Cornelius Kuhnen

Summary

Country: Germany

Publications

  1. pmc Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    World J Surg Oncol 6:71. 2008
  2. ncbi request reprint [EGFR-expression in pulmonary neuroendocrine cell hyperplasia]
    C Kuhnen
    Institut für Pathologie der Ruhr Universität Bochum, Berufsgenossenschaftliche Kliniken Bergmannsheil
    Pathologe 27:147-51. 2006
  3. ncbi request reprint Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma
    Cornelius Kuhnen
    Institute of Pathology, Limb tumor registry, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Virchows Arch 449:572-8. 2006
  4. ncbi request reprint [Myoepithelioma of soft tissue -- case report with clinicopathologic, ultrastructural, and cytogenetic findings]
    C Kuhnen
    Institut für Pathologie der Ruhr Universität Bochum an den Berufsgenossenschaftlichen Kliniken Bergmannsheil
    Pathologe 26:331-7. 2005
  5. ncbi request reprint Dedifferentiated liposarcoma with extensive lymphoid component
    Cornelius Kuhnen
    Institute for Pathology, Limb tumor registry, Ruhr University, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Pathol Res Pract 201:347-53. 2005
  6. ncbi request reprint [Tenosynovial giant cell tumor]
    C Kuhnen
    Institut fur Pathologie, Register für Gliedmassentumoren, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Pathologe 26:96-110. 2005
  7. ncbi request reprint [Desmoid-type fibromatosis (aggressive fibromatosis)]
    C Kuhnen
    Institut fur Pathologie, Register für Gliedmassentumoren, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Pathologe 26:117-26. 2005
  8. ncbi request reprint [Therapy-induced tumor regression in adult soft tissue sarcomas-morphological findings]
    C Kuhnen
    Institut für Pathologie der Ruhr Universität Bochum an den BG Kliniken Bergmannsheil
    Pathologe 25:437-44. 2004
  9. ncbi request reprint [liposarcoma. Aspects of pathomorphology--an analysis of 209 tumos]
    C Kuhnen
    Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Chirurg 75:1151-8. 2004
  10. pmc Elastofibroma dorsi--differential diagnosis in chest wall tumours
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    World J Surg Oncol 5:15. 2007

Detail Information

Publications43

  1. pmc Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    World J Surg Oncol 6:71. 2008
    ..The aim of this study was a clinicopathological analysis with special reference to treatment and outcome...
  2. ncbi request reprint [EGFR-expression in pulmonary neuroendocrine cell hyperplasia]
    C Kuhnen
    Institut für Pathologie der Ruhr Universität Bochum, Berufsgenossenschaftliche Kliniken Bergmannsheil
    Pathologe 27:147-51. 2006
    ....
  3. ncbi request reprint Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma
    Cornelius Kuhnen
    Institute of Pathology, Limb tumor registry, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Virchows Arch 449:572-8. 2006
    ..Further studies should concentrate on the identification of genes especially on chromosomal region 10q22 to elucidate more aspects in the pathogenesis of this rhabdomyosarcoma subtype...
  4. ncbi request reprint [Myoepithelioma of soft tissue -- case report with clinicopathologic, ultrastructural, and cytogenetic findings]
    C Kuhnen
    Institut für Pathologie der Ruhr Universität Bochum an den Berufsgenossenschaftlichen Kliniken Bergmannsheil
    Pathologe 26:331-7. 2005
    ..Based on a local relapse rate of approximately 20% according to the literature, a complete resection with thorough follow-up should be recommended...
  5. ncbi request reprint Dedifferentiated liposarcoma with extensive lymphoid component
    Cornelius Kuhnen
    Institute for Pathology, Limb tumor registry, Ruhr University, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Pathol Res Pract 201:347-53. 2005
    ..An extensive lymphoid "overgrowth" must be considered within the spectrum of unusual variants and in the differential diagnosis of dedifferentiated liposarcoma...
  6. ncbi request reprint [Tenosynovial giant cell tumor]
    C Kuhnen
    Institut fur Pathologie, Register für Gliedmassentumoren, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Pathologe 26:96-110. 2005
    ..Immunohistochemically, the diffuse-type exhibited focal expression of CD31 (in 75% of tumors) and calretinin (in 63%) besides CD68-staining...
  7. ncbi request reprint [Desmoid-type fibromatosis (aggressive fibromatosis)]
    C Kuhnen
    Institut fur Pathologie, Register für Gliedmassentumoren, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Pathologe 26:117-26. 2005
    ....
  8. ncbi request reprint [Therapy-induced tumor regression in adult soft tissue sarcomas-morphological findings]
    C Kuhnen
    Institut für Pathologie der Ruhr Universität Bochum an den BG Kliniken Bergmannsheil
    Pathologe 25:437-44. 2004
    ..g. according to the grading scheme for osteosarcomas following chemotherapy of Salzer-Kuntschik). A report of sarcoma resection specimens should include the percentage of vital tumor tissue...
  9. ncbi request reprint [liposarcoma. Aspects of pathomorphology--an analysis of 209 tumos]
    C Kuhnen
    Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Chirurg 75:1151-8. 2004
    ..Among the heterogeneous group of adult soft tissue sarcomas, liposarcomas represent the largest entity along with malignant fibrous histiocytomas (MFH)...
  10. pmc Elastofibroma dorsi--differential diagnosis in chest wall tumours
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    World J Surg Oncol 5:15. 2007
    ..The pathogenesis of the lesion is still unclear, but repetitive microtrauma by friction between the scapula and the thoracic wall may cause the reactive hyperproliferation of fibroelastic tissue...
  11. pmc Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue
    Karl Ludwig Schaefer
    Institute of Pathology, Heinrich Heine University, Dusseldorf, Germany
    Neoplasia 8:613-22. 2006
    ....
  12. ncbi request reprint Pigmented (melanotic) neurofibroma. Report of an unusual case with immunohistochemical, ultrastructural and cytogenetic analyses
    Cornelius Kuhnen
    Institute of Pathology, Limb tumor registry, University Hospital Bergmannsheil, Bochum, Germany
    Pathol Res Pract 198:125-31. 2002
    ..However, smaller chromosomal defects might have been overlooked by the limited resolution of this screening method. Therefore, other mechanisms up-regulating melanogenesis, such as mutations in regulatory genes, have to be considered...
  13. ncbi request reprint Atypical lipomatous tumor in a 14-year-old patient: distinction from lipoblastoma using FISH analysis
    Cornelius Kuhnen
    Institute for Pathology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Virchows Arch 441:299-302. 2002
    ..This case shows that FISH can serve as a decisive tool in the differential diagnosis of lipoblastoma and lipoma-like liposarcoma apart from its role in distinction between lipoblastoma and myxoid/round cell liposarcoma...
  14. ncbi request reprint Unusual sarcomatoid neoplasm of the lung suggesting a myofibrosarcoma
    Lars Morawietz
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Virchows Arch 447:990-5. 2005
    ..The case report will discuss the evidence for the final diagnosis of a primary pulmonary myofibrosarcoma and the differential diagnosis of sarcomatoid tumors of the lung...
  15. doi request reprint Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    Langenbecks Arch Surg 395:261-75. 2010
    ..This study focused on these tumors and analyzed the association of gene expression profiles to clinical outcome...
  16. pmc Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    BMC Cancer 5:74. 2005
    ..In this study we elucidated the response of a fibrosarcoma cell line to clinically used cytostatic agents on the level of gene expression...
  17. ncbi request reprint Lumbar disk herniation: correlation of histologic findings with marrow signal intensity changes in vertebral endplates at MR imaging
    Gebhard Schmid
    Department of Radiology and Nuclear Medicine, St Josef Hospital, Ruhr Universitat Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Radiology 231:352-8. 2004
    ..To compare findings at preoperative magnetic resonance (MR) imaging with data for tissue composition of herniated disks in patients after microsurgical removal of herniated material...
  18. doi request reprint MFH revisited: outcome after surgical treatment of undifferentiated pleomorphic or not otherwise specified (NOS) sarcomas of the extremities -- an analysis of 140 patients
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Handsurgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Langenbecks Arch Surg 394:313-20. 2009
    ..The objective of this study is to determine prognostic factors for the outcome after surgical treatment with respect to the recent developments in classification...
  19. ncbi request reprint [Desmoplastic neurotropic melanoma. Diagnosis and therapeutic procedures for a rare clinical entity]
    J Hauser
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, BG Kliniken Bergmannsheil Bochum
    Chirurg 77:939-42. 2006
    ..In this paper, a 79-year-old patient with a basal cell carcinoma and desmoplastic melanoma on the scalp is described, and the therapeutic procedure is discussed...
  20. ncbi request reprint Patterns of expression and secretion of vascular endothelial growth factor in malignant soft-tissue tumours
    C Kuhnen
    Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany
    J Cancer Res Clin Oncol 126:219-25. 2000
    ..Further long-term follow-up studies are needed, which should include patients with tumour recurrences...
  21. ncbi request reprint APC and beta-catenin in alveolar soft part sarcoma (ASPS)--immunohistochemical and molecular genetic analysis
    C Kuhnen
    Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany
    Pathol Res Pract 196:299-304. 2000
    ..A nuclear function of APC in ASPS in down-regulating nuclear transcription processes linked to overexpression of beta-catenin, as is known in colorectal carcinogenesis, may be hypothesized...
  22. ncbi request reprint Metachronous bilateral soft tissue sarcoma of the extremities
    A Daigeler
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University, Buerkle de la Camp Platz 1, 44789, Bochum, Germany
    Langenbecks Arch Surg 393:207-12. 2008
    ..Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas...
  23. ncbi request reprint Beta-catenin in soft tissue sarcomas: expression is related to proliferative activity in high-grade sarcomas
    C Kuhnen
    Institute for Pathology, Limb tumor registry, University Hospital Bergmannsheil, Bochum, Germany
    Mod Pathol 13:1005-13. 2000
    ..Mutations of the beta-catenin gene are probably of lesser importance for the accumulation of beta-catenin in soft tissue sarcomas...
  24. ncbi request reprint New model for in vivo investigation after microvascular breakdown in burns: use of intravital fluorescent microscopy
    S Langer
    Department of Plastic and Hand Surgery, Burn Center, Ruhr University Bochum, Buerkle de la Camp Platz 1, D 44789 Bochum, Germany
    Burns 31:168-74. 2005
    ..The aim of the present study was to develop a burn model, which allows repetitive quantitative in vivo analysis of the microcirculation after a burn injury, focusing on the interaction between leukocytes and the endothelium...
  25. ncbi request reprint [Congenital pulmonary fibrosarcoma. Differential diagnosis of infantile pulmonary spindle cell tumors]
    C Kuhnen
    Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789 Bochum
    Pathologe 22:151-6. 2001
    ..Especially in congenital lesions a favorable clinical course is to be expected after complete surgical resection. Additional radio- and/or chemotherapy is not recommended...
  26. ncbi request reprint [Pulmonary lymphangioleiomyomatosis. Morphologic and immunohistochemical findings]
    C Kuhnen
    Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789 Bochum
    Pathologe 22:197-204. 2001
    ..Using the concept of a melanomyopericyte, pulmonary LAM could be classified as a hamartomatous interstitial lung disease showing perivascular smooth muscle and partial melanocytic differentiation...
  27. ncbi request reprint [Retrogastral located gastrointestinal stromal tumor (GIST) as a sonographically detected rare incidental finding]
    S A Esenwein
    Chirurgische Klinik mit Poliklinik, Berufsgenossenschaftliche Kliniken Bergmannsheil, Universitatsklinik der Ruhr Universitat Bochum, Germany
    Zentralbl Chir 127:322-5. 2002
    ..Since no generally accepted consensus on the treatment of the GISTs exists, also patients originally suffering from tumors regarded as borderline-malignant should undergo a close-meshed follow-up in regular intervals...
  28. ncbi request reprint [Myofibroblastic sarcoma of the thoracic wall. Change in appearance in tumour recurrence]
    C Kuhnen
    Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
    Pathologe 24:128-35. 2003
    ....
  29. ncbi request reprint Expression and localization of vascular endothelial growth factor and its receptor flt in pulmonary sarcoidosis
    E Tolnay
    Department of Pulmonology, Semmelweis Medical School, Budapest, Hungary
    Virchows Arch 432:61-5. 1998
    ..We found an increased transcription and protein production of VEGF and an overexpression of flt in activated alveolar macrophages, in epitheloid cells, and in multinuclear giant cells of pulmonary sarcoid granulomas...
  30. ncbi request reprint A novel titanium wound chamber for the study of wound infections in pigs
    Lars Steinstraesser
    Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    Comp Med 56:279-85. 2006
    ..We conclude that the use of titanium chambers in pigs provides a reliable and reproducible in vivo model to investigate wound healing, wound infection, and treatment options...
  31. ncbi request reprint Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation
    Florian Grabellus
    Institute of Pathology, University Hospital of Essen, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Virchows Arch 448:85-9. 2006
    ..The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies...
  32. ncbi request reprint Analysis of neovascularization of PEGT/PBT-copolymer dermis substitutes in balb/c-mice
    Andrej Ring
    Department of Plastic and Hand Surgery, Burn Center, Department of Pathology, University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Burns 32:35-41. 2006
    ..PEGT/PBT block-copolymer matrices have previously been shown as a favorable dermal substitute. In this study, quantitative data on neovascularization of PEGT/PBT block-copolymer matrices are presented...
  33. ncbi request reprint Impact of c-Met expression on angiogenesis in soft tissue sarcomas: correlation to microvessel-density
    Cornelius Kuhnen
    Institute for Pathology, Limb tumor registry, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    J Cancer Res Clin Oncol 129:415-22. 2003
    ..The aim of this study was the analysis of c-Met immunoexpression/-synthesis and microvessel density as parameters for angiogenesis and prognosis in 115 soft tissue sarcomas...
  34. ncbi request reprint Aneurysmal bone cyst of the cervical spine (2008:7b)
    W Pennekamp
    Institute of Diagnostic and Interventional Radiology and Nuclear Medicine, BG Kliniken Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Eur Radiol 18:2356-60. 2008
    ..The typical macroscopic and histological findings were present. The tumor was resected en bloc, after which the patient underwent adjuvant radiation therapy. The patient made a complete recovery...
  35. ncbi request reprint [Solitary plasmacytoma of the shoulder. Diagnosis and therapeutic methods]
    H H Homann
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmassentumoren, Universitatsklinik der Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789 Bochum
    Chirurg 73:736-8. 2002
    ..In this article we present the case of a fifty year old patient with a solitary plasmocytoma of the shoulder region and discuss the diagnostic and therapeutic procedures involved...
  36. ncbi request reprint Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases
    Thomas Mentzel
    Dermatopathologische Gemeinschaftspraxis, Siemenstrasse 6 1, 88048 Friedrichshafen, Germany
    Virchows Arch 449:554-60. 2006
    ....
  37. pmc Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues
    Adrien Daigeler
    Department of Plastic Surgery, Burn Center, Hand Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany
    BMC Surg 6:10. 2006
    ..Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results...
  38. ncbi request reprint SPMSP: a solid-phase PCR with colorimetric read-out for quantitative methylation analysis
    Sonja Sievers
    CMax Planck Institute of Molecular Physiology, Dortmund, Germany
    Anticancer Res 28:2055-60. 2008
    ..As DNA methylation has been determined as an important diagnostic biomarker in cancer management, methods for the detection of quantitative DNA methylation which are high-throughput and low-cost are needed...
  39. ncbi request reprint Clinical symptoms in lumbar disc herniations and their correlation to the histological composition of the extruded disc material
    Roland E Willburger
    Department of Orthopaedic Surgery, Ruhr University Bochum, Germany
    Spine (Phila Pa 1976) 29:1655-61. 2004
    ..Fifty-five consecutive patients undergoing microdiskectomy due to lumbar disc herniation were included in this clinical study over 12 months...
  40. ncbi request reprint Polypoid pleomorphic sarcoma of the colon
    Bernd Roetman
    Chirurgische Klinik und Poliklinik, Bochum, Germany
    Scand J Gastroenterol 40:1502-6. 2005
    ..In this case report we discuss the clinical and pathological characteristics of a rare polypoid-shaped, pleomorphic colonic sarcoma and refer a mark-off to other rare mesenchymal neoplasms of the gut...
  41. ncbi request reprint Co-expression of VEGF, c-Met and HGF/SF in secondary pleural tumors
    Ramin Naim
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 68135 Mannheim, Germany
    Int J Mol Med 14:787-91. 2004
    ..VEGF is reported to increase vascular permeability, which in turn causes pleural effusions. The results presented here may be the basis for possible future palliative therapeutical strategies in malignant pleural effusions...
  42. ncbi request reprint Hypermethylation of the APC promoter but lack of APC mutations in myxoid/round-cell liposarcoma
    Sonja Sievers
    Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Int J Cancer 119:2347-52. 2006
    ..However, the impact of APC methylation on liposarcoma development is quite likely not mediated through WNT signalling...
  43. ncbi request reprint The value of expert second opinion in diagnosis of soft tissue sarcomas
    Marcus Lehnhardt
    Department of Plastic Surgery, Burn Center, Hand Surgery, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    J Surg Oncol 97:40-3. 2008
    ..The value of consultative second opinions has been proven for general surgical pathology; some studies suggest an even higher value for the soft tissue tumour specimens in particular...