Thomas Kuntzen

Summary

Country: Germany

Publications

  1. pmc A set of reference sequences for the hepatitis C genotypes 4d, 4f, and 4k covering the full open reading frame
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Med Virol 80:1370-8. 2008
  2. pmc Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 48:1769-78. 2008
  3. pmc Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual
    Arthur Y Kim
    Partners AIDS Research Center, Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 199:737-41. 2009
  4. pmc Viral sequence evolution in acute hepatitis C virus infection
    Thomas Kuntzen
    Massachusetts General Hospital, Infectious Disease, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:11658-68. 2007
  5. pmc High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    Victoria Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 82:3154-60. 2008
  6. pmc Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase
    Cesar Oniangue-Ndza
    Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
    J Virol 85:11883-90. 2011
  7. pmc Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:5594-605. 2008
  8. pmc Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
    Arthur Y Kim
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, GRB 504, Boston, Massachusetts 02114, USA
    Gastroenterology 140:686-696.e1. 2011
  9. ncbi request reprint Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    Joerg Timm
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 46:339-49. 2007
  10. pmc Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
    Victoria Kasprowicz
    Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Virol 84:1656-63. 2010

Collaborators

Detail Information

Publications16

  1. pmc A set of reference sequences for the hepatitis C genotypes 4d, 4f, and 4k covering the full open reading frame
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Med Virol 80:1370-8. 2008
    ..Reference sequences for accurate HCV genotyping are required for optimized treatment, and a better knowledge of the global viral sequence diversity is needed to guide vaccines or new drugs effective in the world wide epidemic...
  2. pmc Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 48:1769-78. 2008
    ....
  3. pmc Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual
    Arthur Y Kim
    Partners AIDS Research Center, Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 199:737-41. 2009
    ..The persistence of drug-resistance mutations argues for baseline resistance genotyping at the time therapy is initiated to accurately predict the efficacy of treatment...
  4. pmc Viral sequence evolution in acute hepatitis C virus infection
    Thomas Kuntzen
    Massachusetts General Hospital, Infectious Disease, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:11658-68. 2007
    ....
  5. pmc High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    Victoria Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 82:3154-60. 2008
    ..Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection...
  6. pmc Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase
    Cesar Oniangue-Ndza
    Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
    J Virol 85:11883-90. 2011
    ....
  7. pmc Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:5594-605. 2008
    ....
  8. pmc Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
    Arthur Y Kim
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, GRB 504, Boston, Massachusetts 02114, USA
    Gastroenterology 140:686-696.e1. 2011
    ..We aimed to determine the correlations between these alleles and natural outcomes of HCV and determine associated key T-cell responses...
  9. ncbi request reprint Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    Joerg Timm
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 46:339-49. 2007
    ....
  10. pmc Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
    Victoria Kasprowicz
    Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Virol 84:1656-63. 2010
    ..Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation...
  11. pmc Transmission and long-term stability of compensated CD8 escape mutations
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
    J Virol 83:3993-7. 2009
    ..Herein, we illustrate the long-term stability of stereotypic escape mutations in the immunodominant HLA-B27-restricted epitope KK10 in p24/Gag following transmission when accompanied by a specific compensatory mutation...
  12. ncbi request reprint Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    AIDS 22:203-10. 2008
    ..This accelerated pathogenesis is probably influenced by differences in the composition of infiltrating inflammatory cells and the local release of inflammatory and profibrogenic cytokines...
  13. pmc Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection
    Julian Schulze zur Wiesch
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Blood 110:1559-69. 2007
    ....
  14. pmc Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations
    Christoph Neumann-Haefelin
    Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA
    Hepatology 54:1157-66. 2011
    ..Coexpression of these upstream mutations with the rare escape mutations dramatically restored viral replication capacity from <5% to ≥ 70% of wild-type levels...
  15. pmc Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Virol 81:12382-93. 2007
    ....
  16. pmc Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
    Arthur Y Kim
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 3:e492. 2006
    ..Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection...