Karl-Heinz Smalla

Summary

Affiliation: Leibniz Institute for Neurobiology
Location: Magdeburg, Germany
Grants:
Exploring the fucosyl proteome in vitro and in vivo"
K.H. Smalla, W. Tischmeyer and D. Dieterich
(2010 - 2013) LIN Special Project


"Proteomic approach to protein sulfhydryl nitrosylation in epilepsy." K.H. Smalla, T. Kähne, U. Wyneken (2008-2010)
DFG (scientific collaboration with Chile)


„Linking the Microscopic and Macroscopic World: Systematic Study of Water Macromolecule Exchange as a Basis for Ultra-high Field MR Phase Contrast Imaging“. (2009-2012) TP6.1 K.H. Smalla, K. Zhong: Ex vivo macromolecule characterization and WME determination for cellular fractions and tissue extracts CBBS NeuroNetworks/EFRE
(2008-2010)

"Proteomic approach to molecular mechanisms in epilepsy"(2006-2008) K.H. Smalla, E.D. Gundelfinger, U. Wyneken, J.J. Marengo (Federal Ministry of Education and Research; Scientific collaboration with Chile)


Molecular and functional characterisation of protein-protein-interactions of the synaptic glycoprotein neuroplastin. E.D. Gundelfinger, M.R. Kreutz, K.H. Smalla: (2003 - 2005) State Saxony-Anhalt
Publications:
Jork R, Schnurra, I, Smalla KH, Grecksch G, Popov N, Matthies H (1989) Deoxy-galactose mediated amnesia is related to an inhibition of training-induced increase in rat hippocampal glycoprotein fucosylation.
Neurosci Res Commun 5, 3-8

Jork R, Smalla KH, Karsten U, Grecksch G, Rüthrich HL, Matthies H (1991)
Monoclonal Antibody Specific for Histo-Blood Group Antigens H (Types 2 and 4) Interferes with Long-Term Memory Formation in Rats.
Neurosci Res Commun 8: 21-27

Kutyshenko VP, Potekhin SA, Smalla KH (1991)
[Study of the denaturation of the N-terminal fragment of alpha-tropomyosin by NMR spectroscopy].
Biofizika. 36:762-9. ( in Russian).

Zuschratter W, Seidel B, Smalla KH, Karsten U, Scheich H, Jork R (1991) Distribution of (fucogalactosyl-)epitope expressing glycoconjugates in rat brain.
NeuroReport. 8:445-448.

Richter P, Pohle W, Grecksch G, Smalla KH, Jork R, Matthies H (1991)
Enhanced development of morphine tolerance in rats treated with 2-deoxy-D-galactose. Psychopharmacology (Berlin) 104: 279-83.

Smalla KH and Staak S (1991)
Search for a functional role of (fucogalactosyl)-epitope expressimg glycoproteins.
ESF-Network on Neural Mechanisms of Learning and Memory 1991, 57-60

Krug M, Wagner M, Staak S, Smalla, KH (1994)
Fucose and fucose-containing sugar epitopes enhance hippocampal long-term potentiation in the freely moving rat.
Brain Res. 643: 130-135.

Matthies H Jr, Staak S, Smalla KH, Krug M (1997)
Enhancement if hippocampal long-term potentiation in vitro by fucosyl-carbohydrates. In: Neurochemistry: Cellular, Molecular and Clinical Aspects; Eds A. Teelken and J. Korf, Plenum Press 1997, New York and London, 905-908

Smalla KH, Angenstein F, Richter K, Gundelfinger ED and Staak S (1998) Identification of fucose-alpha[1-2]-galactose epitope-containing glycoproteins from rat hippocampus.
NeuroReport 9: 813-817

tom Dieck S, Sanmartí-Vila L, Langnaese K, Richter K, Kindler S, Soyke A, Wex H, Smalla KH, Kämpf U, Fränzer J-T, Stumm M, Garner CC and Gundelfinger ED (1998) Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals.
J. Cell Biol. 142: 499-509

Seidenbecher CI, Langnäse K, Sanmartí-Vila L, Böckers TM, Smalla KH, Sabel BA, Garner CC, Gundelfinger ED and Kreutz MR (1998) Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment.
J. Biol. Chem. 273 (33): 21324-21331

Matthies H Jr, Kretlow J,Matthies H, Smalla KH, Staak S, Krug M (1999) Glycosylation of proteins during a critical time window is necessary for the maintenance of long-term potentiation in the hippocampal CA1 region.
Neuroscience 91: 175-183

Boeckers, TM, Kreutz MR, Winter C, Zuschratter W, Smalla KH, Sanmarti-Vila L, Wex H, Langnaese K, Bockmann J, Garner CC and Gundelfinger ED (1999) Proline-Rich Synapse-Associated Protein-1/Cortactin Binding protein 1 (ProSAP1/CortBP1) Is a PDZ-Domain Protein Highly Enriched in the Postsynaptic Density. J. Neurosci. 19 (15): 6506-6518

Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC and Gundelfinger ED (1999) Proline-Rich Synapse-Associated Proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.
Biochem. Biophys. Res. Comm. 264: 247-252

Spilker C, Richter K, Smalla KH, Manahan-Vaughan D, Gundelfinger ED and Braunewell KH (2000) The neuronal EF-hand calcium-binding protein VILIP-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association.
Neuroscience 96: 121-129

Smalla KH*, Matthies H*, Langnaese K*, Boeckers TM, Wyneken U, Staak S, Krug M, Beesley PW and Gundelfinger ED (2000) The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses.
Proc. Natl. Acad. Sci. USA 97: 4327-4332
* shared first authorship

Schulz R, Bertrand S, Chamaon K, Smalla KH, Gundelfinger ED and Bertrand D (2000). Neuronal Nicotinic Acetylcholine Receptors from Drosophila: Two Different Types of α Subunits Coassemble Within the Same Receptor Complex.
J. Neurochem. 74: 2537-2546

Matthies H, Schröder H, Smalla KH and Krug M (2000) Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus.
Learning & Memory 7: 227-234

Chamaon K, Schulz R, Smalla KH, Seidel B and Gundelfinger ED (2000) Neuronal nicotinic acetylcholine receptors of Drosophila melanogaster: the α-subunit Dα3 and the ß-type subunit ARD co-assemble within the same receptor complex.
FEBS Lett. 24167: 1-4

Keilhoff G, Fansa H, Smalla KH, Schneider W and Wolf G (2000)
Neuroma: a donor-age independent source of human Schwann cells for tissue engineered nerve grafts.
NeuroReport 11: 3805-3809

Wyneken U, Smalla KH, Marengo JJ, Soto D, de la Cerda A, Tischmeyer W, Grimm R, Boeckers TM, Wolf G, Orrego F and Gundelfinger ED (2001) Kainate-induced seizures alter protein composition and NMDA receptor function of rat forebrain postsynaptic densities.
Neuroscience 102: 65-74

Chamaon K*, Smalla KH*, Thomas U and Gundelfinger ED (2001)
Nicotinic acetylcholine receptors of Drosophila: three sununits encoded by genomically linked genes co-assemble into the same receptor complex.
J. Neurochem. 80: 149-157
* shared first authorship

Laube G, Seidenbecher CI, Richter K, Dieterich DC, Hoffmann B, Landwehr M, Smalla KH, Winter C, Böckers TM, Wolf G, Gundelfinger ED and Kreutz MR (2002) The Neuron-Specific Ca2+ -Binding Protein Caldendrin: Gene Structure, Splice Isoforms, and Expression in the Rat Central Nervous System
Mol. Cell. Neurosci. 19: 459-475

Seidenbecher CI, Smalla KH, Fischer N, Gundelfinger ED and Kreutz MR (2002) Brevican isoforms associate with neural membranes.
J. Neurochem: 83, 738-746

Marzban H, Khandzada U, Shabir S, Hawkes R, Langnaese K, Smalla KH, Bockers TM, Gundelfinger ED, Gordon-Weeks PR and Beesley PW (2003) Expression of the Immunoglobulin Superfamily Neuroplastin Adhesion Molecules in Adult and Developing Mouse Cerebellum and Their Localisation to Parasagittal Stripes. J.Comp. Neurol. 462: 286–301

Dieterich DC, Landwehr M, Reissner C, Smalla KH, Richter K, Wolf G, Bockers TM, Gundelfinger ED and Kreutz MR (2003) Gliap - a novel untypical L-asparaginase localized to rat brain astrocytes
J. Neurochem. 85: 1117 –1125

Smalla KH, Seidenbecher CI, Tischmeyer W, Schicknick H, Böckers TM, Gundelfinger ED, Kreutz MR (2003) Kainate-induced epileptic seizures induce a recruitment of caldendrin to postsynaptic density in rat brain. Brain Res Mol Brain Res. 116(1-2): 159-62

Bernstein HG, Seidenbecher CI, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR (2003) Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain.
J. Histochem. Cytochem. 51(8):1109-12.

Roumier A, Bechade C, Poncer JC, Smalla KH, Tomasello E, Vivier E, Gundelfinger ED, Triller A, Bessis A (2004) Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.
J Neurosci. 24(50): 11421-8

Seidenbecher CI, Landwehr M, Smalla KH, Kreutz M, Dieterich DC, Zuschratter W, Reissner C, Hammarback JA, Bockers TM, Gundelfinger ED, Kreutz MR. (2004) Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins.
J Mol Biol. 336(4): 957-70

Li KW, Hornshaw MP, Van Der Schors RC, Watson R, Tate S, Casetta B, Jimenez CR, Gouwenberg Y, Gundelfinger ED, Smalla KH, Smit AB. (2004)
Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology.
J Biol Chem. 279(2): 987-1002

Smalla KH, Li, KW, Smit AB, and ED Gundelfinger (2004)
Proteomic analysis of synaptic structures
Conference “New Methods in Neurobiology”, at Nencki Institute Warsaw, Poland, December 15th 2004, Conference handbook, p.1-4 (www.ptbun.org.pl/ptbun_files/smala.pdf)

Li KW, Hornshaw MP, Smalla KH, Gundelfinger ED, Smit AB. (2005)
Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins
J Proteom Res 4(3):725-33.

John N, Krugel H, Frischknecht R, Smalla KH, Schultz C, Kreutz MR, Gundelfinger ED, Seidenbecher CI (2006) Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures.
Mol Cell Neurosci. 31(4):774-84

Wendholt D, Spilker C, Schmitt A, Dolnik A, Smalla KH, Proepper C, Bockmann J, Sobue K, Gundelfinger ED, Kreutz MR, Boeckers TM (2006) ProSAP interacting protein 1(ProSAPiP1), a novel protein of the postsynaptic density that links the spine associated RapGap (SPAR) to the scaffolding protein ProSAP2 / Shank3.
J Biol Chem. 281(19):13805-16



Mikhaylova M, Sharma Y, Reissner C, Nagel F, Aravind P, Rajini B, Smalla KH, Gundelfinger ED, Kreutz MR (2006) Neuronal Ca2+-signaling via Caldendrin and Calneurons
Biochim Biophys Acta. 1763(11):1229-37. Epub 2006 Sep 6

Bernstein HG, Smalla KH, Bogerts B, Beesley PW, Gundelfinger ED, Kreutz, MR (2007) The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain.
Brain Res. 1134(1):107-12. Epub 2006 Dec 27.

Sandoval M, Sandoval R, Thomas U, Spilker C, Smalla KH, Falcon R, Marengo JJ, Calderón R, Saavedra V, Heumann R, Bronfman F, Garner CC, Gundelfinger ED, Wyneken U (2007). Antagonistic effects of TrkB and p75NTR on NMDA receptor currents in postsynaptic densities transplanted into Xenopus oocytes.
J Neurochem. 101(6):1672-84. Epub 2007 Mar 23.

Langnaese K, Richter K, Smalla KH , Thomas U, Krauss M, Wolf G, Laube G (2007) Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOSα β-finger is largely exposed to antibodies.
Dev Neurobiol. 67(4):422-37.

Putzke J, Spina MG, Buechler J, Kovar K-A, Wolf G, Smalla KH (2007). The effects of p-chloroamphetamine, methamphetamine and 3,4-methylendioxymethamphetamine (ecstasy) on gene expression of cytoskeletal proteins in the rat brain.
Addict Biol. 12(1):69-80

Bernstein HG, Sahin J, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR (2007). A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia.
Schizophr Res. 96(1-3)246-56.; [Epub ahead of print 2007 Aug 23]

Dieterich DC, Karpova A, Mikhaylova M, Zdobnova I, König I, Landwehr M, Kreutz M, Smalla KH, Richter K, Landgraf P, Reissner C, Boeckers TM, Zuschratter W, Spilker C, Seidenbecher CI, Garner CC, Gundelfinger ED, Kreutz MR (2008). Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus.
PLoS Biol. 2008 Feb;6(2):e34.

Schicknick H, Schott BH, Budinger E, Smalla KH, Riedel A, Seidenbecher CI, Scheich H, Gundelfinger ED, Tischmeyer W (2008) Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR.
Cereb Cortex. 18(11):2646-58. Epub 2008 Mar 4.

Smalla KH, Mikhaylova M, Sahin J, Bernstein HG, Bogerts B, Schmitt A, van der Schors R, Smit AB, Li KW, Gundelfinger ED, Kreutz MR (2008) A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia.
Mol Psychiatry 13(9):878-96. Epub 2008 May 27.

Saavedra MV, Smalla KH, Thomas U, Sandoval S, Olavarria K, Castillo K, Delgado MG, Delgado R, Gundelfinger ED, Bacigalupo J and Wyneken U (2008) Scaffolding proteins are present in highly purified rat olfactory cilia membranes.
NeuroReport 19(11):1123-1126

Mikhaylova M, Reddy PP, Munsch T, Landgraf P, Suman SK, Smalla KH, Gundelfinger ED, Sharma Y, Kreutz MR (2009) Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking. Proc Natl Acad Sci U S A 106(22):9093-8. Epub 2009 May 19.

Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR (2009) Altered Postsynaptic-Density-Levels of Caldendrin in the Para-Chloroamphetamine-Induced Serotonin Syndrome but not in the Rat Ketamine Model of Psychosis. Neurochem Res. 34(8):1405-9. Epub 2009 Feb 18.

Jüch M, Smalla KH, Kahne T, Lubec G, Tischmeyer W, Gundelfinger ED, Engelmann M (2009) Congenital lack of nNOS impairs long-term social recognition memory and alters the olfactory bulb proteome. Neurobiol Learn Mem 92(4):469-84
Goswami C, Rademacher N, Smalla KH, Kalscheuer V, Ropers HH, Gundelfinger ED, Hucho T (2010) TRPV1 acts as a synaptic protein and regulates vesicle recycling. J Cell Sci. 123, 2045-57. Epub 2010 May 18.

Dürrschmidt D, Smalla KH, Kreutz MR, Dobrowolny H, Steiner J, Keilhoff G, Bogerts B, Bernstein HG (2010) Increased oligodendroglial expression of the cell proliferation-controlling protein prohibitin in schizophrenia. A hint for cell cycle abnormalities? Acta Clin Croat 49 (Suppl 2), 39-41

Smalla KH and Wyneken U (2011)
2D Gel Electropjoresis-Based Proteomic Analysis of Brain Synapses
in: Neuroproteomics, Humana Press New York, Ed.: Ka Wan Li

Publications

  1. pmc Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
    S tom Dieck
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Cell Biol 142:499-509. 1998
  2. ncbi Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures
    Nora John
    Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany
    Mol Cell Neurosci 31:774-84. 2006
  3. ncbi Neuronal Ca2+ signaling via caldendrin and calneurons
    Marina Mikhaylova
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Biochim Biophys Acta 1763:1229-37. 2006
  4. ncbi The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain
    Hans Gert Bernstein
    Department of Psychiatry, Faculty of Medicine, Otto von Guericke University, Magdeburg, Germany
    Brain Res 1134:107-12. 2007
  5. ncbi A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry, Faculty of Medicine, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Schizophr Res 96:246-56. 2007
  6. pmc Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus
    Daniela C Dieterich
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    PLoS Biol 6:e34. 2008
  7. pmc Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR
    Horst Schicknick
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    Cereb Cortex 18:2646-58. 2008
  8. ncbi A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia
    K H Smalla
    Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Mol Psychiatry 13:878-96. 2008
  9. doi Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis
    Karl Heinz Smalla
    Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Neurochem Res 34:1405-9. 2009
  10. pmc Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking
    Marina Mikhaylova
    Project Group Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Proc Natl Acad Sci U S A 106:9093-8. 2009

Detail Information

Publications25

  1. pmc Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
    S tom Dieck
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Cell Biol 142:499-509. 1998
    ..These data indicate that Bassoon is a strong candidate to be involved in cytomatrix organization at the site of neurotransmitter release...
  2. ncbi Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures
    Nora John
    Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany
    Mol Cell Neurosci 31:774-84. 2006
    ..Furthermore, axon initial segments are strongly covered by a dense brevican coat. Altogether, we show that mature primary cultures can form PNN, and that basic features of these extracellular matrix structures may be studied in vitro...
  3. ncbi Neuronal Ca2+ signaling via caldendrin and calneurons
    Marina Mikhaylova
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Biochim Biophys Acta 1763:1229-37. 2006
    ..Despite some significant structural differences it is conceivable that they are involved in similar Ca2+ regulated processes like caldendrin and neuronal calcium sensor proteins...
  4. ncbi The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain
    Hans Gert Bernstein
    Department of Psychiatry, Faculty of Medicine, Otto von Guericke University, Magdeburg, Germany
    Brain Res 1134:107-12. 2007
    ..In addition we found no segregation of np65 immunolabel in hippocampal subregions like it was reported previously for the rat. These results might indicate different cellular functions of the molecule in different species...
  5. ncbi A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry, Faculty of Medicine, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Schizophr Res 96:246-56. 2007
    ..These observations add to existing evidence for a de-regulation of neuronal Ca(2+)-signaling in schizophrenia...
  6. pmc Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus
    Daniela C Dieterich
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    PLoS Biol 6:e34. 2008
    ....
  7. pmc Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR
    Horst Schicknick
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    Cereb Cortex 18:2646-58. 2008
    ....
  8. ncbi A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia
    K H Smalla
    Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Mol Psychiatry 13:878-96. 2008
    ..Prohibitin, however, could be a new potential marker for the synaptic pathology of schizophrenia and might be causally involved in the disease process...
  9. doi Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis
    Karl Heinz Smalla
    Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Neurochem Res 34:1405-9. 2009
    ..These results underscore the dynamic association of caldendrin with the PSD and suggest a role of this synaptic calcium sensor in the PCA-induced serotonin syndrome...
  10. pmc Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking
    Marina Mikhaylova
    Project Group Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Proc Natl Acad Sci U S A 106:9093-8. 2009
    ..The opposing roles of calneurons and NCS-1 provide a molecular switch to decode local calcium transients at the Golgi and impose a calcium threshold for PI-4Kbeta activity and vesicle trafficking...
  11. doi Congenital lack of nNOS impairs long-term social recognition memory and alters the olfactory bulb proteome
    Mathias Jüch
    Otto von Guericke Universitat, Institut für Biochemie und Zellbiologie, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Neurobiol Learn Mem 92:469-84. 2009
    ..Our data suggest that, in the mouse, NO of nNOS origin is critically involved in the regulation of protein synthesis-dependent olfactory long-term memory consolidation within relevant brain structures including the olfactory bulb...
  12. ncbi Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center of Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Proteome Res 4:725-33. 2005
    ....
  13. ncbi Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse
    Anne Roumier
    Laboratoire de Biologie Cellulaire de la Synapse Normale et Pathologique, Institut National de la Santé et de la Recherche Médicale INSERM U497, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    J Neurosci 24:11421-8. 2004
    ..KARAP/DAP12 may thus alter microglial physiology and subsequently synaptic function and plasticity through a novel microglia-neuron interaction...
  14. ncbi Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins
    Constanze I Seidenbecher
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestr 6 39118 Magdeburg, Germany
    J Mol Biol 336:957-70. 2004
    ..These findings provide molecular evidence that NCS can transduce signals to a specific target interaction irrespective of Ca(2+)-concentrations and CaM-levels...
  15. ncbi Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment
    C I Seidenbecher
    AG Molecular and Cellular Neurobiology, Institute for Medical Psychology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Biol Chem 273:21324-31. 1998
    ..Therefore, this novel Ca2+-binding protein was named caldendrin...
  16. ncbi Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density
    T M Boeckers
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    J Neurosci 19:6506-18. 1999
    ..Both interaction with the actin-binding protein cortactin and early appearance at postsynaptic sites suggest that ProSAP1/CortBP1 may be involved in the assembly of the PSD during neuronal differentiation...
  17. ncbi Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family
    T M Boeckers
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, 39118, Germany
    Biochem Biophys Res Commun 264:247-52. 1999
    ..Therefore, proteins of the ProSAP family represent a novel link between SAP90/PSD-95 bound membrane receptors and the cytoskeleton at glutamatergic synapses of the central nervous system...
  18. pmc Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus
    H Matthies
    Institute of Pharmacology and Toxicology, Faculty of Medicine, University Otto von Guericke, 39120 Magdeburg, Germany
    Learn Mem 7:227-34. 2000
    ..This effect of L-fucose may contribute to the LTP facilitation seen in vitro and in vivo as well as to improvement in memory formation...
  19. ncbi The neuron-specific Ca2+-binding protein caldendrin: gene structure, splice isoforms, and expression in the rat central nervous system
    G Laube
    Institute for Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
    Mol Cell Neurosci 19:459-75. 2002
    ..The presence of caldendrin in the PSD of distinct synapses may have important implications for Ca2+-modulated processes of synaptic plasticity...
  20. ncbi Brevican isoforms associate with neural membranes
    Constanze I Seidenbecher
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    J Neurochem 83:738-46. 2002
    ..Taken together, this could provide a mechanism by which perineuronal nets are anchored on neuronal surfaces...
  21. ncbi Gliap--a novel untypical L-asparaginase localized to rat brain astrocytes
    Daniela C Dieterich
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    J Neurochem 85:1117-25. 2003
    ..In brain Gliap is exclusively expressed in astrocytes and prominently present in structures reminiscent of glial endfeet. These data suggest that Gliap is involved in astroglial production of the neuroactive amino acid L-aspartate...
  22. ncbi Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes
    Hassan Marzban
    Department of Cell Biology and Anatomy, Genes and Development Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Comp Neurol 462:286-301. 2003
    ..The data suggest a role for neuroplastins in the development and maintenance of normal synaptic connections in the cerebellum...
  23. ncbi Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Histochem Cytochem 51:1109-12. 2003
    ..Therefore, one prerequisite for functional studies in rodent models aimed at elucidation of mechanisms with relevance for humans can be based on the present findings...
  24. ncbi Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Research Institute of Neurosciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 279:987-1002. 2004
    ..Together, these results imply that the postsynaptic density may have the ability to function (semi-) autonomously and may direct various cellular functions in order to integrate synaptic physiology...
  25. ncbi TRPV1 acts as a synaptic protein and regulates vesicle recycling
    Chandan Goswami
    Signal Transduction in Pain and Mental Retardation, Department for Molecular Human Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Cell Sci 123:2045-57. 2010
    ..These data suggest that TRPV1 is involved in processes such as neuronal network formation, synapse modulation and release of synaptic transmitters...