Research Topics
| Marcus FändrichSummaryAffiliation: Leibniz Institute for Age Research Country: Germany Publications
| Collaborators
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Detail Information
Publications
On the structural definition of amyloid fibrils and other polypeptide aggregatesM Fändrich
Leibniz Institut für Altersforschung, Beutenbergstrasse 11, 07745, Jena, Germany
Cell Mol Life Sci 64:2066-78. 2007....- Absolute correlation between lag time and growth rate in the spontaneous formation of several amyloid-like aggregates and fibrilsMarcus Fändrich
Leibniz Institut für Altersforschung, Fritz Lipmann Institut, Beutenbergstrasse 11, D 07745 Jena, Germany
J Mol Biol 365:1266-70. 2007..These data suggest mechanistic similarities in the nucleation behaviour of different amyloid-like fibrils and aggregates... 
Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptidesJessica Meinhardt
Leibniz Institut für Altersforschung, Fritz Lipmann Institut, D 07745 Jena, Germany
Protein Sci 16:1214-22. 2007....
Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrilsJessica Meinhardt
Leibniz Institut für Altersforschung Fritz Lipmann Institut, Beutenbergstrabetae 11, D 07745 Jena, Germany
J Mol Biol 386:869-77. 2009..This property differs significantly from native, monomeric protein folding reactions that produce, for one protein sequence, only one ordered conformation and only one set of inter-residue interactions...- Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrilsKarolin Klement
Leibniz Institut für Altersforschung, Beutenbergstrasse 11, D 07745 Jena, Germany
J Mol Biol 373:1321-33. 2007..These observations are important for understanding and predicting aggregation on the basis of simple physico-chemical properties... - Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrilsGernot Habicht
Leibniz Institut für Altersforschung, Fritz Lipmann Institut, 07745 Jena, Germany
Proc Natl Acad Sci U S A 104:19232-7. 2007..These data suggest possible applications of B10 in the detection of amyloid fibrils or in the modulation of their formation... - Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptideCarsten Sachse
Leibniz Institut für Altersforschung, Fritz Lipmann Institut, 07745 Jena, Germany
J Mol Biol 362:347-54. 2006..These data shed new light on the way in which Abeta(1-40) and the protofilaments formed from this peptide are organised within the mature fibril... - Structure and formation of amyloid fibrilsMarcus Fändrich
Institute of Molecular Biotechnology, Jena, Germany
Acta Histochem 105:379. 2003 - Identification of molecular compounds critical to Alzheimer's-like plaque formationGerald P Gellermann
Leibniz Institute for Age Research, Fritz Lipmann Institut, Jena, Germany
J Neurosci Res 85:2037-44. 2007..Altogether, our data demonstrate the utility of this cell model for investigating pathways and molecular interactions critical to amyloidogenesis... - Apomyoglobin reveals a random-nucleation mechanism in amyloid protofibril formationMarcus Fändrich
Institut für Molekulare Biotechnologie IMB, Beutenbergstrasse 11, Postfach 100 813, D 07708 Jena, Germany
Acta Histochem 108:215-9. 2006..Once the appropriate structural characteristics are acquired, PFs are formed by addition of further polypeptide chains... - Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptideTony Christopeit
Institut fur Molekulare Biotechnologie, D 07745 Jena, Germany
Protein Sci 14:2125-31. 2005..These data imply that the two reactions, nucleation and polymerization, are governed by very similar physicochemical principles and that they involve the formation of the same types of noncovalent interactions... - The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleationPeter Hortschansky
, Jena, Germany
Protein Sci 14:1753-9. 2005..These data imply that the nucleation event is under influence of a stochastic factor that can manifest itself in profound macroscopic differences in the aggregation kinetics of otherwise indistinguishable samples... - Mutagenic exploration of the cross-seeding and fibrillation propensity of Alzheimer's beta-amyloid peptide variantsAlexander Peim
, Jena, Germany
Protein Sci 15:1801-5. 2006..Hence, the nucleus acts in this case as a catalyst that promotes the fibrillation of different polypeptide chains according to their intrinsic structural predilection... - Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatinGerald P Gellermann
Leibniz Institute for Age Research, Fritz-Lipmann Institute, Beutenbergstrasse 11, D-07745 Jena, Germany
J Mol Biol 360:251-7. 2006.... - Raft lipids as common components of human extracellular amyloid fibrilsGerald P Gellermann
, Beutenbergstrasse 11, 07745 Jena, Germany
Proc Natl Acad Sci U S A 102:6297-302. 2005..These data suggest the existence of common cellular mechanisms in the generation of different types of clinical amyloid deposits...