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Genomes and Genes | A KuhnSummaryCountry: Germany Publications
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Publications
Use of methotrexate in patients with psoriasisA Kuhn
Department of Dermatology, University of Munster, Munster, Germany
Clin Exp Rheumatol 28:S138-44. 2010..This review summarises the nature of the disease and our present knowledge about MTX in the treatment of psoriasis, including combination therapies...
Treatment of cutaneous lupus erythematosusA Kuhn
Department of Dermatology, University of Munster, Munster, Germany
Lupus 19:1125-36. 2010..Recent advances in biotechnology resulted in the development of novel systemic agents, but randomized controlled trials are necessary for the approval of new therapeutic strategies in CLE...- Cutaneous lupus erythematosus: update of therapeutic options part IIAnnegret Kuhn
Department of Dermatology, University of Munster, Munster, Germany
J Am Acad Dermatol 65:e195-213. 2011..In addition to successful treatment, induction of CLE subtypes by biologics has been reported. In conclusion, many treatment options exist for CLE, but not many are supported by evidence from randomized controlled trials... - Cutaneous lupus erythematosus: update of therapeutic options part IAnnegret Kuhn
Department of Dermatology, University of Munster, Munster, Germany
J Am Acad Dermatol 65:e179-93. 2011..In the second part, additional systemic agents for the treatment of CLE will be discussed... 
Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical featuresRudolf Mierau
Laboratory at Rheumaklinik Aachen, Hauptstrasse 21, Aachen, D 52066, Germany
Arthritis Res Ther 13:R172. 2011..In the present study, we analysed in detail nuclear autoantibodies and their associations in systemic sclerosis (SSc) patients included in the German Network for Systemic Scleroderma Registry...- Effect of bosentan on skin fibrosis in patients with systemic sclerosis: a prospective, open-label, non-comparative trialAnnegret Kuhn
Department of Dermatology, University of Munster, Munster, Germany
Rheumatology (Oxford) 49:1336-45. 2010..To assess the effect of the ET-receptor antagonist bosentan on skin fibrosis and functionality in patients with SSc... - Revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI): a modified outcome instrument for cutaneous lupus erythematosusA Kuhn
Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
Br J Dermatol 163:83-92. 2010..However, the CLASI does not give an accurate assessment of the severity in all disease subtypes... - Development of a Core Set Questionnaire by the European Society of Cutaneous Lupus Erythematosus (EUSCLE)A Kuhn
Department of Dermatology, University of Muenster, Muenster, Germany
Autoimmun Rev 8:702-12. 2009..It enables consistent statistical evaluation, exchange, and comparison of patient's data within several European countries and provides a set of guidelines for standardized diagnostic and therapeutic strategies in CLE... - Photosensitivity, phototesting, and photoprotection in cutaneous lupus erythematosusA Kuhn
Department of Dermatology, University of Munster, Munster, Germany
Lupus 19:1036-46. 2010..In this review, we summarize the current knowledge about photosensitivity in patients with CLE, including an overview of standardized phototesting procedures, possible molecular pathomechanisms, and photoprotection... - The 100th anniversary of lupus erythematosus tumidusAnnegret Kuhn
Department of Dermatology, University of Munster, Munster, Germany
Autoimmun Rev 8:441-8. 2009..On the occasion of the 100th anniversary of the first description of LET, we have reviewed the literature and provide here an overview on the different aspects of the disease... - Photoprovocation in cutaneous lupus erythematosus: a multicenter study evaluating a standardized protocolAnnegret Kuhn
Department of Dermatology, University of Munster, Munster, Germany
J Invest Dermatol 131:1622-30. 2011..This method may therefore be used for future diagnostic testing and clinical trials... - Photoprotective effects of a broad-spectrum sunscreen in ultraviolet-induced cutaneous lupus erythematosus: a randomized, vehicle-controlled, double-blind studyAnnegret Kuhn
Department of Dermatology, University of Muenster, Muenster, Germany
J Am Acad Dermatol 64:37-48. 2011.... - CD4(+)CD25 (+) regulatory T cells in human lupus erythematosusAnnegret Kuhn
Division of Immunogenetics, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
Arch Dermatol Res 301:71-81. 2009..Furthermore, we highlight the need for additional studies that address specific gaps of knowledge regarding the pathophysiological mechanisms as well as the identification of future therapeutic strategies for autoimmune diseases... - Successful treatment of discoid lupus erythematosus with argon laserA Kuhn
Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
Dermatology 201:175-7. 2000..The patient tolerated the laser treatment well without any short-term side effects. These data indicate that argon laser therapy might be a powerful alternative approach in the treatment of vascular skin lesions of DLE... - Lupus erythematosus tumidus--a neglected subset of cutaneous Lupus erythematosus: report of 40 casesA Kuhn
Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
Arch Dermatol 136:1033-41. 2000..Since its first description in 1930, LET has been documented rarely in the literature, and its clinical importance has not been fully appreciated... - [Rediscovery of thalidomide. Successful treatment of discoid lupus erythematosus]A Kuhn
Hautklinik der Heinrich Heine Universität Düsseldorf
Hautarzt 52:726-33. 2001..Our data confirm that thalidomide provides one of the most useful therapeutic alternatives for chronic refractory DLE, despite the risks of teratogenicity and polyneuropathy... - Efficacy of tacrolimus 0.1% ointment in cutaneous lupus erythematosus: a multicenter, randomized, double-blind, vehicle-controlled trialAnnegret Kuhn
Department of Dermatology, University of Muenster, Muenster, Germany
J Am Acad Dermatol 65:54-64, 64.e1-2. 2011..Topical calcineurin inhibitors are licensed for the treatment of atopic dermatitis; however, the efficacy of tacrolimus in cutaneous lupus erythematosus (CLE) has only been shown in single case reports... - Phototesting in lupus erythematosus tumidus--review of 60 patientsA Kuhn
Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
Photochem Photobiol 73:532-6. 2001..In conclusion, the high incidence of positive phototest reactions in correlation with the clinical findings, history of photosensitivity and antinuclear antibodies enable the classification of LET as the most photosensitive type of LE... - Upregulation of epidermal surface molecule expression in primary and ultraviolet-induced lesions of lupus erythematosus tumidusA Kuhn
Department of Dermatology, University of Dusseldorf, Dusseldorf, Germany
Br J Dermatol 146:801-9. 2002..Lupus erythematosus tumidus (LET), a photosensitive skin disorder with characteristic clinical and histological features, has not been generally accepted as a subset of cutaneous lupus erythematosus (CLE)... - [Skin manifestations in lupus erythematosus: clinical aspects and therapy]A Kuhn
Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster, Munster, Deutschland
Z Rheumatol 70:213-26; quiz 227. 2011..Antimalarials are still the first-line systemic therapy and in addition to sunscreens, glucocorticosteroids and calcineurin inhibitors have an important impact as topical agents in this disease... - Characterization of the inflammatory infiltrate and expression of endothelial cell adhesion molecules in lupus erythematosus tumidusAnnegret Kuhn
Institute of Cell Biology, ZMBE, Westfalische Wilhelms University, Munster, Germany
Arch Dermatol Res 294:6-13. 2002..Furthermore, expression of endothelial cell adhesion molecules was equally upregulated in LET compared with the expression in DLE and SCLE, suggesting a similar immunopathomechanism of these subtypes of CLE... - Evaluation of disease activity and damage in different subtypes of cutaneous lupus erythematosus using the CLASID Bein
Department of Dermatology, University of Munster, Munster, Germany
J Eur Acad Dermatol Venereol 25:652-9. 2011..Objective The aim of this study was to evaluate whether the CLASI is a useful instrument which reflects the different subtypes of CLE comparably well in each parameter... - Low number of regulatory T cells in skin lesions of patients with cutaneous lupus erythematosusB Franz
German Cancer Research Center, Heidelberg, Germany
Arthritis Rheum 56:1910-20. 2007..To define the phenotype and function of CD4+,CD25+ regulatory T cells (Treg) in patients with cutaneous lupus erythematosus (CLE), a heterogeneous autoimmune disease characterized primarily by inflammatory skin lesions... - Phototesting in lupus erythematosus: a 15-year experienceA Kuhn
Department of Dermatology, Heinrich-Heine-University, , Germany
J Am Acad Dermatol 45:86-95. 2001..We present phototesting results and clinical correlations of more than 400 patients with different forms of lupus erythematosus and discuss the recent advances in provocative phototesting... - Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosusV Schmitt
Department of Dermatology, University of Munster, 48149 Munster, Germany
Br J Dermatol 162:64-73. 2010..These data strongly indicate that LET should be defined as a separate entity in the classification of CLE... - Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic sclerodermaS Klein
Division of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
Ann Rheum Dis 70:1475-81. 2011..To determine the frequency and suppressive capacity of regulatory T cells (T(reg)) and their association with clinical parameters in patients with systemic scleroderma (SSc)... - Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factorsC Sunderkotter
Department of Dermatology, University of Munster, Von Esmarch Str 58, 48149 Munster, Germany
Br J Dermatol 160:835-43. 2009..For optimal management it would be useful to identify the risk factors for DU. Such statistical analyses have been rare because they require a high number of patients... - The impact of the EUSCLE Core Set Questionnaire for the assessment of cutaneous lupus erythematosusA Kuhn
Department of Dermatology, University of Muenster, Muenster, Germany
Lupus 19:1144-52. 2010..In this review, the impact of the EUSCLE Core Set Questionnaire is discussed in detail with regard to clinical and serological features as well as therapeutic modalities in CLE... - Phototherapy: a promising treatment option for skin sclerosis in scleroderma?C Sunderkotter
Department of Dermatology, University of Munster, D 48149 Munster, Germany
Rheumatology (Oxford) 45:iii52-iii54. 2006..Phototherapy thus represents a therapeutic alternative for antifibrotic treatment with a low rate of adverse effects, which should be applied before the sclerotic process has proceeded too far... - C4.4A as a candidate marker in the diagnosis of colorectal cancerC Paret
Department of Tumour Progression and Immune Defence, German Cancer Research Centre, Heidelberg, Germany
Br J Cancer 97:1146-56. 2007..By de novo expression in colonic cancer tissue, we consider C4.4A as a candidate diagnostic marker in colorectal cancer, which possibly can be detected in body fluids... - The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cellsKarin Loser
Department of Dermatology, University of Munster, Munster, Germany
Nat Med 16:713-7. 2010..These results demonstrate a link between local expression of DAMP molecules and the development of systemic autoimmunity... - The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarityKlaus Ebnet
Institute of Cell Biology, ZMBE, University of Munster, Germany
J Cell Sci 116:3879-91. 2003..Our findings suggest that JAM-2 affects endothelial cell junctions by its regulated clustering at intercellular contacts, and they support a role for JAM-2, and possibly JAM-3, in tight junction formation of endothelial cells... - FK506 controls CD40L-induced systemic autoimmunity in miceKarin Loser
Department of Dermatology, University of Munster, Munster, Germany
J Invest Dermatol 126:1307-15. 2006..Together, these findings show the beneficial therapeutic effects of FK506 for the treatment of CD40L-induced autoimmunity. Additionally, these results demonstrate that FK506 is able to suppress ongoing severe autoimmune responses... - Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skinAnnegret Kuhn
Institute of Cell Biology, ZMBE, University of Munster, Germany Department of Dermatology, University of Dusseldorf, Dusseldorf, Germany
J Invest Dermatol 119:1388-93. 2002..We found endomucin expressed on the endothelium of each tissue, concluding that this novel molecule is a new endothelial-specific marker in the study of normal and diseased human skin... - Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitopeUlrike Samulowitz
Institute of Cell Biology, ZMBE, University of Munster, Germany
Am J Pathol 160:1669-81. 2002..We conclude that human and mouse endomucin are endothelial sialomucins with the potential to function as L-selectin ligands... - Pathogenesis of cutaneous lupus erythematosusA Kuhn
Division of Immunogenetics, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
Lupus 17:389-93. 2008.... - Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cellsKarin Loser
Department of Dermatology, University of Munster, D 48149 Munster, Germany
Nat Med 12:1372-9. 2006..Therefore, environmental stimuli at the skin can rewire the local and systemic immune system by means of RANKL... - A transmembrane tight junction protein selectively expressed on endothelial cells and plateletsInes Nasdala
Institute of Cell Biology, ZMBE, University of Munster, 48149 Munster, Germany
J Biol Chem 277:16294-303. 2002..The 1G8 antigen supports homophilic interactions on transfected Chinese hamster ovary cells. Based on the similarity to the JAM molecules, it is plausible that the 1G8 antigen might be involved in interendothelial cell adhesion... - Pathophysiology of cutaneous lupus erythematosus--novel aspectsA Kuhn
Department of Dermatology, University of Dusseldorf, Germany
Rheumatology (Oxford) 45:iii14-6. 2006..Elucidation of the relevant factors might lead to future development of effective strategies to prevent abnormal reactivity in patients with CLE... - 1st International Conference on Cutaneous Lupus Erythematosus Düsseldorf, Germany, September 1-5, 2004Annegret Kuhn
Department of Dermatology, , , Germany
Autoimmun Rev 4:66-78. 2005 - Clinical manifestations of cutaneous lupus erythematosusAnnegret Kuhn
Department of Dermatology, Düsseldorf University Clinic, Dusseldorf, Germany
J Dtsch Dermatol Ges 5:1124-37. 2007..In the second part of this review, further diagnostic procedures and therapeutic strategies in patients with CLE are discussed... - Papulonodular mucinosis associated with subacute cutaneous lupus erythematosusMonika Sonntag
Department of Dermatology, Heinrich Heine University, , Germany
Dermatology 206:326-9. 2003..For the first time, to our knowledge, we describe 2 patients with subacute cutaneous LE who presented with papulonodular mucinosis as a major clinical manifestation of their disease... - New insight into immunosuppression and treatment of autoimmune diseasesM Bohm
Department of Dermatology, University of Munster, Munster, Germany
Clin Exp Rheumatol 24:S67-71. 2006..However, there is urgent need for specific immunointervention and further therapeutic options, especially for patients with autoimmune diseases in life-threatening situations and for non-responders to standard immunosuppression... - The role of nitric oxideV Kolb-Bachofen
Department of Medicine, Research Group Immunobiology, Heinrich Heine University, Dusseldorf, Germany
Rheumatology (Oxford) 45:iii17-9. 2006..Moreover, we will discuss the role of NO in pro-inflammatory diseases and the potential mechanisms of the anti-inflammatory activity of ET receptor antagonism... - Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomasC D Klemke
Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
Leukemia 20:1123-9. 2006..This lack of T(reg) might account for the more aggressive nature of Sézary syndrome compared with other CTCL... - Histopathologic findings in lupus erythematosus tumidus: review of 80 patientsAnnegret Kuhn
Departments of Dermatology at Heinrich Heine University of Düsseldorf, Dusseldorf, Germany
J Am Acad Dermatol 48:901-8. 2003..In a recent study, we demonstrated that lupus erythematosus (LE) tumidus (LET) is a distinct subset of cutaneous LE (CLE), which is clinically characterized by erythematous, urticaria-like, nonscarring plaques in sun-exposed areas... - Photosensitivity in lupus erythematosusAnnegret Kuhn
Department of Dermatology, University of Dusseldorf, Dusseldorf, Germany
Autoimmunity 38:519-29. 2005..This review summarizes the current understanding of the clinical and molecular mechanisms that initiate photosensitivity in this disease... - Diagnostic approach and treatment of cutaneous lupus erythematosusMichael Sticherling
Department of Dermatology, University of Erlangen, Germany
J Dtsch Dermatol Ges 6:48-59. 2008..Recent advances in biotechnology resulted in the development of several novel systemic agents for the treatment of autoimmune diseases; however, controlled clinical trials are still necessary for the approval of new therapies in CLE... - Multiple cytochrome P450 isozymes in murine skin: induction of P450 1A, 2B, 2E, and 3A by dexamethasoneF K Jugert
Department of Dermatology, University of Cologne, Germany
J Invest Dermatol 102:970-5. 1994.... - Cutaneous lupus erythematosus: molecular and cellular basis of clinical findingsAnnegret Kuhn
Division of Immunogenetics, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
Curr Dir Autoimmun 10:119-40. 2008..However, a complete understanding of the diverse pathophysiologic mechanisms and interactions in CLE does not exist and, as there is yet no convincing animal model of CLE, many studies remain descriptive in nature... - Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiationAnnegret Kuhn
University of Dusseldorf, Dusseldorf, Germany
Arthritis Rheum 54:939-50. 2006..To examine whether apoptosis contributes to the pathogenesis of skin lesions in patients with cutaneous lupus erythematosus (CLE) after ultraviolet (UV) irradiation... - Methotrexate treatment for refractory subacute cutaneous lupus erythematosusAnnegret Kuhn
Department of Dermatology, Heinrich-Heine-University, , Germany
J Am Acad Dermatol 46:600-3. 2002..Treatment with methotrexate resulted in complete clearing of the skin lesions without any side effects... - Lupus erythematosus tumidus in childhood. Report of 3 patientsMonika Sonntag
Department of Dermatology, Heinrich-Heine University, , Germany
Dermatology 207:188-92. 2003..The clinical, photobiological, and histologic features as well as the differential diagnoses of childhood LE tumidus are discussed and compared with the adult form of this disease... - CD127(low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral bloodSandra Klein
Tumor Immunology Program, Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 130:492-9. 2010..The data from this study have important implications for carrying out a quantitative analysis of Tregs in human samples... - A database analysis of cutaneous lupus erythematosus with the EUSCLE Core Set QuestionnaireAnna Maria Meuth
Department of Dermatology, University of Muenster, Muenster, Germany
Acta Derm Venereol 90:386-94. 2010..In conclusion, the EUSCLE Core Set Questionnaire provides a useful tool for standardized collection and statistical analysis of data on cutaneous lupus erythematosus in clinical practice... - Clearance deficiency and systemic lupus erythematosus (SLE)Udo S Gaipl
Institute for Clinical Immunology, Department of Internal Medicine 3, Friedrich Alexander University of Erlangen Nuremberg, Glückstrasse 4a, 91054 Erlangen, Germany
J Autoimmun 28:114-21. 2007..We conclude that impaired clearance in early phases of apoptosis leads to a secondary necrotic status of the cells. Danger signals are released; modified autoantigens are accessible, favouring an autoimmune reaction...