Ulrich Laufs

Summary

Country: Germany

Publications

  1. ncbi request reprint Clinical trial updates and hotline sessions presented at the Scientific Session 2007 of the American Heart Association
    U Laufs
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421, Homburg, Germany
    Clin Res Cardiol 97:1-11. 2008
  2. pmc Nutrition, environment and cardiovascular health (NESCAV): protocol of an inter-regional cross-sectional study
    Ala a Alkerwi
    Centre de Recherche Public Santé, Centre d Etudes en Santé, Grand Duchy of Luxembourg
    BMC Public Health 10:698. 2010
  3. pmc Troponin elevation in acute ischemic stroke (TRELAS)--protocol of a prospective observational trial
    Jan F Scheitz
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    BMC Neurol 11:98. 2011
  4. ncbi request reprint Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription
    U Laufs
    Medizinische Klinik und Poliklink, Universitatskliniken des Saarlandes, Homburg, Germany
    Circulation 102:3104-10. 2000
  5. ncbi request reprint [Stable coronary artery disease -- diagnosis and therapy]
    U Laufs
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes
    Dtsch Med Wochenschr 131:556-62; quiz 563-4. 2006
  6. ncbi request reprint HMG-CoA reductase inhibitors in chronic heart failure: potential mechanisms of benefit and risk
    Ulrich Laufs
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Drugs 66:145-54. 2006
  7. ncbi request reprint Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg, Germany
    Eur J Cardiovasc Prev Rehabil 12:407-14. 2005
  8. ncbi request reprint Beyond lipid-lowering: effects of statins on endothelial nitric oxide
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421, Homburg Saar, Germany
    Eur J Clin Pharmacol 58:719-31. 2003
  9. ncbi request reprint Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    Ulrich Laufs
    Klinik fur Innere Medizin III, niversitätsklinikum des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 25:809-14. 2005
  10. ncbi request reprint ["Anti-aging" from a cardiologist's view]
    U Laufs
    Klinik und Poliklinik Innere Medizin III der Universität des Saarlandes, Homburg Saar
    Urologe A 43:587-95; quiz 596. 2004

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Clinical trial updates and hotline sessions presented at the Scientific Session 2007 of the American Heart Association
    U Laufs
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421, Homburg, Germany
    Clin Res Cardiol 97:1-11. 2008
    ....
  2. pmc Nutrition, environment and cardiovascular health (NESCAV): protocol of an inter-regional cross-sectional study
    Ala a Alkerwi
    Centre de Recherche Public Santé, Centre d Etudes en Santé, Grand Duchy of Luxembourg
    BMC Public Health 10:698. 2010
    ....
  3. pmc Troponin elevation in acute ischemic stroke (TRELAS)--protocol of a prospective observational trial
    Jan F Scheitz
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    BMC Neurol 11:98. 2011
    ..Therefore, there is uncertainty about how acute ischemic stroke patients with increased cTnT levels should be managed regarding diagnostic and therapeutic workup...
  4. ncbi request reprint Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription
    U Laufs
    Medizinische Klinik und Poliklink, Universitatskliniken des Saarlandes, Homburg, Germany
    Circulation 102:3104-10. 2000
    ..Withdrawal of statin treatment could suppress endothelial NO production and may impair vascular function...
  5. ncbi request reprint [Stable coronary artery disease -- diagnosis and therapy]
    U Laufs
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes
    Dtsch Med Wochenschr 131:556-62; quiz 563-4. 2006
  6. ncbi request reprint HMG-CoA reductase inhibitors in chronic heart failure: potential mechanisms of benefit and risk
    Ulrich Laufs
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Drugs 66:145-54. 2006
    ....
  7. ncbi request reprint Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg, Germany
    Eur J Cardiovasc Prev Rehabil 12:407-14. 2005
    ..Exercise is a central component of the primary prevention of vascular diseases. The effect of physical activity on circulating EPC in healthy individuals is not known...
  8. ncbi request reprint Beyond lipid-lowering: effects of statins on endothelial nitric oxide
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421, Homburg Saar, Germany
    Eur J Clin Pharmacol 58:719-31. 2003
    ..Therefore, the ability of statins to improve endothelial function through the release of NO may partially account for their beneficial effects at reducing the incidence of cardiovascular events...
  9. ncbi request reprint Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    Ulrich Laufs
    Klinik fur Innere Medizin III, niversitätsklinikum des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 25:809-14. 2005
    ..The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase...
  10. ncbi request reprint ["Anti-aging" from a cardiologist's view]
    U Laufs
    Klinik und Poliklinik Innere Medizin III der Universität des Saarlandes, Homburg Saar
    Urologe A 43:587-95; quiz 596. 2004
    ..From the cardiologist's perspective, there is at present no evidence indicating the use of vitamins, antioxidants or hormone therapy in cardiovascular prevention...
  11. ncbi request reprint Beneficial effects of statins in patients with non-ischemic heart failure
    U Laufs
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, 66424 Homburg, Germany
    Z Kardiol 93:103-8. 2004
    ..HMG CoA reductase inhibitors (statins) may exert a wide array of cholesterol independent effects including antihypertrophic effects on the heart. Their role in the treatment of heart failure has not been studied...
  12. ncbi request reprint Lipid management with statins. The lower the better?
    U Laufs
    Klinik Innere Medizin III, Universitat des Saarlandes, 66421 Homburg, Germany
    Z Kardiol 93:4-9. 2004
    ..Patients with high vascular risk benefit from statin therapy irrespective of cholesterol levels, underlining the importance of the assessment of global vascular risk as the basis of modern lipid therapy...
  13. ncbi request reprint Down-regulation of Rac-1 GTPase by Estrogen
    Ulrich Laufs
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, 66421 Homburg Saar, Germany
    J Biol Chem 278:5956-62. 2003
    ..Rac1 GTPase gene-transcription and activity is regulated by 17 beta-estradiol, which may be an important molecular mechanism contributing to the cardiovascular effects of estrogens...
  14. ncbi request reprint Perceived psychosocial stress and cardiovascular risk factors in obese and non-obese patients
    Kishor Lahiri
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Clin Res Cardiol 96:365-74. 2007
    ..In the setting of primary prevention, the association of stress and cardiovascular risk factors in obese and non-obese individuals is not known...
  15. doi request reprint [Strategies to improve medication adherence]
    U Laufs
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar
    Dtsch Med Wochenschr 136:1616-21. 2011
    ..However, prospective clinical evaluations with clinical endpoints are missing especially for the German health care system in order to develop recommendations for clinical practice. Joint efforts of physicians and pharmacists are needed...
  16. doi request reprint [Medication adherence in patients with chronic diseases: significance and new approaches]
    U Laufs
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421, Homburg Saar, Deutschland
    Nervenarzt 82:153-4, 156-8. 2011
    ..However, prospective clinical studies evaluating the effects of the proposed interventions on clinical endpoints are rare and therefore evidence-based recommendations are missing...
  17. ncbi request reprint Impact of HMG CoA reductase inhibition on small GTPases in the heart
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg Saar, Germany
    Cardiovasc Res 53:911-20. 2002
    ..Therefore, it was tested if these drugs inhibit Rac1 and RhoA activity in cardiomyocytes and, thereby, prevent angiotensin II-mediated expression of atrial natriuretic factor (ANF) and myosin light chain (MLC)-2 in the heart...
  18. doi request reprint Cardiological evaluation after cerebral ischaemia : Consensus statement of the Working Group Heart and Brain of the German Cardiac Society-Cardiovascular Research (DGK) and the German Stroke Society (DSG)
    Ulrich Laufs
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Germany
    Clin Res Cardiol 99:609-25. 2010
    ....
  19. doi request reprint Who does not need a statin: too late in end-stage renal disease or heart failure?
    U Laufs
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    Postgrad Med J 85:187-9. 2009
    ..The effect of statin withdrawal in ischaemic heart failure or in patients with advanced renal disease is not known. On the basis of the available evidence, current statin treatment should not be stopped in these patients...
  20. ncbi request reprint Who does not need a statin: too late in end-stage renal disease or heart failure?
    U Laufs
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Heart 94:1138-40. 2008
    ..The effect of statin withdrawal in ischaemic heart failure or in patients with advanced renal disease is not known. On the basis of the available evidence, current statin treatment should not be stopped in these patients...
  21. ncbi request reprint Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, Homburg, Germany
    Circulation 109:220-6. 2004
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to exert beneficial effects on atherosclerosis, angiogenesis, and vascular repair...
  22. doi request reprint Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Atherosclerosis 212:55-62. 2010
    ..To determine the effect of heart rate reduction with ivabradine on atherosclerotic lesions and erectile dysfunction...
  23. ncbi request reprint Effects of renal sympathetic denervation on exercise blood pressure, heart rate, and capacity in patients with resistant hypertension
    Sebastian Ewen
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, Geb 40, 66421 Homburg Saar, Germany
    Hypertension 63:839-45. 2014
    ..No changes were observed in the control group. In conclusion, renal denervation reduced blood pressure and heart rate during exercise, improved mean workload, and increased exercise time without impairing chronotropic competence. ..
  24. doi request reprint Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Atherosclerosis 216:23-34. 2011
    ..PPAR-γ agonists may mediate vascular effects in addition to insulin sensitizing. We therefore examined whether pioglitazone regulates vascular telomere biology...
  25. ncbi request reprint Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Circulation 105:2083-91. 2002
    ..It has not been completely clarified whether selective estrogen receptor modulators (SERMs) such as raloxifene exert vasoprotective effects similar to those of estrogens...
  26. ncbi request reprint Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy
    Florian Custodis
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 71:342-51. 2006
    ..NADPH oxidase is a major source of ROS production. The small GTPase Rac1 mediates the activation of NADPH oxidase; however, the mechanism of Rac1 activation is incompletely understood...
  27. doi request reprint Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Circulation 120:2438-47. 2009
    ..This study examines the effects of exercising on vascular telomere biology and endothelial apoptosis in mice and the effects of long-term endurance training on telomere biology in humans...
  28. doi request reprint Ramipril and telmisartan exhibit differential effects in cardiac pressure overload-induced hypertrophy without an additional benefit of the combination of both drugs
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Cardiovasc Pharmacol Ther 18:87-93. 2013
    ..We aimed to characterize different cellular effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin 1 (AT1) receptor blockers (ARBs) as mono- or combination therapy in cardiac pressure overload. Methods and..
  29. pmc Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE-/- mice
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 40, 66421 Homburg Saar, Germany
    Cardiovasc Res 90:484-92. 2011
    ..However, their effects on blood monocytes, endothelial function, atherogenesis, and sterol tissue concentrations are poorly understood...
  30. doi request reprint Improvement of endothelial function of the corpus cavernosum in apolipoprotein E knockout mice treated with irbesartan
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Pharmacol Exp Ther 327:692-8. 2008
    ..This result emphasizes the beneficial effect of inhibition of the renin-angiotensin system even in terms of erectile function...
  31. doi request reprint Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Mol Cell Cardiol 50:678-85. 2011
    ..In cardiac fibroblasts, Rac1 GTPase mediates upregulation of fibronectin via LOX and CTGF. Inhibition of this signaling pathway may therefore represent a target for the prevention of fibrotic atrial remodeling...
  32. ncbi request reprint Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment
    Christoph Maack
    Klinik und Poliklinik für Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 108:1567-74. 2003
    ..Isoprenylation of rac1 can be inhibited by statin therapy. Thus, we examined ROS and rac1 in human failing myocardium and tested their regulation by statins in vivo...
  33. ncbi request reprint Role of Rac1 GTPase activation in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 50:359-67. 2007
    ..We aimed to study the role of Rac1 GTPase in atrial fibrillation (AF)...
  34. doi request reprint Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling
    Jan Christian Reil
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Homburg Saar D 66421, Germany
    Cardiovasc Res 87:485-93. 2010
    ..The small GTPase Rac1 seems to play a role in the pathogenesis of atrial fibrillation (AF). The aim of the present study was to characterize the effects of Rac1 overexpression on atrial electrophysiology...
  35. ncbi request reprint Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1567-72. 2002
    ..Despite the anticipated stem cell plasticity, the role of bone marrow-derived endothelial progenitor cells has not been clarified in vascular lesion development...
  36. doi request reprint ACE inhibition promotes upregulation of endothelial progenitor cells and neoangiogenesis in cardiac pressure overload
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Cardiovasc Res 83:106-14. 2009
    ..We hypothesized that ACE inhibitors may exert beneficial effects during pressure-induced myocardial hypertrophy by regulating progenitor cell function...
  37. doi request reprint Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarland, Homburg Saar, Germany
    J Am Coll Cardiol 55:469-80. 2010
    ..We studied the signal transduction of atrial structural remodeling that contributes to the pathogenesis of atrial fibrillation (AF)...
  38. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance
    Christian Werner
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Diabetes 56:2609-15. 2007
    ..The effect represents a potential regenerative mechanism in atherosclerosis and is observed in normoglycemic individuals with stable coronary artery disease...
  39. ncbi request reprint Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Am J Cardiol 93:84-8. 2004
    ..Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation...
  40. doi request reprint The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in mice
    Janine Pöss
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstr, 66421, Homburg, Saar, Germany
    Basic Res Cardiol 105:725-35. 2010
    ..Aliskiren increased number and function of PAC in mice and prevented atherosclerotic lesion formation. The effects were observed independent of blood pressure lowering...
  41. ncbi request reprint Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury
    Nikos Werner
    Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, 66421 Homburg Saar, Germany
    Circ Res 93:e17-24. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  42. doi request reprint Effects of renal sympathetic denervation on heart rate and atrioventricular conduction in patients with resistant hypertension
    Christian Ukena
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Int J Cardiol 167:2846-51. 2013
    ..Renal sympathetic denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. The present study aimed to investigate the effects of RDN on HR and other electrocardiographic parameters...
  43. ncbi request reprint Cellular antioxidant effects of atorvastatin in vitro and in vivo
    Sven Wassmann
    Medizinische Klinik und Poliklinik Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:300-5. 2002
    ..These effects of atorvastatin may contribute to the vasoprotective effects of statins...
  44. ncbi request reprint Physical activity is inversely associated with microalbuminuria in hypertensive patients at high cardiovascular risk: data from I-SEARCH
    Janine Pöss
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Eur J Prev Cardiol 19:1066-73. 2012
    ..Physical activity improves endothelial function. This analysis aims to explore the impact of regular physical exercise on the prevalence and the degree of MAU in hypertensive individuals at high cardiovascular risk...
  45. doi request reprint Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis
    Andrey Kazakov
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Cardiovasc Res 93:397-405. 2012
    ..We hypothesized that eNOS of the bone marrow (BM) affects cardiac remodelling during myocardial hypertrophy via the regulation of BM-derived vascular progenitor cells...
  46. doi request reprint [Are the guidelines correct? Should all patients with coronary heart disease or diabetes be treated with a statin?]
    Janine Pöss
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Med Klin (Munich) 104:74-8. 2009
    ....
  47. ncbi request reprint Angiotensin II type 1 receptor antagonism improves hypercholesterolemia-associated endothelial dysfunction
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1208-12. 2002
    ..Hypercholesterolemia-induced angiotensin II type 1 (AT1) receptor overexpression is thought to be a key event in the development of endothelial dysfunction...
  48. doi request reprint Alterations in cholesterol homeostasis are associated with coronary heart disease in patients with aortic stenosis
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Coron Artery Dis 20:376-82. 2009
    ..Therefore, the aim of this study was to investigate differences in cholesterol metabolism in relation to vascular diseases in this subset of patients...
  49. ncbi request reprint Improvements in left ventricular hypertrophy and diastolic function following renal denervation: effects beyond blood pressure and heart rate reduction
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany Electronic address
    J Am Coll Cardiol 63:1916-23. 2014
    ..This study sought to investigate the interaction between blood pressure (BP) and heart rate (HR) reduction and changes in left ventricular (LV) structure and function following renal sympathetic denervation (RDN)...
  50. doi request reprint Diesel exhaust particles impair endothelial progenitor cells, compromise endothelial integrity, reduce neoangiogenesis, and increase atherogenesis in mice
    Janine Pöss
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Str, 66421, Homburg, Saar, Germany
    Cardiovasc Toxicol 13:290-300. 2013
    ..001). Diesel exhaust particles impair endothelial progenitor cell number and function in vivo and in vitro. The reduction in EPC was associated with impaired neoangiogenesis and a marked increase in atherosclerotic lesion formation...
  51. doi request reprint Effects of nonpersistence with medication on outcomes in high-risk patients with cardiovascular disease
    Michael Bohm
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    Am Heart J 166:306-314.e7. 2013
    ..The impact of nonpersistence on events and of events on persistence is unclear. We studied the effects of nonpersistence on outcomes and events on nonadherence in a randomized placebo controlled trial in 40 countries on 25,620 patients...
  52. ncbi request reprint Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg, Germany
    Brain Res 942:23-30. 2002
    ..The effects are independent of changes in cholesterol levels and are equivalent or even superior to the protective effects by simvastatin and atorvastatin in this animal model...
  53. doi request reprint Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, Homburg Saar, Germany
    Eur Heart J 33:1223-31. 2012
    ..Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth...
  54. ncbi request reprint Relationship between cholesterol synthesis and intestinal absorption is associated with cardiovascular risk
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 40, D 66421 Homburg Saar, Germany
    Atherosclerosis 210:362-5. 2010
    ..Therefore, prospective clinical trials are needed to evaluate whether subjects with altered cholesterol homeostasis may benefit from treatment strategies that reduce cholesterol absorption in addition to statin treatment...
  55. ncbi request reprint Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Chem Phys Lipids 164:451-6. 2011
    ..The aim of the present study was to evaluate markers of cholesterol metabolism and determine their relationship with CVD in patients without diabetes mellitus who were not receiving statin treatment...
  56. doi request reprint Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, 66424 Homburg Saar, Germany
    Stroke 42:1742-9. 2011
    ..Vascular effects of mental stress are only partially understood. Therefore, we studied effects of chronic stress and heart rate (HR) on endothelial function and cerebral ischemia...
  57. doi request reprint Renal denervation in the treatment of hypertension
    Christian Ukena
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse 1, Homburg Saar, Germany
    Curr Hypertens Rep 15:363-9. 2013
    ..By modulating sympathetic activity, RDN has the potential to provide benefit in a variety of diseases, but these concepts have to be evaluated in well-designed prospective controlled clinical trials. ..
  58. doi request reprint Paclitaxel and sirolimus differentially affect growth and motility of endothelial progenitor cells and coronary artery smooth muscle cells
    Yvonne P Clever
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    EuroIntervention 7:K32-42. 2011
    ..This study investigates the time-dependent influence on growth and motility of paclitaxel and sirolimus alone and combined with the coating additive iopromide on EPC and hCASMC...
  59. doi request reprint Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice
    Florian Custodis
    Kliniken für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Vasc Res 49:432-40. 2012
    ..Therefore, we characterized effects of heart rate reduction (HRR) by I(f) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein E-deficient (ApoE(-)/(-)) mice...
  60. doi request reprint Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Circulation 117:2377-87. 2008
    ..We hypothesized that selective heart rate reduction may influence endothelial function and atherogenesis and tested the effects of the I(f) current inhibitor ivabradine in apolipoprotein E-deficient mice...
  61. doi request reprint Heart rate reduction in cardiovascular disease and therapy
    Jan Christian Reil
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg Saar, Germany
    Clin Res Cardiol 100:11-9. 2011
    ..Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy...
  62. doi request reprint Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy
    Stephanie I Bettink
    Klinik fur Innere Medizin III, Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 397:208-13. 2010
    ..We conclude that in both SDF-1- and angiotensin II-triggered signaling, ILK is a central mediator of rac1-induced oxidative stress and myocardial hypertrophy...
  63. doi request reprint Role of miR-21 in the pathogenesis of atrial fibrosis
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Basic Res Cardiol 107:278. 2012
    ..Activation of Rac1 by angiotensin II leads to a CTGF- and lysyl oxidase-mediated increase of miR-21 expression contributing to structural remodelling of the atrial myocardium...
  64. pmc Blocking interferon {beta} stimulates vascular smooth muscle cell proliferation and arteriogenesis
    Stephan H Schirmer
    Department of Cardiology, Saarland University Hospital, 66421 Homburg Saar, Germany
    J Biol Chem 285:34677-85. 2010
    ..Inhibition of IFNβ stimulates VSMC proliferation and collateral artery growth...
  65. ncbi request reprint Inhibitory effect of estrogen on Rac1-expression in monocytes
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, D 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 386:45-9. 2009
    ..In summary, the data show that down-regulation of Rac1-GTPase contributes to the inhibition of angiotensin II-mediated superoxide release by 17beta-estradiol in monocytes...
  66. doi request reprint An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Atherosclerosis 209:39-41. 2010
    ..Our findings indicate that oxysterols could play an important and so far underestimated role in reverse cholesterol transport...
  67. ncbi request reprint Pressure-induced cardiac overload induces upregulation of endothelial and myocardial progenitor cells
    Patrick Muller
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Cardiovasc Res 77:151-9. 2008
    ..Bone-marrow-derived progenitor cells have been shown to contribute to endothelial homeostasis, repair, and new blood vessel formation. We therefore studied the effects of pressure overload on angiogenesis and progenitor cells...
  68. doi request reprint Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 52:470-82. 2008
    ..The purpose of this study was to study the underlying molecular mechanisms of the protective cardiac effects of physical exercise...
  69. doi request reprint Effects of omega-3 fatty acids on postprandial triglycerides and monocyte activation
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Atherosclerosis 225:166-72. 2012
    ..Monocyte activation plays an important role in vascular diseases. Omega-3 fatty acids (n3-FA) lower fasting TG levels. The effects of n3-FA on ppTG and the role of ppTG for monocyte activation are insufficiently understood...
  70. doi request reprint Vascular pathophysiology in response to increased heart rate
    Florian Custodis
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 56:1973-83. 2010
    ....
  71. ncbi request reprint Regulation of endothelial progenitor cells by prostaglandin E1 via inhibition of apoptosis
    Christoph Gensch
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    J Mol Cell Cardiol 42:670-7. 2007
    ..PGE1-mediated upregulation of EPC is associated with improved EPC function and enhanced angiogenesis...
  72. doi request reprint Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase
    Bettina Johanna Stuck
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, D 66421 Homburg Saar, Germany
    J Biol Chem 283:32562-9. 2008
    ..Stimulation with the AMPK activator AICAR reverses these metabolic changes, increases fatty acid utilization, and inhibits cardiomyocyte hypertrophy...
  73. ncbi request reprint Cardiovascular disease and dyslipidemia: beyond LDL
    Janine Pöss
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany
    Curr Pharm Des 17:861-70. 2011
    ..Ongoing research points towards a shift of the focus from the HDL-C concentrations to parameters of HDL function and from fasting TG to TG kinetics...
  74. ncbi request reprint The PPAR-gamma agonist pioglitazone increases neoangiogenesis and prevents apoptosis of endothelial progenitor cells
    Christoph Gensch
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Atherosclerosis 192:67-74. 2007
    ..Pioglitazone prevents apoptosis of EPC in mice as well as in human EPC in a PI3K-dependent but NO-independent manner. Reduction of EPC apoptosis by TZD may be a potentially beneficial mechanism for patients with vascular diseases...
  75. doi request reprint Prevention of atrial fibrillation with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66424 Homburg Saar, Germany
    Circulation 118:1285-93. 2008
  76. doi request reprint Antioxidative effects of statins
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg, Saar, Germany
    Arch Toxicol 82:885-92. 2008
    ..This review summarizes the effects of statins on endothelial function and oxidative stress...
  77. doi request reprint Vascular effects of diet supplementation with plant sterols
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 51:1553-61. 2008
    ..The purpose of this study was to evaluate vascular effects of diet supplementation with plant sterol esters (PSE)...
  78. pmc The relationships of markers of cholesterol homeostasis with carotid intima-media thickness
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    PLoS ONE 5:e13467. 2010
    ....
  79. ncbi request reprint Does statin therapy influence steroid hormone synthesis?
    M Bohm
    Klinik fur Innere Medizin III, Universitatskliniken des Saarlandes, Kirrberger Strasse, 66421 Homburg, Germany
    Z Kardiol 93:43-8. 2004
    ..There was no compensatory change in FSH or LH. It is concluded that pravastatin does not alter steroid hormones or gonadotropins in a clinically applicable dose, which significantly reduces total and LDL cholesterol...
  80. ncbi request reprint Pleiotropic effects of HMG-CoA reductase inhibitors
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Basic Res Cardiol 97:105-16. 2002
    ..These pleiotropic properties of statins may have important clinical implications in addition to lowering serum cholesterol...
  81. ncbi request reprint [Blood pressure increases with waist circumference]
    Ulrich Laufs
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar
    MMW Fortschr Med 144:43-4. 2002
  82. ncbi request reprint HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Hamburg/Saar, Germany
    Hypertension 37:1450-7. 2001
    ....
  83. ncbi request reprint Heart failure and statins--why do we need a clinical trial?
    M Bohm
    Klinik fur Innere Medizin III, Universitätsklinik des Saarlandes, Kirrberger Strasse, 66421 Homburg, Gemany
    Z Kardiol 94:223-30. 2005
    ..Since there are no safety data on the use of statins in chronic heart failure, a controlled randomized and placebo-controlled trial is urgently needed...
  84. ncbi request reprint [Primary and secondary prevention of the acute coronary syndrome]
    O Weingärtner
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, 66421 Homburg Saar
    Hamostaseologie 26:158-66; quiz 167-8. 2006
    ..In general, the following applies to primary and secondary prevention of the acute coronary syndrome: Change in lifestyle and strict risk factor control improve the quality of life and prognosis when followed consequently...
  85. doi request reprint [HDL and CETP in atherogenesis]
    J Poss
    Klinik fur Innere Medizin III, Universitat des Saarlandes, Homburg
    Dtsch Med Wochenschr 135:188-92. 2010
    ..Important current clinical endpoint studies with new CETP inhibitors will elucidate whether increasing HDL by CETP inhibition leads to a reduction of cardiovascular events...
  86. doi request reprint [Plant sterols as dietary supplements for the prevention of cardiovascular diseases]
    O Weingärtner
    Abteilung fur Kardiologie, Angiologie und Internistische Intensivmedizin, Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar
    Dtsch Med Wochenschr 133:1201-4. 2008
    ..Additional studies investigating relevant clinical endpoints are needed before a diet supplemented with plant sterols can be recommended in the prevention of cardiovascular diseases...
  87. doi request reprint [Lipid metabolism disorders in pregnancy]
    U Laufs
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg
    Dtsch Med Wochenschr 133:2173-6. 2008
  88. ncbi request reprint [The "French Paradox"--effects of alcohol, wine and wine polyphenols on the heart]
    M Bohm
    Medizinische Universitätsklinik und Poliklinik, Innere Medizin III, Kardiologie Angiologie, Homburg Saar, Germany
    Dtsch Med Wochenschr 127:2748-56. 2002
  89. ncbi request reprint [Stable coronary artery disease -- case report]
    F Custodis
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes
    Dtsch Med Wochenschr 131:554-5; quiz 563-4. 2006
  90. ncbi request reprint Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Mol Pharmacol 59:646-54. 2001
    ....
  91. ncbi request reprint Discontinuation of statin treatment in stroke patients
    Matthias Endres
    Klinik und Polikinik für Neurologie, Charite Universitatsmedizin Berlin, Charite Campus Mitte, D 10117 Berlin, Germany
    Stroke 37:2640-3. 2006
    ..Here, we review evidence to suggest that the abrupt discontinuation of statin medication exerts negative vascular effects in patients with acute vascular events...
  92. ncbi request reprint Effects of statins on endothelium and signaling mechanisms
    Matthias Endres
    Klinik und Poliklinik fur Neurologie, Charite Universitatsmedizin Berlin, Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Stroke 35:2708-11. 2004
    ..Withdrawal of statin treatment leads to an overshoot activation of Rho and Rac with dramatic effects on nitric oxide bioavailability, NAD(P)H-oxidase activity, and superoxide production...
  93. ncbi request reprint Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects
    Johann Bauersachs
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Universitat Wurzburg, Germany
    Cardiovasc Res 72:438-46. 2006
    ..The aim of this study was to investigate the effects of hypercholesterolemia and statin treatment in rabbits with experimental MI...
  94. ncbi request reprint Mechanisms of stroke protection by physical activity
    Matthias Endres
    Klinik und Poliklinik fur Neurologie, Charite, Humboldt Universitat zu Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Ann Neurol 54:582-90. 2003
    ..Our results suggest that physical activity not only decreases stroke risk, but also provides a prophylactic treatment strategy for increasing blood flow and reducing brain injury during cerebral ischemia...
  95. ncbi request reprint Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow
    Karen Gertz
    Klinik und Poliklinik fur Neurologie, Charite Campus Mitte, Berlin, Germany
    Circ Res 99:1132-40. 2006
    ..Voluntary physical activity improves long-term stroke outcome by eNOS-dependent mechanisms related to improved angiogenesis and cerebral blood flow...
  96. ncbi request reprint Cardiac effects of statins--advancements and open questions
    Ulrich Laufs
    Cardiovasc Res 66:427-9. 2005
  97. ncbi request reprint Physical exercise and endothelial progenitor cells
    Florian Custodis
    J Cardiopulm Rehabil Prev 27:74-5. 2007
  98. ncbi request reprint Withdrawal of statins increases event rates in patients with acute coronary syndromes
    Christopher Heeschen
    University Hospital Frankfurt, Germany
    Circulation 105:1446-52. 2002
    ..Withdrawal of chronic statin treatment during acute coronary syndromes may impair vascular function independent of lipid-lowering effects and thus increase cardiac event rate...
  99. ncbi request reprint [Functional foods. How healthy is cholesterol controlling margerine? (interview by Dr. Thomas Meissner)]
    Ulrich Laufs
    MMW Fortschr Med 150:6. 2008
  100. pmc Isoprenoid metabolism and the pleiotropic effects of statins
    Ulrich Laufs
    Vascular Medicine Research, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Curr Atheroscler Rep 5:372-8. 2003
  101. ncbi request reprint Targeting eNOS for stroke protection
    Matthias Endres
    Department of Neurology, Charite Hospital, Humboldt University, Schumanstrasse 20 21, D 10117 Berlin, Germany
    Trends Neurosci 27:283-9. 2004
    ..Thus, therapeutic modalities that target eNOS not only serve as preventive measures to reduce stroke incidence but also could represent novel treatment strategies for reducing brain injury during cerebral ischaemia...