Jasmin B Kuemmerle-Deschner

Summary

Country: Germany

Publications

  1. doi request reprint [Cryopyrin-associated periodic syndrome]
    J B Kümmerle-Deschner
    Klinik fur Kinder und Jugendmedizin, Abteilung für pädiatrische Rheumatologie, Autoinflammation Reference Center Tübingen, Universitatsklinikum Tubingen, Hoppe Seyler Str 1, 72076, Tubingen, Deutschland
    Z Rheumatol 71:199-208. 2012
  2. doi request reprint Real-life effectiveness of canakinumab in cryopyrin-associated periodic syndrome
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Children s Hospital Tuebingen
    Rheumatology (Oxford) 55:689-96. 2016
  3. doi request reprint [Childhood vasculitis]
    J B Kümmerle-Deschner
    Klinik fur Kinder und Jugendmedizin, Autoinflammation Reference Center Tübingen, Universitatsklinikum Tubingen, Hoppe Seyler Str 1, 72076, Tubingen, Deutschland
    Z Rheumatol 74:863-77. 2015
  4. doi request reprint Early detection of sensorineural hearing loss in Muckle-Wells-syndrome
    Jasmin B Kuemmerle-Deschner
    Department of Pediatrics, Division of Pediatric Rheumatology, University Hospital Tuebingen, Hoppe Seyler Str 1, D 72076, Tuebingen, Germany
    Pediatr Rheumatol Online J 13:43. 2015
  5. doi request reprint CAPS--pathogenesis, presentation and treatment of an autoinflammatory disease
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Children s Hospital Tuebingen, Hoppe Seyler Strasse 1, 72076, Tuebingen, Germany
    Semin Immunopathol 37:377-85. 2015
  6. pmc Methodological challenges in monitoring new treatments for rare diseases: lessons from the cryopyrin-associated periodic syndrome registry
    Hugh Tilson
    Novartis Pharma AG, Basel, Switzerland
    Orphanet J Rare Dis 8:139. 2013
  7. pmc Abatacept in difficult-to-treat juvenile idiopathic arthritis
    Jasmin B Kuemmerle-Deschner
    Pediatric Rheumatology Clinics, Dept of Pediatrics, University Hospital Tubingen, Germany
    Biologics 2:865-74. 2008
  8. pmc NLRP3 E311K mutation in a large family with Muckle-Wells syndrome--description of a heterogeneous phenotype and response to treatment
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Dept, of Pediatrics, University Hospital Tubingen, Hoppe Seyler Straße 1, 72076 Tuebingen, Germany
    Arthritis Res Ther 13:R196. 2011
  9. ncbi request reprint Safety and efficacy of once-weekly application of Etanercept in children with juvenile idiopathic arthritis
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, University Children s Hospital Tubingen, Tubingen, Germany
    Rheumatol Int 28:153-6. 2007
  10. doi request reprint Two-year results from an open-label, multicentre, phase III study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Hospital Tubingen, Germany
    Ann Rheum Dis 70:2095-102. 2011

Collaborators

Detail Information

Publications18

  1. doi request reprint [Cryopyrin-associated periodic syndrome]
    J B Kümmerle-Deschner
    Klinik fur Kinder und Jugendmedizin, Abteilung für pädiatrische Rheumatologie, Autoinflammation Reference Center Tübingen, Universitatsklinikum Tubingen, Hoppe Seyler Str 1, 72076, Tubingen, Deutschland
    Z Rheumatol 71:199-208. 2012
    ..To prevent severe and possible life-threatening disease sequelae, early and correct diagnosis and immediate initiation of therapy are mandatory...
  2. doi request reprint Real-life effectiveness of canakinumab in cryopyrin-associated periodic syndrome
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Children s Hospital Tuebingen
    Rheumatology (Oxford) 55:689-96. 2016
    ..Limited data are available for the real-life effectiveness of canakinumab in patients living with CAPS. Therefore the aim of the study was to evaluate the real-life dosing and effectiveness of canakinumab in CAPS...
  3. doi request reprint [Childhood vasculitis]
    J B Kümmerle-Deschner
    Klinik fur Kinder und Jugendmedizin, Autoinflammation Reference Center Tübingen, Universitatsklinikum Tubingen, Hoppe Seyler Str 1, 72076, Tubingen, Deutschland
    Z Rheumatol 74:863-77. 2015
    ..In the majority of vasculitides, the etiology remains unknown. Environmental exposure, including infections, is suspected to trigger an autoinflammatory response in predisposed individuals...
  4. doi request reprint Early detection of sensorineural hearing loss in Muckle-Wells-syndrome
    Jasmin B Kuemmerle-Deschner
    Department of Pediatrics, Division of Pediatric Rheumatology, University Hospital Tuebingen, Hoppe Seyler Str 1, D 72076, Tuebingen, Germany
    Pediatr Rheumatol Online J 13:43. 2015
    ..The aims of the study were to characterize the spectrum of hearing loss, optimize the otologic assessment for early disease and determine responsiveness to anti-IL-1-therapy regarding hearing...
  5. doi request reprint CAPS--pathogenesis, presentation and treatment of an autoinflammatory disease
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Children s Hospital Tuebingen, Hoppe Seyler Strasse 1, 72076, Tuebingen, Germany
    Semin Immunopathol 37:377-85. 2015
    ..To prevent CAPS-induced organ damage, early diagnosis and swift initiation of effective treatment are mandatory. ..
  6. pmc Methodological challenges in monitoring new treatments for rare diseases: lessons from the cryopyrin-associated periodic syndrome registry
    Hugh Tilson
    Novartis Pharma AG, Basel, Switzerland
    Orphanet J Rare Dis 8:139. 2013
    ..Creative approaches to observational methodology are needed, harnessing novel registry strategies to ensure Health Care Provider reporting and patient monitoring...
  7. pmc Abatacept in difficult-to-treat juvenile idiopathic arthritis
    Jasmin B Kuemmerle-Deschner
    Pediatric Rheumatology Clinics, Dept of Pediatrics, University Hospital Tubingen, Germany
    Biologics 2:865-74. 2008
    ..Although information on ABA in JIA is still limited, available data suggest a potential role in difficult to treat JIA patients previously treated with other biologic agents and for non-responders to TNF-blockade...
  8. pmc NLRP3 E311K mutation in a large family with Muckle-Wells syndrome--description of a heterogeneous phenotype and response to treatment
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Dept, of Pediatrics, University Hospital Tubingen, Hoppe Seyler Straße 1, 72076 Tuebingen, Germany
    Arthritis Res Ther 13:R196. 2011
    ..The NLRP3/CIAS1 E311K mutation caused a heterogeneous phenotype of MWS in a large family. This study analyzes the clinical spectrum, patterns of inflammatory parameters and reports on response to treatment...
  9. ncbi request reprint Safety and efficacy of once-weekly application of Etanercept in children with juvenile idiopathic arthritis
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, University Children s Hospital Tubingen, Tubingen, Germany
    Rheumatol Int 28:153-6. 2007
    ..At last observation 10/12 patients achieved an ACR-JRA 30 and 8/12 achieved an ACR-JRA70 response. These data indicate that once weekly application of etanercept is safe and efficacous in children...
  10. doi request reprint Two-year results from an open-label, multicentre, phase III study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Hospital Tubingen, Germany
    Ann Rheum Dis 70:2095-102. 2011
    ..Longer-term effects of prolonged selective interleukin-1β blockade with canakinumab were evaluated in the largest cohort of cryopyrin-associated periodic syndrome (CAPS) patients studied to date...
  11. doi request reprint Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome
    Jasmin B Kuemmerle-Deschner
    University Hospital Tubingen, Tubingen, Germany
    Arthritis Rheum 63:840-9. 2011
    ..The recombinant IL-1 receptor antagonist anakinra blocks the biologic activity of IL-1. The aim of this study was to determine the short- and long-term efficacy and safety of anakinra therapy in children and adults with severe MWS...
  12. pmc Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)
    Jasmin B Kuemmerle-Deschner
    Division of Pediatric Rheumatology, Department of Pediatrics, University Children s Hospital Tuebingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Tuebingen, Germany
    Arthritis Res Ther 13:R34. 2011
    ..Canakinumab, a fully human anti-IL-1β antibody, produces sustained selective inhibition of IL-1β. This study was conducted to assess the efficacy, safety, and pharmacokinetics of canakinumab in the treatment of pediatric CAPS patients...
  13. doi request reprint Interferon-alpha--a new therapeutic option in refractory juvenile Behçet's disease with CNS involvement
    J B Kuemmerle-Deschner
    Division of Paediatric Rheumatology, University Children s Hospital Tuebingen, Germany
    Rheumatology (Oxford) 47:1051-3. 2008
    ..To report the successful treatment with recombinant human IFN- alpha 2a (rhIFN-alpha2a) in two male adolescents suffering from severe treatment-resistant Behçet's disease (BD) with central nervous system (CNS) involvement...
  14. doi request reprint Hearing loss in Muckle-Wells syndrome
    Jasmin B Kuemmerle-Deschner
    University Hospital Tuebingen, Tuebingen, Germany
    Arthritis Rheum 65:824-31. 2013
    ..The aims of this study were to determine the otologic characteristics of MWS, define trajectories of hearing loss, and explore the association with distinct NLRP3 genotypes...
  15. doi request reprint Progressive familial hearing loss in Muckle-Wells syndrome
    Assen Koitschev
    Department of Otorhinolaryngology, Klinikum Stuttgart, University Hospital Tubingen, Germany
    Acta Otolaryngol 132:756-62. 2012
    ..The design of further clinical trials should focus on hearing in order to document the long-term effect of anti-interleukin (IL)-1 drugs on hearing preservation...
  16. doi request reprint Challenges in diagnosing Muckle-Wells syndrome: identifying two distinct phenotypes
    Jasmin B Kuemmerle-Deschner
    University Hospital Tubingen, Tubingen, Germany
    Arthritis Care Res (Hoboken) 66:765-72. 2014
    ..The aims of this study were to describe key elements of the diagnostic evaluation process in MWS and compare identified variables between patients diagnosed in childhood and adulthood...
  17. pmc Dynamic knee joint function in children with juvenile idiopathic arthritis (JIA)
    Sandra Hansmann
    Rheumatology, General Pediatrics, Oncology and Hematology University Children s Hospital Tuebingen, Hoppe Seyler Str 1, 72076 Tubingen, Germany
    Pediatr Rheumatol Online J 13:8. 2015
    ..The aim of this study was to quantify and compare dynamic joint function in healthy and arthritic knee joints and to evaluate response to improvement...
  18. doi request reprint Inflammasome and cytokine blocking strategies in autoinflammatory disorders
    Monika Moll
    Division of Pediatric Rheumatology, Department of Pediatrics, University Children s Hospital Tuebingen, Germany
    Clin Immunol 147:242-75. 2013
    ..IL-1 inhibition to date is the most successful specific therapy in autoinflammatory disorders. Here, current treatment strategies in autoinflammatory disorders are reviewed with a focus on inflammasome and cytokine inhibition...