Research Topics
| Matthias LangeSummaryCountry: Germany Publications
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Publications
Pulmonary microvascular hyperpermeability and expression of vascular endothelial growth factor in smoke inhalation- and pneumonia-induced acute lung injuryMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, Galveston, TX 77550, USA
Burns 38:1072-8. 2012..The current study was designed further evaluate the mechanism of pulmonary vascular hyperpermeability in sheep with these injuries...- Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsisMatthias Lange
Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77550, USA
Shock 37:468-72. 2012.... - Time course of the inflammatory and oxidative stress response to pulmonary infection in miceMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA
Exp Lung Res 38:157-63. 2012..In addition, the identification of the time changes of the described pathogenetic factors may enhance the timing of innovate therapeutic approaches in future experiments... 
Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injuryMatthias Lange
Investigational Intensive Care Unit, Dept of Anesthesiology, The Univ of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77550, USA
J Appl Physiol 107:176-84. 2009..Future studies will be needed to clarify the potential therapeutic benefit for patients with this injury...- Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injuryMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA
Crit Care Med 39:718-24. 2011.... - Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemiaMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Str 33, 48149, Muenster, Germany
Inflamm Res 60:429-37. 2011..To test the hypothesis that a continuous infusion of the vasopressin analog terlipressin is associated with less organ dysfunction as compared to intermittent bolus infusion in an ovine sepsis model... - Effects of early neuronal and delayed inducible nitric oxide synthase blockade on cardiovascular, renal, and hepatic function in ovine sepsisMatthias Lange
Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas, USA
Anesthesiology 113:1376-84. 2010..We hypothesized that early neuronal and delayed inducible nitric oxide synthase blockade attenuates multiple organ dysfunctions during sepsis... 
Role of nitric oxide in shock: the large animal perspectiveMatthias Lange
Investigational Intensive Care Unit, University of Texas Medical Branch, 610 Texas Avenue, Galveston, Texas 77550, USA
Front Biosci 14:1979-89. 2009..Further investigation in large animal models is warranted to clarify the time course of increased expression and/or activity of different NOS isoenzymes and the effects of specific inhibition of the NOS isoforms at different time points...- Combined neuronal and inducible nitric oxide synthase inhibition in ovine acute lung injuryMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA
Crit Care Med 37:223-9. 2009.... - Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsisMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX, USA
Crit Care Med 36:1284-9. 2008..To assess the time changes and mechanism of pulmonary and peripheral vascular permeability in sheep with acute lung injury and sepsis... - Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injuryMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
Shock 35:626-31. 2011..This novel treatment strategy may represent a useful therapeutic adjunct for patients with these injuries... - Specific inhibition of nitric oxide synthases at different time points in a murine model of pulmonary sepsisMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
Biochem Biophys Res Commun 404:877-81. 2011..Future investigations should identify the time changes of the expression and activation of NOS isoforms... - Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injuryMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas 77550, USA
Exp Lung Res 37:239-45. 2011..Arterial carboxyhemoglobin in sheep with combined burn and inhalation injury are correlated with the degree of pulmonary failure and edema formation, but not with certain histological alterations including airway obstruction scores... - A murine model of sepsis following smoke inhalation injuryMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
Biochem Biophys Res Commun 391:1555-60. 2010..In conclusion, bacterial pneumonia is predominantly responsible for mortality and morbidity in this novel murine model of smoke inhalation and pulmonary sepsis. Reactive oxygen and nitrogen species mediate the severity of lung injury... - Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injuryMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The Univ of Texas Medical Branch, Shriners Hospitals for Children, Galveston, 77550, USA
Am J Physiol Lung Cell Mol Physiol 300:L167-75. 2011..Administration of an ONOO(-) decomposition catalyst may represent a potential treatment option for this injury... - Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsisMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
Biochem Biophys Res Commun 399:286-91. 2010..Future studies should investigate the effects of specific pharmacological inhibition of nNOS and iNOS at different time points during the disease process... - Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis modelMatthias Lange
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children, 301 University Boulevard, Galveston, Texas 77550, USA
Crit Care 14:R129. 2010..However, the time changes of these pathogenic factors are largely undetermined... - Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn traumaPerenlei Enkhbaatar
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
Burns 37:638-45. 2011.... - Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injuryFiona D Saunders
Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
Am J Physiol Lung Cell Mol Physiol 298:L427-36. 2010.... - Role of neuronal nitric oxide synthase in ovine sepsis modelPerenlei Enkhbaatar
Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
Shock 32:253-7. 2009..The above results suggest that the nNOS-derived NO may be involved in the pathophysiology of sepsis-related multiorgan dysfunction... - Continuous versus bolus infusion of terlipressin in ovine endotoxemiaMatthias Lange
Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
Shock 28:623-9. 2007..Continuous low-dose terlipressin infusion may represent a useful alternative treatment of arterial hypotension related to sepsis and systemic inflammatory response syndrome... - Cardiovascular collapse and vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsisCollette C Jonkam
Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospital for Children, Galveston, Texas, USA
Shock 32:621-5. 2009..These results evidence that excessive production of reactive radicals and VEGF may play a major role in cardiovascular collapse and vascular hyperpermeability in MRSA sepsis... - Continuously infused glipizide reverses the hyperdynamic circulation in ovine endotoxemiaMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Shock 27:701-6. 2007..From these results, we conclude that continuous glipizide infusion may represent a useful therapeutic option in the treatment of arterial hypotension related to sepsis and systemic inflammatory response syndrome... - Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalationPerenlei Enkhbaatar
Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
Clin Sci (Lond) 114:321-9. 2008..In conclusion, the results provide definitive evidence that anticoagulant therapy may be a novel and effective treatment tool in the management of burn patients with concomitant smoke inhalation injury... - Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shockSebastian Rehberg
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Crit Care Med 38:2016-23. 2010..To compare the effects of a first-line therapy of combined arginine vasopressin, levosimendan, and norepinephrine with arginine vasopressin + norepinephrine or norepinephrine alone in ovine septic shock... - Somatostatin infusion increases intestinal ischemia and does not improve vasoconstrictor response to norepinephrine in ovine endotoxemiaStefan Lauer
Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
Shock 30:603-9. 2008..In addition, combined SOMA and NE therapy resulted in intestinal injury. Therefore, SOMA does not seem to represent a therapeutic option to treat arterial hypotension resulting from sepsis and systemic inflammatory response syndrome... - Hemodynamic effects of titrated norepinephrine in healthy versus endotoxemic sheepMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
J Endotoxin Res 13:53-7. 2007.... - Renal effects of saline-based 10% pentastarch versus 6% tetrastarch infusion in ovine endotoxemic shockChristian Ertmer
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Anesthesiology 112:936-47. 2010..The current study evaluates the effects of saline-based 6% HES 130/0.4, 10% HES 200/0.5, and a balanced isotonic crystalloid on renal function and microscopic changes in ovine endotoxemic shock... - Methylprednisolone reverses vasopressin hyporesponsiveness in ovine endotoxemiaChristian Ertmer
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Shock 27:281-8. 2007.... - Employing dobutamine as a useful agent to reverse the terlipressin-linked impairments in cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheepKatrin Bröking
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Shock 29:71-7. 2008..This study provides evidence that dobutamine in a dosage of 2 microg x kg(1) x min(1) is useful to reverse the terlipressin-linked depressions in CI, DO(2)I and SvO(2) in ovine endotoxemia without obvious side effects... - Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injuryPerenlei Enkhbaatar
Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
Crit Care Med 37:208-14. 2009..In this study, we have tested the hypothesis that inhibition of neuronal nitric oxide synthase could ameliorate the severity of acute lung injury using our well-established ovine model of cutaneous burn and smoke inhalation... - Effects of balanced crystalloid vs. 0.9% saline-based vs. balanced 6% tetrastarch infusion on renal function and tubular integrity in ovine endotoxemic shockChristian Ertmer
Departments of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Crit Care Med 39:783-92. 2011..9% saline-based and balanced 6% tetrastarch solutions, on renal function and ultrastructural morphologic correlates of acute kidney injury in an established model of ovine endotoxemic shock... - Role of selective V1a receptor agonism in ovine septic shockSebastian Rehberg
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Crit Care Med 39:119-25. 2011..arginine vasopressin or norepinephrine on cardiopulmonary hemodynamics and organ function in ovine septic shock... - Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injuryAimalohi Esechie
Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, 77550, USA
Br J Pharmacol 158:1442-53. 2009..The present study investigated whether the pathophysiological changes induced by burn and smoke inhalation are modulated by parenteral administration of Na(2)S, a H(2)S donor... - Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implicationsMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, Germany
Shock 28:394-400. 2007.... - Direct delivery of low-dose 7-nitroindazole into the bronchial artery attenuates pulmonary pathophysiology after smoke inhalation and burn injury in an ovine modelAtsumori Hamahata
Department of Plastic and Reconstructive Surgery, Tokyo Woman s Medical University, Tokyo, Japan
Shock 36:575-9. 2011..Our data strongly suggest that local airway production of NO contributes to pulmonary dysfunction following smoke inhalation and burn injury. Most mechanisms that drive this pathophysiology reside in the airway... - gamma-Tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injuryAtsumori Hamahata
University of Texas Medical Branch, Galveston, TX 77555, USA
Free Radic Biol Med 45:425-33. 2008..Pulmonary gT delivery along with a FO source may be a novel effective treatment strategy in management of patients with acute lung injury... - Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsisPerenlei Enkhbaatar
Department of Anesthesiology, University of Texas Medical Branch, and Shriners Hospital for Children, Galveston, TX 77551, USA
Shock 29:642-9. 2008..The smoke inhalation alone had a little or no effect on these variables. This model closely mimics hyperdynamic human sepsis. The excessive production of NO may be extensively involved in the pathogenic process... - Role of arginine vasopressin and terlipressin as first-line vasopressor agents in fulminant ovine septic shockSebastian Rehberg
Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Str 33, 48149, Muenster, Germany
Intensive Care Med 35:1286-96. 2009..To compare the effects of first-line therapy with low-dose arginine vasopressin (AVP) or terlipressin (TP) on mesenteric blood flow, plasma AVP levels, organ function and mortality in ovine septic shock... - Short-term effects of glipizide (an adenosine triphosphate-sensitive potassium channel inhibitor) on cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheepMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, 48161 Muenster, Germany
Shock 26:516-21. 2006..Additional studies are required to determine the effects of continuous infusion of glipizide in the presence of systemic inflammation... - Pulmonary vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsisCollette C Jonkam
Department of Anesthesiology, The University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX 77555 1102, USA
Crit Care 13:R19. 2009..We tested the hypothesis that methicillin-resistant Staphylococcus aureus (MRSA) sepsis following smoke inhalation increases pulmonary transvascular fluid flux via excessive nitric oxide (NO) production... - Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental studySebastian Rehberg
Department of Anesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Str, 33, Muenster 48149, Germany
Crit Care 14:R200. 2010..the mixed V(1a)R/V(2)R-agonist arginine vasopressin (AVP) or placebo in an established ovine model of septic shock... - Vasopressin vs. terlipressin in the treatment of cardiovascular failure in sepsisMatthias Lange
Department of Anesthesiology and Intensive Care, University of Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
Intensive Care Med 34:821-32. 2008..We briefly describe the pathophysiology and pharmacology of septic shock relevant to the treatment with vasopressin analogues. In addition, differences in pharmacokinetics and pharmacodynamics between AVP and TP are discussed... - Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemiaChristian Ertmer
Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
Crit Care 10:R144. 2006..The purpose of the present study was to evaluate whether dobutamine may be titrated to reverse the AVP-related decrease in cardiac index (CI) and systemic oxygen delivery index (DO2I) in an established model of ovine endotoxemia... - Administration of a peroxynitrite decomposition catalyst into the bronchial artery attenuates pulmonary dysfunction after smoke inhalation and burn injury in sheepAtsumori Hamahata
Department of Plastic and Reconstructive Surgery, Tokyo Woman s Medical University, Tokyo, Japan
Shock 38:543-8. 2012..Our data strongly suggest that local airway production of peroxynitrite contributes to pulmonary dysfunction following smoke inhalation and burn injury... - Inhibition of potassium channels in critical illnessMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Curr Opin Anaesthesiol 21:105-10. 2008..Pharmacological blockade of ATP-sensitive potassium channels has been proposed as a goal-directed therapeutic approach to stabilize hemodynamics in septic patients... - Fluid resuscitation in multiple trauma patientsChristian Ertmer
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Curr Opin Anaesthesiol 24:202-8. 2011..The coincidence of brain injury complicates management of these patients. This article summarizes the current knowledge on nonblood component fluid resuscitation and choice of fluids in patients with multiple trauma...