E D Gundelfinger

Summary

Affiliation: Leibniz Institute for Neurobiology
Country: Germany

Publications

  1. pmc Cholinergic and GABAergic pathways in fly motion vision
    T M Brotz
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft Spemannstr, 37 39, D 72076 Tubingen, Germany
    BMC Neurosci 2:1. 2001
  2. ncbi request reprint A role for zinc in postsynaptic density asSAMbly and plasticity?
    Eckart D Gundelfinger
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Trends Biochem Sci 31:366-73. 2006
  3. ncbi request reprint Temporal and spatial coordination of exocytosis and endocytosis
    Eckart D Gundelfinger
    Leibniz Institute for Neurobiology, Department of Neurochemistry and Molecular Biology, Brenneckestr 6, 39118 Magdeburg, Germany
    Nat Rev Mol Cell Biol 4:127-39. 2003
  4. ncbi request reprint Molecular organization of excitatory chemical synapses in the mammalian brain
    E D Gundelfinger
    Leibniz Institut für Neurobiologie, Abteilung Neurochemie und Molekularbiologie, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Naturwissenschaften 87:513-23. 2000
  5. ncbi request reprint The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association
    C Spilker
    Leibniz Institute for Neurobiology, P O Box 1860, D 39008, Magdeburg, Germany
    Neuroscience 96:121-9. 2000
  6. ncbi request reprint Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family
    T M Boeckers
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, 39118, Germany
    Biochem Biophys Res Commun 264:247-52. 1999
  7. ncbi request reprint Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function
    C Spilker
    Signal Transduction Research Group, Leibniz Institute for Neurobiology, Germany
    Biochim Biophys Acta 1600:118-27. 2002
  8. ncbi request reprint Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure
    U Thomas
    Department of Neurochemistry and Molecular Biology, Federal Institute for Neurobiology, Magdeburg, Germany
    Neuron 19:787-99. 1997
  9. ncbi request reprint Neuronal nicotinic acetylcholine receptors from Drosophila: two different types of alpha subunits coassemble within the same receptor complex
    R Schulz
    Leibniz Institute for Neurobiology, Otto von Guericke University, Magdeburg, Germany
    J Neurochem 74:2537-46. 2000
  10. ncbi request reprint Distribution of transcript and protein isoforms of the synaptic glycoprotein neuroplastin in rat retina
    M R Kreutz
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckstr 6, 39118 Magdeburg, Germany
    Invest Ophthalmol Vis Sci 42:1907-14. 2001

Detail Information

Publications87

  1. pmc Cholinergic and GABAergic pathways in fly motion vision
    T M Brotz
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft Spemannstr, 37 39, D 72076 Tubingen, Germany
    BMC Neurosci 2:1. 2001
    ..In the present study we investigated the distribution of the respective neurotransmitter receptors in the fly visual system, namely nicotinic acetylcholine receptors (nAChRs) and GABA receptors (GABARs) demonstrated by antibody labeling...
  2. ncbi request reprint A role for zinc in postsynaptic density asSAMbly and plasticity?
    Eckart D Gundelfinger
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Trends Biochem Sci 31:366-73. 2006
    ..Based on these observations, we propose a new model of synaptic plasticity in which Zn2+ influx directly and instantly modulates the structure and function of the postsynaptic density...
  3. ncbi request reprint Temporal and spatial coordination of exocytosis and endocytosis
    Eckart D Gundelfinger
    Leibniz Institute for Neurobiology, Department of Neurochemistry and Molecular Biology, Brenneckestr 6, 39118 Magdeburg, Germany
    Nat Rev Mol Cell Biol 4:127-39. 2003
    ..This review discusses emerging insights into the coupling of these processes, both in the chemical synapses of neurons and in non-neuronal cells...
  4. ncbi request reprint Molecular organization of excitatory chemical synapses in the mammalian brain
    E D Gundelfinger
    Leibniz Institut für Neurobiologie, Abteilung Neurochemie und Molekularbiologie, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Naturwissenschaften 87:513-23. 2000
    ....
  5. ncbi request reprint The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association
    C Spilker
    Leibniz Institute for Neurobiology, P O Box 1860, D 39008, Magdeburg, Germany
    Neuroscience 96:121-9. 2000
    ..These results suggest that visinin-like protein-3, which is mainly expressed in Purkinje cells in vivo, shows a calcium-dependent association with cell membranes which is mediated by a calcium-myristoyl switch...
  6. ncbi request reprint Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family
    T M Boeckers
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, 39118, Germany
    Biochem Biophys Res Commun 264:247-52. 1999
    ..Therefore, proteins of the ProSAP family represent a novel link between SAP90/PSD-95 bound membrane receptors and the cytoskeleton at glutamatergic synapses of the central nervous system...
  7. ncbi request reprint Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function
    C Spilker
    Signal Transduction Research Group, Leibniz Institute for Neurobiology, Germany
    Biochim Biophys Acta 1600:118-27. 2002
    ....
  8. ncbi request reprint Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure
    U Thomas
    Department of Neurochemistry and Molecular Biology, Federal Institute for Neurobiology, Magdeburg, Germany
    Neuron 19:787-99. 1997
    ..These results indicate a central role for DLG in the structural organization and downstream signaling mechanisms of cell adhesion molecules and ion channels at synapses...
  9. ncbi request reprint Neuronal nicotinic acetylcholine receptors from Drosophila: two different types of alpha subunits coassemble within the same receptor complex
    R Schulz
    Leibniz Institute for Neurobiology, Otto von Guericke University, Magdeburg, Germany
    J Neurochem 74:2537-46. 2000
    ..These data demonstrate that the presence of the two alpha subunits within a single receptor complex confers new receptor properties that cannot be predicted from knowledge of the binary receptor's properties...
  10. ncbi request reprint Distribution of transcript and protein isoforms of the synaptic glycoprotein neuroplastin in rat retina
    M R Kreutz
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckstr 6, 39118 Magdeburg, Germany
    Invest Ophthalmol Vis Sci 42:1907-14. 2001
    ..To examine the expression and localization of the neuroplastins (np), two synapse-enriched members of the immunoglobulin (Ig) superfamily of cell-adhesion molecules, in the developing and adult retina and optic nerve...
  11. ncbi request reprint Neuronal nicotinic acetylcholine receptors of Drosophila melanogaster: the alpha-subunit dalpha3 and the beta-type subunit ARD co-assemble within the same receptor complex
    K Chamaon
    Leibniz Institute for Neurobiology, Department of Neurochemistry and Molecular Biology, Magdeburg, Germany
    FEBS Lett 482:189-92. 2000
    ..Dalpha3 antibodies co-immunoprecipitate Dalpha3 and ARD proteins and, vice versa, anti-ARD antibodies co-precipitate ARD and Dalpha3. These data demonstrate that one type of fly nAChRs includes these two subunits as integral components...
  12. pmc The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses
    K H Smalla
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Proc Natl Acad Sci U S A 97:4327-32. 2000
    ..These data suggest that neuroplastin plays an essential role in implementing long-term changes in synaptic activity, possibly by means of a homophilic adhesion mechanism...
  13. ncbi request reprint The presynaptic cytomatrix of brain synapses
    T Dresbach
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cell Mol Life Sci 58:94-116. 2001
    ..Finally, we will summarize recent progress that has been made in understanding how active zones are assembled during nervous system development...
  14. pmc Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
    S tom Dieck
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Cell Biol 142:499-509. 1998
    ..These data indicate that Bassoon is a strong candidate to be involved in cytomatrix organization at the site of neurotransmitter release...
  15. doi request reprint A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia
    K H Smalla
    Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Mol Psychiatry 13:878-96. 2008
    ..Prohibitin, however, could be a new potential marker for the synaptic pathology of schizophrenia and might be causally involved in the disease process...
  16. ncbi request reprint Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients
    K Braunewell
    Leibniz Institute for Neurobiology, Department of Neurochemistry Molecular Biology, Magdeburg, Germany
    Dement Geriatr Cogn Disord 12:110-6. 2001
    ..Our morphological and neurochemical findings point to an involvement of these two neuronal calcium sensor proteins in pathology and possibly pathophysiology of changed calcium homeostasis in AD...
  17. ncbi request reprint Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density
    T M Boeckers
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    J Neurosci 19:6506-18. 1999
    ..Both interaction with the actin-binding protein cortactin and early appearance at postsynaptic sites suggest that ProSAP1/CortBP1 may be involved in the assembly of the PSD during neuronal differentiation...
  18. ncbi request reprint D alpha3, a new functional alpha subunit of nicotinic acetylcholine receptors from Drosophila
    R Schulz
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    J Neurochem 71:853-62. 1998
    ....
  19. ncbi request reprint Low level expression of calcium-sensor protein VILIP induces cAMP-dependent differentiation in rat C6 glioma cells
    K H Braunewell
    Department of Neurochemistry and Molecular Biology, Federal Institute for Neurobiology, Magdeburg, Germany
    Neurosci Lett 234:139-42. 1997
    ..These results suggest that depending on myristoylation, low level ectopic expression of VILIP affects basal cAMP homeostasis differentially, thereby influencing differentiation of C6 model cells...
  20. ncbi request reprint Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function
    K H Braunewell
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, PO Box 1860, D 39008 Magdeburg, Germany
    Cell Tissue Res 295:1-12. 1999
    ....
  21. ncbi request reprint Functional expression of rat synapse-associated proteins SAP97 and SAP102 in Drosophila dlg-1 mutants: effects on tumor suppression and synaptic bouton structure
    U Thomas
    Federal Institute for Neurobiology, Department of Neurochemistry and Molecular Biology, Magdeburg, Germany
    Mech Dev 62:161-74. 1997
    ....
  22. ncbi request reprint The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity
    K H Braunewell
    Department of Neurochemistry and Molecular Biology, Federal Institute for Neurobiology, Magdeburg, Germany
    J Neurochem 68:2129-39. 1997
    ..These results suggest that VILIP acts as a calcium sensor molecule that modulates cell signaling cascades, possibly by direct or indirect regulation of adenylyl cyclase activity...
  23. ncbi request reprint Transcripts for secreted and GPI-anchored brevican are differentially distributed in rat brain
    C I Seidenbecher
    Leibnitz Institute for Neurobiology, Magdeburg, Germany
    Eur J Neurosci 10:1621-30. 1998
    ..This late appearance of GPI-linked brevican, its predominant expression in glial cells and its tight association with brain myelin fractions suggest a functional role in neuroglia...
  24. ncbi request reprint Spatial and sub-cellular localization of the membrane cytoskeleton-associated protein alpha-adducin in the rat brain
    B Seidel
    Federal Institute for Neurobiology, Department of Neurochemistry and Molecular Biology, Magdeburg, Germany
    Brain Res 700:13-24. 1995
    ..In both cases the majority of synaptic structures does not contain adducin. Significant immunoreactivity is also detected in processes of glial cells both in the hippocampus and the cerebellum...
  25. ncbi request reprint Protein components of a rat brain synaptic junctional protein preparation
    K Langnaese
    Federal Institute for Neurobiology, Department of Neurochemistry and Molecular Biology, Magdeburg, Germany
    Brain Res Mol Brain Res 42:118-22. 1996
    ..This demonstrates that both pre- and postsynaptic elements purify with the PSD fraction...
  26. ncbi request reprint Synaptic membrane glycoproteins gp65 and gp55 are new members of the immunoglobulin superfamily
    K Langnaese
    Department of Neurochemistry and Molecular Biology, Federal Institute for Neurobiology, Magdeburg, Germany
    J Biol Chem 272:821-7. 1997
    ..In situ hybridization experiments with a common and a gp65-specific probe suggest differential expression of gp65 and gp55 transcripts in the rat brain...
  27. ncbi request reprint A new method for reliable and efficient reconstruction of 3-dimensional images from autoradiographs of brain sections
    A Hess
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    J Neurosci Methods 84:77-86. 1998
    ..e. principal axes alignment followed by consistent matrix transformation. The power and efficiency of this new 2-step method is compared to those of various previously described procedures...
  28. ncbi request reprint Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures
    Nora John
    Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany
    Mol Cell Neurosci 31:774-84. 2006
    ..Furthermore, axon initial segments are strongly covered by a dense brevican coat. Altogether, we show that mature primary cultures can form PNN, and that basic features of these extracellular matrix structures may be studied in vitro...
  29. ncbi request reprint Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice
    Frank Angenstein
    Special Laboratory for Non Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cereb Cortex 17:28-36. 2007
    ..Furthermore, this study shows that ME-MRI can become a valuable tool for a structural characterization of genetically modified mice...
  30. ncbi request reprint An architectural framework that may lie at the core of the postsynaptic density
    Marisa K Baron
    Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, Los Angeles, CA 90095 1570, USA
    Science 311:531-5. 2006
    ..Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex...
  31. ncbi request reprint Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment
    Thomas Dresbach
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    J Biol Chem 281:6038-47. 2006
    ..Paradigmatically this establishes Golgi transit as an obligatory step for subcellular trafficking of distinct cytoplasmic scaffolding proteins...
  32. ncbi request reprint Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding
    Thomas Dresbach
    Institute for Anatomy and Cell Biology, Ruprecht Karls University Heidelberg, D 69120 Heidelberg, Germany
    Mol Cell Neurosci 27:227-35. 2004
    ....
  33. ncbi request reprint Ca2+-independent binding and cellular expression profiles question a significant role of calmyrin in transduction of Ca2+-signals to Alzheimer's disease-related presenilin 2 in forebrain
    Magdalena Blazejczyk
    Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Trojdena 4, 02 109 Warsaw, Poland
    Biochim Biophys Acta 1762:66-72. 2006
    ..We therefore conclude that calmyrin will not contribute significantly as a Ca(2+)-sensor that transduces Ca(2+)-signaling events to PS2 in forebrain...
  34. ncbi request reprint Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif
    Constanze Burkhardt
    Abt Molekularbiologie, Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat, Schlossplatz 5, D 48149 Munster, Germany
    FEBS Lett 579:3821-8. 2005
    ..Sema4B co-localizes with PSD-95 at synaptic contacts between cultured hippocampal neurons. This synaptic localization depends on the presence of the PDZ-binding motif...
  35. pmc The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
    Gunnar Schuetz
    MaxDelbrück Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 167:945-52. 2004
    ..These results demonstrate that the Shank3 adaptor protein can mediate cellular signaling, and provide a molecular mechanism for the biological divergence between the Ret9 and Ret51 isoform...
  36. ncbi request reprint Hair cell synaptic ribbons are essential for synchronous auditory signalling
    Darina Khimich
    Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Goettingen, 37099 Goettingen, Germany
    Nature 434:889-94. 2005
    ..We conclude that ribbon-dependent synchronous release of multiple vesicles at the hair cell afferent synapse is essential for normal hearing...
  37. pmc Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex
    Susanne Tom Dieck
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    J Cell Biol 168:825-36. 2005
    ..Finally, we found the RIBEYE homologue CtBP1 at ribbon and conventional synapses, suggesting a novel role for the CtBP/BARS family in the molecular assembly and function of central nervous system synapses...
  38. ncbi request reprint C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3
    Tobias M Boeckers
    Institute of Anatomy and Cell Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Neurochem 92:519-24. 2005
    ..Altogether, our data delineate a hitherto unknown targeting signal in both ProSAP1/Shank2 and ProSAP2/Shank3 and provide evidence for an implication of these proteins and their close homologue, Shank1, in distinct molecular pathways...
  39. ncbi request reprint Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse
    Anne Roumier
    Laboratoire de Biologie Cellulaire de la Synapse Normale et Pathologique, Institut National de la Santé et de la Recherche Médicale INSERM U497, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    J Neurosci 24:11421-8. 2004
    ..KARAP/DAP12 may thus alter microglial physiology and subsequently synaptic function and plasticity through a novel microglia-neuron interaction...
  40. ncbi request reprint ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3
    Doreen Wendholt
    Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    J Biol Chem 281:13805-16. 2006
    ..Thus, ProSAPiP1 and PSD-Zip70 are founders of a novel family of scaffolding proteins, the "Fezzins," which adds further complexity to the organization of the PSD protein network...
  41. ncbi request reprint Molecular organization of the presynaptic active zone
    Susanne Schoch
    Emmy Noether Research Group, Institute of Neuropathology and Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Cell Tissue Res 326:379-91. 2006
    ..These multidomain proteins are instrumental for the diverse functions performed by the presynaptic active zone...
  42. ncbi request reprint SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2
    Christina Spilker
    Project Group Neuroplasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany
    J Neurochem 104:187-201. 2008
    ..Our results imply that SPAR2 is a new RapGAP with specific functions in cerebellar and hippocampal granule cells...
  43. pmc Investigating interactions mediated by the presynaptic protein bassoon in living cells by Foerster's resonance energy transfer and fluorescence lifetime imaging microscopy
    Mini Jose
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    Biophys J 94:1483-96. 2008
    ..Simultaneous analysis of fluorescence decays of the donor and the acceptor probes along with their decay-associated spectra allowed a clear discrimination of energy transfer...
  44. ncbi request reprint Morphological and metabolic changes in the cortex of mice lacking the functional presynaptic active zone protein bassoon: a combined 1H-NMR spectroscopy and histochemical study
    Frank Angenstein
    Special Laboratory for Non Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cereb Cortex 18:890-7. 2008
    ....
  45. ncbi request reprint Three-dimensional architecture of presynaptic terminal cytomatrix
    Lea Siksou
    INSERM U789, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 27:6868-77. 2007
    ..This 3D analysis reveals the morphological constraints exerted by the presynaptic molecular scaffold. SVs are tightly interconnected in the axonal bouton, and this network is preferentially connected to the AZ...
  46. ncbi request reprint Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes
    Mauricio Sandoval
    Laboratorio de Neurociencias, Universidad de Los Andes, Santiago, Chile
    J Neurochem 101:1672-84. 2007
    ..These opposing mechanisms might be present in a large proportion of forebrain synapses and may contribute importantly to synaptic plasticity...
  47. pmc Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation
    Christian Proepper
    Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany
    EMBO J 26:1397-409. 2007
    ..Data show that Abi-1 can act as a specific synapto-nuclear messenger and is essentially involved in dendrite and synapse formation...
  48. ncbi request reprint The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain
    Hans Gert Bernstein
    Department of Psychiatry, Faculty of Medicine, Otto von Guericke University, Magdeburg, Germany
    Brain Res 1134:107-12. 2007
    ..In addition we found no segregation of np65 immunolabel in hippocampal subregions like it was reported previously for the rat. These results might indicate different cellular functions of the molecule in different species...
  49. ncbi request reprint Molecular organization and assembly of the presynaptic active zone of neurotransmitter release
    Anna Fejtova
    Leibniz Institute for Neurobiology, Department of Neurochemistry and Molecular Biology, Magdeburg, Germany
    Results Probl Cell Differ 43:49-68. 2006
    ..Several PTVs can fuse on demand with the presynaptic membrane to rapidly form an active zone...
  50. ncbi request reprint The cell adhesion molecule neuroplastin-65 inhibits hippocampal long-term potentiation via a mitogen-activated protein kinase p38-dependent reduction in surface expression of GluR1-containing glutamate receptors
    Ruth M Empson
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, UK
    J Neurochem 99:850-60. 2006
    ....
  51. pmc Local sharing as a predominant determinant of synaptic matrix molecular dynamics
    Shlomo Tsuriel
    The Rappaport Family Institute for Research in the Medical Sciences, Technion Faculty of Medicine, Haifa, Israel
    PLoS Biol 4:e271. 2006
    ....
  52. pmc Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis
    Sergio Leal-Ortiz
    Deptartment of Psychiatry and Behavioral Science, Nancy Pritzker Laboratory, Stanford University, Palo Alto, CA 94304, USA
    J Cell Biol 181:831-46. 2008
    ..This function is not shared by the highly homologous protein Bassoon, which indicates that Piccolo has a unique role in coupling the mobilization of SVs in the reserve pool to events within the active zone...
  53. ncbi request reprint Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3' untranslated region of Shank1 mRNA
    Tobias M Bockers
    Institut für Anatomie Westfälishe Wilhelms Universität Münster, Germany
    Mol Cell Neurosci 26:182-90. 2004
    ..The widespread presence of Shank mRNAs in dendrites suggests a role for local synthesis of Shanks in response to stimuli that induce alterations in synaptic morphology...
  54. ncbi request reprint Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles
    Mika Shapira
    Rappaport Institute and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Haifa, Israel
    Neuron 38:237-52. 2003
    ..These findings suggest that AZs are assembled from unitary amounts of AZ material carried on PTVs...
  55. ncbi request reprint Novel isoforms of Dlg are fundamental for neuronal development in Drosophila
    Carolina Mendoza
    Programa de Fisiologia y Biofisica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile 6530499
    J Neurosci 23:2093-101. 2003
    ..During embryonic development, proteins that include the S97N domain are essential for proper neuronal differentiation and organization, acting through mechanisms that may include the adequate localization of cell fate determinants...
  56. ncbi request reprint Interactions between Piccolo and the actin/dynamin-binding protein Abp1 link vesicle endocytosis to presynaptic active zones
    Steven D Fenster
    Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 278:20268-77. 2003
    ....
  57. ncbi request reprint Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
    Wilko D Altrock
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Neuron 37:787-800. 2003
    ..These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses...
  58. ncbi request reprint The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo
    Seho Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:6291-300. 2003
    ..These results suggest that, through their multimerization and interaction with Piccolo, the GIT family proteins are involved in the organization of the CAZ...
  59. ncbi request reprint Brevican isoforms associate with neural membranes
    Constanze I Seidenbecher
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    J Neurochem 83:738-46. 2002
    ..Taken together, this could provide a mechanism by which perineuronal nets are anchored on neuronal surfaces...
  60. pmc Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory
    Cord Brakebusch
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Mol Cell Biol 22:7417-27. 2002
    ..Detailed behavioral analysis revealed no statistically significant deficits in learning and memory. These data indicate that brevican is not crucial for brain development but has restricted structural and functional roles...
  61. ncbi request reprint Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1
    Lin Lin
    Neuroscience Center of Excellence, 2020 Gravier Street, Suite D, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 296:827-32. 2002
    ....
  62. ncbi request reprint ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease
    Tobias M Boeckers
    AG Molecular Neurobiology, Institute of Anatomy, UKM, Westfaelische Wilhelms University, Munster, Germany
    J Neurochem 81:903-10. 2002
    ..This ProSAP2/Shank3 haploinsufficiency may cause a syndrome that is characterized by severe expressive language delay, mild mental retardation and minor facial dysmorphisms...
  63. ncbi request reprint Screening for differentially expressed genes in the rat inner retina and optic nerve after optic nerve crush
    Daniela C Dieterich
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, P O Box 1860, 39108 Magdeburg, Germany
    Neurosci Lett 317:29-32. 2002
    ..The method seems to be suitable to address the question of how differential gene expression contributes to degeneration, survival and axonal repair after partial nerve crush...
  64. ncbi request reprint Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes
    Hassan Marzban
    Department of Cell Biology and Anatomy, Genes and Development Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Comp Neurol 462:286-301. 2003
    ..The data suggest a role for neuroplastins in the development and maintenance of normal synaptic connections in the cerebellum...
  65. ncbi request reprint Functional regions of the presynaptic cytomatrix protein bassoon: significance for synaptic targeting and cytomatrix anchoring
    Thomas Dresbach
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118, Magdeburg, Germany
    Mol Cell Neurosci 23:279-91. 2003
    ....
  66. ncbi request reprint Association of Caldendrin splice isoforms with secretory vesicles in neurohypophyseal axons and the pituitary
    Marco Landwehr
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestr 6, 39118, Magdeburg, Germany
    FEBS Lett 547:189-92. 2003
    ..1 calcium channels these data suggest that this interaction takes place in neurohypophyseal axons and pituitary cells indicating functions of the short splice variants in triggering Ca2+ transients to a vesicular target interaction...
  67. ncbi request reprint Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family
    Britta Qualmann
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Neurosci 24:2481-95. 2004
    ..This creates a functional connection between synaptic stimulation and cytoskeletal rearrangements...
  68. ncbi request reprint Postsynaptic density assembly is fundamentally different from presynaptic active zone assembly
    Tal Bresler
    Rappaport Institute and the Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Haifa 31096, Israel
    J Neurosci 24:1507-20. 2004
    ..These findings indicate that the assembly processes of PSDs and AZs may be fundamentally different...
  69. ncbi request reprint Rearrangement of the retino-collicular projection after partial optic nerve crush in the adult rat
    Michael R Kreutz
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Eur J Neurosci 19:247-57. 2004
    ....
  70. ncbi request reprint Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins
    Constanze I Seidenbecher
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestr 6 39118 Magdeburg, Germany
    J Mol Biol 336:957-70. 2004
    ..These findings provide molecular evidence that NCS can transduce signals to a specific target interaction irrespective of Ca(2+)-concentrations and CaM-levels...
  71. ncbi request reprint Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Research Institute of Neurosciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 279:987-1002. 2004
    ..Together, these results imply that the postsynaptic density may have the ability to function (semi-) autonomously and may direct various cellular functions in order to integrate synaptic physiology...
  72. ncbi request reprint A new point-based warping method for enhanced and simplified analysis of functional brain image data
    Rainer Pielot
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Neuroimage 19:1716-29. 2003
    ..Therefore, the new method is a powerful tool, which enhances the comparison of complex biological structures and the quantitative evaluation of functional imaging data...
  73. ncbi request reprint Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain
    Karl Heinz Smalla
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, Magdeburg 39118, Germany
    Brain Res Mol Brain Res 116:159-62. 2003
    ..These findings suggest that the transduction of dendritic Ca2+-signals via caldendrin is altered by epileptic seizures and that caldendrin might be involved in the pathophysiology of temporal lobe epilepsy...
  74. ncbi request reprint Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory
    Wolfgang Tischmeyer
    Leibniz Institute for Neurobiology, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Eur J Neurosci 18:942-50. 2003
    ..Whereas one process is required for the initial maintenance of memory for about one day the second one is involved in the regulation of its long-lasting persistence in conditioning to FMs...
  75. ncbi request reprint Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97
    ANDRE BACHMANN
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    J Cell Sci 117:1899-909. 2004
    ..These results imply that the recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms and that DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses...
  76. doi request reprint Scaffolding proteins in highly purified rat olfactory cilia membranes
    María Verónica Saavedra
    Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile
    Neuroreport 19:1123-6. 2008
    ..Ion channels involved in chemotransduction could be reconstituted into planar lipid bilayers for electrophysiological recordings. Our procedure should allow the identification of further chemotransduction-related proteins...
  77. ncbi request reprint Partial regeneration and long-term survival of rat retinal ganglion cells after optic nerve crush is accompanied by altered expression, phosphorylation and distribution of cytoskeletal proteins
    Daniela C Dieterich
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Eur J Neurosci 15:1433-43. 2002
    ..Axotomized ganglion cells, which contain pNF-H in soma and dendrites appear to have been disconnected from the colliculus at an early stage but survive axonal trauma for long periods...
  78. pmc Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus
    Daniela C Dieterich
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
    PLoS Biol 6:e34. 2008
    ....
  79. doi request reprint DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function
    Carolina Mendoza-Topaz
    Institute of Biomedical Sciences, Universidad de Chile and Centro de Neurociencias Integradas, Santiago, Chile
    J Neurosci 28:304-14. 2008
    ....
  80. pmc The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity
    Peter Landgraf
    Project Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, Magdeburg 39118, Germany
    J Biol Chem 283:25036-45. 2008
    ..This identifies a new mechanism of communication between the nervous and the immune system that might directly affect the wiring of the brain during development...
  81. ncbi request reprint A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry, Faculty of Medicine, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Schizophr Res 96:246-56. 2007
    ..These observations add to existing evidence for a de-regulation of neuronal Ca(2+)-signaling in schizophrenia...
  82. ncbi request reprint The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor
    Lin Lin
    Neuroscience Center of Excellence, Louisiana, New Orleans 70112, USA
    J Biol Chem 277:41872-8. 2002
    ..Collectively, these results suggest that VILIP-1 represents a novel modulator of alpha4beta2 AChRs that increases their surface expression levels and agonist sensitivity in response to changes in the intracellular levels of calcium...
  83. ncbi request reprint Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins
    Ka Wan Li
    Department of Molecular and Cellular Neurobiology, Center of Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    J Proteome Res 4:725-33. 2005
    ....
  84. ncbi request reprint Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities
    Ursula Wyneken
    Laboratorio de Neurociencias, Universidad de los, Santiago, Chile
    Epilepsia 44:243-6. 2003
    ..To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid...
  85. ncbi request reprint Neuronal Ca2+ signaling via caldendrin and calneurons
    Marina Mikhaylova
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Biochim Biophys Acta 1763:1229-37. 2006
    ..Despite some significant structural differences it is conceivable that they are involved in similar Ca2+ regulated processes like caldendrin and neuronal calcium sensor proteins...
  86. ncbi request reprint Brain synaptic junctional proteins at the acrosome of rat testicular germ cells
    Peter Redecker
    Department of Anatomy 1, Medical School of Hannover, Hannover, Germany
    J Histochem Cytochem 51:809-19. 2003
    ..Moreover, our data point to a possible role for neuroactive amino acids in reproductive physiology...
  87. doi request reprint The actin-binding protein Abp1 controls dendritic spine morphology and is important for spine head and synapse formation
    Akvile Haeckel
    Institute for Biochemistry I, Friedrich Schiller University Jena, 07743 Jena, Germany
    J Neurosci 28:10031-44. 2008
    ..Abp1 thus plays an important role in the formation and morphology control of synapses by making a required functional connection between postsynaptic density components and postsynaptic actin dynamics...