Marcus Fändrich

Summary

Affiliation: Leibniz Institute for Age Research
Country: Germany

Publications

  1. ncbi On the structural definition of amyloid fibrils and other polypeptide aggregates
    M Fändrich
    Leibniz Institut für Altersforschung, Beutenbergstrasse 11, 07745, Jena, Germany
    Cell Mol Life Sci 64:2066-78. 2007
  2. ncbi Absolute correlation between lag time and growth rate in the spontaneous formation of several amyloid-like aggregates and fibrils
    Marcus Fändrich
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 365:1266-70. 2007
  3. pmc The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation
    Peter Hortschansky
    Institut für Molekulare Biotechnologie IMB, Jena, Germany
    Protein Sci 14:1753-9. 2005
  4. pmc Mutagenic exploration of the cross-seeding and fibrillation propensity of Alzheimer's beta-amyloid peptide variants
    Alexander Peim
    Leibniz Institut für Altersforschung, Jena, Germany
    Protein Sci 15:1801-5. 2006
  5. ncbi Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin
    Gerald P Gellermann
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 360:251-7. 2006
  6. pmc Thermodynamic analysis of the aggregation propensity of oxidized Alzheimer's beta-amyloid variants
    Peter Hortschansky
    Leibniz Institut für Naturstoff Forschung une Infektionsbiologie, Hans Knöll Institut, D 07745 Jena, Germany
    Protein Sci 14:2915-8. 2005
  7. pmc Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides
    Jessica Meinhardt
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, D 07745 Jena, Germany
    Protein Sci 16:1214-22. 2007
  8. ncbi Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils
    Karolin Klement
    Leibniz Institut für Altersforschung, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 373:1321-33. 2007
  9. doi Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils
    Jessica Meinhardt
    Leibniz Institut für Altersforschung Fritz Lipmann Institut, Beutenbergstrabetae 11, D 07745 Jena, Germany
    J Mol Biol 386:869-77. 2009
  10. ncbi Structure and formation of amyloid fibrils
    Marcus Fändrich
    Institute of Molecular Biotechnology, Jena, Germany
    Acta Histochem 105:379. 2003

Collaborators

Detail Information

Publications17

  1. ncbi On the structural definition of amyloid fibrils and other polypeptide aggregates
    M Fändrich
    Leibniz Institut für Altersforschung, Beutenbergstrasse 11, 07745, Jena, Germany
    Cell Mol Life Sci 64:2066-78. 2007
    ....
  2. ncbi Absolute correlation between lag time and growth rate in the spontaneous formation of several amyloid-like aggregates and fibrils
    Marcus Fändrich
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 365:1266-70. 2007
    ..These data suggest mechanistic similarities in the nucleation behaviour of different amyloid-like fibrils and aggregates...
  3. pmc The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation
    Peter Hortschansky
    Institut für Molekulare Biotechnologie IMB, Jena, Germany
    Protein Sci 14:1753-9. 2005
    ..These data imply that the nucleation event is under influence of a stochastic factor that can manifest itself in profound macroscopic differences in the aggregation kinetics of otherwise indistinguishable samples...
  4. pmc Mutagenic exploration of the cross-seeding and fibrillation propensity of Alzheimer's beta-amyloid peptide variants
    Alexander Peim
    Leibniz Institut für Altersforschung, Jena, Germany
    Protein Sci 15:1801-5. 2006
    ..Hence, the nucleus acts in this case as a catalyst that promotes the fibrillation of different polypeptide chains according to their intrinsic structural predilection...
  5. ncbi Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin
    Gerald P Gellermann
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 360:251-7. 2006
    ....
  6. pmc Thermodynamic analysis of the aggregation propensity of oxidized Alzheimer's beta-amyloid variants
    Peter Hortschansky
    Leibniz Institut für Naturstoff Forschung une Infektionsbiologie, Hans Knöll Institut, D 07745 Jena, Germany
    Protein Sci 14:2915-8. 2005
    ....
  7. pmc Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides
    Jessica Meinhardt
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, D 07745 Jena, Germany
    Protein Sci 16:1214-22. 2007
    ....
  8. ncbi Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils
    Karolin Klement
    Leibniz Institut für Altersforschung, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 373:1321-33. 2007
    ..These observations are important for understanding and predicting aggregation on the basis of simple physico-chemical properties...
  9. doi Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils
    Jessica Meinhardt
    Leibniz Institut für Altersforschung Fritz Lipmann Institut, Beutenbergstrabetae 11, D 07745 Jena, Germany
    J Mol Biol 386:869-77. 2009
    ..This property differs significantly from native, monomeric protein folding reactions that produce, for one protein sequence, only one ordered conformation and only one set of inter-residue interactions...
  10. ncbi Structure and formation of amyloid fibrils
    Marcus Fändrich
    Institute of Molecular Biotechnology, Jena, Germany
    Acta Histochem 105:379. 2003
  11. ncbi Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide
    Carsten Sachse
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, 07745 Jena, Germany
    J Mol Biol 362:347-54. 2006
    ..These data shed new light on the way in which Abeta(1-40) and the protofilaments formed from this peptide are organised within the mature fibril...
  12. pmc Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils
    Gernot Habicht
    Leibniz Institut für Altersforschung, Fritz Lipmann Institut, 07745 Jena, Germany
    Proc Natl Acad Sci U S A 104:19232-7. 2007
    ..These data suggest possible applications of B10 in the detection of amyloid fibrils or in the modulation of their formation...
  13. pmc Raft lipids as common components of human extracellular amyloid fibrils
    Gerald P Gellermann
    Institut fur Molekulare Biotechnologie, Beutenbergstrasse 11, 07745 Jena, Germany
    Proc Natl Acad Sci U S A 102:6297-302. 2005
    ..These data suggest the existence of common cellular mechanisms in the generation of different types of clinical amyloid deposits...
  14. pmc FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils
    Giorgia Zandomeneghi
    Institut für Molekulare Biotechnologie IMB, D 07745 Jena, Germany
    Protein Sci 13:3314-21. 2004
    ..These data imply that amyloid fibril formation from native beta-sheet proteins can involve a substantial structural reorganization...
  15. ncbi Apomyoglobin reveals a random-nucleation mechanism in amyloid protofibril formation
    Marcus Fändrich
    Institut für Molekulare Biotechnologie IMB, Beutenbergstrasse 11, Postfach 100 813, D 07708 Jena, Germany
    Acta Histochem 108:215-9. 2006
    ..Once the appropriate structural characteristics are acquired, PFs are formed by addition of further polypeptide chains...
  16. ncbi Identification of molecular compounds critical to Alzheimer's-like plaque formation
    Gerald P Gellermann
    Leibniz Institute for Age Research, Fritz Lipmann Institut, Jena, Germany
    J Neurosci Res 85:2037-44. 2007
    ..Altogether, our data demonstrate the utility of this cell model for investigating pathways and molecular interactions critical to amyloidogenesis...
  17. pmc Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptide
    Tony Christopeit
    Institut fur Molekulare Biotechnologie, D 07745 Jena, Germany
    Protein Sci 14:2125-31. 2005
    ..These data imply that the two reactions, nucleation and polymerization, are governed by very similar physicochemical principles and that they involve the formation of the same types of noncovalent interactions...