke
    Division of Hematology and Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany
    Ann N Y Acad Sci 1176:219-27. 2009
  7. doi request reprint SOX2 amplification is a common event in squamous cell carcinomas of different organ sites
    Sebastian Maier
    Institute of Pathology, Comprehensive Cancer Center, University Hospital of Tuebingen, 72076 Tuebingen, Germany
    Hum Pathol 42:1078-88. 2011
  8. doi request reprint SOX2 expression associates with stem cell state in human ovarian carcinoma
    Petra M Bareiss
    Departments of Internal Medicine II and Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tuebingen, Tuebingen, Germany
    Cancer Res 73:5544-55. 2013
  9. ncbi request reprint Improved detection of splenosis in patients with haematological disorders: the role of combined transmission-emission tomography
    Marius Horger
    Department of Diagnostic Radiology, Eberhard Karls Universitat, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Eur J Nucl Med Mol Imaging 30:316-9. 2003
  10. ncbi request reprint Cytomegalovirus pneumonia after stem cell transplantation: correlation of CT findings with clinical outcome in 30 patients
    Marius S Horger
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, Tuebingen 72076, Germany
    AJR Am J Roentgenol 187:W636-43. 2006

Collaborators

Detail Information

Publications21

  1. pmc Autologous blood cell therapies from pluripotent stem cells
    Claudia Lengerke
    Division of Hematology and Oncology, University of Tuebingen Medical Center II, 72076 Tuebingen, Germany
    Blood Rev 24:27-37. 2010
    ....
  2. pmc Caudal genes in blood development and leukemia
    Claudia Lengerke
    University of Tübingen Medical Center Hematology and Oncology, Tubingen, Germany
    Ann N Y Acad Sci 1266:47-54. 2012
    ..Here, we will review the role of Cdx genes during hematopoietic development by comparing effects in zebrafish and mice and discuss their participation in malignant blood diseases...
  3. pmc Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma
    Claudia Lengerke
    University of Tuebingen Medical Center II, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    BMC Cancer 11:42. 2011
    ..In breast cancer, SOX2 expression was reported as a feature of basal-like tumors. In this study, we assessed SOX2 expression in 95 primary tumors of postmenopausal breast cancer patients...
  4. pmc Interactions between Cdx genes and retinoic acid modulate early cardiogenesis
    Claudia Lengerke
    Department of Hematology and Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany
    Dev Biol 354:134-42. 2011
    ..Together, our data suggest that cdx proteins affect cardiogenesis by regulating the formation of cardiogenic mesoderm and together with the RA pathway control the early development of cardiac precursor cells...
  5. doi request reprint Disease models from pluripotent stem cells
    Claudia Lengerke
    Division of Hematology and Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany
    Ann N Y Acad Sci 1176:191-6. 2009
    ....
  6. pmc Hematopoietic development from human induced pluripotent stem cells
    Claudia Lengerke
    Division of Hematology and Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany
    Ann N Y Acad Sci 1176:219-27. 2009
    ....
  7. doi request reprint SOX2 amplification is a common event in squamous cell carcinomas of different organ sites
    Sebastian Maier
    Institute of Pathology, Comprehensive Cancer Center, University Hospital of Tuebingen, 72076 Tuebingen, Germany
    Hum Pathol 42:1078-88. 2011
    ..We conclude that SOX2 amplification and consequent SOX2 protein overexpression may represent important mechanisms of tumor initiation and progression in a considerable subset of squamous cell carcinomas...
  8. doi request reprint SOX2 expression associates with stem cell state in human ovarian carcinoma
    Petra M Bareiss
    Departments of Internal Medicine II and Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tuebingen, Tuebingen, Germany
    Cancer Res 73:5544-55. 2013
    ..We propose the existence of SOX2-expressing ovarian CSCs as a mechanism of tumor aggressiveness and therapy resistance in human SOC...
  9. ncbi request reprint Improved detection of splenosis in patients with haematological disorders: the role of combined transmission-emission tomography
    Marius Horger
    Department of Diagnostic Radiology, Eberhard Karls Universitat, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Eur J Nucl Med Mol Imaging 30:316-9. 2003
    ..Diagnostic relevance was highest for intrahepatic, intrapulmonary or pleural splenic implants. It is concluded that TET allows exact localisation of heterotopic splenic tissue in patients with suspected splenosis...
  10. ncbi request reprint Cytomegalovirus pneumonia after stem cell transplantation: correlation of CT findings with clinical outcome in 30 patients
    Marius S Horger
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, Tuebingen 72076, Germany
    AJR Am J Roentgenol 187:W636-43. 2006
    ..The purpose of our study was to assess the correlation between early high-resolution CT findings of cytomegalovirus (CMV) pneumonia in patients with blood disorders and their clinical outcomes...
  11. ncbi request reprint Significance of the "halo" sign for progression and regression of nodular pulmonary amyloidosis: radiographic-pathological correlation (2005:6b)
    Marius Horger
    Department of Diagnostic Radiology, Eberhard Karls University, Tubingen, Germany
    Eur Radiol 15:2037-40. 2005
    ..In our case, this sign had a high prediction for growth kinetics and response to therapy of pulmonary amyloid...
  12. ncbi request reprint Initial CT manifestations of invasive pulmonary aspergillosis in 45 non-HIV immunocompromised patients: association with patient outcome?
    Marius Horger
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Eur J Radiol 55:437-44. 2005
    ....
  13. doi request reprint Prospective isolation of mesenchymal stem cells from human bone marrow using novel antibodies directed against Sushi domain containing 2
    Kavitha Sivasubramaniyan
    Division of Hematology, Immunology, Oncology, Rheumatology and Pulmonology, Department of Internal Medicine II, University Clinic of Tubingen, Tubingen, Germany
    Stem Cells Dev 22:1944-54. 2013
    ..In conclusion, we identified SUSD2 as a novel and specific marker for the prospective isolation of BM-MSCs...
  14. doi request reprint SOX2 expression and prognostic significance in ovarian carcinoma
    Deborah L Pham
    Institute of Pathology, University of Tuebingen, Tuebingen, Germany
    Int J Gynecol Pathol 32:358-67. 2013
    ..21 mo, P=0.041; median overall survival 39 vs. 25 mo, P=0.062). Further studies are needed to explore whether expression of SOX2 has a specific role in prognosis and therapy response...
  15. doi request reprint SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer
    Theresia Wilbertz
    Institute of Pathology, Comprehensive Cancer Center, University Hospital Tuebingen, Tuebingen, Germany
    Mod Pathol 24:944-53. 2011
    ..In conclusion, SOX2 amplification and upregulation are frequent events in squamous cell carcinomas of the lung and are associated with indicators of favorable prognosis...
  16. ncbi request reprint Patterning definitive hematopoietic stem cells from embryonic stem cells
    Claudia Lengerke
    Department of Hematology and Oncology, University Medical Center II, Tuebingen, Germany
    Exp Hematol 33:971-9. 2005
    ....
  17. doi request reprint Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia
    Tamara Riedt
    Department of Hematology Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany
    Blood 113:4049-51. 2009
    ..Thus, CDX2 expression levels may serve as a marker for adverse prognosis in pediatric ALL...
  18. doi request reprint Zebrafish xenografts as a tool for in vivo studies on human cancer
    Martina Konantz
    Department of Hematology and Oncology, University of Tübingen Medical Center II, Tubingen, Germany
    Ann N Y Acad Sci 1266:124-37. 2012
    ..Here, we summarize current data on xenotransplantation of human cells into zebrafish, highlighting the advantages and limitations of this model in comparison to classical murine models of xenotransplantation...
  19. pmc Monitoring the glioma tropism of bone marrow-derived progenitor cells by 2-photon laser scanning microscopy and positron emission tomography
    Kathy Hasenbach
    Department of General Neurology, University Hospital Tubingen, Tubingen, Germany
    Neuro Oncol 14:471-81. 2012
    ..Moreover, the PET reporter-based imaging technique will allow noninvasive monitoring of cell fate in future cell-based therapeutic antiglioma approaches...
  20. doi request reprint Patient-specific pluripotent stem cells: promises and challenges
    Rouven Müller
    Laboratory for Developmental Biology, Department of Hematology and Oncology, University of Tübingen Medical Center II, Tubingen, Germany
    Nat Rev Endocrinol 5:195-203. 2009
    ..This Review critically analyzes the currently available methods for the generation of pluripotent stem cells, and discusses prospects for their clinical use...
  21. ncbi request reprint Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma
    Andreas Schrock
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospital of Bonn, 53127 Bonn, Germany, Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Carcinogenesis 35:1636-42. 2014
    ..Targeting SOX2 and related molecular downstream pathways such as BCL-2 may enhance therapy efficacy in SOX2-expressing HNSCC. ..