Peter Lang

Summary

Country: Germany

Publications

  1. ncbi Immunological aspects of haploidentical stem cell transplantation in children
    R Handgretinger
    Children s University Hospital, Department of Hematology Oncology, Hoppe Seyler Str 1, 72076 Tubingen, Germany
    Ann N Y Acad Sci 938:340-57; discussion 357-8. 2001
  2. ncbi Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia
    Peter Lang
    Children s University Hospital, University of Tuebingen, Germany
    Blood 101:1630-6. 2003
  3. ncbi Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children
    R Handgretinger
    Department of Pediatric Hematology/Oncology and Blood Bank, , , Germany
    Bone Marrow Transplant 27:777-83. 2001
  4. ncbi A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors
    M Eyrich
    Pediatric Stem Cell Transplant Program, Children s Hospital, University of Tuebingen, Germany
    Bone Marrow Transplant 32:379-90. 2003
  5. ncbi Children with myelodysplastic syndrome (MDS) and increasing mixed chimaerism after allogeneic stem cell transplantation have a poor outcome which can be improved by pre-emptive immunotherapy
    Peter Bader
    Department of Hematology Oncology, University Children s Hospital, D 60590 Frankfurt, Germany
    Br J Haematol 128:649-58. 2005
  6. ncbi Retransplantation with stem cells from mismatched related donors after graft rejection in pediatric patients
    Peter Lang
    Department of Pediatric Oncology, University Children s Hospital, Eberhard Karl s University, Tubingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Blood Cells Mol Dis 40:33-9. 2008
  7. doi Haploidentical SCT in children: an update and future perspectives
    P Lang
    Department of Haematology Oncology, Children s University Hospital, University of Tuebingen, Tuebingen, Germany
    Bone Marrow Transplant 42:S54-9. 2008
  8. ncbi Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients who received T-cell-depleted allografts
    Peter Lang
    Department of Pediatric Oncology, University Children s Hospital, University of Tubingen, Tubingen, Germany
    Blood 103:3982-5. 2004
  9. ncbi Transplantation of a combination of CD133+ and CD34+ selected progenitor cells from alternative donors
    Peter Lang
    Children s University Hospital, University of Tuebingen, Tuebingen, Germany
    Br J Haematol 124:72-9. 2004
  10. ncbi Antiviral activity against CMV-infected fibroblasts in pediatric patients transplanted with CD34(+)-selected allografts from alternative donors
    P Lang
    Children s University Hospital, Tuebingen, Germany
    Hum Immunol 65:423-31. 2004

Detail Information

Publications90

  1. ncbi Immunological aspects of haploidentical stem cell transplantation in children
    R Handgretinger
    Children s University Hospital, Department of Hematology Oncology, Hoppe Seyler Str 1, 72076 Tubingen, Germany
    Ann N Y Acad Sci 938:340-57; discussion 357-8. 2001
    ..In this article, we summarize our current results with the transplantation of highly purified stem cells and discuss possible implications for further antileukemic post-transplant therapeutic strategies...
  2. ncbi Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia
    Peter Lang
    Children s University Hospital, University of Tuebingen, Germany
    Blood 101:1630-6. 2003
    ..07). Transplantation of purified peripheral-blood CD34(+) cells from unrelated donors effectively minimizes GVHD and may be a good therapeutic option for patients with relapsed ALL...
  3. ncbi Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children
    R Handgretinger
    Department of Pediatric Hematology/Oncology and Blood Bank, , , Germany
    Bone Marrow Transplant 27:777-83. 2001
    ..This approach offers a promising therapeutic option for every child without an otherwise suitable donor...
  4. ncbi A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors
    M Eyrich
    Pediatric Stem Cell Transplant Program, Children s Hospital, University of Tuebingen, Germany
    Bone Marrow Transplant 32:379-90. 2003
    ....
  5. ncbi Children with myelodysplastic syndrome (MDS) and increasing mixed chimaerism after allogeneic stem cell transplantation have a poor outcome which can be improved by pre-emptive immunotherapy
    Peter Bader
    Department of Hematology Oncology, University Children s Hospital, D 60590 Frankfurt, Germany
    Br J Haematol 128:649-58. 2005
    ..We therefore conclude that pre-emptive immunotherapy is an effective treatment option to prevent impending relapse in children with MDS after allo-SCT...
  6. ncbi Retransplantation with stem cells from mismatched related donors after graft rejection in pediatric patients
    Peter Lang
    Department of Pediatric Oncology, University Children s Hospital, Eberhard Karl s University, Tubingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Blood Cells Mol Dis 40:33-9. 2008
    ..The use of different donors may contribute to avoid a second rejection...
  7. doi Haploidentical SCT in children: an update and future perspectives
    P Lang
    Department of Haematology Oncology, Children s University Hospital, University of Tuebingen, Tuebingen, Germany
    Bone Marrow Transplant 42:S54-9. 2008
    ....
  8. ncbi Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients who received T-cell-depleted allografts
    Peter Lang
    Department of Pediatric Oncology, University Children s Hospital, University of Tubingen, Tubingen, Germany
    Blood 103:3982-5. 2004
    ..We propose that treatment with chimeric CD19 antibodies leading to ADCC by donor-derived NK cells may become a therapeutic option for the post-transplantation treatment of minimal residual B-lineage ALLs...
  9. ncbi Transplantation of a combination of CD133+ and CD34+ selected progenitor cells from alternative donors
    Peter Lang
    Children s University Hospital, University of Tuebingen, Tuebingen, Germany
    Br J Haematol 124:72-9. 2004
    ..Five patients are alive with a median follow-up of 10 months. Our data demonstrates the feasibility of CD133+ selection for transplantation from alternative donors and encourages further trials with total CD133+ separated grafts...
  10. ncbi Antiviral activity against CMV-infected fibroblasts in pediatric patients transplanted with CD34(+)-selected allografts from alternative donors
    P Lang
    Children s University Hospital, Tuebingen, Germany
    Hum Immunol 65:423-31. 2004
    ..Furthermore, our data suggest a potential benefit of using low-dose IL-2 or IL-15, also combined with anti-CMV immunoglobulinG, for immune modulation in CMV disease...
  11. ncbi Haploidentical stem cell transplantation in patients with pediatric solid tumors: preliminary results of a pilot study and analysis of graft versus tumor effects
    P Lang
    Children s University Hospital Tübingen, Germany
    Klin Padiatr 218:321-6. 2006
    ..This approach may form the basis for posttransplant immunomodulation and other therapeutic strategies. Further experience is warranted to evaluate the method...
  12. ncbi Long-term outcome after haploidentical stem cell transplantation in children
    Peter Lang
    Children s University Hospital, University of Tuebingen, Germany
    Blood Cells Mol Dis 33:281-7. 2004
    ..In summary, the use of stem cells from haploidentical parental donors should be strongly considered in all children who need transplantation but lack an identical donor...
  13. ncbi A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study
    P Lang
    Children s University Hospital Tübingen, Germany
    Klin Padiatr 217:334-8. 2005
    ..Since effector cell with potential antileukemic activity are cotransfused, such grafts may be suited in particular for patients with insufficient remission...
  14. doi Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Immunother 31:199-206. 2008
    ..Adoptive T-cell transfer could potentially restore T-cell immunity against adenovirus after allogeneic stem cell transplantation...
  15. ncbi Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: an update
    Wolfgang A Bethge
    Medical Center, University of Tubingen, Hematology Oncology Otfried Mueller Str 1072076 Tuebingen, Germany
    Blood Cells Mol Dis 40:13-9. 2008
    ..In conclusion, this regimen is promising in high risk patients lacking a suitable donor, and a prospective phase I/II study is ongoing...
  16. ncbi Outcome of allogeneic stem cell transplantation in children with non-malignant diseases
    Andre Willasch
    University Children s Hospital, Frankfurt, Germany
    Haematologica 91:788-94. 2006
    ..However, it might be associated with an increased risk of graft rejection, which can be recognized by serial and quantitative characterization of chimerism. Thus, pre-emptive immunotherapy might be helpful to avoid graft rejection...
  17. ncbi Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation
    Rupert Handgretinger
    Children s University Hospital, University of Tuebingen, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    Ann N Y Acad Sci 1106:279-89. 2007
    ..For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation...
  18. ncbi Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation
    Tobias Feuchtinger
    Department of Paediatric Haematology Oncology, University Children s Hospital, Eberhard Karls University, Tuebingen, Germany
    Br J Haematol 134:64-76. 2006
    ..In conclusion, induction of a specific T-cell response through adoptive transfer was feasible and effective. When performed early in the course of infection, adoptive T-cell transfer may protect from HAdV-related complications...
  19. doi Dendritic cell vaccination in an allogeneic stem cell recipient receiving a transplant from a human cytomegalovirus (HCMV)-seronegative donor: induction of a HCMV-specific T(helper) cell response
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Tubingen, Germany
    Cytotherapy 12:945-50. 2010
    ..For protection from subsequent HCMV reactivation, a sustained immune response is necessary, including antigen-specific CD4(+) T cells...
  20. ncbi Impaired T-cell activation and cytokine productivity after transplantation of positively selected CD34+ allogeneic hematopoietic stem cells
    Matthias Eyrich
    Children s Hospital, Pediatric Stem Cell Transplant Program, University of Tubingen, Tubingen, Germany
    Hematol J 5:329-40. 2004
    ..Further studies will focus on the elimination of host factors that may adversely affect T-cell function after transplantation...
  21. doi Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children
    Patrick Schlegel
    Department of Pediatric Hematology and Oncology, University Children s Hospital Tuebingen, University of Tuebingen, Germany
    Best Pract Res Clin Haematol 24:443-52. 2011
    ....
  22. ncbi Haploidentical allogeneic hematopoietic cell transplantation in adults with reduced-intensity conditioning and CD3/CD19 depletion: fast engraftment and low toxicity
    Wolfgang A Bethge
    Medical Center, University of Tuebingen, Tuebingen, Germany
    Exp Hematol 34:1746-52. 2006
    ....
  23. doi Natural killer cell activity influences outcome after T cell depleted stem cell transplantation from matched unrelated and haploidentical donors
    Peter Lang
    Department of Pediatric Oncology, University Children s Hospital, Eberhard Karl s University Tübingen, Hoppe Seyler Strasse 1, Tubingen, Germany
    Best Pract Res Clin Haematol 24:403-11. 2011
    ..Since NK activity could be markedly increased by in vitro stimulation with Interleukin 2 (IL-2), in vivo administration should be considered...
  24. ncbi Intensity of HLA class I expression and KIR-mismatch determine NK-cell mediated lysis of leukaemic blasts from children with acute lymphatic leukaemia
    Matthias Pfeiffer
    Department of Paediatric Haematology Oncology, University Children s Hospital, Eberhard Karl s University, Tuebingen, Germany
    Br J Haematol 138:97-100. 2007
    ..87), whereas KIR-ligand-mismatch alone was not significant. Assessment of these factors might identify patients who could benefit from NK-mediated graft-versus-leukaemia effects after mismatched stem cell transplantation...
  25. doi Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation
    Lena Oevermann
    Department of Hematology Oncology, Children s University Hospital, Tubingen, Germany
    Ann N Y Acad Sci 1266:161-70. 2012
    ....
  26. ncbi Isolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-gamma secretion for adjuvant immunotherapy
    Tobias Feuchtinger
    University Children s Hospital, Eberhard Karls University, Tubingen, Germany
    Exp Hematol 32:282-9. 2004
    ..The aim of this study was to isolate and expand donor-derived human ADV-specific T lymphocytes for adoptive transfer of sufficient cell numbers to restore protective immunity after allogeneic stem cell transplantation...
  27. doi Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Tubingen, Germany
    Blood 116:4360-7. 2010
    ..Our findings indicate that the infusion of low numbers of CMV-specific T cells is safe, feasible, and effective as a treatment on demand for refractory CMV infection and CMV disease after allo-SCT...
  28. ncbi Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, D 72076 Tuebingen, Germany
    Br J Haematol 128:503-9. 2005
    ..5%) of ADV-specific T cells until day 200 post-SCT, than patients without ADV-infection (0.12 +/- 0.1%). These data suggest that ADV-specific T-cell reconstitution is protective against life-threatening ADV-infections postallogeneic SCT...
  29. doi High proportion of leukemic stem cells at diagnosis is correlated with unfavorable prognosis in childhood acute myeloid leukemia
    Kai Erik Witte
    Department of Hematology Oncology, University Children s Hospital, Tubingen, Germany
    Pediatr Hematol Oncol 28:91-9. 2011
    ..Future treatment in childhood AML should specifically target this immature population as well as the mature blast population...
  30. pmc Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation
    Michaela Döring
    Department of Pediatric Hematology and Oncology, University Children s Hospital Tubingen, Tubingen, Germany
    BMC Infect Dis 12:263. 2012
    ..To address this issue, we retrospectively assessed the safety, feasibility, and initial efficacy of prophylactic posaconazole in children...
  31. ncbi Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children
    Matthias Eyrich
    Children s Hospital, Pediatric Stem Cell Transplant Program, University of Tubingen, Germany
    Biol Blood Marrow Transplant 11:194-205. 2005
    ..Onset and plateau of thymic activity are independently regulated by different transplant-related factors...
  32. pmc Dynamics of the emergence of a human cytomegalovirus UL97 mutant strain conferring ganciclovir resistance in a pediatric stem-cell transplant recipient
    Katharina Göhring
    Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tubingen, Tubingen, Germany
    J Mol Diagn 11:364-8. 2009
    ..In conclusion, for our pediatric patient, during peak viral load, the UL97 wild-type strain predominates, while during clinical deterioration with low viral load, the predominant mutant strain persists...
  33. doi Ex vivo detection of adenovirus specific CD4+ T-cell responses to HLA-DR-epitopes of the Hexon protein show a contracted specificity of T(HELPER) cells following stem cell transplantation
    Celine Serangeli
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strabetae 1, D 72076 Tubingen, Germany
    Virology 397:277-84. 2010
    ..The ex vivo detection of Hexon-specific CD4(+) T-cells, without any long-term culture in vitro, enables the detection and generation of HAdV-specific CD4(+) T cells for adoptive T-cell transfer against HAdV-infection post SCT...
  34. doi Long-term human CD34+ stem cell-engrafted nonobese diabetic/SCID/IL-2R gamma(null) mice show impaired CD8+ T cell maintenance and a functional arrest of immature NK cells
    Maya C André
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Tuebingen, Germany
    J Immunol 185:2710-20. 2010
    ....
  35. ncbi Cytotoxic activity of natural killer cells lacking killer-inhibitory receptors for self-HLA class I molecules against autologous hematopoietic stem cells in healthy individuals
    Roger Grau
    Department of Hematology, Children s University Hospital, Tuebingen, Germany
    Exp Mol Pathol 76:90-8. 2004
    ..Our findings demonstrate the presence of potentially autoreactive natural killer cells in otherwise healthy individuals...
  36. ncbi Pitfalls in detection of contaminating neuroblastoma cells by tyrosine hydroxylase RT-PCR due to catecholamine-producing hematopoietic cells
    Zyrafete Kuçi
    Department of Hematology and Oncology, Children s University Hospital, D 72076 Tubingen, Germany
    Anticancer Res 26:2075-80. 2006
    ..Due to reports in the literature showing that hematopoietic cells are also able to produce catecholamines, we investigated whether TH-RT-PCR is really suitable for this purpose...
  37. ncbi Clinical scale isolation of T cell-depleted CD56+ donor lymphocytes in children
    P Lang
    Children s University Hospital, University of Tuebingen, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    Bone Marrow Transplant 29:497-502. 2002
    ....
  38. doi Depletion of T-cell receptor alpha/beta and CD19 positive cells from apheresis products with the CliniMACS device
    Michael Schumm
    Children s Hospital, University Hospital Tubingen, Tubingen, Germany
    Cytotherapy 15:1253-8. 2013
    ..The CliniMACS device (Miltenyi Biotec, Bergisch Gladbach, Germany) was used for depletion of T-cell receptor alpha/beta positive (TCRαβ(+)) and CD19 positive (CD19(+)) cells from apheresis products...
  39. doi Surgical management of stem cell transplantation-related complications in children
    Justus Lieber
    Department of Pediatric Surgery and Pediatric Urology, University Children s Hospital, Tuebingen, Germany
    Pediatr Transplant 16:471-9. 2012
    ..Survival was 50% in the group with surgery and 62% in the group without (p=0.275). Even though this difference was not statistically significant, surgical intervention should be encouraged in all cases to achieve favorable results...
  40. ncbi Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?
    Peter Bader
    Department of Pediatric Hematology and Oncology, University Children s Hospital, and Department of Medical Biometry, University of Tubingen, Tuebingen, Germany
    J Clin Oncol 22:1696-705. 2004
    ....
  41. pmc Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children
    Matthias M Pfeiffer
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karl s University, Tuebingen, Germany
    Haematologica 95:1381-8. 2010
    ....
  42. ncbi A prospective analysis of the pattern of immune reconstitution in a paediatric cohort following transplantation of positively selected human leucocyte antigen-disparate haematopoietic stem cells from parental donors
    M Eyrich
    University Children's Hospital, Paediatric Stem Cell Transplant Program, Tuebingen, Germany
    Br J Haematol 114:422-32. 2001
    ..This, together with the absence of significant GvHD, provides a strong indication for this approach to be considered in children who lack a HLA-matched donor...
  43. pmc Caspofungin as antifungal prophylaxis in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis
    Michaela Döring
    Department of Pediatric Hematology Oncology, University Children s Hospital Tubingen, Tubingen, Germany
    BMC Infect Dis 12:151. 2012
    ..There are no guidelines for antifungal prophylaxis in children in this situation. Caspofungin (CAS), a broad-spectrum echinocandin, could be an effective alternative with lower nephrotoxicity than L-AmB...
  44. ncbi Establishment of a rhabdomyosarcoma xenograft model in human-adapted mice
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    Oncol Rep 24:1067-72. 2010
    ..This model offers a basic tool for further analyzing novel immunotherapeutic approaches in RMS, and could possibly be used in other solid pediatric tumors...
  45. ncbi Adenovirus infection after allogeneic stem cell transplantation
    Tobias Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University Tuebingen, Germany
    Leuk Lymphoma 48:244-55. 2007
    ..Furthermore, adoptive immunotherapy is a new treatment option for patients with absent specific T-cell response and present systemic adenoviral infection...
  46. doi Long-term remission after first-line single-agent treatment with arsenic trioxide of relapsed acute promyelocytic leukemia in an 8-year-old boy
    Martin Ebinger
    Department of Hematology Oncology, University Children s Hospital, Tubingen, Germany
    Pediatr Hematol Oncol 28:334-7. 2011
    ..Acute or late side effects of arsenic were not observed. At present, the boy is in complete remission 4 years after the diagnosis of the relapse...
  47. doi Engraftment of low numbers of pediatric acute lymphoid and myeloid leukemias into NOD/SCID/IL2Rcγnull mice reflects individual leukemogenecity and highly correlates with clinical outcome
    Jeanette Woiterski
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Tuebingen, Germany
    Int J Cancer 133:1547-56. 2013
    ..Thus, we propose an in vivo model that provides a valuable preclinical tool to explore the heterogeneity of leukemic disease and exploit patient-tailored leukemia-targeting strategies within multivariate analyses. ..
  48. doi Adoptive transfer of epstein-barr virus (EBV) nuclear antigen 1-specific t cells as treatment for EBV reactivation and lymphoproliferative disorders after allogeneic stem-cell transplantation
    Vanya Icheva
    University Children s Hospital, Tubingen, Germany
    J Clin Oncol 31:39-48. 2013
    ..Since EBV-specific T cells could prevent PTLD, cellular immunotherapy has been a promising treatment option. However, generation of antigen-specific T-cell populations has been difficult within a short time frame...
  49. ncbi WT1 protein expression in childhood acute leukemia
    Gunter Kerst
    Department of Pediatric Cardiology, University Children s Hospital, Tuebingen, Germany
    Am J Hematol 83:382-6. 2008
    ..The results of this study indicate the following: (i) there are considerable discrepancies between WT1 transcripts and protein expression; (ii) WT1 is not a suitable marker for flow cytometric MRD detection in childhood acute leukemia...
  50. ncbi Granulocyte colony-stimulating factor induced pulmonary hemorrhage in a healthy stem cell donor
    Hans Georg Kopp
    Department of Medical Oncology, Hematology, Immunology, Rheumatology, and Pulmology, Medical Center II, Eberhard Karls University, Tubingen, Germany
    J Clin Oncol 25:3174-5. 2007
  51. doi Poor outcome for children and adolescents with progressive disease or relapse of lymphoblastic lymphoma: a report from the berlin-frankfurt-muenster group
    Birgit Burkhardt
    Department of Pediatric Hematology Oncology, Children s University Hospital, Giessen, Germany
    J Clin Oncol 27:3363-9. 2009
    ..Little is known about the outcome of pediatric patients with lymphoblastic lymphoma (LBL) who suffer from progressive disease or relapse...
  52. doi High frequency of immature cells at diagnosis predicts high minimal residual disease level in childhood acute lymphoblastic leukemia
    Martin Ebinger
    Department of Hematology and Oncology University Children s Hospital, Hoppe Seyler Strasse 1, D 72076, Tubingen, Germany
    Leuk Res 34:1139-42. 2010
    ..Our results suggest that the initial frequency of CD34(+)/CD38(-) cells may serve as a prognostic marker in pediatric ALL...
  53. doi Capture of endothelial progenitor cells by a bispecific protein/monoclonal antibody molecule induces reendothelialization of vascular lesions
    Harald F Langer
    Medical Clini III, Department of Cardiovascular Medicine, Eberhard Karls University of Tubingen, Tubingen, Germany
    J Mol Med (Berl) 88:687-99. 2010
    ..In vivo, GPVI-CD133 augments reendothelialization of vascular lesions. Thus, this bifunctional protein could be a potential new therapeutic option for cardiovascular diseases...
  54. ncbi Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors
    Matthias Eyrich
    Pediatric Stem Cell Transplant Program, University of Tuebingen, Germany
    Blood 100:1915-8. 2002
    ....
  55. ncbi Adenoviral infections after transplantation of positive selected stem cells from haploidentical donors in children: an update
    T Feuchtinger
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Tubingen, Germany
    Klin Padiatr 217:339-44. 2005
    ..Although control of infection seems to require T-cells, the characterization of HAdV-specific T-cells post SCT has not been introduced in surveillance and treatment decisions...
  56. ncbi Transplantation of highly purified peripheral-blood CD34+ progenitor cells from related and unrelated donors in children with nonmalignant diseases
    P Lang
    Children s University Hospital, Tubingen, Germany
    Bone Marrow Transplant 33:25-32. 2004
    ..7 years. In total, 19 patients (76%) are free of disease or of progression. Transplantation of highly purified peripheral-blood CD34(+) stem cells is associated with low toxicity in patients with nonmalignant diseases...
  57. ncbi Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantation
    Ingo Müller
    Department of General Pediatrics, Hematology and Oncology, University Children s Hospital Tubingen, Hoppe Seyler St 1, 72076, Tubigen, Germany
    Blood Cells Mol Dis 40:25-32. 2008
    ..Transfusion of MSC was safe and encouraging improvements in some patients were observed...
  58. ncbi Rapid development of ganciclovir-resistant cytomegalovirus infection in children after allogeneic stem cell transplantation in the early phase of immune cell recovery
    T Eckle
    Institute of Medical Virology and Epidemiology of Viral Diseases, Tubingen, Germany
    Bone Marrow Transplant 30:433-9. 2002
    ..These results suggest that GCV treatment of an HCMV infection in the early posttransplant phase of children after T cell-depleted PBSCT/BMT should promote more stringent resistance screening...
  59. doi Cytolytic activity of NK cell clones against acute childhood precursor-B-cell leukaemia is influenced by HLA class I expression on blasts and the differential KIR phenotype of NK clones
    T Feuchtinger
    Department of Paediatric Haematology Oncology, University Children s Hospital, Eberhard Karls University, Tubingen, Germany
    Bone Marrow Transplant 43:875-81. 2009
    ....
  60. doi The history and future prospective of haplo-identical stem cell transplantation
    R Handgretinger
    Children s University Hospital, University of Tuebingen, Tuebingen, Germany
    Cytotherapy 10:443-51. 2008
    ....
  61. ncbi Flow cytometry with anti HLA-antibodies: a simple but highly sensitive method for monitoring chimerism and minimal residual disease after HLA-mismatched stem cell transplantation
    M Schumm
    Department of Pediatric Oncology, University Children s Hospital Tuebingen, Tuebingen, Germany
    Bone Marrow Transplant 39:767-73. 2007
    ..Information about the chimerism status is given on a single-cell level and allows fast and convenient analysis of sub-populations...
  62. ncbi OKT-3-based reconditioning regimen for early graft failure in HLA-non-identical stem cell transplants
    P G Schlegel
    Paediatric Stem Cell Transplant Programme, Department of Paediatric Haematology Oncology, University Children s Hospital, Tuebingen, Germany
    Br J Haematol 111:668-73. 2000
    ....
  63. ncbi Determination of residual T- and B-cell content after immunomagnetic depletion: proposal for flow cytometric analysis and results from 103 separations
    M Schumm
    Children s University Hospital Tübingen, Tubingen, Germany
    Cytotherapy 8:465-72. 2006
    ..However, the large number of non-T and -B cells in the graft requires special protocols for the determination of extremely low frequencies of residual T cells...
  64. ncbi Increasing mixed chimerism defines a high-risk group of childhood acute myelogenous leukemia patients after allogeneic stem cell transplantation where pre-emptive immunotherapy may be effective
    P Bader
    Department of Paediatric Hematology and Oncology, University Children s Hospital, Tuebingen, Germany
    Bone Marrow Transplant 33:815-21. 2004
    ..05). These results prove that pediatric AML patients with increasing MC are at highest risk for relapse and that early immunological intervention can prevent relapse in these patients...
  65. doi Cellular immune reconstitution after haploidentical transplantation in children
    R Handgretinger
    Children s University Hospital, University of Tuebingen, Germany
    Biol Blood Marrow Transplant 14:59-65. 2008
    ....
  66. doi Influence of a mutation in IFN-γ receptor 2 (IFNGR2) in human cells on the generation of Th17 cells in memory T cells
    Ursula Holzer
    Children s Hospital, University of Tuebingen, Tuebingen, Germany
    Hum Immunol 74:693-700. 2013
    ..This data confirm the interference of these two T helper subsets and points to a balance of Th1 and Th17 cells obtained by their own cytokine production and their interplay with APCs...
  67. pmc Eradication of pulmonary aspergillosis in an adolescent patient undergoing three allogeneic stem cell transplantations for acute lymphoblastic leukemia
    Michaela Döring
    Department of Pediatric Hematology Oncology, University Children s Hospital Tubingen, Hoppe Seyler Strß 1, 72076 Tubingen, Germany
    Case Rep Transplant 2012:672923. 2012
    ....
  68. ncbi CD155 is involved in NK-cell mediated lysis of human hepatoblastoma in vitro
    Matthias Pfeiffer
    Department of Pediatric Oncology, University Children s Hospital Tuebingen, Tuebingen, Germany
    Front Biosci (Elite Ed) 3:1456-66. 2011
    ..The inclusion of a NK-based immunotherapy into novel treatment strategies might be a promising alternative especially for advanced tumors...
  69. ncbi Rituximab mediates in vitro antileukemic activity in pediatric patients after allogeneic transplantation
    M Pfeiffer
    Department of Pediatric Oncology, University Children s Hospital, University of Tuebingen, Tuebingen, Germany
    Bone Marrow Transplant 36:91-7. 2005
    ....
  70. ncbi Isolation and transplantation of highly purified autologous peripheral CD34(+) progenitor cells: purging efficacy, hematopoietic reconstitution and long-term outcome in children with high-risk neuroblastoma
    R Handgretinger
    Children s University Hospital, University of Tuebingen, Tuebingen, Germany
    Bone Marrow Transplant 29:731-6. 2002
    ..In summary, we show that, through a highly effective positive selection method, a high purging efficacy can be obtained without compromising the hematopoietic reconstitution capacity of the graft...
  71. doi Efficient in vitro generation of adult multipotent cells from mobilized peripheral blood CD133+ cells
    S Kuci
    University Children s Hospital, Department of Hematology Oncology, University of Tubingen, Tubingen, Germany
    Cell Prolif 41:12-27. 2008
    ..To generate non-haematopoietic tissues from mobilized haematopoietic CD133(+) stem cells...
  72. pmc Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia
    Matthias Manuel Pfeiffer
    Department of Pediatric Hematology and Oncology, University Children s Hospital, Eberhard Karls University Tuebingen Tuebingen, Germany
    Front Oncol 3:99. 2013
    ....
  73. ncbi Preliminary evaluation of one conventional nested and two real-time PCR assays for the detection of Toxoplasma gondii in immunocompromised patients
    Thomas Hierl
    Department of Medical Microbiology and Hospital Hygiene, University of Tubingen, Germany
    J Med Microbiol 53:629-32. 2004
    ..Thus, real-time PCR substantially accelerates the detection of T. gondii DNA in the majority of positive specimens; however, conventional nested PCR is required for detection of T. gondii DNA in some samples...
  74. ncbi Late effects after stem cell transplantation (SCT) in children--growth and hormones
    M B Ranke
    Haematology Oncology and Endocrinology, Department of Paediatrics, University of Tubingen, Tubingen, Germany
    Bone Marrow Transplant 35:S77-81. 2005
    ..Patients and their families need to be made familiar with this concept early and physicians need to understand that such a system must be implemented as part of a comprehensive care...
  75. ncbi Transplantation of highly purified CD34+ progenitor cells from alternative donors in children with refractory severe aplastic anaemia
    Martin Benesch
    Department of Paediatric Haematology Oncology, Children s University Hospital, Karl Franzens University Graz, Graz, Austria
    Br J Haematol 125:58-63. 2004
    ..One patient died on day +238 as a consequence of GVHD. The use of highly purified mobilized CD34+ stem cells warrants further clinical exploration in children with refractory SAA...
  76. ncbi Determinants of antileukemia effects of allogeneic NK cells
    Wing Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 172:644-50. 2004
    ..These findings provide new insights into the determinants of antileukemia effects of allogeneic NK cells and therapeutic strategies...
  77. ncbi Successful treatment of primary refractory acute myeloid leukemia with megadose stem cell transplantation, bone marrow boost and reduced intensity conditioning avoiding chronic graft vs. host disease and severe late toxicity
    Thorsten Langer
    Division of Pediatric Oncology, Hospital for Children and Adolescents, University of Erlangen, Germany
    Pediatr Transplant 7:494-6. 2003
    ....
  78. ncbi Effective lysis of lymphoma cells with a stabilised bispecific single-chain Fv antibody against CD19 and FcgammaRIII (CD16)
    Joerg Bruenke
    Chair of Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Br J Haematol 130:218-28. 2005
    ..Thus, ds[CD19 x CD16] holds promise for the treatment of CD19(+) B-lineage malignancies...
  79. ncbi Allogeneic haematopoietic stem cell transplantation in relapsed or refractory anaplastic large cell lymphoma of children and adolescents--a Berlin-Frankfurt-Münster group report
    Willi Woessmann
    Department of Paediatric Haematology and Oncology, Justus Liebig University, D 35392 Giessen, Germany
    Br J Haematol 133:176-82. 2006
    ..Allogeneic HSCT is effective and has acceptable toxicity as rescue therapy for high-risk ALCL relapse. It even offers cure for patients refractory to chemotherapy, suggesting a graft-versus-ALCL effect...
  80. ncbi Experiences with haploidentical stem cell transplantation in children with acute lymphoblastic leukemia
    Thomas Klingebiel
    Klinik für Kinderheilkunde III Pediatric Hematology, Oncology and Haemostaselogy, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Pathol Biol (Paris) 53:159-61. 2005
  81. ncbi Influence of variable N-glycosylation on the cytolytic potential of chimeric CD19 antibodies
    Karin Barbin
    Genetics, University of Erlangen Nuremberg, D 91058 Erlangen, Germany
    J Immunother 29:122-33. 2006
    ..The data demonstrate the influence of the N-glycosylation pattern on the ADCC activity of chimeric CD19 antibodies and point to the importance of suitable expression systems for the production of highly active therapeutic antibodies...
  82. ncbi Stem cell transplantation for polycythemia vera
    Harald Reinhard
    Pediatric Hematology and Oncology, University Hospital, Homburg Saar, Germany
    Pediatr Blood Cancer 50:124-6. 2008
    ..A single dose of donor T-lymphocytes was given at month 3. One year after transplantation, chimerism was complete. The patient is in complete remission and shows no signs of transplant-related morbidity at month 78...
  83. ncbi Graft-versus-Ewing sarcoma effect and long-term remission induced by haploidentical stem-cell transplantation in a patient with relapse of metastatic disease
    Ewa Koscielniak
    J Clin Oncol 23:242-4. 2005
  84. ncbi Megadose transplantation of highly purified haploidentical stem cells: current results and future prospects
    Rupert Handgretinger
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Pediatr Transplant 7:51-5. 2003
    ..We present the results obtained so far by CD34+ positive selection and discuss new techniques of graft engineering which might hopefully further improve the outcome of haploidentical stem cell transplantation...
  85. ncbi Haploidentical transplantation for acute lymphoblastic leukemia in childhood
    Thomas Klingebiel
    Klinik für Kinderheilkunde III, Zentrum für Kinderheilkunde und Jugendmedizin der Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Blood Rev 18:181-92. 2004
    ..This approach offers a promising treatment option for patients with acute lymphoblastic leukemia needing urgently transplantation but lacking a suitable donor...
  86. ncbi CD34 stem cell dose and development of extensive chronic graft-versus-host disease
    Rupert Handgretinger
    Blood 99:3875-6; author reply 3876-7. 2002
  87. ncbi Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro
    Harald Langer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Germany
    Circ Res 98:e2-10. 2006
    ..We conclude that platelets may play a critical part in the capture and subsequent differentiation of murine eEPCs at sites of vascular lesions, revealing a possible new role of platelets in neoendothelization after vascular injury...
  88. ncbi Morphology of bicuspid aortic valve in children and adolescents
    Susan M Fernandes
    Department of Cardiology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Am Coll Cardiol 44:1648-51. 2004
    ..The aim of this study was to determine the relationship between aortic valve morphology and valve dysfunction...
  89. ncbi Staged repair of tetralogy of Fallot and diminutive pulmonary arteries with a fenestrated ventricular septal defect patch
    Audrey C Marshall
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 126:1427-33. 2003
    ..We report the short-term outcome and medium-term follow-up after using a fenestrated ventricular septal defect patch as a component of staged repair in selected patients...
  90. ncbi Effect of pulmonary artery angioplasty on exercise function after repair of tetralogy of Fallot
    Nicole J Sutton
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Am Heart J 155:182-6. 2008
    ..The purpose of this study was to determine whether, in patients with rTOF, improvements in PBFM after a successful balloon angioplasty procedure (BAP) result in improvements in peak VO2 and gas exchange during exercise...