Christoph Kaether

Summary

Affiliation: Leibniz Institute for Age Research
Country: Germany

Publications

  1. pmc Notch1 signaling is mediated by importins alpha 3, 4, and 7
    Kerstin Huenniger
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstr 11, 07745, Jena, Germany
    Cell Mol Life Sci 67:3187-96. 2010
  2. pmc NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner
    Marcel Kramer
    Genome Analysis, Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    BMC Res Notes 3:224. 2010
  3. ncbi request reprint Assembly, trafficking and function of gamma-secretase
    Christoph Kaether
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany
    Neurodegener Dis 3:275-83. 2006
  4. pmc Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1
    Christoph Kaether
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Ludwig Maximilians Universitat, München 80336, Germany
    EMBO Rep 8:743-8. 2007
  5. ncbi request reprint Gamma-secretase complex assembly within the early secretory pathway
    Anja Capell
    Adolf Butenandt Institut, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians Universitat, Schillerstrasse 44, 80336 Munich, Germany
    J Biol Chem 280:6471-8. 2005
  6. pmc The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity
    Christoph Kaether
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians Universitat, Munchen, Germany
    EMBO J 23:4738-48. 2004
  7. ncbi request reprint Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide
    Sven Lammich
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 277:44754-9. 2002
  8. pmc Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane
    Christoph Kaether
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Cell Biol 158:551-61. 2002
  9. ncbi request reprint The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase
    Aya Yamasaki
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 26:3821-8. 2006
  10. ncbi request reprint Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
    Anja Capell
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstrasse 44, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 278:52519-23. 2003

Collaborators

Detail Information

Publications21

  1. pmc Notch1 signaling is mediated by importins alpha 3, 4, and 7
    Kerstin Huenniger
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstr 11, 07745, Jena, Germany
    Cell Mol Life Sci 67:3187-96. 2010
    ..siRNA-mediated knockdown experiments showed that importins alpha3, alpha4 (and to a lesser extent, alpha7) mediate nuclear import of NICD and thus are directly involved in Notch signaling...
  2. pmc NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner
    Marcel Kramer
    Genome Analysis, Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    BMC Res Notes 3:224. 2010
    ..NOD2 displays a tandem caspase recruitment domain (CARD) architecture, which is unique within the NLR family...
  3. ncbi request reprint Assembly, trafficking and function of gamma-secretase
    Christoph Kaether
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany
    Neurodegener Dis 3:275-83. 2006
    ..Finally, Rer1 was identified as a PEN-2-binding protein that serves a role as an auxiliary factor for gamma-secretase complex assembly...
  4. pmc Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1
    Christoph Kaether
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Ludwig Maximilians Universitat, München 80336, Germany
    EMBO Rep 8:743-8. 2007
    ..To our knowledge, Rer1 is the first identified interaction partner of mammalian transmembrane-based retention/retrieval signals...
  5. ncbi request reprint Gamma-secretase complex assembly within the early secretory pathway
    Anja Capell
    Adolf Butenandt Institut, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians Universitat, Schillerstrasse 44, 80336 Munich, Germany
    J Biol Chem 280:6471-8. 2005
    ....
  6. pmc The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity
    Christoph Kaether
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians Universitat, Munchen, Germany
    EMBO J 23:4738-48. 2004
    ..Deletion of the retention signal results in the release of PS1 from the ER and the assembly of a nonfunctional gamma-secretase complex, suggesting that at least a part of the retention motif may also be required for the function of PS1...
  7. ncbi request reprint Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide
    Sven Lammich
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 277:44754-9. 2002
    ..The dual cleavage mechanism is required for nuclear signaling as well as removal of remaining transmembrane domains, a general function of PS in membrane protein metabolism...
  8. pmc Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane
    Christoph Kaether
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Cell Biol 158:551-61. 2002
    ..Our data suggest that PS is targeted as a biologically active complex with Nct through the secretory pathway to the cell surface and suggest a dual function of PS in gamma-secretase processing and in trafficking...
  9. ncbi request reprint The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase
    Aya Yamasaki
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 26:3821-8. 2006
    ..Our data thus implicate a role of the GxGD motif in catalytic function and substrate identification of gamma-secretase...
  10. ncbi request reprint Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
    Anja Capell
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstrasse 44, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 278:52519-23. 2003
    ..We identified the N-terminal region of the NCT TMD as a functionally important entity of NCT. These data thus demonstrate that NCT interacts with other gamma-secretase complex components via its TMD...
  11. ncbi request reprint Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
    Christoph Kaether
    Department of Biochemistry, Adolf Butenandt Institute, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munchen, Germany
    Traffic 7:408-15. 2006
    ..Similar results were obtained for another gamma-secretase substrate, NotchDeltaE. Our results suggest that intracellular domains are generated by gamma-secretase at the plasma membrane and/or early endosomes...
  12. ncbi request reprint Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
    Dieter Edbauer
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstr 44, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 279:37311-5. 2004
    ..We conclude that cooperative effects may stabilize a trim-eric complex of APH-1a G122D together with PS1 and NCT. Upon successful complex assembly, the GXXXG motif becomes dispensable for gamma-secretase activity...
  13. pmc Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity
    Ralf P Friedrich
    Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany
    Proc Natl Acad Sci U S A 107:1942-7. 2010
    ..These data imply a mechanism where the pathogenic activity of Abeta is attributed, at least in part, to intracellular aggregates...
  14. pmc A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation
    Christoph Kaether
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilans University, Munchen, Germany
    J Cell Biol 167:809-12. 2004
    ..These findings describe a novel mechanism for controlling proteolytic activity by building a lipid boundary between proteases and their substrates...
  15. pmc Klotho is a substrate for alpha-, beta- and gamma-secretase
    Laura Bloch
    Leibniz Institut für Altersforschung Fritz Lipmann Institut, Beutenbergstr 11, 07745 Jena, Germany
    FEBS Lett 583:3221-4. 2009
    ..Our data suggest that therapeutic approaches targeting these proteases should be carefully analyzed for potential side effects on Klotho-mediated physiological processes...
  16. pmc Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death
    Katrin Juenemann
    Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745, Jena, Germany
    Neurotox Res 20:120-33. 2011
    ..Our data indicate that the N-terminal proteolytic processing of mutant huntingtin can be modulated with an effect on aggregation and cell death rate...
  17. pmc Trafficking and proteolytic processing of APP
    Christian Haass
    DZNE German Center for Neurodegenerative Diseases, 80336 Munich, Germany Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    Cold Spring Harb Perspect Med 2:a006270. 2012
    ..Furthermore, we illuminate how neuronal activity and mutations which cause familial Alzheimer disease affect amyloid β-peptide generation and therefore disease onset and progression...
  18. ncbi request reprint Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment
    Tobias Straub
    Department of Molecular Biology, Adolf Butenandt Institute, Schillerstr 44, 80336, Munich, Germany
    Chromosoma 114:352-64. 2005
    ..Our findings have profound implications for the mechanism underlying dosage compensation and furthermore provide a new, conceptual reference of stability in an otherwise highly dynamic nuclear environment...
  19. pmc Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production
    Tobias Moehlmann
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 99:8025-30. 2002
    ..Finally, we show that PS1 L166 mutants affect the generation of NICD and AICD in a similar manner, supporting the concept that S3 protease and S3-like gamma-secretase cleavages are mediated by identical proteolytic activities...
  20. doi request reprint Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons
    André Steinecke
    Institut für Allgemeine Zoologie und Tierphysiologie, Universitat Jena, 07743 Jena, Germany
    J Neurosci 32:738-45. 2012
    ..These findings provide a possible link between clinical studies reporting alterations of cortical interneurons in schizophrenic patients and the current notion of schizophrenia as a neurodevelopmental disorder...
  21. ncbi request reprint Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides
    Claire Goldsbury
    Max Planck Unit for Structural Molecular Biology, c o DESY, Notkestrasse 85, 22607 Hamburg, Germany
    Traffic 7:873-88. 2006
    ..The results do not support the above hypothesis. Instead, they indicate that APP is transported on vesicles distinct from the secretase components and that amyloid-beta is not generated in transit when transport is blocked by tau...