Tanja Lange

Summary

Country: Germany

Publications

  1. ncbi Sleep after vaccination boosts immunological memory
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 187:283-90. 2011
  2. ncbi Effects of sleep and circadian rhythm on the human immune system
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Ann N Y Acad Sci 1193:48-59. 2010
  3. ncbi Number and function of circulating human antigen presenting cells regulated by sleep
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Germany
    Sleep 30:401-11. 2007
  4. ncbi Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans
    Stoyan Dimitrov
    Department of Neuroendocrinology, , Ratzeburger Allee 160, Haus 23a, , Germany
    Brain Behav Immun 18:341-8. 2004
  5. ncbi Acute sleep deprivation reduces energy expenditure in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Clin Nutr 93:1229-36. 2011
  6. ncbi Cortisol and epinephrine control opposing circadian rhythms in T cell subsets
    Stoyan Dimitrov
    Departments of Neuroendocrinology, University of Lubeck, Germany
    Blood 113:5134-43. 2009
  7. ncbi Selective mobilization of cytotoxic leukocytes by epinephrine
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    J Immunol 184:503-11. 2010
  8. ncbi Shift of monocyte function toward cellular immunity during sleep
    Tanja Lange
    Department of Internal Medicine, , , Germany
    Arch Intern Med 166:1695-700. 2006
  9. ncbi Blockade of mineralocorticoid receptors enhances naïve T-helper cell counts during early sleep in humans
    Luciana Besedovsky
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Brain Behav Immun 26:1116-21. 2012
  10. ncbi Circadian clocks in mouse and human CD4+ T cells
    Thomas Bollinger
    Institute of Medical Microbiology and Hygiene, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e29801. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Sleep after vaccination boosts immunological memory
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 187:283-90. 2011
    ..Like the nervous system, the immune system takes advantage of the offline conditions during sleep to foster adaptive immune responses resulting in improved immunological memory...
  2. ncbi Effects of sleep and circadian rhythm on the human immune system
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Ann N Y Acad Sci 1193:48-59. 2010
    ....
  3. ncbi Number and function of circulating human antigen presenting cells regulated by sleep
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Germany
    Sleep 30:401-11. 2007
    ....
  4. ncbi Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans
    Stoyan Dimitrov
    Department of Neuroendocrinology, , Ratzeburger Allee 160, Haus 23a, , Germany
    Brain Behav Immun 18:341-8. 2004
    ..001). Though unexpected, the most pronounced effect of sleep on T cell cytokine production was a robust decrease in TNF-alpha producing CD8+ cells probably reflecting increased extravasation of cytotoxic effector and memory T cells...
  5. ncbi Acute sleep deprivation reduces energy expenditure in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Clin Nutr 93:1229-36. 2011
    ..Epidemiologic evidence indicates that chronic sleep curtailment increases risk of developing obesity, but the mechanisms behind this relation are largely unknown...
  6. ncbi Cortisol and epinephrine control opposing circadian rhythms in T cell subsets
    Stoyan Dimitrov
    Departments of Neuroendocrinology, University of Lubeck, Germany
    Blood 113:5134-43. 2009
    ..Thus, activation of the major stress hormones during daytime favor immediate effector defense but diminish capabilities for initiating adaptive immune responses...
  7. ncbi Selective mobilization of cytotoxic leukocytes by epinephrine
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    J Immunol 184:503-11. 2010
    ..Epinephrine rapidly attenuates this attachment to allow demargination and release of the cells into the circulation that, because of their cytotoxic effector function, provide immediate protection from invading pathogens...
  8. ncbi Shift of monocyte function toward cellular immunity during sleep
    Tanja Lange
    Department of Internal Medicine, , , Germany
    Arch Intern Med 166:1695-700. 2006
    ....
  9. ncbi Blockade of mineralocorticoid receptors enhances naïve T-helper cell counts during early sleep in humans
    Luciana Besedovsky
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Brain Behav Immun 26:1116-21. 2012
    ....
  10. ncbi Circadian clocks in mouse and human CD4+ T cells
    Thomas Bollinger
    Institute of Medical Microbiology and Hygiene, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e29801. 2011
    ..Collectively, these data demonstrate for the first time that CD4+ T cell responses are regulated by an intrinsic cellular circadian oscillator capable of driving rhythmic CD4+ T cell immune responses...
  11. ncbi Suppressing the morning rise in cortisol impairs free recall
    Ulrike Rimmele
    Department of Neuroendocrinology, University of Lubeck, Luebeck 23562, Germany
    Learn Mem 17:186-90. 2010
    ..Thus, not only high, but also very low glucocorticoid levels impair retrieval, with the latter effect possibly reflecting insufficient occupation of hippocampal/amygdalar mineralocorticoid receptors (MRs)...
  12. ncbi Sleep and circadian rhythm regulate circulating complement factors and immunoregulatory properties of C5a
    Edimara S Reis
    Institute for Systemic Inflammation Research, University of Lubeck, Lubeck, Germany
    Brain Behav Immun 25:1416-26. 2011
    ..Our findings that continuous wakefulness has a negative impact on complement activation may provide a rationale for the immunosupportive functions of sleep...
  13. ncbi Sleep enhances IL-6 trans-signaling in humans
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, Lubeck 23538, Germany
    FASEB J 20:2174-6. 2006
    ..The selective increase in sIL-6R implicates an enhanced trans-signaling capacity whereby sleep distinctly widens the profile of IL-6 actions, enabling an integrated influence on brain and peripheral organs...
  14. ncbi Sleep enhances the human antibody response to hepatitis A vaccination
    Tanja Lange
    Department of Neuroendocrinology, , , Germany
    Psychosom Med 65:831-5. 2003
    ..Results underscore the importance of sleep for immunocompetence...
  15. ncbi Sleep-like concentrations of growth hormone and cortisol modulate type1 and type2 in-vitro cytokine production in human T cells
    Tanja Lange
    Department of Internal Medicine, , Germany
    Int Immunopharmacol 6:216-25. 2006
    ..Yet, our finding of predominant type1 activity after cortisol administration, rules out any relevance of this suppression for the shift towards type1 activity during SWS...
  16. ncbi Systemic immune parameters and sleep after ultra-low dose administration of IL-2 in healthy men
    Tanja Lange
    Department of Internal Medicine, , Germany
    Brain Behav Immun 16:663-74. 2002
    ..Also, IL-2 increased the TSH concentration. There were no hints at a sleep promoting effect of IL-2. Immune changes suggest that nocturnal IL-2 administration induces a shift towards Th2 mediated defense...