Research Topics
| A A BrakhageSummaryAffiliation: Leibniz Institute for Natural Product Research and Infection Biology Country: Germany Publications
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Detail Information
Publications
Regulation of penicillin biosynthesis in filamentous fungiAxel A Brakhage
University of Hannover, Institute of Microbiology, Schneiderberg 50, 30167 Hannover, Germany
Adv Biochem Eng Biotechnol 88:45-90. 2004..Furthermore, such investigations have contributed to the elucidation of signals leading to the production of penicillin and can be expected to have a major impact on rational strain improvement programs...
Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by ironPeter Hortschansky
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, and Friedrich Schiller University Jena, Jena, Germany
EMBO J 26:3157-68. 2007..Remarkably, CBC-mediated regulation has an inverse impact on the expression of the same gene set in A. nidulans, compared with Saccharomyces cerevisae...
Regulation of fungal secondary metabolismAxel A Brakhage
Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
Nat Rev Microbiol 11:21-32. 2013....- Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approachJörg Linde
Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
BMC Syst Biol 6:6. 2012..Even though some regulatory interactions are known, we are still far from a complete understanding of the way iron homeostasis is regulated... - Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungiAnke Burmester
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Beutenbergstrasse 11a, Jena, 07745, Germany
Genome Biol 12:R7. 2011.... - Integrative analysis of the heat shock response in Aspergillus fumigatusDaniela Albrecht
Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
BMC Genomics 11:32. 2010..fumigatus. The study was augmented by bioinformatical analysis of transcription factor binding sites (TFBSs) in the promoter region of genes whose corresponding proteins were differentially regulated upon heat shock... - Aspergillus fumigatus conidial pigment and cAMP signal transduction: significance for virulenceA A Brakhage
Leibniz lnstitute for Natural Products Research and Infection Biology Hans Knoell lnstitute, Department of Molecular and Applied Microbiology, Jena, Germany
Med Mycol 43:S75-82. 2005..However, besides its contribution to the biosynthesis of DHN-like melanin, PKSP also appears to be involved in the formation of another compound which is immunosuppressive... - Evolution of beta-lactam biosynthesis genes and recruitment of trans-acting factorsAxel A Brakhage
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knoell Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
Phytochemistry 66:1200-10. 2005..Alternatively, it is conceivable that only a part of the beta-lactam biosynthesis gene cluster was transferred to some fungi, e.g., the acvA and ipnA gene without a regulatory gene... - Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factorsAxel A Brakhage
Department of Molecular and Applied Microbiology, University of Jena, Jena, Germany
Phytochemistry 70:1801-11. 2009..We propose that during the assembly of aatA and acvA-ipnA into a single gene cluster, recruitment of transcriptional regulators occurred along with acquisition of the duplicated aatA ancestor gene and its cis-acting sites... - Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinantsAxel A Brakhage
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, D 07745 Jena, Germany
Curr Drug Targets 6:875-86. 2005..fumigatus. The review discusses aspects of the current knowledge of the infection process, mechanisms of protection of the fungus against immune effector cells, and virulence determinants of A. fumigatus... - Activation of fungal silent gene clusters: a new avenue to drug discoveryAxel A Brakhage
Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Friedrich Schiller University, Jena, Germany
Prog Drug Res 66:1, 3-12. 2008..The activation of these gene clusters by genetic engineering will lead to the discovery of many so far unknown products and therefore represents a novel avenue to drug discovery... - Fungal secondary metabolites - strategies to activate silent gene clustersAxel A Brakhage
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstr 11a, 07745 Jena, Germany
Fungal Genet Biol 48:15-22. 2011..These simulation strategies will help discover new natural products in the future, and may also provide fundamental new insights into microbial communication... - Interaction of phagocytes with filamentous fungiAxel A Brakhage
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
Curr Opin Microbiol 13:409-15. 2010..In addition, A. fumigatus interferes with the innate immunity, with both the complement system and defense mechanisms of phagocytes, thereby evading at least in part the innate immune system... - Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodASandra Bruns
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute HKI, Jena, Germany
PLoS Pathog 6:e1000873. 2010..fumigatus, but suggest that it does not play a major role in killing this fungus. Instead, NETs may have a fungistatic effect and may prevent further spreading... - Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatusChristina Grosse
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Friedrich Schiller University Jena, 07745 Jena, Germany
Appl Environ Microbiol 74:4923-33. 2008..In contrast, proteins which were involved in nucleotide and amino acid biosynthesis were downregulated, as were enzymes involved in catabolism of carbon sources other than glucose... - Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicansJudith Behnsen
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
PLoS Pathog 3:e13. 2007..This could explain why "delocalized" Aspergillus infections such as hematogeneous spread are almost uncontrollable diseases, even in immunocompetent individuals... - Proteome analysis for pathogenicity and new diagnostic markers for Aspergillus fumigatusOlaf Kniemeyer
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute HKI, Jena, Germany
Med Mycol 47:S248-54. 2009..Thus, besides pathogenicity studies, proteomics also delivers the tools to screen for new antigens which could improve the diagnosis of diseases caused by A. fumigatus... - Missing values in gel-based proteomicsDaniela Albrecht
Research group Systems Biology Bioinformatics, Hans Knölle Institute, Jena, Germany
Proteomics 10:1202-11. 2010..We summarize reasons for missing values and explore their distribution in data sets. We also provide a comparison and evaluation of hitherto proposed imputation methods for gel-based proteomics data... - FungiFun: a web-based application for functional categorization of fungal genes and proteinsSteffen Priebe
Research group Systems Biology Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Jena, Germany
Fungal Genet Biol 48:353-8. 2011..FungiFun is freely accessible at https://www.omnifung.hki-jena.de/FungiFun/... - Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatusJanka Teutschbein
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Jena, Germany
J Proteome Res 9:3427-42. 2010..The generated data lay the foundations for further proteomic analyses and a better understanding of fungal pathogenesis... - The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection modelFranziska Lessing
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Jena, Germany
Eukaryot Cell 6:2290-302. 2007..fumigatus wild-type and DeltaAfyap1 mutant germlings by human neutrophilic granulocytes worked equally well irrespective of whether the ROI scavenger glutathione or an NADPH-oxidase inhibitor was added to the cells... - Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene clusterPetra Spröte
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, 07745 Jena, Germany
Mol Microbiol 70:445-61. 2008..Our findings suggest that aatB is a paralogue of aatA. They extend the model of evolution of the penicillin biosynthesis gene cluster by recruitment of a biosynthesis gene and its cis-regulatory sites upon gene duplication... - Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxinSandra Bruns
Department of Molecular and Applied Microbiology, Hans Knöll Institute, Jena, Germany
Proteomics 10:3097-107. 2010..It may confer A. fumigatus protection from the host immune system and also enable its survival and persistence in chronic lung infections such as aspergilloma... - Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulansVolker Schroeckh
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, 07745 Jena, Germany
Proc Natl Acad Sci U S A 106:14558-63. 2009.... - Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatusVenelina Sugareva
Department of Microbiology and Molecular Biology, Friedrich-Schiller-University, Jena, Germany
Arch Microbiol 186:345-55. 2006..An abr2p-lacZ gene fusion was expressed during sporulation, but not during vegetative growth confirming the pattern of laccase activity due to Abr2... - Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatusOlaf Kniemeyer
Department of Microbiology and Molecular Biology, Friedrich-Schiller-University, Jena, Germany
Curr Genet 49:178-89. 2006..In A. fumigatus, differential patterns of enzymes of the gluconeogenesis, glyoxylate cycle and ethanol degradation pathway during growth on glucose and ethanol were observed... - The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress responseVito Valiante
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
Fungal Genet Biol 45:618-27. 2008..The expression of mpkA was induced by cell wall damaging conditions. Despite its involvement in cell wall signaling no influence on virulence of the deletion of mpkA was observed in a murine infection model... - Apoptosis inhibition of alveolar macrophages upon interaction with conidia of Aspergillus fumigatusKatrin Volling
Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute HKI, and Friedrich Schiller University Jena, Jena, Germany
FEMS Microbiol Lett 275:250-4. 2007..This unexpected result was due to inhibition of caspase 3 by a yet unknown mechanism... - Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatusJeannette Schmaler-Ripcke
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute and Friedrich Schiller University Jena, Beutenbergstrasse 11a, 07745 Jena, Germany
Appl Environ Microbiol 75:493-503. 2009..fumigatus. Homogentisic acid is the major intermediate, and the L-tyrosine degradation pathway leading to pyomelanin is similar to that in humans leading to alkaptomelanin... - Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatusMartin Vödisch
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute HKI, Jena, Germany
Proteomics 9:1407-15. 2009..Furthermore, we established a protocol for the isolation of mitochondria of A. fumigatus and developed a mitochondrial proteome reference map. 147 proteins represented by 234 spots were identified... - Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5Judith Behnsen
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, Jena, Germany
Infect Immun 78:3585-94. 2010..Thus, the protease Alp1 is responsible for the observed cleavage and degrades a broad range of different substrates. In summary, we identified a novel mechanism in A. fumigatus that contributes to evasion from the host complement attack... - The CCAAT-binding complex coordinates the oxidative stress response in eukaryotesMarcel Thön
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, D 07745 Jena, Germany
Nucleic Acids Res 38:1098-113. 2010..The underlying fine-tuned mechanism very likely represents a general feature of the CCAAT-binding complexes in eukaryotes... - The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesisPetra Spröte
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
Arch Microbiol 188:69-79. 2007..These findings were confirmed by the analysis of a regulatable niiAp-veA gene fusion. Under niiAp-inducing conditions, penicillin titres and acvAp-uidA expression were much lower than in untransformed wild-type strains... - The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatusVito Valiante
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
Fungal Genet Biol 46:909-18. 2009..Interestingly, this MAP kinase module affects the formation of pyomelanin derived from tyrosine degradation... - The CCAAT-binding complex of eukaryotes: evolution of a second NLS in the HapB subunit of the filamentous fungus Aspergillus nidulans despite functional conservation at the molecular level between yeast, A.nidulans and humanAndré Tüncher
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
J Mol Biol 352:517-33. 2005..nidulans hapB mutant was complemented, at least in part, by both the human NF-YA and S.cerevisiae Hap2p this finding suggests that the piggy-back mechanism of nuclear transport found for A.nidulans is conserved in yeast and human... - The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement systemJudith Behnsen
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
Infect Immun 76:820-7. 2008..These data show that A. fumigatus conidia bind to complement regulators, and these bound host regulators may contribute to evasion of a host complement attack... - Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosisFelicitas Schöbel
Leibniz Institute for Natural Products Research and Infection Biology, Beutenbergstr 11a, 07745 Jena, Germany
Infect Immun 75:1237-44. 2007..Therefore, an antifungal drug inhibiting fungal isocitrate lyases, postulated to act against Candida infections, is assumed to be ineffective against A. fumigatus... - Analysis of mating-dependent transcription of Blakeslea trispora carotenoid biosynthesis genes carB and carRA by quantitative real-time PCRAndré D Schmidt
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knoell Institute, Jena, Germany
Appl Microbiol Biotechnol 67:549-55. 2005..Transcription levels of both carB and carRA were strongly induced only under mating conditions. These data suggest that beta-carotene production in B. trispora is due to increased transcription of the biosynthesis genes carB and carRA... - Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulansPetra Spröte
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, Jena, Germany
Eukaryot Cell 8:421-3. 2009..This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum... - Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene clusterSebastian Bergmann
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
Appl Environ Microbiol 76:8143-9. 2010..To the best of our knowledge, this is the first report of regulatory cross talk between two biosynthesis gene clusters located on different chromosomes... - Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatusDaniel H Scharf
Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena, Germany
J Am Chem Soc 132:10136-41. 2010..GliT thus not only represents the prototype of ETP-forming enzymes in eukaryotes but also delineates a novel mechanism for self-resistance... - Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin productionMartina Herrmann
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI, Beutenbergstrasse 11a, D-07745 Jena, Germany
Appl Environ Microbiol 72:2957-70. 2006..The involvement of Pkc in penicillin biosynthesis is also interesting in light of the fact that in the yeast Saccharomyces cerevisiae, Pkc plays a major role in maintaining cell integrity... - Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulansSebastian Bergmann
Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Beutenbergstr 11a, 07745 Jena, Germany
Nat Chem Biol 3:213-7. 2007..Here we report a new strategy for the successful induction of a silent metabolic pathway in the important model organism Aspergillus nidulans, which led to the discovery of novel PKS-NRPS hybrid metabolites... - The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatusBurghard Liebmann
, , Schneiderberg 50, D-30167 Hannover, Germany
Infect Immun 72:5193-203. 2004..Taken together, these findings indicate that the cAMP-PKA signal transduction pathway is required for A. fumigatus pathogenicity... - Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosisOumaima Ibrahim-Granet
Aspergillus Unit, Institute Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Cell Microbiol 10:134-48. 2008..fumigatus. Thus, blocking of methylcitrate synthase activity abrogates fungal growth and provides a suitable target for new antifungals... - Biosynthesis of fungal melanins and their importance for human pathogenic fungiKim Langfelder
, , Schneiderberg 50, 30167, Hannover, Germany
Fungal Genet Biol 38:143-58. 2003..In addition, in several fungi the production of fungal virulence factors, such as melanin, has been linked to a cAMP-dependent signaling pathway. Many of the components involved in the signaling pathway have been identified... - Functional characterization of the Aspergillus fumigatus calcineurinMárcia Eliana da Silva Ferreira
Faculdade de Ciências Farmacêuticas de Ribeirão, Universidade de Sao Paulo, Brazil
Fungal Genet Biol 44:219-30. 2007..These results suggest that calcineurin is involved in the regulation of the PHO pathway in A. fumigatus. Our work on calcineurin opens new venues for the research on sensing and nutrient acquisition in A. fumigatus... - Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection modelClaudio Kupfahl
Institute for Medical Microbiology and Hygiene, Faculty for Clinical Medicine Mannheim of the University Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Mol Microbiol 62:292-302. 2006..fumigatus. Gliotoxin is not required for pathogenicity of the fungus in immunocompromised mice, despite the fact that a reduced cytotoxicity of the culture supernatant of gliP deletion strains was demonstrated... - SreA-mediated iron regulation in Aspergillus fumigatusMarkus Schrettl
Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
Mol Microbiol 70:27-43. 2008..As all detrimental effects of sreA disruption are restricted to iron-replete conditions these data underscore that A. fumigatus faces iron-depleted conditions during infection... - Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosisBurghard Liebmann
, , Schneiderberg 50, 30167, Hannover, Germany
Arch Microbiol 181:378-83. 2004..In this murine model, the Delta lysF mutant was avirulent, suggesting that lysine biosynthesis, or at least a functional homoaconitase, is important for survival of A. fumigatus in vivo and a potential target for antifungal drugs... - PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophagesBernhard Jahn
Institut fur Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg Universitat Mainz, Hochhaus am Augustusplatz, D 55101 Mainz, Germany
Cell Microbiol 4:793-803. 2002..This finding might help explain the attenuated virulence of pksP mutant strains in a murine animal model and provides a conceptual frame to understand the virulence of A. fumigatus... - Novel basic-region helix-loop-helix transcription factor (AnBH1) of Aspergillus nidulans counteracts the CCAAT-binding complex AnCF in the promoter of a penicillin biosynthesis geneMaria Louise Caruso
, , Schneiderberg 50, 30167 Hannover, Germany
J Mol Biol 323:425-39. 2002..The analysis of aatAp-lacZ expression in such a strain indicated that AnBH1 acts as a repressor of aatA gene expression and therefore counteracts the positive action of AnCF... - A basic-region helix-loop-helix protein-encoding gene (devR) involved in the development of Aspergillus nidulansAndré Tüncher
Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
Mol Microbiol 52:227-41. 2004..Taken together, devR encodes a bHLH regulatory protein that is part of the tcsA signal transduction network and required for development under standard growth conditions... - A novel method used to delete a new Aspergillus fumigatus ABC transporter-encoding geneKim Langfelder
, , Am Schneiderberg 50, 30167 Hannover, Germany
Curr Genet 41:268-74. 2002..fumigatus knock-out mutant was generated, providing evidence that this method of generating gene deletions can also be used in A. fumigatus and significantly broadens our repertoire of molecular techniques to study A. fumigatus... - A single subunit of a heterotrimeric CCAAT-binding complex carries a nuclear localization signal: piggy back transport of the pre-assembled complex to the nucleusStefan Steidl
, , Schneiderberg 50, D-30167 Hannover, Germany
J Mol Biol 342:515-24. 2004..This enables the cell to provide equimolar concentrations of all subunits to the nucleus... - Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug developmentFrank Ebel
Max-von-Pettenkofer-Institute, Munich, Germany
Fungal Genet Biol 43:476-89. 2006..Lipids, as potential substrates, were detected in conidia and macrophages. Additionally, germinating conidia within macrophages contain ICL, suggesting that the glyoxylate shunt might be a relevant target for development of antifungals... - Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidiaClaudia Maerker
Institute of Microbiology, University of Hannover, Germany
FEBS J 272:3615-30. 2005..Therefore, an impact of methylcitrate synthase in the infection process is discussed... - Menacing mold: the molecular biology of Aspergillus fumigatusAxel A Brakhage
Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, Germany
Annu Rev Microbiol 56:433-55. 2002..This review summarizes the current knowledge on the biology, molecular genetics, and genomics of A. fumigatus... - Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2Kathrin Luther
Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany
Cell Microbiol 9:368-81. 2007..Additionally we found that TLR2 and the adaptor protein MyD88 are required for efficient conidial phagocytosis, suggesting a link between the TLR2-mediated recognition of A. fumigatus and the phagocytic response... - The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatusMárcia Eliana da Silva Ferreira
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Departamento de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
Eukaryot Cell 5:207-11. 2006..fumigatus strain. Deletion of akuB(KU80) had no influence on pathogenicity in a low-dose murine infection model... - Transcriptome analysis of Aspergillus fumigatus exposed to voriconazoleMárcia Eliana da Silva Ferreira
Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
Curr Genet 50:32-44. 2006.... - Nuclear translocation of the heterotrimeric CCAAT binding factor of Aspergillus oryzae is dependent on two redundant localising signals in a single subunitHideya Goda
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464-8601 Japan
Arch Microbiol 184:93-100. 2005..nidulans. The nuclear translocation of the A. oryzae complex was found to be dependent on two redundant localising signals in HapB...