Peter F Zipfel

Summary

Affiliation: Leibniz Institute for Natural Product Research and Infection Biology
Country: Germany

Publications

  1. ncbi request reprint The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Vaccine 26:I67-74. 2008
  2. doi request reprint Complement regulators and inhibitory proteins
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, Jena, Germany
    Nat Rev Immunol 9:729-40. 2009
  3. doi request reprint DEAP-HUS: deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergst 11a, 07745, Jena, Germany
    Pediatr Nephrol 25:2009-19. 2010
  4. pmc The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b
    Katrin Haupt
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    PLoS Pathog 4:e1000250. 2008
  5. pmc Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin
    Crisanto M Lopez
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    PLoS ONE 9:e90796. 2014
  6. doi request reprint Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Beutenbergstr 11a, 07745 Jena, Germany Friedrich Schiller University Jena, 07745 Jena, Germany Electronic address
    Int J Med Microbiol 304:188-94. 2014
  7. doi request reprint Human complement control and complement evasion by pathogenic microbes--tipping the balance
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Mol Immunol 56:152-60. 2013
  8. ncbi request reprint Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena, Germany
    Adv Exp Med Biol 735:173-87. 2013
  9. ncbi request reprint Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745, Jena, Germany
    Adv Exp Med Biol 734:173-87. 2013
  10. doi request reprint Complement, Candida, and cytokines: the role of C5a in host response to fungi
    Peter F Zipfel
    Leibniz Institute for Natural Product Research and Infection Biology, Department of Infection Biology, Beutenbergstrasse, Jena, Germany
    Eur J Immunol 42:822-5. 2012

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Vaccine 26:I67-74. 2008
    ..Remarkably, pathogenic microbes copy this mechanism of immune surveillance: they mimic the composition of host cell's, bind Factor H to their surface and engage acquired host Factor H for immune disguise...
  2. doi request reprint Complement regulators and inhibitory proteins
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, Jena, Germany
    Nat Rev Immunol 9:729-40. 2009
    ..Therefore, insights into the mechanisms of complement regulation are crucial for understanding disease pathology and for enabling the development of diagnostic tools and therapies for complement-associated diseases...
  3. doi request reprint DEAP-HUS: deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergst 11a, 07745, Jena, Germany
    Pediatr Nephrol 25:2009-19. 2010
    ....
  4. pmc The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b
    Katrin Haupt
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    PLoS Pathog 4:e1000250. 2008
    ..Thus, Sbi is a multifunctional bacterial protein, which binds host complement components Factor H and C3 as well as IgG and beta(2)-glycoprotein I and interferes with innate immune recognition...
  5. pmc Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin
    Crisanto M Lopez
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    PLoS ONE 9:e90796. 2014
    ..Thus fungal Gpm1 and human vitronectin represent a new set of proteins that are relevant for fungal attachment to human cells interaction. Blockade of the Gpm1 vitronectin interaction might provide a new target for therapy...
  6. doi request reprint Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Beutenbergstr 11a, 07745 Jena, Germany Friedrich Schiller University Jena, 07745 Jena, Germany Electronic address
    Int J Med Microbiol 304:188-94. 2014
    ....
  7. doi request reprint Human complement control and complement evasion by pathogenic microbes--tipping the balance
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Mol Immunol 56:152-60. 2013
    ..These conserved and common escape features are relevant and they provide challenging options for new therapeutic approaches. ..
  8. ncbi request reprint Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena, Germany
    Adv Exp Med Biol 735:173-87. 2013
    ....
  9. ncbi request reprint Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745, Jena, Germany
    Adv Exp Med Biol 734:173-87. 2013
    ....
  10. doi request reprint Complement, Candida, and cytokines: the role of C5a in host response to fungi
    Peter F Zipfel
    Leibniz Institute for Natural Product Research and Infection Biology, Department of Infection Biology, Beutenbergstrasse, Jena, Germany
    Eur J Immunol 42:822-5. 2012
    ..albicans. The authors show that the complement activation fragment C5a, which is formed in response to Candida infection, induces the cellular release of the inflammatory cytokines IL-6 and IL-1β...
  11. pmc Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4
    Nathalie D van Burgel
    Department of Medical Microbiology, Centre of Infectious Diseases, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands
    BMC Microbiol 10:43. 2010
    ..One important immune escape mechanism for evading complement activation is the binding of complement regulators Factor H (CFH) or Factor H-like protein1 (FHL-1) to Complement Regulator-Acquiring Surface Proteins (CRASPs)...
  12. ncbi request reprint Complement and diseases: defective alternative pathway control results in kidney and eye diseases
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knoell Institute, Beutenbergstr 11a, 07745 Jena, Germany
    Mol Immunol 43:97-106. 2006
    ..These scenarios explain how defects of a single regulator lead to local, organ specific damage...
  13. doi request reprint Thrombotic microangiopathies: new insights and new challenges
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Infection Biology and Natural Product Research, Jena, Germany
    Curr Opin Nephrol Hypertens 19:372-8. 2010
    ..In TTP thrombi formation occurs subsequently to the release of multimers of von Willebrand factor (vWF), and in HUS endothelial cell damage is considered the reason for complement and platelet activation leading to thrombus formation...
  14. doi request reprint The role of complement in AMD
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, Jena, Germany
    Adv Exp Med Biol 703:9-24. 2010
    ..Here we describe the role of complement in the retina and summarize the current concept how defective or inappropriate local complement control contributes to inflammation and the pathophysiology of AMD...
  15. ncbi request reprint The role of defective complement control in hemolytic uremic syndrome
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research, Jena, Germany
    Semin Thromb Hemost 32:146-54. 2006
    ..This article explains how alternative pathway activation proceeds and how defective control increases activation, which ultimately leads to endothelial cell damage...
  16. doi request reprint Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Int J Med Microbiol 301:423-30. 2011
    ..Candida Pra1 represents a promising candidate for immune interference...
  17. doi request reprint Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura?
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena, Germany
    Pediatr Nephrol 26:1947-56. 2011
    ..Here we summarize the most relevant topics and timely issues that were presented and discussed at the 4th International Workshop on Thrombotic Microangiopathies held in Weimar in October 2009 (www.hus-ttp.de)...
  18. ncbi request reprint Complement dysfunction in hemolytic uremic syndrome
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Beutenbergstrasse 11a, D 07743 Jena, Germany
    Curr Opin Rheumatol 18:548-55. 2006
    ..The atypical form, which occurs in adult patients, is associated with defective complement control...
  19. doi request reprint Complement and immune defense: from innate immunity to human diseases
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstr 11a, 07745 Jena, Germany
    Immunol Lett 126:1-7. 2009
    ..This can result in diseases, like severe renal diseases hemolytic uremic syndrome (HUS) and dense deposit disease (DDD), in age related macular degeneration a common form of blindness and also in other forms of autoimmune diseases...
  20. ncbi request reprint The alternative pathway of complement: a pattern recognition system
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute for Natural Products Research, Jena, Germany
    Adv Exp Med Biol 598:80-92. 2007
  21. ncbi request reprint Complement evasion of pathogens: common strategies are shared by diverse organisms
    Peter F Zipfel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Mol Immunol 44:3850-7. 2007
    ..Here we summarize the current scenarios of this emerging field which identifies multiple virulence factors and complement evasion strategies, but which at the same time reveals common mechanisms for immune and complement defense...
  22. doi request reprint Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3
    Shanshan Luo
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    J Immunol 185:2164-73. 2010
    ..Thus, Pra1 is, to our knowledge, the first potent fungal complement inhibitor that favors C. albicans immune escape by inactivating and controlling host complement attack at the level of C3...
  23. ncbi request reprint Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans
    Sophia Poltermann
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745, Jena, Germany
    J Biol Chem 282:37537-44. 2007
    ..Thus, the surface-expressed CaGpm1p is a virulence factor that utilizes the host Factor H, FHL-1, and plasminogen for immune evasion and degradation of extracellular matrices...
  24. doi request reprint Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen
    Teresia Hallström
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany
    J Immunol 189:4939-50. 2012
    ..aeruginosa that binds Factor H, FHL-1, CFHR1, and plasminogen, and the Lpd-attached regulators are relevant for innate immune escape and most likely contribute to tissue invasion...
  25. doi request reprint Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein
    Shanshan Luo
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Mol Immunol 47:541-50. 2009
    ..As a released protein, Pra1 enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack...
  26. doi request reprint Complement regulator-acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen
    Teresia Hallström
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    J Infect Dis 202:490-8. 2010
    ..burgdorferi that binds to several human extracellular matrix proteins and plasminogen. These interactions may contribute to adhesion, bacterial colonization, and organ tropism and may allow dissemination of B. burgdorferi in the host...
  27. ncbi request reprint Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome
    Mihaly Jozsi
    Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Blood 110:1516-8. 2007
    ..These results suggest that aHUS-associated FH autoantibodies mimic the effect of C-terminal FH mutations, as they inhibit the regulatory function of FH at cell surfaces by blocking its C-terminal recognition region...
  28. doi request reprint Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation
    Stefan Heinen
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Blood 114:2439-47. 2009
    ..These findings provide new insights into complement regulation on the cell surface and biosurfaces and likely define the role of CFHR1 in human diseases...
  29. ncbi request reprint The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence
    Sophia Poltermann
    Leibniz Institute for Natural Products Research and Infection Biology Hans Knöll Institute, Department of Infection Biology, Beutenbergstrasse 11, D 07745 Jena, Germany
    Microbiology 151:1645-55. 2005
    ..In summary, the V-ATPase subunit Vma7p is involved in vacuolar ion transport and this transport is required for hyphal growth and virulence of C. albicans...
  30. ncbi request reprint Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency
    Mihaly Jozsi
    Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Blood 111:1512-4. 2008
    ..Screening for both factors is obviously relevant for HUS patients as reduction of CFH autoantibody levels represents a therapeutic option...
  31. ncbi request reprint Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins
    Katrin Haupt
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    J Infect Dis 196:124-33. 2007
    ..Isolates of Borrelia burgdorferi, the causative agent of Lyme disease, express up to 5 distinct complement regulator-acquiring surface proteins (CRASP-1, -2, -3, -4, and -5)...
  32. ncbi request reprint The vesicle transport protein Vac1p is required for virulence of Candida albicans
    Kathrin Franke
    University of Applied Sciences, Department of Medical Engineering, Carl Zeiss Promenade 2, D 07745 Jena, Germany
    Microbiology 152:3111-21. 2006
    ..In summary, the Vac1p protein is required for several cellular pathways, in particular those that control virulence and pathogenicity. Consequently, Vac1p is a novel and interesting target for antifungal drugs...
  33. ncbi request reprint Role of the Vps34p-interacting protein Ade5,7p in hyphal growth and virulence of Candida albicans
    Susann Jezewski
    Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Beutenbergstrasse 11, D 07745 Jena, Germany
    Microbiology 153:2351-62. 2007
    ..In summary, Ade5,7p interacts with the multifunctional virulence regulator PtdIns 3-kinase Vps34p, and ade5,7 and vps34 null mutant strains show similar phenotypes regarding sensitivity to metal ions, hyphal growth and virulence...
  34. pmc Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b
    Tina K Koch
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection, Biology, Jena, Germany
    PLoS ONE 7:e47638. 2012
    ..aureus from host innate immune reactions...
  35. doi request reprint Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant
    Nadine Lauer
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany
    J Immunol 187:4374-83. 2011
    ..The increased protective capacity of the Tyr(402) Factor H variant allows better and more efficient clearance and removal of cellular debris and reduces inflammation and pathology...
  36. doi request reprint Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome
    Stefanie Strobel
    Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology Hans KnöllInstitute, Jena, Germany
    Nephrol Dial Transplant 25:136-44. 2010
    ..Recently, an autoimmune aHUS form has been described that is associated with complement factor H (CFH) autoantibodies. The aim of this study was to address the pathologic relevance of CFH autoantibodies in aHUS...
  37. doi request reprint Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells
    Michael Mihlan
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    Mol Immunol 46:335-44. 2009
    ..In addition, CFHR4 facilitated binding of native CRP to the surface of necrotic cells. Altogether these data identify CFHR4 as a novel ligand for native CRP, and suggest a role for CFHR4 in opsonization of necrotic cells...
  38. ncbi request reprint Autoantibodies in haemolytic uraemic syndrome (HUS)
    Christine Skerka
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstr 11a, 07745 Jena, Germany
    Thromb Haemost 101:227-32. 2009
    ....
  39. doi request reprint Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity
    Josephine Losse
    Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    J Immunol 184:912-21. 2010
    ..Thus, CFH and CFHR1, when bound on the surface of C. albicans, enhance antimicrobial activity of human neutrophils...
  40. doi request reprint Monomeric C-reactive protein modulates classic complement activation on necrotic cells
    Michael Mihlan
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena, Germany
    FASEB J 25:4198-210. 2011
    ..Protein levels were enhanced 6 h to 5 d after infarction. Thus, mCRP bound to damaged cardiomyocytes recruits C1q to activate and also C4bp to control the classic complement pathway...
  41. doi request reprint The yeast Candida albicans evades human complement attack by secretion of aspartic proteases
    Katharina Gropp
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute Beutenbergstrasse 11, D 07745 Jena, Germany
    Mol Immunol 47:465-75. 2009
    ..Secretion of complement degrading proteases provides a highly efficient complement defense response of this human pathogenic yeast that acts after the immediate acquisition of host complement regulators to the cell surface...
  42. pmc Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome
    Peter F Zipfel
    Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
    PLoS Genet 3:e41. 2007
    ..The identification of CFHR1/CFHR3 deficiency in aHUS patients may lead to the design of new diagnostic approaches, such as enhanced testing for these genes...
  43. ncbi request reprint The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+ -ATPase subunit Vma7p
    Raimund Eck
    Department of Infection Biology, Hans Knöll Institute for Natural Products Research, Beutenbergstrasse 11, D 07745 Jena, Germany
    Int J Med Microbiol 295:57-66. 2005
    ..In addition, the vps34 null mutant of C. albicans shows defective autophagocytosis. The relevance of these functions for virulence of C. albicans is discussed...
  44. pmc The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system
    Judith Behnsen
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    Infect Immun 76:820-7. 2008
    ..These data show that A. fumigatus conidia bind to complement regulators, and these bound host regulators may contribute to evasion of a host complement attack...
  45. doi request reprint Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles
    Christine Skerka
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Mol Immunol 46:2801-7. 2009
    ....
  46. ncbi request reprint Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells
    Stefan Heinen
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knoell Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
    J Am Soc Nephrol 18:506-14. 2007
    ..These effects explain how mutant factor H causes defective complement control and in HUS-particularly under condition of inflammation and complement activation-causes endothelial cell damage...
  47. pmc Binding of the human complement regulators CFHR1 and factor H by streptococcal collagen-like protein 1 (Scl1) via their conserved C termini allows control of the complement cascade at multiple levels
    Michael Reuter
    Department of Infection Biology, Hans Knoell Institute, 07745 Jena, Germany
    J Biol Chem 285:38473-85. 2010
    ....
  48. ncbi request reprint Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration
    Christine Skerka
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Mol Immunol 44:3398-406. 2007
    ..As a consequence, these processes may lead to AMD pathogenesis...
  49. pmc The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion
    Shanshan Luo
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany
    J Biol Chem 286:8021-9. 2011
    ..In summary, Candida Pra1 represents the first fungal C4BP-binding surface protein. Pra1, via binding to C4BP, mediates human complement control, thereby favoring the immune and complement evasion of C. albicans...
  50. pmc Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5
    Judith Behnsen
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, Jena, Germany
    Infect Immun 78:3585-94. 2010
    ..Thus, the protease Alp1 is responsible for the observed cleavage and degrades a broad range of different substrates. In summary, we identified a novel mechanism in A. fumigatus that contributes to evasion from the host complement attack...
  51. doi request reprint Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils
    Josephine Losse
    Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Beutenbergstr 11a, D 07745 Jena, Germany
    Mol Immunol 48:2135-43. 2011
    ..albicans, especially hyphal cells, by human neutrophils and enhances neutrophil antimicrobial responses. However, the fungus can counteract some of these defense mechanisms by releasing soluble Pra1...
  52. ncbi request reprint Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions
    Mihaly Jozsi
    Department of Infection Biology, Leibniz Institute for Natural Product Research, and Infection Biology, Beutenbergstrasse 11a, 07745 Jena, Germany
    J Am Soc Nephrol 17:170-7. 2006
    ..The buried type B mutations seem to affect ligand interaction of factor H more severely than the surface-exposed mutations...
  53. doi request reprint Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity
    Diana Barthel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    J Immunol 188:379-85. 2012
    ..Thus, PE is a major plasminogen-binding protein of the Gram-negative bacterium H. influenzae, and when converted to plasmin, PE-bound plasmin aids in immune evasion and contributes to bacterial virulence...
  54. doi request reprint Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans
    Shanshan Luo
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Germany
    J Infect Dis 207:594-603. 2013
    ..Thus, candida Gpd2 is a novel fungal immune evasion protein that binds several human complement regulators and, in addition, binds human cells...
  55. ncbi request reprint Two factor H-related proteins from the mouse: expression analysis and functional characterization
    Jens Hellwage
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    Immunogenetics 58:883-93. 2006
    ..Using mouse plasma, the native presumptive FHR proteins were also analyzed in binding assays. In summary, we identify two FHR proteins in mice and for the first time characterize a murine FHR as a heparin- and C3b-binding protein...
  56. ncbi request reprint Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein
    Anja Kunert
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Beutenbergstrasse 11a, 07745 Jena, Germany
    J Immunol 179:2979-88. 2007
    ..Acquisition of host effector proteins to the surface of the pathogen allows complement control and may facilitate tissue invasion...
  57. pmc Human factor H-related protein 2 (CFHR2) regulates complement activation
    Hannes U Eberhardt
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    PLoS ONE 8:e78617. 2013
    ..Interestingly CFHR2 hardly competes off factor H from C3b. Thus CFHR2 likely acts in concert with factor H, as CFHR2 inhibits convertases while simultaneously allowing factor H assisted degradation by factor I. ..
  58. doi request reprint Factor H family proteins and human diseases
    Mihaly Jozsi
    Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena D 07745, Germany
    Trends Immunol 29:380-7. 2008
    ..Therefore, dissecting the exact functions of the individual CFHR proteins will provide insights into the pathophysiology of such inflammatory and infectious diseases and will define the therapeutic potential of these proteins...
  59. doi request reprint The autoimmune disease DEAP-hemolytic uremic syndrome
    Christine Skerka
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Semin Thromb Hemost 36:625-32. 2010
    ..Thus early diagnosis of DEAP-HUS and immunosuppressive treatments are important factors to treat this particular type of HUS...
  60. ncbi request reprint Complement factor H related proteins in immune diseases
    Christine Skerka
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Vaccine 26:I9-14. 2008
    ..We here summarize the current knowledge about the role or association of CFHR1 and CFHR3 in the human diseases HUS and AMD...
  61. doi request reprint Interaction of phagocytes with filamentous fungi
    Axel A Brakhage
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
    Curr Opin Microbiol 13:409-15. 2010
    ..In addition, A. fumigatus interferes with the innate immunity, with both the complement system and defense mechanisms of phagocytes, thereby evading at least in part the innate immune system...
  62. ncbi request reprint The DNA topoisomerase IIbeta binding protein 1 (TopBP1) interacts with poly (ADP-ribose) polymerase (PARP-1)
    Yvonne Wollmann
    Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
    J Cell Biochem 102:171-82. 2007
    ..Finally, cellular (ADP-ribosyl)ating activity impairs binding of TopBP1 to Myc-interacting zinc finger protein-1 (Miz-1). The results indicate an influence of post-translational modifications of TopBP1 on its function during DNA repair...
  63. doi request reprint Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans
    Shanshan Luo
    Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Mol Immunol 56:161-9. 2013
    ....
  64. pmc Plasminogen is a complement inhibitor
    Diana Barthel
    Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    J Biol Chem 287:18831-42. 2012
    ..This complement-inhibitory activity of plasmin provides a new explanation why pathogenic microbes utilize plasmin(ogen) for immune evasion and tissue penetration...
  65. ncbi request reprint Genetic screening in haemolytic uraemic syndrome
    Peter F Zipfel
    Department of Infection Biology, Hans Knoell Institute for Natural Products Research, Jena, Germany
    Curr Opin Nephrol Hypertens 12:653-7. 2003
    ....
  66. ncbi request reprint FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene
    Mihaly Jozsi
    Department of Infection Biology, Hans Knöll Institute for Natural Products Research, Jena, Germany
    Eur J Hum Genet 13:321-9. 2005
    ..To our knowledge, FHR-4A provides the first evidence for alternative splicing among Factor H-related genes...
  67. pmc The C-terminus of complement factor H is essential for host cell protection
    Mihaly Jozsi
    Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
    Mol Immunol 44:2697-706. 2007
    ..Altogether these data point to a highly relevant, yet so far underestimated role of factor H for complement control at cellular surfaces, and reveal a decisive role of the factor H C-terminus in host cell recognition and protection...
  68. ncbi request reprint Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H
    Jens Hellwage
    Department of Bacteriology and Immunology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Immunol 169:6935-44. 2002
    ..Mutations in this region, as recently reported in patients with familial hemolytic uremic syndrome, may lead to indiscriminatory C attack against self cells...
  69. ncbi request reprint De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome
    Stefan Heinen
    Department for Infection Biology, Hans Knoell Institute for Natural Products Research, Jena, Germany
    Hum Mutat 27:292-3. 2006
    ..We, therefore, provide conclusive evidence that gene conversion is responsible for functionally significant CFH mutations in aHUS...
  70. pmc Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome
    Tamara Manuelian
    Hans Knoell Institute for Natural Products Research, Beutenbergstrasse 11a, D 07745 Jena, Germany
    J Clin Invest 111:1181-90. 2003
    ....
  71. ncbi request reprint Generation and functional in vivo characterization of a lipid kinase defective phosphatidylinositol 3-kinase Vps34p of Candida albicans
    Juliane Günther
    Hans Knöll Institute for Natural Products Research, Department of Infection Biology, Beutenbergstrasse 11, D 07745 Jena, Germany
    Microbiology 151:81-9. 2005
    ..On the other hand, the lipid-kinase-defective strain and the vps34 null mutant differ in their temperature- and osmotic-stress response. This indicates a possible role for activities different from the lipid kinase function of Vps34p...
  72. ncbi request reprint A fluorogenic substrate as quantitative in vivo reporter to determine protein expression and folding of tobacco etch virus protease in Escherichia coli
    Mario Kraft
    Department for Pilot Plant for Natural Products, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    Protein Expr Purif 52:478-84. 2007
    ..This provides an effective tool to monitor the accumulation of active recombinant TEV protease in crude extracts and intact cells...
  73. ncbi request reprint Combined C3b and Factor B Autoantibodies and MPGN Type II
    Qian Chen
    Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    N Engl J Med 365:2340-2. 2011
    ..These autoantibodies enhance C3 convertase activity, probably leading to nephritis...
  74. pmc Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi
    Anke Burmester
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Beutenbergstrasse 11a, Jena, 07745, Germany
    Genome Biol 12:R7. 2011
    ....
  75. ncbi request reprint Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65
    Gerhard D Wieland
    Department of Infection Biology, Leibniz Institute for Natural Products, Research and Infection Biology, Hans Knoell Institute, Butenbergstrasse 11a, 07745 Jena, Germany
    J Cell Sci 118:3203-12. 2005
    ..In summary, in T cells, the two zinc-finger proteins EGR-4 and EGR-3 interact with the specific nuclear mediator NF-kappaB and control transcription of genes encoding inflammatory cytokines...
  76. doi request reprint Chronic course of a hemolytic uremic syndrome caused by a deficiency of factor H-related proteins (CFHR1 and CFHR3)
    Michael J Koziolek
    Department of Nephrology and Rheumatology, Georg August University Goettingen, Goettingen, Germany
    Kidney Int 74:384-8. 2008
  77. pmc The molecular basis for hereditary porcine membranoproliferative glomerulonephritis type II: point mutations in the factor H coding sequence block protein secretion
    Guido A Hegasy
    Research Group for Biomolecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Am J Pathol 161:2027-34. 2002
    ..This observation is also of interest for other human diseases in which factor H is involved, such as human factor H-associated form of hemolytic uremic syndrome...
  78. ncbi request reprint The group B streptococcal beta and pneumococcal Hic proteins are structurally related immune evasion molecules that bind the complement inhibitor factor H in an analogous fashion
    Hanna Jarva
    Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Finland
    J Immunol 172:3111-8. 2004
    ..Importantly, the respective virulence factors could be exploited in the development of protein-based vaccines against these pathogens...
  79. ncbi request reprint Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins
    Peter Kraiczy
    Institute of Medical Microbiology, University Hospital of Frankfurt, Paul Ehrlich Strasse 40, D 60596 Frankfurt, Germany
    J Biol Chem 279:2421-9. 2004
    ..is the key molecule of the complement resistance of spirochetes, and (iii). is distinct from the Erp protein family. Thus, BbCRASP-1 most likely contributes to persistence of B. burgdorferi and to pathogenesis of Lyme disease...
  80. ncbi request reprint Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H
    Hanna Jarva
    Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    J Immunol 168:1886-94. 2002
    ..Hic binds to a previously unrecognized microbial interaction site in the middle part of factor H...
  81. ncbi request reprint Onchocerca volvulus microfilariae avoid complement attack by direct binding of factor H
    Taru Meri
    Department of Bacteriology and Immunology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, FIN 00014 Helsinki, Finland
    J Infect Dis 185:1786-93. 2002
    ..Thus, mf of the nematode O. volvulus may evade human complement by binding fH and by promoting inactivation of C3b into iC3b...
  82. pmc Recruitment of complement factor H-like protein 1 promotes intracellular invasion by group A streptococci
    Vinod Pandiripally
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City 66160, USA
    Infect Immun 71:7119-28. 2003
    ..To our knowledge, this is the first report of a bacterial pathogen exploiting a soluble complement regulatory protein for entry into host cells...
  83. ncbi request reprint Immune evasion of Borrelia burgdorferi: insufficient killing of the pathogens by complement and antibody
    Peter Kraiczy
    Institute of Medical Microbiology, Frankfurt University Hospital, Germany
    Int J Med Microbiol 291:141-6. 2002
    ..These antigens may include the recently detected CRASPs...
  84. ncbi request reprint Successful (?) therapy of hemolytic-uremic syndrome with factor H abnormality
    Angela Gerber
    Zentrum für Kinderheilkunde und Jugendmedizin, Universitat Freiburg, Freiburg, Germany
    Pediatr Nephrol 18:952-5. 2003
    ..Before justification of liver transplantation as the ultimate treatment for these patients, an international registry should be developed to optimize and standardize therapeutic alternatives...
  85. ncbi request reprint Mapping of the adrenomedullin-binding domains in human complement factor H
    Alfredo Martinez
    Cell and Cancer Biology Branch, Vascular Biology Faculty, National Cancer Institute, NIH, Building 10, Room 13N262, Bethesda, MD 20892, USA
    Hypertens Res 26:S55-9. 2003
    ..These structure-function data support previous biochemical observations. Our understanding of the binding between AM and factor H may help in the development of new treatments for diseases in which these molecules play active roles...
  86. ncbi request reprint Successful plasma therapy for atypical hemolytic uremic syndrome caused by factor H deficiency owing to a novel mutation in the complement cofactor protein domain 15
    Christoph Licht
    Division of Pediatric Nephrology, Children s Hospital of the University of Cologne, Cologne, Germany
    Am J Kidney Dis 45:415-21. 2005
    ..Based on the measured factor H half-life of about 6 days, regular plasma infusions in 2-week intervals were given, which prevented further aHUS episodes and stopped the decline of kidney function...
  87. ncbi request reprint Complement factor H as a marker for detection of bladder cancer
    Zhu Zhu Cheng
    Department of Bacteriology and Immunology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Clin Chem 51:856-63. 2005
    ..The BTA TRAK and BTA stat tests for bladder cancer use monoclonal antibodies (mAbs) X13.2 and X52.1 to detect factor H (FH)-related material in urine. The exact ligands remain unknown...
  88. doi request reprint Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation
    Anne lie Ståhl
    Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Blood 111:5307-15. 2008
    ..In summary, mutated FH enables complement activation on the surface of platelets and their activation, which may contribute to the development of thrombocytopenia in aHUS...
  89. pmc The complement factor H R1210C mutation is associated with atypical hemolytic uremic syndrome
    Ruben Martinez-Barricarte
    Centro de Investigaciones Biologicas, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Am Soc Nephrol 19:639-46. 2008
    ..In conclusion, the R1210C mutation of complement factor H is a prototypical aHUS mutation that is present as a rare polymorphism in geographically separated human populations...
  90. ncbi request reprint New approaches to the treatment of dense deposit disease
    Richard J H Smith
    Department of Internal Medicine and Otolaryngology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    J Am Soc Nephrol 18:2447-56. 2007
    ..As the understanding of DDD increases, novel therapies should be integrated into existing protocols for DDD and evaluated using an open-label Bayesian study design...
  91. pmc Human pathogenic Borrelia spielmanii sp. nov. resists complement-mediated killing by direct binding of immune regulators factor H and factor H-like protein 1
    Pia Herzberger
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul Ehrlich Str 40, D 60596 Frankfurt, Germany
    Infect Immun 75:4817-25. 2007
    ..This is the first report describing an immune evasion mechanism utilized by B. spielmanii sp. nov., and it demonstrates the capture of human immune regulators to resist complement-mediated killing...
  92. ncbi request reprint Dual binding specificity of a Borrelia hermsii-associated complement regulator-acquiring surface protein for factor H and plasminogen discloses a putative virulence factor of relapsing fever spirochetes
    Evelyn Rossmann
    Infectious Immunology Group, Institute for Immunology, University of Heidelberg, Heidelberg, Germany
    J Immunol 178:7292-301. 2007
    ..hermsii and its resistance to innate immunity...
  93. ncbi request reprint The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells
    Sven Hammerschmidt
    University of Wuerzburg, Research Center for Infectious Diseases, Wuerzburg, Germany
    J Immunol 178:5848-58. 2007
    ....
  94. ncbi request reprint The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models
    Rebecca E Saunders
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, University College London, London, United Kingdom
    Hum Mutat 28:222-34. 2007
    ..The database emphasizes the causative role of the alternative pathway of complement in disease and provides a repository of knowledge to assist future diagnosis and novel therapeutic approaches...
  95. ncbi request reprint MPGN II--genetically determined by defective complement regulation?
    Christoph Licht
    Pediatr Nephrol 22:2-9. 2007
    ..Identification of patients with MPGN II caused by defective complement control may allow treatment by replacement of the missing factor via plasma infusion, thus possibly preventing or at least delaying disease progress...
  96. ncbi request reprint Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1
    Kristina Hartmann
    Institute of Medical Microbiology, University Hospital of Frankfurt, Paul Ehrlich Str 40, 60596 Frankfurt, Germany
    Mol Microbiol 61:1220-36. 2006
    ..The characterization of BbCRASP-2 now provides a complete picture of the three diverse complement regulator-binding protein families of B. burgdorferi yielding new insights into the pathogenesis of Lyme disease...
  97. ncbi request reprint Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome
    Philipp A Lang
    Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany
    J Mol Med (Berl) 84:378-88. 2006
    ..In conclusion, our present observations disclose a novel, pathophysiological, factor-H dependent mechanism leading to injury of erythrocytes during the course of hemolytic uremic syndrome...
  98. pmc Identification and functional characterization of complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes Borrelia afzelii and Borrelia garinii
    Reinhard Wallich
    Infectious Immunology Group, Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Infect Immun 73:2351-9. 2005
    ....
  99. ncbi request reprint Comparison of surface recognition and C3b binding properties of mouse and human complement factor H
    Zhu Zhu Cheng
    Department of Bacteriology and Immunology, Haartman Institute and HUSLAB, University and University Hospital of Helsinki, Haartmaninkatu 3, FIN 00290 Helsinki, Finland
    Mol Immunol 43:972-9. 2006
    ..Based on the results in this report it is conceptually attractive to establish a murine model for aHUS...
  100. pmc Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site
    T Sakari Jokiranta
    Department of Bacteriology and Immunology, Haartman Institute and HUSLAB, FIN 00014, University of Helsinki, Helsinki, Finland
    Am J Pathol 167:1173-81. 2005
    ..Thus, defective heparin/glycosaminoglycan-binding site on domains 19 to 20 of FH most probably mediates complement-induced endothelial cell damage in aHUS...