Anis Larbi

Summary

Country: Germany

Publications

  1. doi Aging of the immune system as a prognostic factor for human longevity
    Anis Larbi
    University of Tubingen, Center for Medical Research, Tubingen, Germany
    Physiology (Bethesda) 23:64-74. 2008
  2. ncbi Oxidative stress modulation and T cell activation
    Anis Larbi
    Center for Medical Research, Tuebingen Ageing and Tumor Immunology group, University of Tuebingen, Waldhornlestrasse 22, 72072 Tuebingen, Germany
    Exp Gerontol 42:852-8. 2007
  3. ncbi A satellite symposium of the 1st European Congress of Immunology Paris, France, September 2006, Aging Research in Immunology: the genomic facet in Paris
    Anis Larbi
    Center for Medical Research, Tuebingen Aging and Tumor Immunology group Waldhornlestrasse 22, 72072, University of Tuebingen, Tuebingen, Germany
    Exp Gerontol 42:379-84. 2007
  4. doi Immune receptor signaling, aging and autoimmunity
    Anis Larbi
    Center for Medical Research ZMF, Tübingen Aging and Tumour Immunology Group, Section for Transplantation Immunology and Immunohematology, University of Tubingen, Waldhornlestrasse 22, D 72072 Tubingen, Germany
    Adv Exp Med Biol 640:312-24. 2008
  5. ncbi The heat shock proteins in cellular aging: is zinc the missing link?
    Anis Larbi
    Center for Medical Research, Tüebingen Aging and Tumor Immunology group, University of Tuebingen, Waldhornlestrasse 22, 72072, Tuebingen, Germany
    Biogerontology 7:399-408. 2006
  6. doi Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation
    Anis Larbi
    Center for Medical Research, Tübingen Aging and Tumor Immunology Group, University of Tubingen, 72072 Tubingen, Germany
    Free Radic Biol Med 48:26-34. 2010
  7. doi Induction of HIF-1alpha and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells
    Anis Larbi
    Center for Medical Research ZMF, Tübingen Aging and Tumor Immunology Group Sektion für Transplantationsimmunologie und Immunhämatologie, Waldhornlestrasse 22, 72072 Tubingen, Germany
    J Leukoc Biol 87:265-73. 2010
  8. doi Cytomegalovirus and human immunosenescence
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany
    Rev Med Virol 19:47-56. 2009
  9. ncbi Cytomegalovirus infection: a driving force in human T cell immunosenescence
    Sven Koch
    Department of Immunology, University of Tubingen, Auf der Morgenstelle 15, D 72076, Tubingen, Germany
    Ann N Y Acad Sci 1114:23-35. 2007
  10. doi Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
    Evelyna Derhovanessian
    Center for Medical Research, ZMF, University of Tubingen Medical School, Tubingen, Germany
    Curr Opin Immunol 21:440-5. 2009

Collaborators

Detail Information

Publications41

  1. doi Aging of the immune system as a prognostic factor for human longevity
    Anis Larbi
    University of Tubingen, Center for Medical Research, Tubingen, Germany
    Physiology (Bethesda) 23:64-74. 2008
    ..The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here...
  2. ncbi Oxidative stress modulation and T cell activation
    Anis Larbi
    Center for Medical Research, Tuebingen Ageing and Tumor Immunology group, University of Tuebingen, Waldhornlestrasse 22, 72072 Tuebingen, Germany
    Exp Gerontol 42:852-8. 2007
    ..Here, we discuss the relevance of oxidative stress modulation to prevent T cell dysfunction. We draw attention to some technical, but critical, aspects of T cell culture under hyperoxic conditions...
  3. ncbi A satellite symposium of the 1st European Congress of Immunology Paris, France, September 2006, Aging Research in Immunology: the genomic facet in Paris
    Anis Larbi
    Center for Medical Research, Tuebingen Aging and Tumor Immunology group Waldhornlestrasse 22, 72072, University of Tuebingen, Tuebingen, Germany
    Exp Gerontol 42:379-84. 2007
  4. doi Immune receptor signaling, aging and autoimmunity
    Anis Larbi
    Center for Medical Research ZMF, Tübingen Aging and Tumour Immunology Group, Section for Transplantation Immunology and Immunohematology, University of Tubingen, Waldhornlestrasse 22, D 72072 Tubingen, Germany
    Adv Exp Med Biol 640:312-24. 2008
    ..g., rheumatoid arthritis, systemic lupus erythematosus and cancer. In this chapter, we will summarize our knowledge about multichain immune recognition receptor signaling, mainly the TCR, in aging and autoimmune diseases...
  5. ncbi The heat shock proteins in cellular aging: is zinc the missing link?
    Anis Larbi
    Center for Medical Research, Tüebingen Aging and Tumor Immunology group, University of Tuebingen, Waldhornlestrasse 22, 72072, Tuebingen, Germany
    Biogerontology 7:399-408. 2006
    ..In this short review we will briefly outline the role of heat-shock proteins and zinc deficiency in aging in order to finally discuss our own results in the context of a link between HSPs, aging and zinc...
  6. doi Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation
    Anis Larbi
    Center for Medical Research, Tübingen Aging and Tumor Immunology Group, University of Tubingen, 72072 Tubingen, Germany
    Free Radic Biol Med 48:26-34. 2010
    ..Altogether, this study highlights the importance of controlling oxygen levels in culture when investigating oxygen-dependent phenomena such as oxidative stress...
  7. doi Induction of HIF-1alpha and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells
    Anis Larbi
    Center for Medical Research ZMF, Tübingen Aging and Tumor Immunology Group Sektion für Transplantationsimmunologie und Immunhämatologie, Waldhornlestrasse 22, 72072 Tubingen, Germany
    J Leukoc Biol 87:265-73. 2010
    ....
  8. doi Cytomegalovirus and human immunosenescence
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany
    Rev Med Virol 19:47-56. 2009
    ..Whether the IRP is informative in younger individuals and the mechanism of the CMV effect is discussed in this review...
  9. ncbi Cytomegalovirus infection: a driving force in human T cell immunosenescence
    Sven Koch
    Department of Immunology, University of Tubingen, Auf der Morgenstelle 15, D 72076, Tubingen, Germany
    Ann N Y Acad Sci 1114:23-35. 2007
    ..These findings support the hypothesis that persistent herpesviruses, especially CMV, act as chronic antigenic stressors and play a major causative role in immunosenescence and associated mortality...
  10. doi Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
    Evelyna Derhovanessian
    Center for Medical Research, ZMF, University of Tubingen Medical School, Tubingen, Germany
    Curr Opin Immunol 21:440-5. 2009
    ....
  11. doi Flow cytometric lymphocyte subset analysis using material from frozen whole blood
    Iftikhar Alam
    Tübingen Aging and Tumour Immunology Group, Sektion für Transplantationsimmunologie und Immunohämatologie, University of Tubingen, Zentrum für MedizinischeForschung, Tubingen, Germany
    J Immunoassay Immunochem 33:128-39. 2012
    ....
  12. doi Immune profiling of Alzheimer patients
    Mariavaleria Pellicano
    Department of Internal Medicine II, Center for Medical Research, University of Tubingen, Tübingen Aging and Tumor Immunology Group, Waldhornlestr 22, 72072 Tubingen, Germany
    J Neuroimmunol 242:52-9. 2012
    ..Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease...
  13. doi Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease
    Anis Larbi
    Center for Medical Research, University of Tubingen, Tubingen, Germany
    J Alzheimers Dis 17:91-103. 2009
    ....
  14. doi Immunosenescence and cancer
    Graham Pawelec
    Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tübingen Clinical School, Waldhornlestr 22, D 72072 Tubingen, Germany
    Crit Rev Oncol Hematol 75:165-72. 2010
    ..This review weighs some of the evidence for and against this possibility...
  15. pmc Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective
    Iftikhar Alam
    University of Tubingen, Tubingen, Germany
    Mediators Inflamm 2012:456456. 2012
    ..What causes this transition to occur and what is the role of obesity-related mediators of inflammation during this transition is discussed in this paper...
  16. doi Multi-parametric phospho-flow cytometry: a crucial tool for T lymphocyte signaling studies
    David Goldeck
    Center for Medical Research ZMF, Tübingen Aging and Tumor Immunology Group, Tubingen, Germany
    Cytometry A 83:265-72. 2013
    ..This enables precise identification of subset-specific signaling and alterations of signaling pathways in physiological and pathological situations. The importance of such detailed analysis is discussed...
  17. pmc Relationship between anthropometric variables and nutrient intake in apparently healthy male elderly individuals: a study from Pakistan
    Iftikhar Alam
    Tübingen Aging and Tumour Immunology Group, Sektion für Transplantationsimmunologie und Immunohämatologie, University of Tubingen, Zentrum für MedizinischeForschung, Waldhörnlestraße 22, 72072 Tubingen, Germany
    Nutr J 10:111. 2011
    ..The elderly population is increasing worldwide, which warrants their nutritional status assessment more important. The present study was undertaken to establish the nutritional status of the least-studied elderly population in Pakistan...
  18. pmc Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan
    Iftikhar Alam
    Tubingen Ageing and Tumour Immunology Group, Zentrum für Medizinische Forschung, University of Tubingen, Waldhörnlestraße 22, D 72072, Tubingen, Germany
    Immun Ageing 9:16. 2012
    ....
  19. doi Human mesenchymal stromal cells express CD14 cross-reactive epitopes
    Gregor A Pilz
    Center for Regenerative Medicine ZRM, UKT, Eberhard Karls University, Tubingen, Germany
    Cytometry A 79:635-45. 2011
    ..This investigation does not contradict previous work but provides a more accurate characterization of MSC...
  20. ncbi Immunity and ageing in man: Annual Review 2006/2007
    Graham Pawelec
    University of Tübingen Center for Medical Research, Waldhornlestr 22, D 72072, Tubingen, Germany
    Exp Gerontol 43:34-8. 2008
    ..Here, we summarise some of the developments in this area and in other important areas of immunosenescence research over the past year...
  21. ncbi Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes
    Anis Larbi
    Research Center on Aging, Geriatric Institute, Clinical Research Center, University of Sherbrooke, 1036 Belvédère St South, Sherbrooke, QC, Canada J1H 4C4
    J Leukoc Biol 75:373-81. 2004
    ..Our data suggest that some properties of lipid rafts are altered in aging, and this finding may be part of the causes for the decline in T cell functions that are observed in elderly individuals...
  22. ncbi Do membrane rafts contribute to human immunosenescence?
    Andru Tomoiu
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, 1036 rue Belvedere sud, Sherbrooke J1H 4C4, Quebec, Canada
    Ann N Y Acad Sci 1100:98-110. 2007
    ..The alterations in membrane rafts composition and function can underline this altered activation of T cells with aging and then contribute to human immunosenescence. The experimental data in favor of this hypothesis will be reviewed...
  23. ncbi Effects of methyl-beta-cyclodextrin on T lymphocytes lipid rafts with aging
    Anis Larbi
    Research Center on Aging, Sherbrooke Geriatric University Institute, University of Sherbrooke, Sherbrooke, Que, Canada J1H 5N4
    Exp Gerontol 39:551-8. 2004
    ..Altogether these results suggest that defects in cholesterol cellular homeostasis may be part of T-cell immunosenescence via lipid rafts dysfunction...
  24. ncbi Low-grade inflammation with aging has consequences for T-lymphocyte signaling
    Anis Larbi
    Research Center on Aging, University of Sherbrooke Geriatric Institute, Sherbrooke, Quebec, Canada
    Ann N Y Acad Sci 1030:125-33. 2004
    ..In conclusion, we show a link between aging, T-lymphocyte lipid rafts, immune senescence, and low-grade inflammation...
  25. pmc Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune system
    Tamas Fulop
    Research Center on Ageing, Sherbrooke Geriatric University Institute, University of Sherbrooke, Quebec, Canada
    Arthritis Res Ther 5:290-302. 2003
    ..The putative contribution of altered T-cell signalling with ageing in the development of autoimmune diseases will be also discussed...
  26. pmc Immunosupportive therapies in aging
    Tamas Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Clin Interv Aging 2:33-54. 2007
    ..We will then discuss possible interventions that might one day become applicable in an appropriate ethical environment...
  27. ncbi Modulation of T-cell signalling by non-esterified fatty acids
    Pascal Brassard
    Department of Medicine and Centre de recherche Clinique Etienne Le Bel, Faculty of Medicine, Universite de Sherbrooke, QC, Canada
    Prostaglandins Leukot Essent Fatty Acids 77:337-43. 2007
    ..Further mechanistic studies and randomized controlled clinical trials are needed to assess more accurately their effects in healthy and pathological states...
  28. ncbi The role of lipid rafts in T lymphocyte signal transduction with aging
    Tamas Fulop
    Institut Universitaire de Geriatrie de Sherbrooke, Center on Aging Research, Faculty of Medicine, Université de Shebrooke, Sherbrooke, QC, J1H, 4C4 Canada
    Ann N Y Acad Sci 973:302-4. 2002
  29. ncbi The role of Mcl-1 and Bax expression alteration in the decreased rescue of human neutrophils from apoptosis by GM-CSF with aging
    Tamas Fulop
    Institut Unversitiare de Gériatire de Sherbrooke, Center on Aging Research, Department of Medicine, Service de Geriatrie, Faculty of Medicine, Université de Shebrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Ann N Y Acad Sci 973:305-8. 2002
  30. ncbi Insulin receptor and ageing
    Tamas Fulop
    Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Service de Geriatrie, Departement de Medecine, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada J1H 4C4
    Pathol Biol (Paris) 51:574-80. 2003
    ..The understanding of the IR physiology with ageing will help to develop more adequate preventive and therapeutic strategies in order to decrease the burden of the complications related to insulin resistance...
  31. ncbi Signal transduction and functional changes in neutrophils with aging
    Tamas Fulop
    Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Programme d Immunologie, Universite de Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Aging Cell 3:217-26. 2004
    ..Alterations were also found in the neutrophil membrane lipid rafts. These alterations in neutrophil functions and signal transduction that occur during aging might contribute to the significant increase in infections in old age...
  32. ncbi Presence and active synthesis of the 67 kDa elastin-receptor in human circulating white blood cells
    Anis Larbi
    Laboratoire de Bio gérontologie, Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada
    Biochem Biophys Res Commun 332:787-92. 2005
    ..The presence of El-R is very important for the interaction of circulating cell with the matrix as these cells intervene during atherosclerosis and in host defence...
  33. ncbi Dysregulation of T-cell function in the elderly : scientific basis and clinical implications
    Tamas Fulop
    Immunology Program, Geriatric Division, Research Center on Aging, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Drugs Aging 22:589-603. 2005
    ..Considering the public health consequences of decreased immune competence in old age, strategies for immune response modulation are desirable to decrease the health burden for the elderly and improve their quality of life...
  34. ncbi Elastin peptides induced oxidation of LDL by phagocytic cells
    Tamas Fulop
    Centre de recherche sur le vieillissement, Faculte de Medecine, Universite de Sherbrooke, Que, Canada
    Pathol Biol (Paris) 53:416-23. 2005
    ..In our present study, the HDL was able to decrease the LDL oxidation by KE. This is a new mechanism by which elastin peptides might participate in the initiation and progression of the atherosclerotic process...
  35. ncbi Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging
    Anis Larbi
    Research Center on Aging, 1036 Belvedere Street South, Sherbrooke, Quebec, Canada
    Cell Signal 18:1017-30. 2006
    ..This study emphasizes the differential role of lipid rafts in CD4+ and CD8+ T-cell activation in aging and suggests that the differential localization of CD28 may explain disparities in response to stimulation in human aging...
  36. ncbi Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans
    Anis Larbi
    Division of Geriatrics, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Clin Nutr 82:949-56. 2005
    ..Previous studies have shown suppressive effects of polyunsaturated fatty acids (PUFAs) on T cell proliferation, but the precise mechanism for this effect has not been fully investigated in vivo in humans...
  37. ncbi Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    Carl F Fortin
    Laboratory for Immunology, Research Center on Aging, Clinical Research Center, and Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    J Leukoc Biol 79:1061-72. 2006
    ..Our results suggest an alteration of the SHP-1 modulation by GM-CSF in lipid rafts of PMN with aging. These alterations could contribute to the decreased GM-CSF effects on PMN...
  38. ncbi T cell response in aging: influence of cellular cholesterol modulation
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Sherbrooke, J1H 4C4, Quebec, Canada
    Adv Exp Med Biol 584:157-69. 2006
  39. ncbi GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals
    Carl F Fortin
    Department of Medicine, Research Center on Aging, Laboratory of Biogerontology, Sherbrooke Geriatric University Institute, 1036, rue Belvedere Sud, J1H 4C4 Sherbrooke, QC, Canada
    Biogerontology 8:173-87. 2007
    ....
  40. ncbi Role of lipid rafts in activation-induced cell death: the fas pathway in aging
    Anis Larbi
    Research Center on Aging, Immunological Graduate Programme, Department of Medicine, University of Sherbrooke, Sherbrooke, J1H 4C4, Quebec, Canada
    Adv Exp Med Biol 584:137-55. 2006
  41. ncbi Modulation of human lymphocyte proliferative response with aging
    Nadine Douziech
    Centre de recherche en gérontologie et gériatrie, Institut Universitaire de Geriatrie de Sherbrooke, 1036 rue Belvedere sud, Sherbrooke, Quebec, Canada J1H 4C4
    Exp Gerontol 37:369-87. 2002
    ..The direct activation of certain molecules or the modulation of the cholesterol content of the membrane seems to be effective immunomodulatory interventions with aging...