Research Topics
| Thomas KuntzenSummaryCountry: Germany Publications
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Detail Information
Publications
A set of reference sequences for the hepatitis C genotypes 4d, 4f, and 4k covering the full open reading frameThomas Kuntzen
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Med Virol 80:1370-8. 2008..Reference sequences for accurate HCV genotyping are required for optimized treatment, and a better knowledge of the global viral sequence diversity is needed to guide vaccines or new drugs effective in the world wide epidemic...- Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patientsThomas Kuntzen
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Hepatology 48:1769-78. 2008.... - Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individualArthur Y Kim
Partners AIDS Research Center, Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Infect Dis 199:737-41. 2009..The persistence of drug-resistance mutations argues for baseline resistance genotyping at the time therapy is initiated to accurately predict the efficacy of treatment... - Viral sequence evolution in acute hepatitis C virus infectionThomas Kuntzen
Massachusetts General Hospital, Infectious Disease, 13th Street, Charlestown, MA 02129, USA
J Virol 81:11658-68. 2007.... - High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcomeVictoria Kasprowicz
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
J Virol 82:3154-60. 2008..Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection... - Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymeraseCesar Oniangue-Ndza
Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
J Virol 85:11883-90. 2011.... - Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsidArne Schneidewind
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Virol 82:5594-605. 2008.... - Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopesArthur Y Kim
Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, GRB 504, Boston, Massachusetts 02114, USA
Gastroenterology 140:686-696.e1. 2011..We aimed to determine the correlations between these alleles and natural outcomes of HCV and determine associated key T-cell responses... 
Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolutionJoerg Timm
Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Hepatology 46:339-49. 2007....- Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolutionVictoria Kasprowicz
Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Virol 84:1656-63. 2010..Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation... - Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAARTThomas Kuntzen
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
AIDS 22:203-10. 2008..This accelerated pathogenesis is probably influenced by differences in the composition of infiltrating inflammatory cells and the local release of inflammatory and profibrogenic cytokines... - Transmission and long-term stability of compensated CD8 escape mutationsArne Schneidewind
Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
J Virol 83:3993-7. 2009..Herein, we illustrate the long-term stability of stereotypic escape mutations in the immunodominant HLA-B27-restricted epitope KK10 in p24/Gag following transmission when accompanied by a specific compensatory mutation... - Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infectionJulian Schulze zur Wiesch
Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Blood 110:1559-69. 2007.... - Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutationsChristoph Neumann-Haefelin
Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA
Hepatology 54:1157-66. 2011..These data support a role for the targeting of highly constrained regions by HLA-B27 in its ability to assert immune control of HCV and other highly variable pathogens... - Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replicationArne Schneidewind
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Virol 81:12382-93. 2007.... - Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfectionArthur Y Kim
Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Med 3:e492. 2006..Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection...