H Lauble

Summary

Country: Germany

Publications

  1. ncbi request reprint Structure of hydroxynitrile lyase from Manihot esculenta in complex with substrates acetone and chloroacetone: implications for the mechanism of cyanogenesis
    H Lauble
    Universitat Stuttgart, Institut fur Organische Chemie, Pfaffenwaldring 55, D 70569 Stuttgart, Germany
    Acta Crystallogr D Biol Crystallogr 57:194-200. 2001
  2. pmc Mechanistic aspects of cyanogenesis from active-site mutant Ser80Ala of hydroxynitrile lyase from Manihot esculenta in complex with acetone cyanohydrin
    H Lauble
    Institut für Organische Chemie der Universität Stuttgart, D 70569 Stuttgart, Germany
    Protein Sci 10:1015-22. 2001
  3. pmc Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta
    Hanspeter Lauble
    Institut für Organische Chemie der Universität Stuttgart, D 70569 Stuttgart, Germany
    Protein Sci 11:65-71. 2002
  4. ncbi request reprint Crystal structure of hydroxynitrile lyase from Sorghum bicolor in complex with the inhibitor benzoic acid: a novel cyanogenic enzyme
    Hanspeter Lauble
    Institut fur Organische Chemie, Universitat Stuttgart, Pfaffenwaldring 55, D 70569 Stuttgart, Germany
    Biochemistry 41:12043-50. 2002
  5. ncbi request reprint Crystallization and preliminary x-ray diffraction analysis of hydroxynitrile lyase from cassava (Manihot esculenta)
    H Lauble
    Institut für Organische Chemie und Isotopenforschung, Universitat Stuttgart, D 70569 Stuttgart, Germany
    Acta Crystallogr D Biol Crystallogr 55:904-6. 1999

Detail Information

Publications5

  1. ncbi request reprint Structure of hydroxynitrile lyase from Manihot esculenta in complex with substrates acetone and chloroacetone: implications for the mechanism of cyanogenesis
    H Lauble
    Universitat Stuttgart, Institut fur Organische Chemie, Pfaffenwaldring 55, D 70569 Stuttgart, Germany
    Acta Crystallogr D Biol Crystallogr 57:194-200. 2001
    ..These studies support a mechanism for cyanogenesis as well as for the stereospecific MeHNL-catalyzed formation of (S)-cyanohydrins, which closely resembles the base-catalyzed chemical reaction of HCN with carbonyl compounds...
  2. pmc Mechanistic aspects of cyanogenesis from active-site mutant Ser80Ala of hydroxynitrile lyase from Manihot esculenta in complex with acetone cyanohydrin
    H Lauble
    Institut für Organische Chemie der Universität Stuttgart, D 70569 Stuttgart, Germany
    Protein Sci 10:1015-22. 2001
    ..The His236 imidazolium cation then facilitates the leaving of the nitrile group by proton donating...
  3. pmc Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta
    Hanspeter Lauble
    Institut für Organische Chemie der Universität Stuttgart, D 70569 Stuttgart, Germany
    Protein Sci 11:65-71. 2002
    ..1 A resolution shows the presence of two hydroxybenzaldehyde molecules in a sandwich type arrangement in the active site with an additional hydrogen bridge to the reacting center...
  4. ncbi request reprint Crystal structure of hydroxynitrile lyase from Sorghum bicolor in complex with the inhibitor benzoic acid: a novel cyanogenic enzyme
    Hanspeter Lauble
    Institut fur Organische Chemie, Universitat Stuttgart, Pfaffenwaldring 55, D 70569 Stuttgart, Germany
    Biochemistry 41:12043-50. 2002
    ..The implications of this structure on the evolution of catalysis in the hydroxynitrile lyase superfamily are discussed...
  5. ncbi request reprint Crystallization and preliminary x-ray diffraction analysis of hydroxynitrile lyase from cassava (Manihot esculenta)
    H Lauble
    Institut für Organische Chemie und Isotopenforschung, Universitat Stuttgart, D 70569 Stuttgart, Germany
    Acta Crystallogr D Biol Crystallogr 55:904-6. 1999
    ..52, b = 127.09 and c = 78.08 A, have two molecules in the asymmetric unit and diffract to beyond 2.0 A resolution. A complete native data set has been collected to 2.2 A resolution...