Angelika Lampert

Summary

Country: Germany

Publications

  1. doi Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials
    Angelika Lampert
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Biochem Biophys Res Commun 390:319-24. 2009
  2. ncbi Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating
    Angelika Lampert
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 281:36029-35. 2006
  3. pmc A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation
    Angelika Lampert
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    J Biol Chem 283:24118-27. 2008
  4. pmc Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Epilepsia 50:44-55. 2009
  5. ncbi Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury
    Angelika Lampert
    Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Brain Res 174:660-6. 2006

Detail Information

Publications5

  1. doi Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials
    Angelika Lampert
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Biochem Biophys Res Commun 390:319-24. 2009
    ..7 leads to a pronounced hyperpolarizing shift of activation, a change that is expected to increase nociceptor excitability despite the hyperpolarizing shift in fast-inactivation, which is unique among the IEM mutations...
  2. ncbi Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating
    Angelika Lampert
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 281:36029-35. 2006
    ..We conclude that the linker between S4 and S5 in domain I of Nav1.7 modulates gating of this channel, and that a larger side chain at position 241 interferes with its gating mechanisms...
  3. pmc A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation
    Angelika Lampert
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    J Biol Chem 283:24118-27. 2008
    ..We propose that the four aromatic residues contribute to the gate at the cytoplasmic pore aperture, and that their ring side chains form a hydrophobic plug which stabilizes the closed state of Na(v)1.7...
  4. pmc Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Epilepsia 50:44-55. 2009
    ..6 is crucial for action potential generation. The goal of the present study was to investigate the possible role of changes in Nav1.6 expression in abnormal, activity-dependent plasticity of hippocampal circuits...
  5. ncbi Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury
    Angelika Lampert
    Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Brain Res 174:660-6. 2006
    ..The increased persistent sodium current and ramp current, which are consistent with upregulation of Nav1.3 within dorsal horn neurons, suggest a basis for the hyperresponsiveness of these neurons following SCI...