Genomes and Genes
- Functional analyses of C13orf19/P38IP in prostate cell linesDoreen Kunze
Department of Urology, Technical University Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
Oncol Rep 15:1599-604. 2006..No interaction between C13orf19 and p38MAPK was identified. Therefore, the gene should forthwith be named C13orf19 or Fam48A and not P38IP...
- Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cellsDoreen Kunze
Department of Urology, University Hospital Carl Gustav Carus, Technical University of Dresden, D 01307 Dresden, Germany
Int J Oncol 41:1271-7. 2012..5-fold enhancement in apoptosis rate and reduced cellular viability by 40%. Therefore, simultaneous knockdown of antiapoptotic BCL2, Bcl‑xL, XIAP and survivin may represent a promising treatment option for bladder cancer...
- Enhanced inhibition of bladder cancer cell growth by simultaneous knockdown of antiapoptotic Bcl-xL and survivin in combination with chemotherapyDoreen Kunze
Department of Urology, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Int J Mol Sci 14:12297-312. 2013....
- siRNA-mediated inhibition of antiapoptotic genes enhances chemotherapy efficacy in bladder cancer cellsDoreen Kunze
Department of Urology, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
Anticancer Res 32:4313-8. 2012..Therefore, the knockdown of these four genes could sensitise bladder cancer (BCa) cells towards chemotherapy...
- [In vitro and in vivo evaluation of inhibitory nucleic acid constructs for specific therapy of human urinary bladder carcinoma]D Kunze
Klinik für Urologie, Medizinische Fakultat, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden
Urologe A 46:1289. 2007
- Antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancer cells in vitro and in vivoDoreen Kunze
Department of Urology, Faculty of Medicine, Technical University of Dresden, 01307 Dresden, Germany
Int J Oncol 32:1049-56. 2008..In vivo studies with 9 consecutive intraperitoneal injections with 20 mg/kg AS-ODNs or 4.6 mg/kg siRNAs revealed the biocompatibility of both antisense inhibitor types and showed anti-tumoural activity of the AS-ODNs used...
- Multitarget siRNA inhibition of antiapoptotic genes (XIAP, BCL2, BCL-X(L)) in bladder cancer cellsDoreen Kunze
Department of Urology, Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
Anticancer Res 28:2259-63. 2008..The knockdown of XIAP, BCL2 and BCL-X(L) by siRNAs represents a promising treatment option for bladder cancer (BCa) since the overexpression of antiapoptotic genes is often associated with tumor progression and treatment resistance...
- Synthetic nucleic acids as potential therapeutic tools for treatment of bladder carcinomaSusanne Fuessel
Department of Urology, Technical University of Dresden, Dresden, Germany
Eur Urol 51:315-26; discussion 326-7. 2007..Therefore, silencing of abnormally activated genes appears to be a rational approach for specific target-directed and sensitising therapies...
- Carbon nanotubes filled with a chemotherapeutic agent: a nanocarrier mediates inhibition of tumor cell growthSilke Hampel
Leibniz Institute for Solid State and Materials Research Dresden, PF 270116, 01171 Dresden, Germany
Nanomedicine (Lond) 3:175-82. 2008..The drug was introduced into CNTs to demonstrate that they are suited as nanocontainers and nanocarriers and can release the drug to initialize its medical virtue...