Florian Lang

Summary

Country: Germany

Publications

  1. ncbi request reprint 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice
    Oliver Borst
    2Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany
    FASEB J 28:2108-19. 2014
  2. pmc Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4
    Ahmad Almilaji
    Department of Physiology, University of Tubingen, Tubingen, Germany
    PLoS ONE 8:e70988. 2013
  3. pmc Adhesion of annexin 7 deficient erythrocytes to endothelial cells
    Majed Abed
    Department of Physiology, Eberhard Karls University, Tuebingen, Germany
    PLoS ONE 8:e56650. 2013
  4. pmc Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3
    Evi Schmid
    Department of Physiology, University of Tubingen, Tubingen, Germany
    PLoS ONE 9:e88637. 2014
  5. pmc Stimulation of HERG channel activity by β-catenin
    Carlos Munoz
    Department of Physiology, University of Tubingen, Tubingen, Germany
    PLoS ONE 7:e43353. 2012
  6. pmc Up-regulation of hERG K⁺ channels by B-RAF
    Tatsiana Pakladok
    Department of Physiology, University of Tubingen, Tubingen, Germany
    PLoS ONE 9:e87457. 2014
  7. ncbi request reprint IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1
    N Gamper
    Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia
    Pflugers Arch 443:625-34. 2002
  8. doi request reprint Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate
    Mohamed Siyabeldin E Ahmed
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
    BMC Nephrol 14:244. 2013
  9. pmc Triggering of suicidal erythrocyte death by penta-O-galloyl-β-D-glucose
    Kousi Alzoubi
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
    Toxins (Basel) 6:54-65. 2014
  10. ncbi request reprint Regulation of STIM1/Orai1-dependent Ca2+ signalling in platelets
    F Lang
    Florian Lang, MD, Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany, Tel 49 7071 29 72194, Fax 49 7071 29 5618, E mail
    Thromb Haemost 110:925-30. 2013

Collaborators

Detail Information

Publications207 found, 100 shown here

  1. ncbi request reprint 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice
    Oliver Borst
    2Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany
    FASEB J 28:2108-19. 2014
    ..Leibrock, C., Szteyn, K., Schmidt, S., Elvers, M., Faggio, C., Shumilina, E., Kuro-o, M., Gawaz, M., Lang, F. 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca(2+) signaling and thrombus formation in klotho-deficient mice. ..
  2. pmc Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4
    Ahmad Almilaji
    Department of Physiology, University of Tubingen, Tubingen, Germany
    PLoS ONE 8:e70988. 2013
    ..In conclusion, Klotho is a novel, powerful regulator of the excitatory amino acid transporters EAAT3 and EAAT4...
  3. pmc Adhesion of annexin 7 deficient erythrocytes to endothelial cells
    Majed Abed
    Department of Physiology, Eberhard Karls University, Tuebingen, Germany
    PLoS ONE 8:e56650. 2013
    ..The present observations demonstrate that enhanced eryptosis of annexin7 deficient cells is paralleled by increased adhesion of erythrocytes to the vascular wall, an effect, which may impact on microcirculation during ischemia...
  4. pmc Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3
    Evi Schmid
    Department of Physiology, University of Tubingen, Tubingen, Germany
    PLoS ONE 9:e88637. 2014
    ....
  5. pmc Stimulation of HERG channel activity by β-catenin
    Carlos Munoz
    Department of Physiology, University of Tubingen, Tubingen, Germany
    PLoS ONE 7:e43353. 2012
    ..The experiments uncover a novel function of APC/ß-catenin, i.e. the regulation of HERG channels...
  6. pmc Up-regulation of hERG K⁺ channels by B-RAF
    Tatsiana Pakladok
    Department of Physiology, University of Tubingen, Tubingen, Germany
    PLoS ONE 9:e87457. 2014
    ..In conclusion, B-RAF is a powerful regulator of hERG channel activity and cell surface hERG protein abundance...
  7. ncbi request reprint IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1
    N Gamper
    Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia
    Pflugers Arch 443:625-34. 2002
    ..In conclusion, IGF-1 through PI3-kinase, PDK1 and SGK1 up-regulates Kv channels, an effect required for the proliferative action of the growth factor...
  8. doi request reprint Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate
    Mohamed Siyabeldin E Ahmed
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
    BMC Nephrol 14:244. 2013
    ..Mechanisms triggering eryptosis in endstage renal disease remained enigmatic. The present study explored the effect of indoxyl sulfate, an uremic toxin accumulated in blood of patients with chronic kidney disease...
  9. pmc Triggering of suicidal erythrocyte death by penta-O-galloyl-β-D-glucose
    Kousi Alzoubi
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
    Toxins (Basel) 6:54-65. 2014
    ..In conclusion, penta-O-galloyl-β-D-glucose stimulates suicidal erythrocyte death or eryptosis, an effect partially due to stimulation of ceramide formation with subsequent sensitization of erythrocytes to Ca2+...
  10. ncbi request reprint Regulation of STIM1/Orai1-dependent Ca2+ signalling in platelets
    F Lang
    Florian Lang, MD, Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany, Tel 49 7071 29 72194, Fax 49 7071 29 5618, E mail
    Thromb Haemost 110:925-30. 2013
    ..Future studies are required defining the significance of those mechanisms for platelet Orai1 abundance and function, for SOCE into platelets and for platelet function in cardiovascular diseases. ..
  11. ncbi request reprint Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth
    Florian Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Hormones (Athens) 12:160-71. 2013
    ..Moreover, excessive salt intake and/or excessive release of glucocorticoids, mineralocorticoids, and TGFβ up-regulates SGK1 expression thus predisposing to SGK1-related diseases...
  12. pmc Effect of thioridazine on erythrocytes
    Elisabeth Lang
    Department of Physiology, Eberhard Karls University of Tuebingen, Gmelinstr 5, Tuebingen 72076, Germany
    Toxins (Basel) 5:1918-31. 2013
    ..Triggers of eryptosis include increase of cytosolic Ca²⁺-concentration ([Ca²⁺](i)) and activation of p38 kinase. The present study explored, whether thioridazine elicits eryptosis...
  13. pmc Triggering of suicidal erythrocyte death by celecoxib
    Adrian Lupescu
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, Tuebingen 72076, Germany
    Toxins (Basel) 5:1543-54. 2013
    ..In conclusion, celecoxib stimulates suicidal erythrocyte death or eryptosis, an effect partially due to stimulation of Ca2+ entry. ..
  14. pmc Effects of Gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial
    Rasha Babiker
    Department of Physiology, University of Medical Sciences and Technology, Khartoum, Sudan
    Nutr J 11:111. 2012
    ..This study was conducted to determine effects of regular Gum Arabic (GA) ingestion on body mass index and body fat percentage among healthy adult females...
  15. pmc Fluoxetine induced suicidal erythrocyte death
    Kashif Jilani
    Department of Physiology, University of Tuebingen, Gmelinstr 5, Tuebingen 72076, Germany
    Toxins (Basel) 5:1230-43. 2013
    ..The effect on annexin V binding was significantly blunted, but not abolished, in the absence of extracellular Ca2+. In conclusion, fluoxetine stimulates eryptosis, an effect at least in part due to increase of cytosolic Ca2+ activity. ..
  16. doi request reprint Therapeutic potential of serum and glucocorticoid inducible kinase inhibition
    Florian Lang
    University of Tuebingen, Department of Physiology, Tuebingen, Germany
    Expert Opin Investig Drugs 22:701-14. 2013
    ..SGK1 regulates several enzymes (e.g., glycogen synthase kinase-3, ubiquitin-ligase Nedd4-2) and transcription factors (e.g., forkhead transcription factor 3a, β-catenin, nuclear factor kappa B)...
  17. doi request reprint Chorein sensitivity of cytoskeletal organization and degranulation of platelets
    Eva Maria Schmidt
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, 72076 Tubingen, Germany
    FASEB J 27:2799-806. 2013
    ..These observations reveal a completely novel function of chorein, i.e., regulation of secretion and aggregation of blood platelets...
  18. doi request reprint Vascular calcification--is aldosterone a culprit?
    Florian Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Nephrol Dial Transplant 28:1080-4. 2013
    ..Future studies in CKD patients will be required to define the role of aldosterone and the potential impact of its inhibition by spironolactone in the pathophysiology of vascular calcification...
  19. pmc Carmustine-induced phosphatidylserine translocation in the erythrocyte membrane
    Kashif Jilani
    Department of Physiology, University of Tuebingen, Gmelinstr 5, Tuebingen D 72076, Germany
    Toxins (Basel) 5:703-16. 2013
    ..The effect on annexin V binding was significantly blunted in the absence of extracellular Ca²⁺. In conclusion, carmustine stimulates eryptosis at least partially by increasing cytosolic Ca²⁺ activity...
  20. doi request reprint Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1
    Florian Lang
    Department of Physiology, University of Tuebingen, Gmelinstrasse 5, 72076 Tuebingen, Germany
    FASEB J 27:3-12. 2013
    ..Therefore, SGK1 may be considered an attractive therapeutic target despite its broad range of functions...
  21. doi request reprint OSR1-sensitive small intestinal Na+ transport
    Venkanna Pasham
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Gastrointest Liver Physiol 303:G1212-9. 2012
    ..In conclusion, OSR1 is expressed in intestine and partial WNK insensitivity of OSR1 increases intestinal NHE activity and colonic ENaC activity...
  22. doi request reprint Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells
    Majed Abed
    Physiologisches Institut, Eberhard Karls Universitat Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Cell Physiol 303:C991-9. 2012
    ..Thus exposure to sphingomyelinase or C6-ceramide triggers eryptosis followed by phosphatidylserine- and CXCL16-sensitive adhesion of eryptotic erythrocytes to HUVEC...
  23. doi request reprint Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK
    Florian Lang
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Cell Calcium 52:347-54. 2012
    ....
  24. doi request reprint AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation
    Michael Foller
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    FASEB J 26:4243-53. 2012
    ..In summary, AMPK is a potent regulator of BK channels. It may thus participate in the signaling cascades that protect the inner ear from damage following acoustic overstimulation...
  25. doi request reprint OSR1-sensitive regulation of Na+/H+ exchanger activity in dendritic cells
    Venkanna Pasham
    Department of Physiology, University of Tubingen, Germany
    Am J Physiol Cell Physiol 303:C416-26. 2012
    ..In conclusion, partial OSR1 deficiency influences Na(+)/H(+) exchanger activity, ROS formation, and migration of dendritic cells...
  26. ncbi request reprint Regulation of renal tubular glucose reabsorption by Akt2/PKBβ
    Daniela S Kempe
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Renal Physiol 298:F1113-7. 2010
    ..In conclusion, Akt2/PKBβ plays a role in the regulation of renal glucose transport...
  27. doi request reprint Enhanced Ca²⁺ entry and Na+/Ca²⁺ exchanger activity in dendritic cells from AMP-activated protein kinase-deficient mice
    Meerim K Nurbaeva
    Department of Physiology, University of Tubingen, Tubingen, Germany
    FASEB J 26:3049-58. 2012
    ..NCX and NCKX currents were similarly increased in ampk(-/-) DCs. Moreover, CXCL12 (50 ng/ml)-induced DC migration was enhanced in ampk(-/-) DCs. AMPK thus inhibits SOC entry, Na(+)/Ca(2+) exchangers, and migration of DCs...
  28. doi request reprint Mechanisms and significance of eryptosis, the suicidal death of erythrocytes
    Florian Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Blood Purif 33:125-30. 2012
    ..If the compensation is not sufficient, clinically relevant anemia develops. Beyond that, adhesion of eryptotic erythrocytes to the vascular wall may lead to impairment of microcirculation...
  29. doi request reprint Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis
    Michael Foller
    Department of Physiology, Universitat Tubingen, Tubingen, Germany
    FASEB J 26:1526-34. 2012
    ..Our observations reveal chorein as a novel powerful regulator of cytoskeletal architecture and cell survival, thus explaining erythrocyte misshape and possibly neurodegeneration in chorea-acanthocytosis...
  30. doi request reprint Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport
    Florian Lang
    Department of Physiology, University of Tuebingen, Gmelinstrasse 5, 72076, Tuebingen, Germany
    Clin Exp Nephrol 16:73-80. 2012
    ..Thus, SGK1 has a profound effect on K(+) homeostasis and on a multitude of K(+)-sensitive cellular functions...
  31. pmc Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo
    Shuchen Gu
    Department of Physiology, University of Tubingen, Germany
    Mol Cancer 8:114. 2009
    ..Membrane androgen receptors (mAR) have been implicated in the regulation of cell growth, motility and apoptosis in prostate and breast cancer. Here we analyzed mAR expression and function in colon cancer...
  32. pmc Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells
    Natalia Papadopoulou
    Department of Biochemistry, University of Crete Medical School, Heraklion, Greece
    Mol Cancer 7:88. 2008
    ....
  33. pmc Anti-malarial effect of gum arabic
    Adil Ballal
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Malar J 10:139. 2011
    ..The present study tested whether gum arabic may influence the clinical course of malaria...
  34. pmc Azathioprine favourably influences the course of malaria
    Diwakar Bobbala
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Malar J 8:102. 2009
    ..The present study thus explored whether azathioprine influences eryptosis of Plasmodium-infected erythrocytes, development of parasitaemia and thus the course of malaria...
  35. pmc Beneficial effect of aurothiomalate on murine malaria
    Ioana Alesutan
    Department of Physiology, University of Tubingen, Gmelinstr, 5, 72076 Tubingen, Germany
    Malar J 9:118. 2010
    ..The present study thus tested whether sodium aurothiomalate influences the intraerythrocytic parasite development in vitro and the clinical course of murine malaria in vivo...
  36. pmc Phylogenetic nomenclature and evolution of mannose-binding lectin (MBL2) haplotypes
    Angelica B W Boldt
    Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    BMC Genet 11:38. 2010
    ..We recently used haplotype-specific sequencing to identify 23 MBL2 haplotypes, associated with enhanced susceptibility to several diseases...
  37. pmc SGK, renal function and hypertension
    Florian Lang
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    J Nephrol 23:S124-9. 2010
    ..Thus, SGK1 may participate in the pathogenesis of metabolic syndrome or syndrome X, a condition characterized by the coincidence of essential hypertension, procoagulant state, obesity, insulin resistance and hyperinsulinemia...
  38. ncbi request reprint Channel-induced apoptosis of infected host cells-the case of malaria
    Florian Lang
    Physiologisches Institut der Universitat Tubingen, Gmelinstrasse 5, 72076 Tubingen, Germany
    Pflugers Arch 448:319-24. 2004
    ..Absence of the channels is not compatible with pathogen growth, enhanced channel activity accelerates erythrocyte "apoptosis" that may represent a host defence mechanism serving to eliminate infected erythrocytes...
  39. doi request reprint Colorectal carcinoma cells--regulation of survival and growth by SGK1
    Florian Lang
    Department of Physiology, University of Tuebingen, Tubingen, Germany
    Int J Biochem Cell Biol 42:1571-5. 2010
    ....
  40. ncbi request reprint PGE(2) in the regulation of programmed erythrocyte death
    P A Lang
    Department of Physiology, University of Tubingen, Germany
    Cell Death Differ 12:415-28. 2005
    ..In conclusion, hyperosmotic shock or Cl(-) removal stimulates erythrocyte PS exposure through PGE(2) formation and subsequent activation of Ca(2+)-permeable cation channels...
  41. ncbi request reprint Erythrocyte ion channels in regulation of apoptosis
    Florian Lang
    Department of Physiology, Eberhard Karls University of Tuebingen, Gmelinstrasse 5, D 72076 Tuebingen, Germany
    Adv Exp Med Biol 559:211-7. 2004
    ..Infection with Plasmodium falciparum leads to activation of the cation channel eventually triggering erythrocyte "apoptosis."..
  42. pmc Significance of SGK1 in the regulation of neuronal function
    Florian Lang
    Department of Physiology I, University of Tubingen, Gmelinstrasse 5, D72076 Tübingen, Germany
    J Physiol 588:3349-54. 2010
    ..g. Parkinson's disease, schizophrenia, depression, Alzheimer's disease). Despite multiple SGK1 functions, the phenotype of the SGK1 knockout mouse is mild and becomes only apparent under challenging conditions...
  43. ncbi request reprint Ceramide in suicidal death of erythrocytes
    Florian Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 26:21-8. 2010
    ..Additional experiments are needed to conclusively define the ceramide-generating enzyme and the ceramide-dependent cellular events eventually leading to suicidal erythrocyte death...
  44. ncbi request reprint Cell volume and the regulation of apoptotic cell death
    Florian Lang
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, D 72076 Tubingen, Germany
    J Mol Recognit 17:473-80. 2004
    ..In conclusion, cell volume-sensitive mechanisms participate in the triggering of apoptosis following receptor stimulation or cell injury...
  45. ncbi request reprint Transport regulation by the serum- and glucocorticoid-inducible kinase SGK1
    F Lang
    Department of Physiology, Eberhard Karls University of Tuebingen, Gmelinstrasse 5, D 72076 Tuebingen, Germany
    Biochem Soc Trans 33:213-5. 2005
    ..At least partially through its effect on transport, SGK1 contributes to a number of pathophysiological conditions including metabolic syndrome and fibrosing disease...
  46. ncbi request reprint Renal tubular transport and the genetic basis of hypertensive disease
    Florian Lang
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Clin Exp Nephrol 9:91-9. 2005
    ..Both gene variants are associated with slightly increased blood pressure. SGK1 further stimulates the glucose transporter SGLT1, and the SGK1 gene variant correlates, in addition, with increased body mass index...
  47. ncbi request reprint Functional significance of channels and transporters expressed in the inner ear and kidney
    Florian Lang
    Department of Physiology, Eberhard Karls University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Am J Physiol Cell Physiol 293:C1187-208. 2007
    ..Thus, defects of channels and transporters expressed in the kidney and inner ear result in simultaneous dysfunctions of these seemingly unrelated organs...
  48. ncbi request reprint Osmotic shock-induced suicidal death of erythrocytes
    F Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Acta Physiol (Oxf) 187:191-8. 2006
    ..The mechanisms involved in eryptosis may not only affect the survival of erythrocytes but may be similarly operative in nucleated cells exposed to osmotic shock...
  49. ncbi request reprint Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1
    Florian Grahammer
    Department of Physiology, University of Tubingen, Germany
    Am J Physiol Gastrointest Liver Physiol 290:G1114-23. 2006
    ..In conclusion, basic functions of SGLT1 and NHE3 in the intestine do not require stimulation by SGK1. However, the effects of glucocorticoids on SGLT1 are fully, and on NHE3 partially, dependent on SGK1...
  50. ncbi request reprint [The basics of kidney physiology]
    Florian Lang
    Physiologisches Institut, Universitat Tubingen
    Pharm Unserer Zeit 35:294-301. 2006
  51. ncbi request reprint Mechanisms and significance of eryptosis
    Florian Lang
    Department of Physiology, Eberhard Karls University of Tubingen, Germany
    Antioxid Redox Signal 8:1183-92. 2006
    ..Conditions with excessive eryptosis include iron deficiency, lead or mercury intoxication, sickle cell anemia, thalassemia, glucose 6- phosphate dehydrogenase deficiency, malaria, and infection with hemolysin-forming pathogens...
  52. ncbi request reprint (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms
    Florian Lang
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Physiol Rev 86:1151-78. 2006
    ..There is little doubt that further targets will be identified that are modulated by the SGK isoforms and that further SGK-dependent in vivo physiological functions and pathophysiological conditions will be defined...
  53. ncbi request reprint Ion channels and cell volume in regulation of cell proliferation and apoptotic cell death
    Florian Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Contrib Nephrol 152:142-60. 2006
    ..Accordingly, the same ion channel blockers may interfere with both, cell proliferation and apoptosis depending on cell type, regulatory environment and condition of the cell...
  54. ncbi request reprint Eryptosis, a window to systemic disease
    Florian Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 22:373-80. 2008
    ..Examples presented include drug side effects, sepsis, haemolytic uremic syndrome, Wilson's disease, phosphate depletion and a rare condition caused by a mutation in GLUT1 turning the carrier into a cation channel...
  55. ncbi request reprint Ion channels in cell proliferation and apoptotic cell death
    F Lang
    Department of Physiology, University of Tubingen, Germany
    J Membr Biol 205:147-57. 2005
    ..Clearly, considerable further experimental effort is required to fully understand the complex interplay between ion channels, cell proliferation and apoptosis...
  56. pmc Targeting SGK1 in diabetes
    Florian Lang
    Eberhard Karls University of Tuebingen, Department of Physiology, Gmelinstrasse 5, Tuebingen 72076, Germany
    Expert Opin Ther Targets 13:1303-11. 2009
    ..Accordingly, targeting SGK1 may favourably influence occurrence and course of type 2 diabetes...
  57. ncbi request reprint Plasma membrane ion channels in suicidal cell death
    Florian Lang
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, D72076 Tuebingen, Germany
    Arch Biochem Biophys 462:189-94. 2007
    ..The present brief review addresses the role of ion channels in the regulation of suicidal cell death with special emphasis on the role of channels in CD95 induced apoptosis of lymphocytes and suicidal death of erythrocytes or eryptosis...
  58. doi request reprint Heterocyclic indazole derivatives as SGK1 inhibitors, WO2008138448
    Florian Lang
    Department of Physiology, Eberhard Karls University of Tuebingen, Gmelinstrasse 5, D 72076 Tuebingen, Germany
    Expert Opin Ther Pat 20:129-35. 2010
    ..In vitro and in vivo experiments suggested a critical role of SGK1 in renal fluid retention and hypertension, glucose-induced obesity, coagulation and increased matrix protein formation...
  59. pmc The physiological impact of the serum and glucocorticoid-inducible kinase SGK1
    Florian Lang
    Department of Physiology, University of Tuebingen, Gmelinstrasse 5, Tuebingen 72076, Germany
    Curr Opin Nephrol Hypertens 18:439-48. 2009
    ..The role of serum and glucocorticoid-inducible kinase 1 (SGK1) in renal physiology and pathophysiology is reviewed with particular emphasis on recent advances...
  60. ncbi request reprint Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms
    F Lang
    Department of Physiology, University of Tubingen, Germany
    Sci STKE 2001:re17. 2001
    ..This raises the possibility that specific inhibitors of SGK1 may have therapeutic potential for the treatment of several diseases...
  61. ncbi request reprint Downregulation of Klotho expression by dehydration
    Cai Tang
    Am J Physiol Renal Physiol 301:F745-50. 2011
    ..In conclusion, the present observations disclose a powerful effect of dehydration on Klotho expression, an effect at least partially mediated by enhanced release of ADH and aldosterone...
  62. ncbi request reprint Cell volume in the regulation of cell proliferation and apoptotic cell death
    F Lang
    Department for Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 10:417-28. 2000
    ..Thus, considerable further experimental effort is required in this exciting area of cell physiology...
  63. ncbi request reprint Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride
    K S Lang
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, 72076 Tubingen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 367:391-6. 2003
    ..EIPA is an effective inhibitor of this cation channel and of channel mediated triggering of erythrocyte apoptosis...
  64. ncbi request reprint Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation
    F Lang
    Department for Physiology, University of Tubingen, Germany
    Pflugers Arch 440:902-7. 2000
    ..This effect contributes to CD95-induced cytosolic acidification, DNA fragmentation and cell shrinkage...
  65. ncbi request reprint The involvement of caspases in the CD95(Fas/Apo-1)- but not swelling-induced cellular taurine release from Jurkat T-lymphocytes
    F Lang
    Physiologisches Institut, der Universität Tübingen, Germany
    Pflugers Arch 440:93-9. 2000
    ..In conclusion, CD95-receptor triggering leads to caspase-dependent stimulation of cellular taurine release, which facilitates, but is not sufficient for, the triggering of apoptotic DNA fragmentation and cell shrinkage...
  66. ncbi request reprint h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine
    S Waldegger
    Institute of Physiology, University of Tubingen, Tubingen, Germany
    Gastroenterology 116:1081-8. 1999
    ..The aim of this study was to localize h-sgk messenger RNA (mRNA) expression in normal and inflamed intestinal mucosa and to identify potential transcriptional regulators...
  67. ncbi request reprint Cation channels, cell volume and the death of an erythrocyte
    Florian Lang
    Physiologisches Institut der Universitat Tubingen, Gmelinstrasse 5, 72076 Tubingen, Germany
    Pflugers Arch 447:121-5. 2003
    ..Beyond their role in the limitation of erythrocyte survival, cation channels may contribute to the triggering of apoptosis in nucleated cells exposed to osmotic shock and/or oxidative stress...
  68. ncbi request reprint Regulation of channels by the serum and glucocorticoid-inducible kinase - implications for transport, excitability and cell proliferation
    Florian Lang
    Department of Physiology, University of Tuebingen, Germany
    Cell Physiol Biochem 13:41-50. 2003
    ..There is little doubt that further channels will be identified which are modulated by the SGKs and that further in vivo physiological functions will be defined where channel regulation by the SGKs plays a critical role...
  69. ncbi request reprint Mechanisms and significance of cell volume regulation
    Florian Lang
    Department of Physiology I, University of Tubingen, Tubingen, Germany
    J Am Coll Nutr 26:613S-623S. 2007
    ..Deranged cell volume regulation significantly contributes to the pathophysiology of several disorders such as liver insufficiency, diabetic ketoacidosis, hypercatabolism, fibrosing disease, sickle cell anemia, and infection...
  70. ncbi request reprint Ceramide formation as a target in beta-cell survival and function
    Florian Lang
    University of Tubingen, Institute of Physiology, Germany
    Expert Opin Ther Targets 15:1061-71. 2011
    ..Ceramide may be synthesized de novo or generated by sphingomyelinase-dependent hydrolysis of sphingomyelin...
  71. ncbi request reprint Cell volume regulatory mechanisms in apoptotic cell death
    F Lang
    Department for Physiology, University of Tubingen
    Herz 24:232-5. 1999
    ..However, activation of ORCC is paralleled by inhibition of cell volume regulatory K+ channel Kv1.3. It is only 40 to 60 minutes after triggering of the CD95-receptor when the cells release the organic osmolyte taurine and shrink...
  72. ncbi request reprint The diversity of volume regulatory mechanisms
    F Lang
    Institute of Physiology, University of Tubingen, Germany
    Cell Physiol Biochem 8:1-45. 1998
    ..The diversity of cell volume regulatory mechanisms allows the cells to defend the constancy of cell volume against a myriad of challenges with relatively little impairment of cellular function...
  73. pmc SGK1-sensitive renal tubular glucose reabsorption in diabetes
    Teresa F Ackermann
    Dept of Physiology, Univ of Tübingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Renal Physiol 296:F859-66. 2009
    ..The data provide the first evidence that SGK1 participates in the stimulation of renal tubular glucose transport in diabetic kidneys...
  74. ncbi request reprint PGE2-induced apoptotic cell death in K562 human leukaemia cells
    Michael Foller
    Department of Physiology, University of Tubingen, Germany
    Cell Physiol Biochem 17:201-10. 2006
    ..In conclusion, K562 cells express Ca2+-permeable TRPC7 channels, which are activated by PGE2 and participate in the triggering of apoptosis...
  75. ncbi request reprint APC sensitive gastric acid secretion
    Anand Rotte
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 23:133-42. 2009
    ..The effect of APC requires H+/K+ ATPase activity and is at least partially due to SGK1-dependent upregulation of KCNQ1...
  76. doi request reprint Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC
    Madhuri Bhandaru
    Dept of Physiology, Univ of Tübingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Regul Integr Comp Physiol 297:R571-5. 2009
    ..The experiments reveal an influence of defective APC on adrenal hormone release and renal function, effects partially but not completely explained by APC dependence of SGK1 expression...
  77. ncbi request reprint Effect of osmotic shock and urea on phosphatidylserine scrambling in thrombocyte cell membranes
    Sergios Gatidis
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 299:C111-8. 2010
    ..The observations reveal that hyperosmotic shock and oxidative stress trigger a procoagulant platelet phenotype, an effect blunted by the presence of high urea concentrations...
  78. doi request reprint Regulation of erythrocyte survival by AMP-activated protein kinase
    Michael Foller
    Department of Physiology, University of Tubingen, Tubingen, Germany
    FASEB J 23:1072-80. 2009
    ..The observations disclose a critical role of AMPK in the survival of circulating erythrocytes...
  79. ncbi request reprint Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1
    Monica Palmada
    Dept of Physiology I, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 15:175-82. 2005
    ..The experiments demonstrate the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3...
  80. ncbi request reprint Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse
    Ciprian Sandu
    Department of Physiology I, University of Tubingen, Germany
    Am J Physiol Gastrointest Liver Physiol 291:G868-76. 2006
    ..In conclusion, defective PDK1 expression leads to significant impairment of NHE3 activity in the intestine, pointing to a role of PDK1-dependent signaling in the regulation of NHE-mediated electrolyte transport...
  81. ncbi request reprint Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1
    Ferruh Artunc
    Department of Physiology, University of Tubingen, Gmelinstr 5, 72076, Tubingen, Germany
    J Mol Med (Berl) 84:737-46. 2006
    ..In conclusion, a lack of SGK1 protects against DOCA/high-salt-induced albuminuria and renal fibrosis...
  82. ncbi request reprint Renal function of gene-targeted mice lacking both SGK1 and SGK3
    Florian Grahammer
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R945-50. 2006
    ..Additional lack of the isoform kinase does not substantially compound the phenotype for either property...
  83. ncbi request reprint Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1
    Ekaterina Shumilina
    Department of Physiology, University of Tuebingen, Germany
    J Cell Physiol 204:87-98. 2005
    ..In conclusion, lack of SGK1 does not abrogate Kv channel activity but abolishes regulation of those channels by serum, glucocorticoids and IGF-1, an effect influencing capacitative Ca(2+) entry...
  84. ncbi request reprint Triggering of dendritic cell apoptosis by xanthohumol
    Nguyen Thi Xuan
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Mol Nutr Food Res 54:S214-24. 2010
    ..In conclusion, xanthohumol stimulated Asm leading to caspase activation and apoptosis of bone marrow-derived DCs...
  85. doi request reprint Pioglitazone induced gastric acid secretion
    Anand Rotte
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 24:193-200. 2009
    ..In conclusion, pioglitazone increases gastric acid secretion, an effect at least partially due to stimulation of SGK1 expression and SGK1-dependent upregulation of KCNQ1...
  86. ncbi request reprint Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet
    Dan Yang Huang
    Department of Pharmacology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Renal Physiol 291:F1264-73. 2006
    ..Thus lack of SGK1 protects against the hypertensive effects of a combined high-fat/high-salt diet...
  87. ncbi request reprint Decreased cation channel activity and blunted channel-dependent eryptosis in neonatal erythrocytes
    Tobias Hermle
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 291:C710-7. 2006
    ..In conclusion, cation channel activity, Ca(2+) leakage, and thus channel-dependent triggering of eryptosis are blunted, whereas spontaneous and oxidative stress-induced eryptosis is more pronounced in neonatal erythrocytes...
  88. doi request reprint Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets
    Patrick Münzer
    Department of Physiology, University of Tubingen, Germany
    Biochem Biophys Res Commun 436:25-30. 2013
    ..In conclusion, activation of platelets stimulates the translational expression of Orai1, thus augmenting platelet Ca(2+) signaling...
  89. doi request reprint p38 MAPK activation and function following osmotic shock of erythrocytes
    Sergios Gatidis
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:1279-86. 2011
    ..In conclusion, p38 kinase is expressed in erythrocytes and participates in the machinery triggering eryptosis following hyperosmotic shock...
  90. ncbi request reprint Enhanced suicidal death of erythrocytes from gene-targeted mice lacking the Cl-/HCO(3)(-) exchanger AE1
    Ahmad Akel
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 292:C1759-67. 2007
    ..In conclusion, lack of AE1 is associated with enhanced Ca(2+) entry and subsequent scrambling of cell membrane phospholipids...
  91. doi request reprint Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone
    Rexhep Rexhepaj
    Department of Physiology, University of Tubingen, Gmelinstr 5, 72076, Tubingen, Germany
    Pflugers Arch 459:191-202. 2009
    ..Moreover, chronic exposure to glycyl-glycine stimulates Na(+)/H(+) exchanger activity, an effect again involving SGK1...
  92. ncbi request reprint The peptide transporter PEPT2 is targeted by the protein kinase SGK1 and the scaffold protein NHERF2
    Christoph Boehmer
    Department of Physiology I, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 22:705-14. 2008
    ..In conclusion, the present results reveal two novel PEPT2 posttranslational modulators, SGK1 and NHERF2, which might regulate transport of oligopeptides and peptidomimetic drugs...
  93. ncbi request reprint Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases
    Hamdy M Embark
    Department of Physiology I, University of Tubingen, Germany
    Kidney Int 66:1918-25. 2004
    ..ClC-Ka also possesses a SGK1 consensus site in its sequence. We hypothesized that ClC-Ka/barttin is stimulated by SGK1, and down-regulated by Nedd4-2, an effect that may be reversed by SGK1 and its isoforms, SGK2 or SGK3...
  94. doi request reprint Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX
    Oliver Borst
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 302:C644-51. 2012
    ..The present observations demonstrate that eryptotic erythrocytes adhere to endothelial cells of the vascular wall in part by interaction of phosphatidylserine exposed at the erythrocyte surface with endothelial CXCL16...
  95. ncbi request reprint Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1
    Dan Yang Huang
    Department of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R935-44. 2006
    ..The observations reveal a pivotal role of SGK1 in insulin-mediated sodium retention and the salt-sensitizing hypertensive effect of high fructose intake...
  96. ncbi request reprint Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl-
    Karl S Lang
    Physiologisches Institut, der Universität Tübingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Renal Physiol 286:F1046-53. 2004
    ..Whereas Cl(-) is effective through inhibition of the cation conductance, urea exerts its effect through inhibition of sphingomyelinase, thus blunting formation of ceramide...
  97. doi request reprint Triggering of suicidal erythrocyte death by amphotericin B
    Hasan Mahmud
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 24:263-70. 2009
    ..In conclusion, amphotericin B stimulates suicidal cell death of erythrocytes, which may in turn contribute to the clearance of circulating erythrocytes and thus to anemia...
  98. doi request reprint Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency
    Philipp A Lang
    Department of Physiology, University of Tubingen, Germany
    Cell Physiol Biochem 24:415-28. 2009
    ..In conclusion, PS exposure on erythrocytes results in accelerated clearance of Plasmodium ring stage-infected HbA/S or annexin-A7(-/-) erythrocytes and thus confers partial protection against malaria in vivo...
  99. pmc Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3
    Nathalie Strutz-Seebohm
    Department of Physiology I, University of Tuebingen, 72076 Tuebingen, Germany
    J Physiol 565:381-90. 2005
    ..The present observations disclose a novel mechanism in the regulation of GluR1...
  100. doi request reprint Regulation of the glutamate transporter EAAT2 by PIKfyve
    Eva Maria Gehring
    Department of Physiology I, University of Tubingen, Germany
    Cell Physiol Biochem 24:361-8. 2009
    ..Confocal microscopy reveals that PIKfyve enhances the EAAT2 protein abundance in the cell membrane. The observations disclose that PIKfyve indeed participates in the regulation of EAAT2...