Marcus Lehnhardt

Summary

Country: Germany

Publications

  1. pmc Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    BMC Cancer 5:74. 2005
  2. ncbi request reprint [Plastic surgery reconstruction of radiation injuries to the extremities]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumore, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Dtsch Med Wochenschr 132:939-44. 2007
  3. doi request reprint Major and lethal complications of liposuction: a review of 72 cases in Germany between 1998 and 2002
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Plast Reconstr Surg 121:396e-403e. 2008
  4. doi request reprint [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases]
    M Lehnhardt
    Klinik für Plastische Chirurgie u Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Universitatsklinikum Bergmannsheil, Burkle de la Camp Platz 1, Bochum, Germany
    Chirurg 80:341-7. 2009
  5. ncbi request reprint [Serious complications of injections--retrospective analysis of incidences, complication-management, prophylaxis and economic aspects]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Zentrum für Gliedmassentumoren, Bochum
    Zentralbl Chir 130:162-9. 2005
  6. ncbi request reprint The value of expert second opinion in diagnosis of soft tissue sarcomas
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    J Surg Oncol 97:40-3. 2008
  7. ncbi request reprint Fournier's gangrene after Milligan-Morgan hemorrhoidectomy requiring subsequent abdominoperineal resection of the rectum: report of a case
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Handsurgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Dis Colon Rectum 47:1729-33. 2004
  8. ncbi request reprint [Gorham-Stout disease: report of a case affecting the right hand with a follow-up of 24 years]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Handchir Mikrochir Plast Chir 36:249-54. 2004
  9. ncbi request reprint [Liposarcoma of the extremities: recent developments in surgical therapy--analysis of 167 patients]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Operatives Referenzzentrum für Gliedmassentumoren, Handchirurgiezentrum, BG Kliniken Bergmannsheil Bochum, Ruhr Universitat Bochum
    Chirurg 75:1182-90. 2004
  10. doi request reprint The versatility of the pedicled vertical rectus abdominis myocutaneous flap in oncologic patients
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Buerkle de la Camp Place 1, 44789, Bochum, Germany
    Langenbecks Arch Surg 396:1271-9. 2011

Collaborators

Detail Information

Publications67

  1. pmc Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    BMC Cancer 5:74. 2005
    ..In this study we elucidated the response of a fibrosarcoma cell line to clinically used cytostatic agents on the level of gene expression...
  2. ncbi request reprint [Plastic surgery reconstruction of radiation injuries to the extremities]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumore, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Dtsch Med Wochenschr 132:939-44. 2007
  3. doi request reprint Major and lethal complications of liposuction: a review of 72 cases in Germany between 1998 and 2002
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Plast Reconstr Surg 121:396e-403e. 2008
    ..The public perception of liposuction as minor surgery fails to consider the potential of major complications or a possibly fatal outcome...
  4. doi request reprint [Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases]
    M Lehnhardt
    Klinik für Plastische Chirurgie u Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Universitatsklinikum Bergmannsheil, Burkle de la Camp Platz 1, Bochum, Germany
    Chirurg 80:341-7. 2009
    ..For optimal treatment of soft tissue sarcomas, we suggest obtaining expert second opinion to ensure adequate surgical therapy and precise indications for radiation and chemotherapy...
  5. ncbi request reprint [Serious complications of injections--retrospective analysis of incidences, complication-management, prophylaxis and economic aspects]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Zentrum für Gliedmassentumoren, Bochum
    Zentralbl Chir 130:162-9. 2005
    ..Besides the consequences for the patient these disastrous complications have a high socioeconomic impact and result in reduced reimbursement for the hospital stay...
  6. ncbi request reprint The value of expert second opinion in diagnosis of soft tissue sarcomas
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    J Surg Oncol 97:40-3. 2008
    ..The value of consultative second opinions has been proven for general surgical pathology; some studies suggest an even higher value for the soft tissue tumour specimens in particular...
  7. ncbi request reprint Fournier's gangrene after Milligan-Morgan hemorrhoidectomy requiring subsequent abdominoperineal resection of the rectum: report of a case
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Handsurgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Dis Colon Rectum 47:1729-33. 2004
    ..The rectum had to be removed by abdominoperineal resection. This disastrous complication was completely unexpected and unpredictable after Milligan-Morgan hemorrhoidectomy because of the lack of predisposing factors...
  8. ncbi request reprint [Gorham-Stout disease: report of a case affecting the right hand with a follow-up of 24 years]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Handchir Mikrochir Plast Chir 36:249-54. 2004
    ..Despite radiotherapy and repeated bone grafting, the osteolysis progressed until today (24 years). The pathologic features and various treatment methods for hand involvement are discussed...
  9. ncbi request reprint [Liposarcoma of the extremities: recent developments in surgical therapy--analysis of 167 patients]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Operatives Referenzzentrum für Gliedmassentumoren, Handchirurgiezentrum, BG Kliniken Bergmannsheil Bochum, Ruhr Universitat Bochum
    Chirurg 75:1182-90. 2004
    ..The 5-year survival rate in primary tumors was 71/79 (90%, P<0.05) whereas 61/88 of recurrences relapsed locally (69%, P<0.05). Multidisciplinary cooperation in a tumor board is a precondition for adequate treatment...
  10. doi request reprint The versatility of the pedicled vertical rectus abdominis myocutaneous flap in oncologic patients
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Buerkle de la Camp Place 1, 44789, Bochum, Germany
    Langenbecks Arch Surg 396:1271-9. 2011
    ..Detailed long-time follow-up studies in oncologic patients including complications and donor site morbidity are rare. In this study, complications and donor site morbidity were analysed...
  11. pmc TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    J Exp Clin Cancer Res 27:82. 2008
    ..Disseminated soft tissue sarcoma still represents a therapeutic dilemma because effective cytostatics are missing. Therefore we tested TRAIL and Tarolidine (TRD), two substances with apoptogenic properties on human fibrosarcoma (HT1080)...
  12. doi request reprint Reconstruction of the thoracic wall-long-term follow-up including pulmonary function tests
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789, Bochum, Germany
    Langenbecks Arch Surg 394:705-15. 2009
    ....
  13. pmc Proximal major limb amputations--a retrospective analysis of 45 oncological cases
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    World J Surg Oncol 7:15. 2009
    ..The aim of this retrospective study was to analyse outcome in those patients, including the postoperative course, survival, pain, quality of life, and prosthesis usage...
  14. doi request reprint Sternal osteomyelitis: long-term results after pectoralis muscle flap reconstruction
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Plast Reconstr Surg 123:910-7. 2009
    ..Reports regarding long-term follow-up including quality-of-life assessment, pulmonary function, and donor-site morbidity after operative treatment for sternal osteomyelitis are rare...
  15. doi request reprint MFH revisited: outcome after surgical treatment of undifferentiated pleomorphic or not otherwise specified (NOS) sarcomas of the extremities -- an analysis of 140 patients
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Handsurgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Langenbecks Arch Surg 394:313-20. 2009
    ..The objective of this study is to determine prognostic factors for the outcome after surgical treatment with respect to the recent developments in classification...
  16. doi request reprint Synergistic effects of sonoporation and taurolidin/TRAIL on apoptosis in human fibrosarcoma
    Adrien Daigeler
    Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Unfallkrankenhaus, Ludwigshafen, Germany
    Ultrasound Med Biol 36:1893-906. 2010
    ..Further studies are needed to explore the options of sonodynamic therapy on soft tissue sarcoma and its molecular mechanisms...
  17. ncbi request reprint [The interdisciplinary approach in reconstructive surgery of the extremities]
    H U Steinau
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Chirurg 75:390-8. 2004
    ....
  18. doi request reprint The effectiveness of pedicled groin flaps in the treatment of hand defects: results of 49 patients
    Ole Goertz
    Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz1, 44789 Bochum, Germany
    J Hand Surg Am 37:2088-94. 2012
    ....
  19. pmc Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    BMC Cancer 8:313. 2008
    ..This study was performed to identify gene expression changes in liposarcoma after doxorubicin treatment...
  20. doi request reprint The pedicled gastrocnemius muscle flap: a review of 218 cases
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Plast Reconstr Surg 123:250-7. 2009
    ..Data regarding donor-site morbidity, postoperative clinical course, and functional and aesthetic outcome after gastrocnemius muscle flaps are rare...
  21. pmc Intravascular leiomyosarcoma of the brachiocephalic region -- report of an unusual tumour localisation: case report and review of the literature
    Daniel Johannes Tilkorn
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
    World J Surg Oncol 6:113. 2008
    ..Intravascular leiomyosarcoma is a rare tumour entity originating from venous vessel structures and most frequently affecting the inferior vena cava...
  22. doi request reprint Trocar injury of the retroperitoneal vessels followed by life-threatening postischemic compartment syndrome of both lower extremities
    Joerg Hauser
    Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
    Surg Laparosc Endosc Percutan Tech 18:222-4. 2008
    ..Lesions of the intra-abdominal organs and vessels caused by trocars and Verres needles are rare but serious complications during laparoscopic surgery...
  23. pmc Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    World J Surg Oncol 6:71. 2008
    ..The aim of this study was a clinicopathological analysis with special reference to treatment and outcome...
  24. doi request reprint Tendon transfers for drop foot correction: long-term results including quality of life assessment, and dynamometric and pedobarographic measurements
    Hans Ulrich Steinau
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Arch Orthop Trauma Surg 131:903-10. 2011
    ....
  25. pmc Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
    BMC Surg 6:10. 2006
    ..Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results...
  26. doi request reprint Influence of topically applied antimicrobial agents on muscular microcirculation
    Ole Goertz
    Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Ann Plast Surg 67:407-12. 2011
    ..If the antimicrobial efficacy is comparable, the antiseptic with less toxic effects should be chosen, especially in critically perfused wounds...
  27. pmc Elastofibroma dorsi--differential diagnosis in chest wall tumours
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    World J Surg Oncol 5:15. 2007
    ..The pathogenesis of the lesion is still unclear, but repetitive microtrauma by friction between the scapula and the thoracic wall may cause the reactive hyperproliferation of fibroelastic tissue...
  28. doi request reprint Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    Langenbecks Arch Surg 395:261-75. 2010
    ..This study focused on these tumors and analyzed the association of gene expression profiles to clinical outcome...
  29. doi request reprint Influence of antiseptics on microcirculation after neuronal and receptor blockade
    Ole Goertz
    Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Int Wound J 8:365-73. 2011
    ..Interestingly, the benefit of polyhexanide and octenidine on muscular perfusion is eliminated when the antiseptics are combined with other vasoactive agents, especially β blockers...
  30. ncbi request reprint Dedifferentiated liposarcoma with extensive lymphoid component
    Cornelius Kuhnen
    Institute for Pathology, Limb tumor registry, Ruhr University, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Pathol Res Pract 201:347-53. 2005
    ..An extensive lymphoid "overgrowth" must be considered within the spectrum of unusual variants and in the differential diagnosis of dedifferentiated liposarcoma...
  31. doi request reprint Intravital pathophysiological comparison of acid- and alkali-burn injuries in a murine model
    Ole Goertz
    Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    J Surg Res 182:347-52. 2013
    ..Available data for alkali and acid injuries are rare. To determine the pathophysiological similarities and differences, two comparable in vivo acid and alkali burn models were developed...
  32. ncbi request reprint Prognostic significance of erythroblasts in burns
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Hand Surgery, and Institute of Clinical Chemistry, Transfusion and Laboratory Medicine, BG University Hospital, Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Plast Reconstr Surg 115:120-7. 2005
    ..It seems attractive to think about an incorporation of erythroblasts into further refinements of burn scores...
  33. doi request reprint A follow-up study of adults with suicidal burns: psychosocial adjustment and quality of life
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, 44789 Bochum, Germany
    J Burn Care Res 30:844-51. 2009
    ..Patients who survive the suicide attempt can become integrated in social life again. More data are needed to reliably identify patients at risk in advance...
  34. ncbi request reprint [Unclear soft-tissue tumor]
    J Hauser
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Operatives Referenzzentrum für Gliedmassentumoren, BG Kliniken Bergmannsheil, Universitatsklinik der Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789 Bochum
    Chirurg 78:62-4. 2007
    ..The patient was treated by radical compartmental resection. No postoperative complication was noted, and almost no functional loss occurred...
  35. doi request reprint Prospective comparison of three risk score models at three different surgical intensive care units
    Ole Goertz
    Department of Plastic Surgery, Burn Center, Hand Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Shock 40:95-100. 2013
    ..One of the score systems is solely based on routine laboratory parameters. Data were collected on three different ICUs units, with each showing a large variety in patients' health conditions...
  36. ncbi request reprint A novel titanium wound chamber for the study of wound infections in pigs
    Lars Steinstraesser
    Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    Comp Med 56:279-85. 2006
    ..We conclude that the use of titanium chambers in pigs provides a reliable and reproducible in vivo model to investigate wound healing, wound infection, and treatment options...
  37. pmc Burn wounds infected with Pseudomonas aeruginosa triggers weight loss in rats
    Lars Steinstraesser
    Dept of Surgery, University of Michigan, Ann Arbor, MI 48109 0666, USA
    BMC Surg 5:19. 2005
    ..The aim of this study was to shed light on the impact of acute burn injury with or without infection on cytokine profiles...
  38. doi request reprint Photoplanimetric evaluation and impedance measurement of split-thickness skin grafts: a new model for objective wound-healing assessment in clinical trials
    J Hauser
    Department of Plastic and Hand Surgery, Burn Center, University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Skin Res Technol 15:168-71. 2009
    ..Here, we present a wound model and non-invasive analysis techniques to evaluate human wound healing. The model described was used in a clinical trial on 167 patients treated with a new wound therapeutic agent...
  39. doi request reprint [Transosseous route of vascular pedicles in microsurgical tissue transfer]
    O Goertz
    Klinik für Plastische Chirurgie, Schwerbrandverletzte, Handchirurgiezentrum, BG Universitatsklinikum Bergmannsheil, Ruhr Universitat Bochum, Deutschland
    Chirurg 82:74-7. 2011
    ..The following article presents an alternative transosseous route of vascular pedicles for improved access to the recipient vessel based on three case studies...
  40. doi request reprint Lymph node metastases in soft tissue sarcomas: a single center analysis of 1,597 patients
    A Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Langenbecks Arch Surg 394:321-9. 2009
    ..The aim of this study was to examine the clinical course of patients with the rare finding of regional lymph node metastasis (RLNM) from soft tissue sarcoma...
  41. doi request reprint [Functional reconstruction of the superficial posterior compartment of the leg after tumour ablation in an infant]
    Ole Goertz
    BG Universitatsklinikum Bergmannsheil, Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, Ruhr Universitat Bochum, Bochum
    Handchir Mikrochir Plast Chir 41:244-7. 2009
    ..The soleus and gastrocnemius muscle including the Achilles tendon and the subcutis and cutis were resected. The defect was functionally reconstructed by a neurovascular musculocutaneous latissimus dorsi free-flap transfer...
  42. ncbi request reprint [Plastic surgery reconstruction of radiation-induced trunk and body cavity defects]
    D Druecke
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumore, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Dtsch Med Wochenschr 132:945-9. 2007
  43. ncbi request reprint [Stump retention and extension on the lower extremity]
    H H Homann
    Universitätsklinik für Plastische Chirurgie, Schwerbrandverletzte, Handchirurgiezentrum, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum, Bochum
    Chirurg 78:308-15. 2007
    ..In case of insufficient bearing ability of the stump, various reconstructive possibilities must be considered to assure optimal outcome...
  44. ncbi request reprint [Differential diagnosis of "sterile" phlegmonous hand infections]
    A Daigeler
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Kliniken Bergmannsheil Bochum, Ruhr Universitat Bochum
    Chirurg 77:1040-5. 2006
    ..In these cases, operative treatment would be harmful. Therefore two cases-pyoderma gangrenosum and tuberculosis-are presented here in relation to common bacterial hand infection...
  45. ncbi request reprint [Manifestations of scleroderma at the hand--options for hand surgery in an interdisciplinary concept]
    A Daigeler
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, Berufsgenossenschaftliche Kliniken Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum
    Handchir Mikrochir Plast Chir 39:128-34. 2007
    ..With reference to several cases seen at our institution, we propose an interdisciplinary treatment concept for acral manifestations of scleroderma...
  46. doi request reprint [Anterolateral thigh flaps for reconstruction of traumatological and oncological defects]
    S Langer
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Extremitätentumore, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum, Germany
    Unfallchirurg 111:323-30. 2008
    ..The article presents the authors' experience using the ALT flap for various indications in the upper and lower extremities...
  47. ncbi request reprint Metachronous bilateral soft tissue sarcoma of the extremities
    A Daigeler
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University, Buerkle de la Camp Platz 1, 44789, Bochum, Germany
    Langenbecks Arch Surg 393:207-12. 2008
    ..Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas...
  48. ncbi request reprint [Therapeutic management of acral manifestations of systemic sclerosis]
    Martin F Meyer
    Medizinische Klinik I, Zentrum fur Innere Medizin, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr Universitat Bochum, Bochum, Deutschland
    Med Klin (Munich) 102:209-18. 2007
    ....
  49. doi request reprint Bacterial burden in the operating room: impact of airflow systems
    Tobias Hirsch
    Department of Plastic and Reconstructive Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Am J Infect Control 40:e228-32. 2012
    ..This study analyzes the impact of currently used ventilation systems in the operating room to reduce bacterial contamination during surgical procedures...
  50. ncbi request reprint Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus
    Adrien Daigeler
    Department of General and Visceral Surgery, St Josef Hospital Ruhr University, Bochum, Germany
    Int J Oncol 32:1205-20. 2008
    ..Taking into consideration that the non-toxic TRD was able to reduce rhTRAIL toxicity and dose, combined therapy with TRD and rhTRAIL may offer new options for treatment in esophageal cancer...
  51. pmc A qualitative and quantitative analysis of protein substitution in human burn wounds
    Hamid Joneidi-Jafari
    Department of Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
    Eplasty 9:e42. 2009
    ..We quantified and qualified the systemic and local protein loss in burn patients during protein substitution, comparing fresh frozen plasma and the human serum protein solution Biseko...
  52. pmc Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides
    Lars Steinstraesser
    Department for Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Retrovirology 2:2. 2005
    ..A lentiviral vector-based screening assay was used to determine the inhibitory effect of HDPs on early steps in the replication cycle and on cell metabolism...
  53. ncbi request reprint Chondroma or chondrosarcoma? An indication for sternum resection
    Thomas Muehlberger
    Department of Plastic Surgery, DRK Kliniken Berlin Westend, Humboldt Universitat, Berlin, Germany
    Plast Reconstr Surg 121:145e-146e. 2008
  54. ncbi request reprint [Effector molecules of the innate immune system for treatment of wound infections]
    L Steinsträsser
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, BG Kliniken Bergmannsheil, Ruhr Universitat, Burkle de la Camp Platz 1, 44789 Bochum
    Chirurg 78:343-8. 2007
    ..The epithelium has an essential function in recognizing colonies of micro-organisms and in initial antimicrobial defenses...
  55. ncbi request reprint Combined pollicization and toe transfer for thumb reconstruction
    H U Steinau
    Department of Plastic Surgery, Hand Center, Burn Unit, University Hospital Bergmannsheil, Ruhr University Bochum, Germany
    J Hand Surg Br 28:414-6. 2003
    ..A 45-year-old orthopaedic surgeon sustained a complete thumb amputation and severe injuries to his index finger in a lawn mower accident. He was treated with a combined second toe transfer and an index finger pollicization...
  56. ncbi request reprint [Joint infection caused by radiogenic defect: prevention and therapeutic options]
    H H Homann
    Klinik für Plastische Chirurgie, Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, Universitätsklinik Bergmannsheil, Ruhr Universitat, Burkle de la Camp Platz 1, 44789 Bochum
    Kongressbd Dtsch Ges Chir Kongr 119:736-7. 2002
    ..If regional flap coverage is desired, distant flaps with long, not irradiated pedicles must be chosen. Prevention due to special considerations during the first surgery is essential...
  57. doi request reprint Mitomycin-C-treated peripheral blood mononuclear cells (PBMCs) prolong allograft survival in composite tissue allotransplantation
    Christian Andreas Radu
    Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Plastic and Hand Surgery, University of Heidelberg, Germany
    J Surg Res 176:e95-e101. 2012
    ..Mitomycin C (MMC) is an alkylating agent that suppresses allogeneic T-cell responses. MMC-treated dendritic cells/PBMCs have been shown to induce donor-specific tolerance in solid organ allograft transplantations...
  58. ncbi request reprint [Solitary plasmacytoma of the shoulder. Diagnosis and therapeutic methods]
    H H Homann
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, Universitatsklinik der Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789 Bochum
    Chirurg 73:736-8. 2002
    ..In this article we present the case of a fifty year old patient with a solitary plasmocytoma of the shoulder region and discuss the diagnostic and therapeutic procedures involved...
  59. ncbi request reprint Activity of histone H1.2 in infected burn wounds
    F Jacobsen
    Department for Plastic Surgery, BG University Hospital Bergmannsheil, University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    J Antimicrob Chemother 55:735-41. 2005
    ..The aim of this study was to investigate the in vitro and in vivo activity of histone H1.2 in infected burn wounds and its potential toxicity...
  60. ncbi request reprint Antimicrobial activity of the recombinant designer host defence peptide P-novispirin G10 in infected full-thickness wounds of porcine skin
    F Jacobsen
    Department of Plastic Surgery, Burn Centre, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    J Antimicrob Chemother 59:493-8. 2007
    ..Therefore, the aim of this study was to investigate the antimicrobial activity of proline-novispirin G10 (P-novispirin G10) in vitro and in the infected porcine titanium wound chamber model...
  61. ncbi request reprint [Carl von Reyher's studies of wound therapy]
    M Lehnhardt
    Universitätsklinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Kliniken Bergmannsheil Bochum
    Chirurg 73:721-4. 2002
    ..Finally more than 30 years later in World War I, the Inter-allied Surgical Conference officially endorsed primary excision with delayed wound closure as the rule for treatment of gunshot wounds...
  62. ncbi request reprint [Monitoring growth factors during wound healing as the basic principle of effective clinical growth factor therapy?]
    P M Vogt
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgie Zentrum, BG Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Langenbecks Arch Chir Suppl Kongressbd 114:1373-5. 1997
    ..This model may be useful in clinical research of modulators of healing and wound pharmacology...
  63. ncbi request reprint Patterns of expression and secretion of vascular endothelial growth factor in malignant soft-tissue tumours
    C Kuhnen
    Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany
    J Cancer Res Clin Oncol 126:219-25. 2000
    ..Further long-term follow-up studies are needed, which should include patients with tumour recurrences...
  64. ncbi request reprint Polybrene improves transfection efficacy of recombinant replication-deficient adenovirus in cutaneous cells and burned skin
    F Jacobsen
    Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    J Gene Med 8:138-46. 2006
    ..The aim of this study was to evaluate and optimize the local administration of transient cutaneous adenoviral gene delivery in wounds...
  65. ncbi request reprint Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections
    F Jacobsen
    Plastic Surgery Research Department for Plastic Surgery, Burn Center, Handsurgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Gene Ther 12:1494-502. 2005
    ....
  66. doi request reprint Surgical treatment of angiosarcoma of the scalp: less is more
    Alexandra Buschmann
    Department of Plastic Surgery and Hand Surgery, DRK Kliniken Berlin Westend, Humboldt Universitat Berlin, Berlin, Germany
    Ann Plast Surg 61:399-403. 2008
    ..5 months. In view of the difficult diagnosis, an often delayed therapy and the rapid formation of metastases, a time-saving procedure with a low rate of complications should be given preference over other reconstructive methods...
  67. ncbi request reprint Hypermethylation of the APC promoter but lack of APC mutations in myxoid/round-cell liposarcoma
    Sonja Sievers
    Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Int J Cancer 119:2347-52. 2006
    ..However, the impact of APC methylation on liposarcoma development is quite likely not mediated through WNT signalling...