D W Lachenmeier

Summary

Country: Germany

Publications

  1. doi The margin of exposure to formaldehyde in alcoholic beverages
    Yulia B Monakhova
    Department of Chemistry, Saratov State University, Russia
    Arh Hig Rada Toksikol 63:227-37. 2012
  2. pmc Unrecorded alcohol consumption in Russia: toxic denaturants and disinfectants pose additional risks
    Yuriy V Solodun
    Irkutsk Forensic Institute, Prosecutor General s Office, Shevzov Street 1, 664035 Irkutsk, Russia
    Interdiscip Toxicol 4:198-205. 2011
  3. doi Is there a relationship between alcohol quality and health?
    Dirk W Lachenmeier
    corresponding author
    Alcohol Alcohol 48:127-9. 2013
  4. doi What happens if people start drinking mouthwash as surrogate alcohol? A quantitative risk assessment
    Dirk W Lachenmeier
    Epidemiological Research Unit, Institute for Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    Food Chem Toxicol 51:173-8. 2013
  5. doi What is a food and what is a medicinal product in the European Union? Use of the benchmark dose (BMD) methodology to define a threshold for "pharmacological action"
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    Regul Toxicol Pharmacol 64:286-95. 2012
  6. doi Detailed exposure assessment of dietary furan for infants consuming commercially jarred complementary food based on data from the DONALD study
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Karlsruhe, Germany
    Matern Child Nutr 8:390-403. 2012
  7. doi Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach
    Dirk W Lachenmeier
    Epidemiological Research Unit, Institute for Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    Int J Cancer 131:E995-1003. 2012
  8. pmc NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany
    Chin Med 7:8. 2012
  9. pmc Cancer risk assessment of ethyl carbamate in alcoholic beverages from Brazil with special consideration to the spirits cachaça and tiquira
    Dirk W Lachenmeier
    Departamento de Neurologia, Psicologia e Psiquiatria, Botucatu Medical School UNESP, Sao Paulo State University, CP 540 Distrito Rubiao Junior, 18618 970 Botucatu, Sao Paulo, Brazil
    BMC Cancer 10:266. 2010
  10. ncbi Application of tandem mass spectrometry combined with gas chromatography to the routine analysis of ethyl carbamate in stone-fruit spirits
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D76187 Karlsruhe, Germany
    Rapid Commun Mass Spectrom 19:108-12. 2005

Collaborators

Detail Information

Publications67

  1. doi The margin of exposure to formaldehyde in alcoholic beverages
    Yulia B Monakhova
    Department of Chemistry, Saratov State University, Russia
    Arh Hig Rada Toksikol 63:227-37. 2012
    ..g. to reduce the contamination) is very low. The major risk in alcoholic beverages derives from ethanol and acetaldehyde...
  2. pmc Unrecorded alcohol consumption in Russia: toxic denaturants and disinfectants pose additional risks
    Yuriy V Solodun
    Irkutsk Forensic Institute, Prosecutor General s Office, Shevzov Street 1, 664035 Irkutsk, Russia
    Interdiscip Toxicol 4:198-205. 2011
    ..It was shown, however, that concentration levels of DEP and PHMG in some surrogate alcohols make these samples unfit for human consumption as even moderate drinking would exceed acceptable daily intakes...
  3. doi Is there a relationship between alcohol quality and health?
    Dirk W Lachenmeier
    corresponding author
    Alcohol Alcohol 48:127-9. 2013
    ..We suggest the use of clearly defined terms instead, such as 'taste quality' or 'brand price', whenever possible...
  4. doi What happens if people start drinking mouthwash as surrogate alcohol? A quantitative risk assessment
    Dirk W Lachenmeier
    Epidemiological Research Unit, Institute for Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    Food Chem Toxicol 51:173-8. 2013
    ..Only in extreme exposures, ingredients such as thymol or methyl salicylate could exacerbate the effects of ethanol, especially by contributing to metabolic acidosis...
  5. doi What is a food and what is a medicinal product in the European Union? Use of the benchmark dose (BMD) methodology to define a threshold for "pharmacological action"
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    Regul Toxicol Pharmacol 64:286-95. 2012
    ....
  6. doi Detailed exposure assessment of dietary furan for infants consuming commercially jarred complementary food based on data from the DONALD study
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Karlsruhe, Germany
    Matern Child Nutr 8:390-403. 2012
    ..Mitigative measures to avoid furan in complementary foods should be of high priority for risk management...
  7. doi Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach
    Dirk W Lachenmeier
    Epidemiological Research Unit, Institute for Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    Int J Cancer 131:E995-1003. 2012
    ....
  8. pmc NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany
    Chin Med 7:8. 2012
    ..abstract:..
  9. pmc Cancer risk assessment of ethyl carbamate in alcoholic beverages from Brazil with special consideration to the spirits cachaça and tiquira
    Dirk W Lachenmeier
    Departamento de Neurologia, Psicologia e Psiquiatria, Botucatu Medical School UNESP, Sao Paulo State University, CP 540 Distrito Rubiao Junior, 18618 970 Botucatu, Sao Paulo, Brazil
    BMC Cancer 10:266. 2010
    ..15 mg/l. This study aims to estimate human exposure in Brazil and provide a quantitative risk assessment...
  10. ncbi Application of tandem mass spectrometry combined with gas chromatography to the routine analysis of ethyl carbamate in stone-fruit spirits
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D76187 Karlsruhe, Germany
    Rapid Commun Mass Spectrom 19:108-12. 2005
    ..07 and 7.70 mg/L (mean 1.21 mg/L). The main advantage of the developed GC/MS/MS method is the reliability of the results without the need for time-consuming confirmatory analyses...
  11. ncbi Retrospective trends and current status of ethyl carbamate in German stone-fruit spirits
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Str 3, D 76187 Karlsruhe, Germany
    Food Addit Contam 22:397-405. 2005
    ..Even for small distilleries, simple possibilities like destoning exist to minimize the ethyl carbamate content...
  12. doi Chemical composition of vintage preban absinthe with special reference to thujone, fenchone, pinocamphone, methanol, copper, and antimony concentrations
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    J Agric Food Chem 56:3073-81. 2008
    ..Analyses of pinocamphone, fenchone, base spirits, copper, and antimony were inconspicuous. All things considered, nothing besides ethanol was found in the absinthes that was able to explain the syndrome "absinthism"...
  13. doi The composition of alcohol products from markets in Lithuania and Hungary, and potential health consequences: a pilot study
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Germany
    Alcohol Alcohol 44:93-102. 2009
    ..The rates of alcohol-attributable mortality in Lithuania and Hungary have been shown to be higher than those in most other European countries. Quality of alcohol products is investigated as a possible explanation...
  14. doi The role of acetaldehyde outside ethanol metabolism in the carcinogenicity of alcoholic beverages: evidence from a large chemical survey
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D 76187 Karlsruhe, Germany
    Food Chem Toxicol 46:2903-11. 2008
    ..A re-evaluation of the 'generally recognized as safe' status of acetaldehyde is also required, which does not appear to be in agreement with its toxicity and carcinogenicity...
  15. doi Long-term stability of thujone, fenchone, and pinocamphone in vintage preban absinthe
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    J Agric Food Chem 57:2782-5. 2009
    ..A previous evaluation of preban absinthe was therefore valid and not confounded by significant thujone deterioration over time...
  16. doi Risk assessment of furan in commercially jarred baby foods, including insights into its occurrence and formation in freshly home-cooked foods for infants and young children
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Karlsruhe, 76187 Germany
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:776-85. 2009
    ..Research regarding reduction of furan in commercial baby foods should be conducted, with a priority aimed at reducing this heat-induced contaminant without concomitantly increasing the microbiological risk...
  17. pmc Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    J Occup Med Toxicol 3:26. 2008
    ..The research focus should be set on the chronic toxic effects of ethanol and acetaldehyde at the point of impact, with special regard to children and individuals with genetic deficiencies in ethanol metabolism...
  18. doi Salivary acetaldehyde increase due to alcohol-containing mouthwash use: a risk factor for oral cancer
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe, Germany
    Int J Cancer 125:730-5. 2009
    ..However, the local acetaldehyde contents in the saliva are reaching concentrations associated with DNA adduct formation and sister chromatid exchange in vitro, so that concerns for local carcinogenic effects in the oral cavity remain...
  19. pmc Ethyl carbamate in alcoholic beverages from Mexico (tequila, mezcal, bacanora, sotol) and Guatemala (cuxa): market survey and risk assessment
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe, Germany
    Int J Environ Res Public Health 6:349-60. 2009
    ..15 mg/L). Risk assessment found the Margin of Exposure (MOE) in line with that of European spirits. It is therefore unlikely that EC plays a role in high rates of liver cirrhosis reported in Mexico...
  20. doi Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe, Germany
    Addiction 104:533-50. 2009
    ..This study aims to estimate human exposure to acetaldehyde from alcoholic beverages and provide a quantitative risk assessment...
  21. pmc The quality of alcohol products in Vietnam and its implications for public health
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany
    Int J Environ Res Public Health 6:2090-101. 2009
    ..Based on this small sample, there is insufficient evidence to conclude that alcohol quality, beyond the effects of ethanol, has an influence on health in Vietnam. However, future research with larger samples is needed...
  22. doi Poppy seed foods and opiate drug testing--where are we today?
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Germany
    Ther Drug Monit 32:11-8. 2010
    ..Research is needed to prove if the morphine contents in today's foods still pose the possibility of influencing drug tests. Future trials should consider processing-related morphine losses...
  23. pmc Rapid and mobile determination of alcoholic strength in wine, beer and spirits using a flow-through infrared sensor
    Dirk W Lachenmeier
    , Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    Chem Cent J 4:5. 2010
    ..The device also gives the opportunity for mobile on-site control in the context of labelling control of wine, beer and spirits, the process monitoring of fermentations, or the evaluation of unrecorded alcohols...
  24. doi The composition of unrecorded alcohol from eastern Ukraine: is there a toxicological concern beyond ethanol alone?
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    Food Chem Toxicol 48:2842-7. 2010
    ..Further research is needed on potential mitigative measures and the origin of the metal contamination in particular alcoholic beverages...
  25. pmc Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.)
    Stephan G Walch
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    Chem Cent J 5:44. 2011
    ..abstract:..
  26. ncbi Quality of illegally and informally produced alcohol in Europe: Results from the AMPHORA project
    Dirk W Lachenmeier
    Chemisches und Veterinäruntersuchungsamt, Karlsruhe, Germany
    Adicciones 23:133-40. 2011
    ..This study reports the results from the Alcohol Measures for Public Health Research Alliance (AMPHORA) project, which assessed the quality of unrecorded alcohol in a Europe-wide study...
  27. doi Is contaminated unrecorded alcohol a health problem in the European Union? A review of existing and methodological outline for future studies
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe, Germany
    Addiction 106:20-30. 2011
    ....
  28. doi Alcohol under the radar: do we have policy options regarding unrecorded alcohol?
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    Int J Drug Policy 22:153-60. 2011
    ..This paper summarizes and evaluates the evidence base about policy and intervention options regarding unrecorded alcohol consumption...
  29. pmc Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany
    J Exp Clin Cancer Res 30:3. 2011
    ..This study was conducted to evaluate the role of the acetaldehyde that is found as a component of alcoholic beverages as an additional factor in the aetiology of oral cancer...
  30. doi Epidemiology-based risk assessment using the benchmark dose/margin of exposure approach: the example of ethanol and liver cirrhosis
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Karlsruhe, Germany
    Int J Epidemiol 40:210-8. 2011
    ..With this BMD we will be able to calculate the margin of exposure (MOE) for alcohol consumption, which can be used for comparative risk assessment and applied to setting public health policy...
  31. doi Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of regulatory changes?
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weißenburger Strasse 3, D 76187 Karlsruhe, Germany
    Regul Toxicol Pharmacol 58:437-43. 2010
    ..In conclusion, the evidence does not point to any need for changes in regulations but confirms the current limits as sufficiently protective for consumers...
  32. pmc NMR-spectroscopy for nontargeted screening and simultaneous quantification of health-relevant compounds in foods: the example of melamine
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, Karlsruhe, Germany
    J Agric Food Chem 57:7194-9. 2009
    ..NMR was found to be suitable for routine nontargeted and targeted analyses of foods, and its use will significantly increase food safety...
  33. doi Association between quality of cheap and unrecorded alcohol products and public health consequences in Poland
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Germany
    Alcohol Clin Exp Res 33:1757-69. 2009
    ..The research aimed to study the quality of cheap alcohol products in Poland. These included unrecorded alcohols (i.e., home-produced or illegally imported), estimated to constitute more than 25% of total consumption and fruit wines...
  34. doi Occurrence of benzene as a heat-induced contaminant of carrot juice for babies in a general survey of beverages
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, D 76187 Karlsruhe, Germany
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:1216-24. 2008
    ..The formation of benzene in carrot juice was predominantly caused by a heat-induced mechanism, which explains the higher levels in infant carrot juices that are subject to higher heat-treatment to exclude microbiological contamination...
  35. pmc Absinthism: a fictitious 19th century syndrome with present impact
    Stephan A Padosch
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weißenburger Str, 3, D 76187 Karlsruhe, Germany
    Subst Abuse Treat Prev Policy 1:14. 2006
    ....
  36. ncbi Automated determination of ethyl carbamate in stone-fruit spirits using headspace solid-phase microextraction and gas chromatography-tandem mass spectrometry
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D 76187 Karlsruhe, Germany
    J Chromatogr A 1108:116-20. 2006
    ..956, Bias = 0.08 mg/l). The new HS-SPME/GC/MS/MS procedure is suitable for the fast, reliable and inexpensive determination of ethyl carbamate in alcoholic beverages in an automated, and therefore, convenient procedure...
  37. ncbi Rapid screening for ethyl carbamate in stone-fruit spirits using FTIR spectroscopy and chemometrics
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany
    Anal Bioanal Chem 382:1407-12. 2005
    ..6 mg L(-1). Through use of FTIR screening, 60-70% of all samples can be classified as negative and removed, leaving only conspicuous analysis results exceeding cut-off to be confirmed by complex and labour-intensive reference analyses...
  38. ncbi Thujone--cause of absinthism?
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D 76187 Karlsruhe, Germany
    Forensic Sci Int 158:1-8. 2006
    ..It may be deduced that thujone plays none, or only a minor role in the clinical picture of absinthism...
  39. ncbi Multivariate analysis of FTIR and ion chromatographic data for the quality control of tequila
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany
    J Agric Food Chem 53:2151-7. 2005
    ..004; isobutanol, p = 0.005) in the 100% agave (methanol, 297.9 +/- 49.5; isobutanol, 251.3 +/- 34.9) than in the mixed tequilas (methanol, 197.8 +/- 118.5; isobutanol, 151.4 +/- 52.8)...
  40. ncbi Quantification of selected volatile constituents and anions in Mexican Agave spirits (Tequila, Mezcal, Sotol, Bacanora)
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany
    J Agric Food Chem 54:3911-5. 2006
    ..In conclusion, the composition of Mexican Agave spirits was found to vary over a relatively large range...
  41. ncbi Determination of cannabinoids in hemp food products by use of headspace solid-phase microextraction and gas chromatography-mass spectrometry
    Dirk W Lachenmeier
    Institut fur Rechtsmedizin, Rheinische Friedrich Wilhelms Universitat, Stiftsplatz 12, 53111 Bonn, Germany
    Anal Bioanal Chem 378:183-9. 2004
    ..In comparison with other studies relatively low THC concentrations between 0.01 and 15.53 mg kg(-1) were determined...
  42. ncbi Application of tandem mass spectrometry combined with gas chromatography and headspace solid-phase dynamic extraction for the determination of drugs of abuse in hair samples
    Dirk W Lachenmeier
    Institute of Legal Medicine, University of Bonn, Germany
    Rapid Commun Mass Spectrom 17:472-8. 2003
    ..The main advantage of the SPDE technique in relation to SPME is the robustness of the capillary...
  43. ncbi Absinthe--a review
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D 76187, Karlsruhe, Germany
    Crit Rev Food Sci Nutr 46:365-77. 2006
    ..Products, which are advertized as being of premium grade should be made by distillation, should have an alcoholic strength of at least 45%vol, and should not contain artificial dye...
  44. ncbi Surrogate alcohol: what do we know and where do we go?
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe, Germany
    Alcohol Clin Exp Res 31:1613-24. 2007
    ..e., nonbeverage alcohols and illegally produced alcohols) was shown to impact on different causes of death, not only poisoning or liver disease, and appears to be a major public health problem in Russia and elsewhere...
  45. ncbi [Thujone-attributable effects of absinthe are only an urban legend--toxicology uncovers alcohol as real cause of absinthism]
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, 76187 Karlsruhe
    Med Monatsschr Pharm 31:101-6. 2008
    ..Scientifically unproven speculations about the influence of certain drinking rituals of absinthe on its toxicity must be rebutted. A return to more evidence and less conjecture in the reporting about absinthe would be desirable...
  46. doi Defining maximum levels of higher alcohols in alcoholic beverages and surrogate alcohol products
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    Regul Toxicol Pharmacol 50:313-21. 2008
    ....
  47. ncbi [Absinthe - history of dependence to thujone or to alcohol?]
    D W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe
    Fortschr Neurol Psychiatr 75:306-8. 2007
    ..The current state of research considers absinthism to be a type of alcoholism with thujone playing none or only a secondary role...
  48. ncbi Results of hair analyses for drugs of abuse and comparison with self-reports and urine tests
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 156:118-23. 2006
    ....
  49. doi Benzene in infant carrot juice: further insight into formation mechanism and risk assessment including consumption data from the DONALD study
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D 76187 Karlsruhe, Germany
    Food Chem Toxicol 48:291-7. 2010
    ..Nevertheless, carcinogenic contaminants should be reduced to levels as low as reasonably achievable. The focus should be set on improving the sterilization conditions...
  50. ncbi Rapid analysis of taurine in energy drinks using amino acid analyzer and Fourier transform infrared (FTIR) spectroscopy as basis for toxicological evaluation
    S Triebel
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe, Germany
    Amino Acids 33:451-7. 2007
    ..So far, the high taurine concentrations of energy drinks in comparison to the rest of the diet are scientifically doubtful, as the advertised physiological effects and the value of supplemented taurine are unproven...
  51. doi Analysis and risk assessment of furan in coffee products targeted to adolescents
    J Waizenegger
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe, Germany
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 29:19-28. 2012
    ..The lowest MOE was found for consumers in the age group 10-12 years (especially females) and for both sexes in the age group 16-18 years...
  52. ncbi Automated headspace solid-phase dynamic extraction for the determination of cannabinoids in hair samples
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 133:32-8. 2003
    ..Compared to SPME, we found a higher extraction rate, coupled with a faster automated operation and greater stability of the device...
  53. ncbi Methadone substitution: medicolegal problems in Germany
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 133:118-24. 2003
    ..In most of the cases, up to five additional drugs were also being taken: benzodiazepines (61%), ethanol (40%), morphine (39%), cannabinoids (35%), cocaine (28%), anti-depressants (3%), and amphetamines (2%)...
  54. ncbi Fully automated determination of cannabinoids in hair samples using headspace solid-phase microextraction and gas chromatography-mass spectrometry
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    J Anal Toxicol 26:554-60. 2002
    ..29-2.20 (mean 1.7) ng/mg, CBN 0.55-4.54 (mean 1.2) ng/mg, and CBD 0.53-18.36 (mean 1.3) ng/mg. 11-nor-Delta9-tetrahydrocannabinol-9-carboxylic acid could not be detected with this method...
  55. doi Multivariate curve resolution of spectrophotometric data for the determination of artificial food colors
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe
    J Agric Food Chem 56:5463-8. 2008
    ..93 and a specificity of 0.85. Besides the artificial colors, the algorithm detected a further component in some samples that could be assigned to natural coloring from chlorophyll...
  56. pmc Chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol
    Jenny Leitz
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Karlsruhe, Germany
    PLoS ONE 4:e8127. 2009
    ..The aim of this study was to develop and validate a method for determining phthalates in alcohol samples and to provide a risk assessment for consumers of such products...
  57. ncbi Simultaneous gas chromatographic-mass spectrometric determination of dopamine, norsalsolinol and salsolinol enantiomers in brain samples of a large human collective
    F Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Stiftsplatz 12, 53111 Bonn, Germany
    Cell Mol Biol (Noisy-le-grand) 49:837-49. 2003
    ..Our data can serve as reference for other studies in humans concerning the etiology of alcoholism or other neurodegenerative diseases with the involvement of tetrahydroisoquinolines...
  58. ncbi Fully automated determination of amphetamines and synthetic designer drugs in hair samples using headspace solid-phase microextraction and gas chromatography-mass spectrometry
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Germany
    J Chromatogr Sci 40:359-64. 2002
    ..It uses minimal sample amounts and has the same degree of sensitivity and reproducibility...
  59. doi Headspace solid-phase microextraction-gas chromatography-mass spectrometry for the quantitative determination of the characteristic flavouring agent eugenol in serum samples after enzymatic cleavage to validate post-offence alcohol drinking claims
    Katja Schulz
    Institut fur Rechtsmedizin, Technische Universitat Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    J Chromatogr A 1211:113-9. 2008
    ..1 to 172.3 ng/ml. These test results, in particular, confirm that the analysis of volatile compounds can be useful in forensic toxicology for the verification of post-offence alcohol consumption claims...
  60. ncbi Determination of volatile constituents in spirits using headspace trap technology
    Katja Schulz
    Institut fur Rechtsmedizin, Technische Universitat Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    J Chromatogr A 1145:204-9. 2007
    ..An excellent agreement of analysis results in comparison to the European reference procedure was found (R>0.98, p<0.0001). The fully automated headspace trap procedure requires only minimal sample preparation and is easy to apply...
  61. doi Headspace solid-phase microextraction-gas chromatography-mass spectrometry determination of the characteristic flavourings menthone, isomenthone, neomenthol and menthol in serum samples with and without enzymatic cleavage to validate post-offence alcohol
    Katja Schulz
    Institut fur Rechtsmedizin, Technische Universitat Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Anal Chim Acta 646:128-40. 2009
    ..These test results confirmed that the analysis of characteristic beverage aroma compounds, such as menthone, isomenthone, neomenthol and menthol, can be used for specific verification of post-offence alcohol consumption claims...
  62. ncbi Automated headspace solid-phase dynamic extraction for the determination of amphetamines and synthetic designer drugs in hair samples
    Frank Musshoff
    Institute of Legal Medicine, University of Bonn, Germany
    J Chromatogr A 958:231-8. 2002
    ..Results indicated that SPDE is a rapid and sensitive method for the analysis of biological samples. Compared to solid-phase microextraction we found a higher extraction rate coupled with a faster automated operation...
  63. ncbi Systematic regional study of dopamine, norsalsolinol, and (R/S)-salsolinol levels in human brain areas of alcoholics
    Frank Musshoff
    Institute of Legal Medicine, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Alcohol Clin Exp Res 29:46-52. 2005
    ..In a prospective study, the regional distribution of DA, (R)-salsolinol (SAL), and (S)-SAL, as well as norsalsolinol (NorSAL) was examined systematically in a large collective of human brain samples obtained by autopsy...
  64. ncbi Absinthe and tobacco--a new look at an old problem? (Comment on: Absinthe--is its history relevant for current public health?)
    Dirk W Lachenmeier
    Int J Epidemiol 37:217-8; author reply 219. 2008
  65. ncbi Contribution of the fermenting yeast strain to ethyl carbamate generation in stone fruit spirits
    Beatus Schehl
    Institut für Lebensmitteltechnologie, Fachgebiet Gärungstechnologie, Universitat Hohenheim, Garbenstr 25, Stuttgart, Germany
    Appl Microbiol Biotechnol 74:843-50. 2007
    ..Nevertheless, using this strain for fermentation of stoneless cherry mashes did not completely impede EC formation. This indicates another, as yet unidentified, source for this compound...
  66. ncbi Analysis of heat-induced contaminants (acrylamide, chloropropanols and furan) in carbohydrate-rich food
    Thomas Wenzl
    Institute for Reference Materials and Measurements, European Commission, Directorate General Joint Research Centre, Retieseweg 111, 2440 Geel, Belgium
    Anal Bioanal Chem 389:119-37. 2007
    ..The aim of this publication is to give an overview of analytical approaches for the determination of acrylamide, furan and chloropropanols in foodstuffs...
  67. ncbi Optimized LC/MS/MS analysis of morphine and codeine in poppy seed and evaluation of their fate during food processing as a basis for risk analysis
    Constanze Sproll
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D 76187 Karlsruhe, Germany
    J Agric Food Chem 54:5292-8. 2006
    ..Ground poppy seed showed significantly lower recoveries than untreated seed. Morphine elimination during food processing has to be taken into account in the current discussion about its maximum limits in poppy seed...