Christoph Laske

Summary

Country: Germany

Publications

  1. ncbi request reprint Autoantibody reactivity in serum of patients with major depression, schizophrenia and healthy controls
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Osianderstr 24, Tubingen D 72076, Germany
    Psychiatry Res 158:83-6. 2008
  2. ncbi request reprint Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies
    Kateryna Sopova
    Department of Psychiatry and Psychotherapy, University of Tubingen, Calwer Street 14, D 72076 Tubingen, Germany
    Curr Alzheimer Res 11:27-39. 2014
  3. doi request reprint Immune profiling in blood identifies sTNF-R1 performing comparably well as biomarker panels for classification of Alzheimer's disease patients
    Christoph Laske
    Section for Dementia Research, Hertie Institute of Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tubingen, Germany
    J Alzheimers Dis 34:367-75. 2013
  4. ncbi request reprint Platelet activation in Alzheimer's disease: from pathophysiology to clinical value
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Calwer Str 14, D 72076 Tubingen, Germany
    Curr Vasc Pharmacol 10:626-30. 2012
  5. ncbi request reprint Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 15:451-60. 2008
  6. doi request reprint Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 17:115-23. 2009
  7. ncbi request reprint [Depression in Hashimoto's encephalopathy. Successful treatment of a severe depressive episode with a glucocorticoid as an add-on therapy]
    C Laske
    Universitätsklinik für Psychiatrie und Psychotherapie Tübingen
    Nervenarzt 76:617-22. 2005
  8. doi request reprint Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Germany
    Int J Neuropsychopharmacol 13:595-602. 2010
  9. doi request reprint Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients
    Christoph Laske
    Department of Psychiatry and Psychotherapy, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Int J Neuropsychopharmacol 14:399-404. 2011
  10. doi request reprint Identification of a blood-based biomarker panel for classification of Alzheimer's disease
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    Int J Neuropsychopharmacol 14:1147-55. 2011

Detail Information

Publications36

  1. ncbi request reprint Autoantibody reactivity in serum of patients with major depression, schizophrenia and healthy controls
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Osianderstr 24, Tubingen D 72076, Germany
    Psychiatry Res 158:83-6. 2008
    ..These results point towards the existence of an unspecific (auto) immune disposition or reaction in at least a subgroup of patients with major depression and schizophrenia...
  2. ncbi request reprint Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies
    Kateryna Sopova
    Department of Psychiatry and Psychotherapy, University of Tubingen, Calwer Street 14, D 72076 Tubingen, Germany
    Curr Alzheimer Res 11:27-39. 2014
    ....
  3. doi request reprint Immune profiling in blood identifies sTNF-R1 performing comparably well as biomarker panels for classification of Alzheimer's disease patients
    Christoph Laske
    Section for Dementia Research, Hertie Institute of Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tubingen, Germany
    J Alzheimers Dis 34:367-75. 2013
    ..The objective of the present study was to determine whether singular markers or a set of inflammatory biomarkers in peripheral blood allow discrimination between AD patients and healthy controls at the individual level...
  4. ncbi request reprint Platelet activation in Alzheimer's disease: from pathophysiology to clinical value
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Calwer Str 14, D 72076 Tubingen, Germany
    Curr Vasc Pharmacol 10:626-30. 2012
    ..The present review will summarize and highlight the latest findings of this research area and provide novel insight and understanding in the association between platelet activation and AD...
  5. ncbi request reprint Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 15:451-60. 2008
    ..Further studies are needed to examine whether a manipulation of HGFs such as SCF could be a promising new therapeutic strategy for AD...
  6. doi request reprint Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 17:115-23. 2009
    ..Further studies are needed to examine whether a modulation of hematopoietic growth factors such as G-CSF could be a promising new therapeutic strategy for AD...
  7. ncbi request reprint [Depression in Hashimoto's encephalopathy. Successful treatment of a severe depressive episode with a glucocorticoid as an add-on therapy]
    C Laske
    Universitätsklinik für Psychiatrie und Psychotherapie Tübingen
    Nervenarzt 76:617-22. 2005
    ..Diagnosis of HE should be included in diagnostic procedures in cases of therapy-refractory depression because of a good response of HE to steroids...
  8. doi request reprint Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Germany
    Int J Neuropsychopharmacol 13:595-602. 2010
    ..This mechanism may contribute to the beneficial therapeutic and relapse-preventing effects of physical activity on MD...
  9. doi request reprint Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients
    Christoph Laske
    Department of Psychiatry and Psychotherapy, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Int J Neuropsychopharmacol 14:399-404. 2011
    ..Further longitudinal studies are necessary to elucidate the kinetics and the potential role of serum BDNF as a surrogate marker of disease progression in AD patients...
  10. doi request reprint Identification of a blood-based biomarker panel for classification of Alzheimer's disease
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    Int J Neuropsychopharmacol 14:1147-55. 2011
    ..Future studies should examine whether blood-based biomarkers may also be useful to differentiate AD patients from other dementias...
  11. doi request reprint Stem cell factor plasma levels are decreased in Alzheimer's disease patients with fast cognitive decline after one-year follow-up period: the Pythia-study
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 26:39-45. 2011
    ..Thus, treatment strategies increasing SCF plasma levels could be useful for delaying the progression of AD. Further prospective studies are needed to elucidate the value of plasma SCF in a multimarker approach determining AD prognosis...
  12. doi request reprint Decreased α-synuclein serum levels in patients with Lewy body dementia compared to Alzheimer's disease patients and control subjects
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Osianderstrasse 24, Tubingen, Germany
    Dement Geriatr Cogn Disord 31:413-6. 2011
    ..001), reaching an area under the curve of >0.70. Conclusion: Although these results do not justify a definition of serum α-synuclein as a potential single biomarker, results may contribute to a multimarker strategy in DLB diagnosis...
  13. doi request reprint Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Abeta 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia
    Christoph Laske
    Dept of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstr 24, 72076, Tuebingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:80-5. 2009
    ....
  14. ncbi request reprint Decreased CXCL12 (SDF-1) plasma levels in early Alzheimer's disease: a contribution to a deficient hematopoietic brain support?
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    J Alzheimers Dis 15:83-95. 2008
    ..583; p = 0.009). Our findings indicate a lack of chemotactic activity in early AD and support the view of a deficient regenerative hematopoietic brain support in early AD with putative pathogenic and therapeutic relevance...
  15. ncbi request reprint [Brain-derived neurotrophic factor: from nerve growth factor to modulator of brain plasticity in cognitive processes and psychiatric diseases]
    C Laske
    Universitätsklinik für Psychiatrie und Psychotherapie Tübingen
    Nervenarzt 77:523-37. 2006
    ..Measurement of BDNF serum concentrations may be of diagnostic value. Additionally, the influence of different strategies for BDNF allocation seems to be relevant for the treatment and prevention of the above psychiatric disorders...
  16. ncbi request reprint BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstr 24, D 72076 Tuebingen, Germany
    J Psychiatr Res 41:387-94. 2007
    ..Further examinations have to follow to elucidate the potential sources and the meaning of reduced BDNF levels in the blood in AD and NPH...
  17. ncbi request reprint Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstrasse 24, D 72076 Tuebingen, Germany
    J Psychiatr Res 41:600-5. 2007
    ..In conclusion, the results from our study indicate that BDNF may be involved in the pathophysiology of pain in FM. Nevertheless, how BDNF increases susceptibility to pain is still not known...
  18. ncbi request reprint Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer's disease
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstrasse 24, D 72076 Tuebingen, Germany
    J Psychiatr Res 42:746-51. 2008
    ..Our results suggest an association of sGPVI with the pathogenesis of AD. These findings encourage future research into whether sGPVI plasma levels may reflect or even mediate neuroprotective mechanisms in AD...
  19. doi request reprint Increased circulating progenitor cells in Alzheimer's disease patients with moderate to severe dementia: evidence for vascular repair and tissue regeneration?
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Alzheimers Dis 19:591-600. 2010
    ..Our findings suggest a stage-dependent upregulation of circulating CD34+/CD133+ and CD34+ progenitor cells in AD patients, which could take part in tissue healing processes of the brain in AD...
  20. pmc Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Mueller Straße 10, Tubingen, Germany
    J Cereb Blood Flow Metab 30:1817-20. 2010
    ..These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients...
  21. pmc Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease
    Niklas K U Koehler
    Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tubingen, Germany
    PLoS ONE 8:e64649. 2013
    ..These observations may foster the development of novel, possibly preclinical biomarkers and immunotherapeutic strategies that target α-synuclein in neurodegenerative disease...
  22. ncbi request reprint Amyloid-β peptides in plasma and cognitive decline after 1 year follow-up in Alzheimer's disease patients
    Christoph Laske
    Department of Psychiatry and Psychotherapy Eberhard Karls Universität Tübingen, Tubingen, Germany
    J Alzheimers Dis 21:1263-9. 2010
    ..These results suggest that Aβ₁₋₄₂ plasma levels are associated with the rate of cognitive decline in AD patients and may be influenced by atherosclerotic vasculopathies such as stroke and myocardial infarction...
  23. ncbi request reprint Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's disease
    Guido Straten
    Depatment of Anesthesiology and Intensive Care, University of Tubingen, Germany
    Curr Alzheimer Res 8:853-9. 2011
    ..3 ± 37.4 pg/ml versus 72.8 ± 43.9 pg/ml, p = 0.511). The findings of the present investigation indicated that beneficial effects of the lithium treatment might reduce the necessity of enhanced GDNF expression in the CNS in early AD...
  24. doi request reprint Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebrospinal fluid and serum of patients with early Alzheimer's disease and normal controls
    Guido Straten
    Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    J Alzheimers Dis 18:331-7. 2009
    ..Decreased serum concentration of GDNF might be related to altered function of the blood brain barrier thus disturbing clearance or facilitating passover of potentially harmful metabolites...
  25. doi request reprint Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease
    Thomas Leyhe
    Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    J Alzheimers Dis 16:649-56. 2009
    ..The results of the present investigation encourage performing studies with longer treatment phases to observe potential positive long-term effects of lithium in AD patients...
  26. ncbi request reprint Altered lymphocyte distribution in Alzheimer's disease
    Elke Richartz-Salzburger
    University of Tuebingen, Psychiatry and Psychotherapy, Osianderstrasse 24, 72076 Tuebingen, Germany
    J Psychiatr Res 41:174-8. 2007
    ..A putative association with premature immunosenescence in AD and possible pathogenetic implications are discussed...
  27. doi request reprint Increase of SCF plasma concentration during donepezil treatment of patients with early Alzheimer's disease
    Thomas Leyhe
    Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    Int J Neuropsychopharmacol 12:1319-26. 2009
    ..Our findings indicate that donepezil treatment of AD patients is associated with an up-regulation of SCF plasma levels, which may contribute to neuroprotection and neurogenesis in the CNS...
  28. pmc Adipocytokines and CD34 progenitor cells in Alzheimer's disease
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    PLoS ONE 6:e20286. 2011
    ..Adipocytokines and CD34(+) progenitor cells are associated with the progression and prognosis of atherosclerotic diseases. Their role in AD is not adequately elucidated...
  29. pmc Elevated angiopoietin-1 serum levels in patients with Alzheimer's disease
    Brigitte Schreitmüller
    Department of Psychiatry and Psychotherapy, University of Tubingen, 72076 Tuebingen, Germany
    Int J Alzheimers Dis 2012:324016. 2012
    ..We could also show an association between Ang-1 serum levels and the cognitive status in all patients and healthy controls. Thus, serum Ang-1 could be a potential candidate for a biomarker panel for AD diagnosis...
  30. doi request reprint Increased occurrence of weaknesses in attention testing in patients with Hashimoto's thyroiditis compared to patients with other thyroid illnesses
    Thomas Leyhe
    Department of Psychiatry and Psychotherapy, University of Tubingen, Osianderstrasse 24, 72076 Tubingen, Germany
    Psychoneuroendocrinology 33:1432-6. 2008
    ..This could either be due to an association with an unknown autoimmune disorder affecting the CNS or a pathogenetic role of thyroid antibodies themselves...
  31. ncbi request reprint Stage-dependent BDNF serum concentrations in Alzheimer's disease
    C Laske
    Department of Psychiatry and Psychotherapy, University of Tübinger, Germany
    J Neural Transm 113:1217-24. 2006
    ..BDNF should be further evaluated as a candidate marker for clinical diagnosis and therapeutic monitoring in Alzheimer's disease...
  32. ncbi request reprint [Dementia as a primary symptom in late onset multiple sclerosis. Case series and review of the literature]
    T Leyhe
    Klinik für Psychiatrie und Psychotherapie der Universität Tübingen
    Nervenarzt 76:748-55. 2005
    ..Until now dementia as the primary symptomatology has not been described in patients older than 60 years. Possibly MS as a differential diagnosis in dementia as well as cognitive impairment as an initial symptom of MS is under-recognized...
  33. ncbi request reprint Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease
    T Leyhe
    Department of Psychiatry and Psychotherapy, University of Tubingen, Osianderstrasse 24, Tubingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:124-8. 2008
    ..Thus, up-regulation of BDNF might be part of a neuroprotective effect of AChE-inhibitors. The molecular mechanism of this potentially disease-modifying mechanism of action of donepezil should be clarified...
  34. doi request reprint [Premature immunosenescence: a pathogenetic factor in Alzheimer's disease?]
    E Richartz-Salzburger
    Universitatsklinik fur Psychiatrie und Psychotherapie, Tubingen, Tubingen, Deutschland
    Nervenarzt 81:837-43. 2010
    ..Presumably, premature immunosenescence may lead to inadequate immune reactions. Against this background, the development of different immunotherapeutic strategies seems to be a promising challenge for future research...
  35. ncbi request reprint Decreased brain-derived neurotrophic factor (BDNF)- and beta-thromboglobulin (beta-TG)- blood levels in Alzheimer's disease
    Christoph Laske
    Thromb Haemost 96:102-3. 2006