Kyle R Legate

Summary

Country: Germany

Publications

  1. ncbi request reprint ILK, PINCH and parvin: the tIPP of integrin signalling
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsreid, Germany
    Nat Rev Mol Cell Biol 7:20-31. 2006
  2. doi request reprint Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Cell Sci 122:187-98. 2009
  3. pmc Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 30:4539-53. 2011
  4. ncbi request reprint What mouse mutants teach us about extracellular matrix function
    A Aszodi
    Department of Molecular Medicine, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Annu Rev Cell Dev Biol 22:591-621. 2006
  5. doi request reprint Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, 82152 Germany
    J Cell Sci 125:5636-46. 2012
  6. doi request reprint Genetic and cell biological analysis of integrin outside-in signaling
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Genes Dev 23:397-418. 2009
  7. doi request reprint Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor
    S Babak Azimifar
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Sci 125:435-48. 2012
  8. doi request reprint The tail of integrins, talin, and kindlins
    Markus Moser
    Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Science 324:895-9. 2009

Collaborators

Detail Information

Publications8

  1. ncbi request reprint ILK, PINCH and parvin: the tIPP of integrin signalling
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsreid, Germany
    Nat Rev Mol Cell Biol 7:20-31. 2006
    ..All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell-cell adhesion...
  2. doi request reprint Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Cell Sci 122:187-98. 2009
    ....
  3. pmc Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    EMBO J 30:4539-53. 2011
    ..Furthermore, it suggests that force coupling relies heavily on locally generated PtdIns(4,5)P(2) rather than bulk membrane PtdIns(4,5)P(2)...
  4. ncbi request reprint What mouse mutants teach us about extracellular matrix function
    A Aszodi
    Department of Molecular Medicine, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Annu Rev Cell Dev Biol 22:591-621. 2006
    ..The application of reverse genetics has demonstrated the multifunctionality of matrix proteins in a biological context and, in addition, has brought a novel perspective to the understanding of human pathologies...
  5. doi request reprint Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, 82152 Germany
    J Cell Sci 125:5636-46. 2012
    ....
  6. doi request reprint Genetic and cell biological analysis of integrin outside-in signaling
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany
    Genes Dev 23:397-418. 2009
    ..This review discusses recent work that has tremendously broadened our understanding of the complexity of integrin-mediated signaling...
  7. doi request reprint Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor
    S Babak Azimifar
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Sci 125:435-48. 2012
    ..This study provides evidence for a novel function of integrin-ILK and EGF signalling crosstalk in mediating Cyld tyrosine phosphorylation and fast actin-based cytoskeletal rearrangements...
  8. doi request reprint The tail of integrins, talin, and kindlins
    Markus Moser
    Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Science 324:895-9. 2009
    ..This review focuses on the mechanisms whereby two key proteins, talin and the kindlins, regulate integrin activation by binding the tails of integrin-beta subunits...