Helen Morrison

Summary

Affiliation: Leibniz Institute for Age Research
Country: Germany

Publications

  1. ncbi request reprint Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
    Hongchuan Jin
    Leibniz Institute of Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    Nature 442:576-9. 2006
  2. ncbi request reprint Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
    Helen Morrison
    Institute of Age Research, Fritz Lipmann Institute, Jena, Germany
    Cancer Res 67:520-7. 2007
  3. pmc Activation of Ras requires the ERM-dependent link of actin to the plasma membrane
    Tobias Sperka
    Morrison Laboratory, Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    PLoS ONE 6:e27511. 2011
  4. pmc Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling
    Alexander Schulz
    1 Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany
    Brain 137:420-32. 2014
  5. pmc Regulation of Son of sevenless by the membrane-actin linker protein ezrin
    Katja J Geissler
    H M Laboratory, P H Laboratory, and M E T Laboratory, Leibniz Institute for Age Research Fritz Lipmann Institute, 07745 Jena, Germany
    Proc Natl Acad Sci U S A 110:20587-92. 2013
  6. pmc Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration
    Alexander Schulz
    Leibniz Institute on Aging, Fritz Lipmann Institute, 07745, Jena, Germany
    PLoS ONE 11:e0159718. 2016
  7. doi request reprint CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins
    Lars Björn Riecken
    Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany
    Oncotarget . 2016
  8. doi request reprint Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy
    Alexander Schulz
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany
    Nat Neurosci 16:426-33. 2013
  9. pmc The importance of nerve microenvironment for schwannoma development
    Alexander Schulz
    Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745, Jena, Germany
    Acta Neuropathol 132:289-307. 2016
  10. doi request reprint Merlin inhibits neurite outgrowth in the CNS
    Alexander Schulz
    Institute of Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, Jena, Germany
    J Neurosci 30:10177-86. 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
    Hongchuan Jin
    Leibniz Institute of Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    Nature 442:576-9. 2006
    ..MYPT-1-PP1delta and its substrate merlin are part of a previously undescribed tumour suppressor cascade that can be hindered in two ways, by mutation of the NF2 gene and by upregulation of the oncoprotein CPI-17...
  2. ncbi request reprint Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
    Helen Morrison
    Institute of Age Research, Fritz Lipmann Institute, Jena, Germany
    Cancer Res 67:520-7. 2007
    ..We propose that the interference of merlin with Ras- and Rac-dependent signal transfer represents part of the tumor-suppressive action of merlin...
  3. pmc Activation of Ras requires the ERM-dependent link of actin to the plasma membrane
    Tobias Sperka
    Morrison Laboratory, Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    PLoS ONE 6:e27511. 2011
    ..An important component in the activation of Ras is Son of sevenless (SOS), which catalyzes the nucleotide exchange on Ras...
  4. pmc Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling
    Alexander Schulz
    1 Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany
    Brain 137:420-32. 2014
    ..Collectively, we have identified that neuronally expressed merlin can influence Schwann cell activity in a cell-extrinsic manner. ..
  5. pmc Regulation of Son of sevenless by the membrane-actin linker protein ezrin
    Katja J Geissler
    H M Laboratory, P H Laboratory, and M E T Laboratory, Leibniz Institute for Age Research Fritz Lipmann Institute, 07745 Jena, Germany
    Proc Natl Acad Sci U S A 110:20587-92. 2013
    ..We propose an additional essential step in SOS/Ras control that is relevant for human cancer as well as all physiological processes involving Ras. ..
  6. pmc Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration
    Alexander Schulz
    Leibniz Institute on Aging, Fritz Lipmann Institute, 07745, Jena, Germany
    PLoS ONE 11:e0159718. 2016
    ..This mechanism could explain the clinical observation that NF2 patients suffer from higher incidences of slowly recovering facial nerve paralysis after vestibular schwannoma surgery. ..
  7. doi request reprint CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins
    Lars Björn Riecken
    Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany
    Oncotarget . 2016
    ..The in vivo significance of this oncogenic switch is highlighted by demonstrating CPI-17's involvement in human melanoma pathogenesis...
  8. doi request reprint Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy
    Alexander Schulz
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany
    Nat Neurosci 16:426-33. 2013
    ..Sciatic nerves from these mice and sural nerve biopsies from NF2 patients revealed reduced phosphorylation of the neurofilament H subunit, decreased interfilament spacings and irregularly shaped axons...
  9. pmc The importance of nerve microenvironment for schwannoma development
    Alexander Schulz
    Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745, Jena, Germany
    Acta Neuropathol 132:289-307. 2016
    ..Furthermore, we provide evidence supporting the potential efficacy of anti-inflammatory drugs in the treatment of schwannomas. ..
  10. doi request reprint Merlin inhibits neurite outgrowth in the CNS
    Alexander Schulz
    Institute of Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, Jena, Germany
    J Neurosci 30:10177-86. 2010
    ..We thus provide evidence that merlin plays a pivotal role in controlling the neuronal wiring in the developing CNS...
  11. doi request reprint Properties of an ezrin mutant defective in F-actin binding
    Henri S Saleh
    Leibniz Institute of Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    J Mol Biol 385:1015-31. 2009
    ..Taken together, these observations highlight the importance of ezrin/F-actin function in the development of dynamic membrane/actin structures critical for cell shape and motility, as well as signal transduction...
  12. doi request reprint Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells
    Astrid Petermann
    Institute of Molecular Cell Biology, CMB, Jena University Hospital, Hans Knöll Strasse 2, 07745, Jena, Germany
    J Neurooncol 122:451-9. 2015
    ..The studies suggest induction of MMP-9 expression promoted by DEP-1 deficiency, or potentially by growth factors and inflammatory cytokines, as a mechanism contributing to meningioma brain invasiveness. ..
  13. doi request reprint Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability
    Lars Björn Riecken
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany
    Hum Mutat 36:270-8. 2015
    ..To our knowledge, this is the first report of an autosomal recessively inherited loss-of-function mutation causing reduced Ras activity and thus extends and complements the pathogenicity spectrum of known Ras-MAPK pathway disturbances...
  14. doi request reprint Merlin's wizardry guides cohesive migration
    Ansgar Zoch
    Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany
    Nat Cell Biol 17:212-3. 2015
    ..The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin-Rich1 complex and the Rac1 small GTPase. ..
  15. doi request reprint Tumor Suppressor NF2 Blocks Cellular Migration by Inhibiting Ectodomain Cleavage of CD44
    Monika Hartmann
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany
    Mol Cancer Res 13:879-90. 2015
    ..Disruption of the actin cytoskeleton however, also inhibited NRG1 cleavage. This current study presents one of the first examples of substrate-selective cleavage regulation...
  16. pmc Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin
    Veronique Orian-Rousseau
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, 76021 Karlsruhe, Germany
    Mol Biol Cell 18:76-83. 2007
    ..So far the cytoskeleton has mainly been identified as a "responder" to signal transduction. Here, we show now that F-actin acts as an "inducer" that actively organizes the signaling cascade...
  17. pmc Listeria monocytogenes exploits ERM protein functions to efficiently spread from cell to cell
    Sascha Pust
    Department of Cell Biology, Gesellschaft fur Biotechnologische Forschung GBF, Braunschweig, Germany
    EMBO J 24:1287-300. 2005
    ..As a consequence, Listeria cell-to-cell spread is severely impaired. Thus, ERM proteins are exploited by Listeria to escape the host immune response and to succeed in the development of the infection...
  18. ncbi request reprint Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling
    Daniel R Scoles
    Cedars Sinai Medical Center, School of Medicine, University of California at Los Angeles, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Hum Mol Genet 11:3179-89. 2002
    ..These data are consistent with the hypothesis that schwannomin requires HRS interaction to be fully functionally active and to inhibit STAT activation...