Tanja Lange

Summary

Country: Germany

Publications

  1. doi request reprint Sleep after vaccination boosts immunological memory
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 187:283-90. 2011
  2. doi request reprint Effects of sleep and circadian rhythm on the human immune system
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Ann N Y Acad Sci 1193:48-59. 2010
  3. ncbi request reprint Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Brain Behav Immun 18:341-8. 2004
  4. ncbi request reprint Shift of monocyte function toward cellular immunity during sleep
    Tanja Lange
    Department of Internal Medicine, University of Lubeck, Lubeck, Germany
    Arch Intern Med 166:1695-700. 2006
  5. ncbi request reprint Sleep-like concentrations of growth hormone and cortisol modulate type1 and type2 in-vitro cytokine production in human T cells
    Tanja Lange
    Department of Internal Medicine, University of Lubeck, Germany
    Int Immunopharmacol 6:216-25. 2006
  6. pmc Cortisol and epinephrine control opposing circadian rhythms in T cell subsets
    Stoyan Dimitrov
    Departments of Neuroendocrinology, University of Lubeck, Germany
    Blood 113:5134-43. 2009
  7. ncbi request reprint Number and function of circulating human antigen presenting cells regulated by sleep
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Germany
    Sleep 30:401-11. 2007
  8. doi request reprint Acute sleep deprivation reduces energy expenditure in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Clin Nutr 93:1229-36. 2011
  9. doi request reprint Selective mobilization of cytotoxic leukocytes by epinephrine
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    J Immunol 184:503-11. 2010
  10. doi request reprint Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4
    Luciana Besedovsky
    1Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Lubeck 23538, Germany
    FASEB J 28:67-75. 2014

Collaborators

Detail Information

Publications19

  1. doi request reprint Sleep after vaccination boosts immunological memory
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, 23538 Lubeck, Germany
    J Immunol 187:283-90. 2011
    ..Like the nervous system, the immune system takes advantage of the offline conditions during sleep to foster adaptive immune responses resulting in improved immunological memory...
  2. doi request reprint Effects of sleep and circadian rhythm on the human immune system
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Ann N Y Acad Sci 1193:48-59. 2010
    ....
  3. ncbi request reprint Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, 23538 Lubeck, Germany
    Brain Behav Immun 18:341-8. 2004
    ..001). Though unexpected, the most pronounced effect of sleep on T cell cytokine production was a robust decrease in TNF-alpha producing CD8+ cells probably reflecting increased extravasation of cytotoxic effector and memory T cells...
  4. ncbi request reprint Shift of monocyte function toward cellular immunity during sleep
    Tanja Lange
    Department of Internal Medicine, University of Lubeck, Lubeck, Germany
    Arch Intern Med 166:1695-700. 2006
    ..We hypothesized that sleep achieves this effect by shifting the balance between types 1 and 2 cytokine activity toward increased type 1 activity, thereby supporting adaptive cellular immune responses...
  5. ncbi request reprint Sleep-like concentrations of growth hormone and cortisol modulate type1 and type2 in-vitro cytokine production in human T cells
    Tanja Lange
    Department of Internal Medicine, University of Lubeck, Germany
    Int Immunopharmacol 6:216-25. 2006
    ..Yet, our finding of predominant type1 activity after cortisol administration, rules out any relevance of this suppression for the shift towards type1 activity during SWS...
  6. pmc Cortisol and epinephrine control opposing circadian rhythms in T cell subsets
    Stoyan Dimitrov
    Departments of Neuroendocrinology, University of Lubeck, Germany
    Blood 113:5134-43. 2009
    ..Thus, activation of the major stress hormones during daytime favor immediate effector defense but diminish capabilities for initiating adaptive immune responses...
  7. ncbi request reprint Number and function of circulating human antigen presenting cells regulated by sleep
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Germany
    Sleep 30:401-11. 2007
    ....
  8. doi request reprint Acute sleep deprivation reduces energy expenditure in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Clin Nutr 93:1229-36. 2011
    ..Epidemiologic evidence indicates that chronic sleep curtailment increases risk of developing obesity, but the mechanisms behind this relation are largely unknown...
  9. doi request reprint Selective mobilization of cytotoxic leukocytes by epinephrine
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    J Immunol 184:503-11. 2010
    ..Epinephrine rapidly attenuates this attachment to allow demargination and release of the cells into the circulation that, because of their cytotoxic effector function, provide immediate protection from invading pathogens...
  10. doi request reprint Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4
    Luciana Besedovsky
    1Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Lubeck 23538, Germany
    FASEB J 28:67-75. 2014
    ....
  11. ncbi request reprint Blockade of mineralocorticoid receptors enhances naïve T-helper cell counts during early sleep in humans
    Luciana Besedovsky
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Brain Behav Immun 26:1116-21. 2012
    ....
  12. ncbi request reprint Sleep enhances IL-6 trans-signaling in humans
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, Haus 23a, Lubeck 23538, Germany
    FASEB J 20:2174-6. 2006
    ..The selective increase in sIL-6R implicates an enhanced trans-signaling capacity whereby sleep distinctly widens the profile of IL-6 actions, enabling an integrated influence on brain and peripheral organs...
  13. ncbi request reprint Sleep enhances the human antibody response to hepatitis A vaccination
    Tanja Lange
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Psychosom Med 65:831-5. 2003
    ..The antibody response to vaccination provides a valid tool to assess the influence of sleep on adaptive immune functioning in humans, which is also clinically relevant...
  14. doi request reprint Suppressing the morning rise in cortisol impairs free recall
    Ulrike Rimmele
    Department of Neuroendocrinology, University of Lubeck, Luebeck 23562, Germany
    Learn Mem 17:186-90. 2010
    ..Thus, not only high, but also very low glucocorticoid levels impair retrieval, with the latter effect possibly reflecting insufficient occupation of hippocampal/amygdalar mineralocorticoid receptors (MRs)...
  15. pmc Circadian clocks in mouse and human CD4+ T cells
    Thomas Bollinger
    Institute of Medical Microbiology and Hygiene, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e29801. 2011
    ..Collectively, these data demonstrate for the first time that CD4+ T cell responses are regulated by an intrinsic cellular circadian oscillator capable of driving rhythmic CD4+ T cell immune responses...
  16. doi request reprint Sleep and circadian rhythm regulate circulating complement factors and immunoregulatory properties of C5a
    Edimara S Reis
    Institute for Systemic Inflammation Research, University of Lubeck, Lubeck, Germany
    Brain Behav Immun 25:1416-26. 2011
    ..Our findings that continuous wakefulness has a negative impact on complement activation may provide a rationale for the immunosupportive functions of sleep...
  17. ncbi request reprint Cortisol increases CXCR4 expression but does not affect CD62L and CCR7 levels on specific T cell subsets in humans
    Luciana Besedovsky
    Department of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Tubingen, Germany Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Physiol Endocrinol Metab 306:E1322-9. 2014
    ....
  18. ncbi request reprint Activated CD4+ T cells enter the splenic T-cell zone and induce autoantibody-producing germinal centers through bystander activation
    David Banczyk
    Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University of Lubeck, Lubeck, Germany
    Eur J Immunol 44:93-102. 2014
    ..The activated B cells then form GCs whereby CD154-dependent T-cell help is needed. Thus, activated T cells may contribute to the development of autoimmune diseases by activating autoreactive B cells in an Ag-independent manner...
  19. ncbi request reprint Systemic immune parameters and sleep after ultra-low dose administration of IL-2 in healthy men
    Tanja Lange
    Department of Internal Medicine, University of Lubeck, Germany
    Brain Behav Immun 16:663-74. 2002
    ..Also, IL-2 increased the TSH concentration. There were no hints at a sleep promoting effect of IL-2. Immune changes suggest that nocturnal IL-2 administration induces a shift towards Th2 mediated defense...