Steffen Kunzmann

Summary

Country: Germany

Publications

  1. ncbi request reprint Ephrin-A1 suppresses Th2 cell activation and provides a regulatory link to lung epithelial cells
    Jan G Wohlfahrt
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    J Immunol 172:843-50. 2004
  2. ncbi request reprint TGF-beta1 in SP-A preparations influence immune suppressive properties of SP-A on human CD4+ T lymphocytes
    Steffen Kunzmann
    University Children s Hospital, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Am J Physiol Lung Cell Mol Physiol 291:L747-56. 2006
  3. ncbi request reprint Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling
    Steffen Kunzmann
    University Children s Hospital, Wurzburg, Germany
    J Allergy Clin Immunol 119:1398-407. 2007
  4. pmc Poractant alfa (Curosurf®) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo
    Coen Hmp Willems
    Department of Pediatrics, School for Mental Health and Neuroscience NUTRIM, School for Oncology and Developmental Biology GROW, Maastricht University Medical Centre, Maastricht, The Netherlands
    Respir Res 13:17. 2012
  5. pmc Antenatal inflammation reduces expression of caveolin-1 and influences multiple signaling pathways in preterm fetal lungs
    Steffen Kunzmann
    University Children s Hospital, University of Wurzburg, Germany
    Am J Respir Cell Mol Biol 45:969-76. 2011
  6. doi request reprint Immune-mediated severe hemolytic crisis with a hemoglobin level of 1.6 g/dl caused by anti-piperacillin antibodies in a patient with cystic fibrosis
    S Kunzmann
    University Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Infection 38:131-4. 2010
  7. doi request reprint Connective tissue growth factor does not affect transforming growth factor-beta 1-induced Smad3 phosphorylation and T lymphocyte proliferation inhibition
    S Kunzmann
    University Children s Hospital, University of Wurzburg, Wurzburg, Germany
    Int Arch Allergy Immunol 147:152-60. 2008
  8. doi request reprint Amplification of steroid-mediated SP-B expression by physiological levels of caffeine
    Markus Fehrholz
    Univ Children s Hospital, Univ of Wuerzburg, Josef Schneider Str 2, D 97080 Wuerzburg, Germany
    Am J Physiol Lung Cell Mol Physiol 306:L101-9. 2014
  9. pmc IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells
    Roderich Laug
    Orthopedic Center for Musculoskeletal Research, Molecular Orthopedics, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e45430. 2012
  10. pmc Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep
    Steffen Kunzmann
    University Children s Hospital, Wurzburg, Germany
    Am J Obstet Gynecol 202:476.e1-9. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Ephrin-A1 suppresses Th2 cell activation and provides a regulatory link to lung epithelial cells
    Jan G Wohlfahrt
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    J Immunol 172:843-50. 2004
    ..That the natural ligands of ephrin-A1 are most abundantly expressed in the lung may be relevant for Th2 cell regulation in asthma and Th2 cell generation by mucosal allergens...
  2. ncbi request reprint TGF-beta1 in SP-A preparations influence immune suppressive properties of SP-A on human CD4+ T lymphocytes
    Steffen Kunzmann
    University Children s Hospital, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Am J Physiol Lung Cell Mol Physiol 291:L747-56. 2006
    ..Monitoring of SP-A preparations for possible TGF-beta1 is essential...
  3. ncbi request reprint Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling
    Steffen Kunzmann
    University Children s Hospital, Wurzburg, Germany
    J Allergy Clin Immunol 119:1398-407. 2007
    ..TGF-beta and its downstream mediator connective tissue growth factor (CTGF) are playing a key role in these processes, resulting in irreversible airway remodelling...
  4. pmc Poractant alfa (Curosurf®) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo
    Coen Hmp Willems
    Department of Pediatrics, School for Mental Health and Neuroscience NUTRIM, School for Oncology and Developmental Biology GROW, Maastricht University Medical Centre, Maastricht, The Netherlands
    Respir Res 13:17. 2012
    ..g. phospholipids and hydrophobic surfactant proteins. In this study, we assessed the influence of exogenous poractant alfa (Curosurf®) instillation on the in vivo phagocytosis of apoptotic neutrophils by alveolar macrophages...
  5. pmc Antenatal inflammation reduces expression of caveolin-1 and influences multiple signaling pathways in preterm fetal lungs
    Steffen Kunzmann
    University Children s Hospital, University of Wurzburg, Germany
    Am J Respir Cell Mol Biol 45:969-76. 2011
    ..The decreased concentrations of Cav-1 and changes in other signaling pathways may contribute to BPD...
  6. doi request reprint Immune-mediated severe hemolytic crisis with a hemoglobin level of 1.6 g/dl caused by anti-piperacillin antibodies in a patient with cystic fibrosis
    S Kunzmann
    University Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Infection 38:131-4. 2010
    ..Furthermore, drug-fever under piperacillin application could be a warning sign for the development of hemolytic anemia...
  7. doi request reprint Connective tissue growth factor does not affect transforming growth factor-beta 1-induced Smad3 phosphorylation and T lymphocyte proliferation inhibition
    S Kunzmann
    University Children s Hospital, University of Wurzburg, Wurzburg, Germany
    Int Arch Allergy Immunol 147:152-60. 2008
    ..Overall, these data support the hypothesis that CTGF does not act on CD4+ T lymphocytes...
  8. doi request reprint Amplification of steroid-mediated SP-B expression by physiological levels of caffeine
    Markus Fehrholz
    Univ Children s Hospital, Univ of Wuerzburg, Josef Schneider Str 2, D 97080 Wuerzburg, Germany
    Am J Physiol Lung Cell Mol Physiol 306:L101-9. 2014
    ..Our findings indicate that caffeine is able to amplify main effects of glucocorticoids that result from changes in surfactant production, maturation, and release. ..
  9. pmc IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells
    Roderich Laug
    Orthopedic Center for Musculoskeletal Research, Molecular Orthopedics, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e45430. 2012
    ..The inverse correlation between IFN-γ and CTGF expression in LEC could mean that screwing the Th2 response to a Th1 response with an additional IFN-γ production might be beneficial to avoid airway remodeling in asthma...
  10. pmc Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep
    Steffen Kunzmann
    University Children s Hospital, Wurzburg, Germany
    Am J Obstet Gynecol 202:476.e1-9. 2010
    ..We asked whether fetal inflammation caused by chorioamnionitis would modulate thymus development...
  11. doi request reprint Thrown off balance: the effect of antenatal inflammation on the developing lung and immune system
    Steffen Kunzmann
    Children s Hospital, University of Wurzburg, Germany
    Am J Obstet Gynecol 208:429-37. 2013
    ....
  12. doi request reprint Funisitis is associated with increased interleukin-10 gene expression in cord blood mononuclear cells in preterm infants ≤32 weeks of gestation
    Johannes Wirbelauer
    University Children s Hospital, University of Wuerzburg, Wuerzburg, Germany
    Eur J Obstet Gynecol Reprod Biol 155:31-5. 2011
    ..The objective of our study was to examine the pro-inflammatory and anti-inflammatory responses in umbilical cord blood mononuclear cells (CBMC) of preterm infants on the transcriptional level...
  13. doi request reprint Immunomodulatory properties of surfactant preparations
    Iliana Bersani
    University Children s Hospital, University of Wurzburg, Germany
    Expert Rev Anti Infect Ther 11:99-110. 2013
    ..In perspective, detailed characterization of these anti-inflammatory effects could help to improve the next generation of surfactant preparations...
  14. doi request reprint Surfactant proteins A and D in pulmonary diseases of preterm infants
    Iliana Bersani
    University Children s Hospital, Wurzburg, Germany
    Expert Rev Anti Infect Ther 10:573-84. 2012
    ..Based on these assumptions, new-generation surfactants, enriched with SP-A and/or SP-D, may enhance the function of immune system and lungs in neonates, potentially improving the clinical outcome...
  15. doi request reprint Osteoarticular infection by Candida albicans in an infant with cystic fibrosis
    Kerstin Radike
    Children s Hospital University of Würzburg, Wurzburg, Germany
    J Med Microbiol 60:1542-5. 2011
    ..In the case of an invasive infection, prolonged treatment with a combination of antifungal drugs may be required...
  16. ncbi request reprint Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs
    Steffen Kunzmann
    Department of Pediatrics, Academisch Ziekenhuis Maastricht, Postbus 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 292:L223-31. 2007
    ..These effects may contribute to the impaired alveolar and pulmonary vascular development that is the hallmark of the new form of BPD...
  17. ncbi request reprint T cell phenotype in allergic asthma and atopic dermatitis
    Jan G Wohlfahrt
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 131:272-82. 2003
    ..In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pathogenesis of allergic diseases...
  18. ncbi request reprint Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response
    Machteld M Tiemessen
    Department of Dermatology Allergology, University Medical Center, PO Box 85 500, 3508 GA Utrecht, The Netherlands
    Int Immunol 15:1495-504. 2003
    ..In summary, TGF-beta has a pronounced inhibitory effect on antigen-specific T cell proliferation without modulating their cytokine production...
  19. ncbi request reprint TGF-{beta} signaling of human T cells is modulated by the ancillary TGF-{beta} receptor endoglin
    Carsten B Schmidt-Weber
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Int Immunol 17:921-30. 2005
    ..Furthermore, CD105 acts as a regulatory receptor, counteracting TGF-beta-mediated suppression...
  20. ncbi request reprint TGF-beta-mediated control of allergen-specific T-cell responses
    Carsten B Schmidt-Weber
    Swiss Institute of Allergy and Asthma Research, Obere Str 22, CH 7270, Davos, Switzerland
    Curr Allergy Asthma Rep 2:259-62. 2002
    ....