Research Topics
Genomes and Genes | Christoph KaetherSummaryAffiliation: Leibniz Institute for Age Research Country: Germany Publications
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Publications
Notch1 signaling is mediated by importins alpha 3, 4, and 7Kerstin Huenniger
Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstr 11, 07745, Jena, Germany
Cell Mol Life Sci 67:3187-96. 2010..siRNA-mediated knockdown experiments showed that importins alpha3, alpha4 (and to a lesser extent, alpha7) mediate nuclear import of NICD and thus are directly involved in Notch signaling...- NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent mannerMarcel Kramer
Genome Analysis, Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
BMC Res Notes 3:224. 2010..NOD2 displays a tandem caspase recruitment domain (CARD) architecture, which is unique within the NLR family... - Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1Christoph Kaether
Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Ludwig Maximilians Universitat, München 80336, Germany
EMBO Rep 8:743-8. 2007..To our knowledge, Rer1 is the first identified interaction partner of mammalian transmembrane-based retention/retrieval signals... 
Assembly, trafficking and function of gamma-secretaseChristoph Kaether
Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany
Neurodegener Dis 3:275-83. 2006..Finally, Rer1 was identified as a PEN-2-binding protein that serves a role as an auxiliary factor for gamma-secretase complex assembly...- Gamma-secretase complex assembly within the early secretory pathwayAnja Capell
Adolf Butenandt Institut, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians Universitat, Schillerstrasse 44, 80336 Munich, Germany
J Biol Chem 280:6471-8. 2005.... - The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activityChristoph Kaether
Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians Universitat, Munchen, Germany
EMBO J 23:4738-48. 2004..Deletion of the retention signal results in the release of PS1 from the ER and the assembly of a nonfunctional gamma-secretase complex, suggesting that at least a part of the retention motif may also be required for the function of PS1... - Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptideSven Lammich
Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
J Biol Chem 277:44754-9. 2002..The dual cleavage mechanism is required for nuclear signaling as well as removal of remaining transmembrane domains, a general function of PS in membrane protein metabolism... - The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretaseAya Yamasaki
Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany
J Neurosci 26:3821-8. 2006..Our data thus implicate a role of the GxGD motif in catalytic function and substrate identification of gamma-secretase... - Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membraneChristoph Kaether
Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
J Cell Biol 158:551-61. 2002..Our data suggest that PS is targeted as a biologically active complex with Nct through the secretory pathway to the cell surface and suggest a dual function of PS in gamma-secretase processing and in trafficking... - Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surfaceChristoph Kaether
Department of Biochemistry, Adolf Butenandt Institute, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munchen, Germany
Traffic 7:408-15. 2006..Similar results were obtained for another gamma-secretase substrate, NotchDeltaE. Our results suggest that intracellular domains are generated by gamma-secretase at the plasma membrane and/or early endosomes... - Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domainAnja Capell
Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstrasse 44, Ludwig Maximilians University, 80336 Munich, Germany
J Biol Chem 278:52519-23. 2003..We identified the N-terminal region of the NCT TMD as a functionally important entity of NCT. These data thus demonstrate that NCT interacts with other gamma-secretase complex components via its TMD... - Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1Dieter Edbauer
Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstr 44, Ludwig Maximilians University, 80336 Munich, Germany
J Biol Chem 279:37311-5. 2004..We conclude that cooperative effects may stabilize a trim-eric complex of APH-1a G122D together with PS1 and NCT. Upon successful complex assembly, the GXXXG motif becomes dispensable for gamma-secretase activity... - Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicityRalf P Friedrich
Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany
Proc Natl Acad Sci U S A 107:1942-7. 2010..These data imply a mechanism where the pathogenic activity of Abeta is attributed, at least in part, to intracellular aggregates... - A lipid boundary separates APP and secretases and limits amyloid beta-peptide generationChristoph Kaether
Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig Maximilans University, , Germany
J Cell Biol 167:809-12. 2004..These findings describe a novel mechanism for controlling proteolytic activity by building a lipid boundary between proteases and their substrates... - Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell deathKatrin Juenemann
Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745, Jena, Germany
Neurotox Res 20:120-33. 2011..Our data indicate that the N-terminal proteolytic processing of mutant huntingtin can be modulated with an effect on aggregation and cell death rate... - Klotho is a substrate for alpha-, beta- and gamma-secretaseLaura Bloch
Leibniz Institut für Altersforschung Fritz Lipmann Institut, Beutenbergstr 11, 07745 Jena, Germany
FEBS Lett 583:3221-4. 2009..Our data suggest that therapeutic approaches targeting these proteases should be carefully analyzed for potential side effects on Klotho-mediated physiological processes... - Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartmentTobias Straub
Department of Molecular Biology, Adolf Butenandt Institute, Schillerstr 44, 80336, Munich, Germany
Chromosoma 114:352-64. 2005..Our findings have profound implications for the mechanism underlying dosage compensation and furthermore provide a new, conceptual reference of stability in an otherwise highly dynamic nuclear environment... - Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 productionTobias Moehlmann
Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
Proc Natl Acad Sci U S A 99:8025-30. 2002..Finally, we show that PS1 L166 mutants affect the generation of NICD and AICD in a similar manner, supporting the concept that S3 protease and S3-like gamma-secretase cleavages are mediated by identical proteolytic activities... - Trafficking and proteolytic processing of APPChristian Haass
DZNE German Center for Neurodegenerative Diseases, 80336 Munich, Germany Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
Cold Spring Harb Perspect Med 2:a006270. 2012..Furthermore, we illuminate how neuronal activity and mutations which cause familial Alzheimer disease affect amyloid β-peptide generation and therefore disease onset and progression... 
Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneuronsAndré Steinecke
Institut für Allgemeine Zoologie und Tierphysiologie, Universitat Jena, 07743 Jena, Germany
J Neurosci 32:738-45. 2012..These findings provide a possible link between clinical studies reporting alterations of cortical interneurons in schizophrenic patients and the current notion of schizophrenia as a neurodevelopmental disorder...- Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptidesClaire Goldsbury
Max Planck Unit for Structural Molecular Biology, c o DESY, Notkestrasse 85, 22607 Hamburg, Germany
Traffic 7:873-88. 2006..The results do not support the above hypothesis. Instead, they indicate that APP is transported on vesicles distinct from the secretase components and that amyloid-beta is not generated in transit when transport is blocked by tau...