Rejko Kruger

Summary

Country: Germany

Publications

  1. ncbi request reprint Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
    Frank P Marx
    Department of Neurology, Laboratory of Neurodegeneration, University of Tubingen, Tubingen, Germany
    Hum Mol Genet 12:1223-31. 2003
  2. ncbi request reprint The role of synphilin-1 in synaptic function and protein degradation
    Rejko Kruger
    Neurodegeneration Laboratory, Department of General Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Cell Tissue Res 318:195-9. 2004
  3. doi request reprint A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Neurobiol Aging 32:548.e9-18. 2011
  4. pmc LRRK2 in Parkinson's disease - drawing the curtain of penetrance: a commentary
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    BMC Med 6:33. 2008
  5. pmc Vertebral artery dissection presenting with ispilateral acute C5 and C6 sensorimotor radiculopathy: A case report
    Ghazaleh Tabatabai
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Cases J 1:139. 2008
  6. ncbi request reprint Genes in familial parkinsonism and their role in sporadic Parkinson's disease
    Rejko Kruger
    Neurodegeneration Laboratory, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    J Neurol 251:VI/2-6. 2004
  7. pmc Combined STN/SNr-DBS for the treatment of refractory gait disturbances in Parkinson's disease: study protocol for a randomized controlled trial
    Daniel Weiss
    German Centre of Neurodegenerative Diseases, Tubingen, Germany
    Trials 12:222. 2011
  8. doi request reprint A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients
    Claudia Wahl
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    J Neural Transm 115:1141-8. 2008
  9. ncbi request reprint Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)
    Robert Hering
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    Hum Mutat 24:321-9. 2004
  10. ncbi request reprint Parkinson's disease: one biochemical pathway to fit all genes?
    Rejko Kruger
    Dept of Neurology, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Trends Mol Med 8:236-40. 2002

Detail Information

Publications34

  1. ncbi request reprint Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
    Frank P Marx
    Department of Neurology, Laboratory of Neurodegeneration, University of Tubingen, Tubingen, Germany
    Hum Mol Genet 12:1223-31. 2003
    ....
  2. ncbi request reprint The role of synphilin-1 in synaptic function and protein degradation
    Rejko Kruger
    Neurodegeneration Laboratory, Department of General Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Cell Tissue Res 318:195-9. 2004
    ..The present article provides an overview of the current concepts of the role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in PD...
  3. doi request reprint A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Neurobiol Aging 32:548.e9-18. 2011
    ..This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide...
  4. pmc LRRK2 in Parkinson's disease - drawing the curtain of penetrance: a commentary
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    BMC Med 6:33. 2008
    ....
  5. pmc Vertebral artery dissection presenting with ispilateral acute C5 and C6 sensorimotor radiculopathy: A case report
    Ghazaleh Tabatabai
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Cases J 1:139. 2008
    ..These symptoms completely resolved after anticoagulation and physical therapy...
  6. ncbi request reprint Genes in familial parkinsonism and their role in sporadic Parkinson's disease
    Rejko Kruger
    Neurodegeneration Laboratory, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    J Neurol 251:VI/2-6. 2004
    ..This implicates novel perspectives for neuroprotective therapeutic approaches that might be beneficial also to sporadic PD...
  7. pmc Combined STN/SNr-DBS for the treatment of refractory gait disturbances in Parkinson's disease: study protocol for a randomized controlled trial
    Daniel Weiss
    German Centre of Neurodegenerative Diseases, Tubingen, Germany
    Trials 12:222. 2011
    ..High-frequent stimulation of the substantia nigra pars reticulata preferentially modulated axial symptoms and therefore is suggested as a novel therapeutic candidate target for neuromodulation of refractory gait disturbances in PD...
  8. doi request reprint A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients
    Claudia Wahl
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    J Neural Transm 115:1141-8. 2008
    ..The identification of a genetic link between a regulatory proteasomal subunit and PD further underscores the relevance of disturbed protein degradation in PD...
  9. ncbi request reprint Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)
    Robert Hering
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    Hum Mutat 24:321-9. 2004
    ....
  10. ncbi request reprint Parkinson's disease: one biochemical pathway to fit all genes?
    Rejko Kruger
    Dept of Neurology, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Trends Mol Med 8:236-40. 2002
    ..Future identification of disease genes is required to confirm this hypothesis, thereby unifying the clinical and genetic heterogeneity of PD, including the common sporadic form of the disease, by one biochemical pathway...
  11. pmc Large-scale replication and heterogeneity in Parkinson disease genetic loci
    Manu Sharma
    Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurology 79:659-67. 2012
    ..The extent to which these genetic effects are consistent across different populations is unknown...
  12. pmc Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis
    Lena F Burbulla
    DZNE, German Center for Neurodegenerative Diseases, Tubingen, Germany
    Hum Mol Genet 19:4437-52. 2010
    ..Our results support the role of this mitochondrial chaperone in neurodegeneration and underscore the concept of impaired mitochondrial protein quality control in PD...
  13. pmc Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
    Guido Krebiehl
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e9367. 2010
    ..Although a critical role of DJ-1 in oxidative stress response and mitochondrial function has been recognized, the effects on mitochondrial dynamics and downstream consequences remain to be determined...
  14. pmc A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants
    Manu Sharma
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and DZNE German Center for Neurodegenerative Diseases, Tubingen, Hoppe Seyler Str 3, Tubingen 72076, Germany
    J Med Genet 49:721-6. 2012
    ..Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive...
  15. ncbi request reprint Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease
    Katherine J Schweitzer
    Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
    J Neurol 254:613-6. 2007
    ..As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD...
  16. doi request reprint Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease
    Manu Sharma
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Neurobiol Aging 30:1706-9. 2009
    ..In conclusion, our study did not lend support to the finding that the reported SNPs are directly influencing the susceptibility to sporadic form of PD at least in our population...
  17. doi request reprint Deep-brain-stimulation does not impair deglutition in Parkinson's disease
    Sabrina Lengerer
    Department for Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Straße 3, 72076 Tubingen, Germany
    Parkinsonism Relat Disord 18:847-53. 2012
    ..e., aspirational pneumonia. So far, little is known on how deep-brain-stimulation of the subthalamic nucleus influences deglutition in PD...
  18. doi request reprint Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease
    Manu Sharma
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tuebingen, Germany
    Neurobiol Aging 32:2108.e1-5. 2011
    ..However, taking the initial mapping of the PARK3 into account, the role of a population-specific effect warrants consideration in future studies...
  19. ncbi request reprint The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease
    Frank P Marx
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    FASEB J 21:1759-67. 2007
    ..Our data suggest a direct interaction of synphilin-1 with the regulatory complex of the proteasome modulating proteasomal function...
  20. doi request reprint Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings
    Daniel Weiss
    Center of Neurology and Hertie Institute for Clinical Brain Research, and German Center for Neurodegenerative Diseases, University of Tubingen, Germany
    Mov Disord 26:323-7. 2011
    ..Corticomuscular coherence at tremor frequency was completely suppressed by Vim-DBS. Our case study demonstrates central oscillators underlying neuropathic tremor and implies a strong pathophysiological rationale for Vim-DBS...
  21. pmc Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Nicole Kieper
    Center of Neurology and Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Exp Cell Res 316:1213-24. 2010
    ..Our results underscore a critical role of impaired mitochondrial dynamics in neurodegenerative disorders...
  22. ncbi request reprint Mutation analysis of the neurofilament M gene in Parkinson's disease
    Rejko Kruger
    Department of Neurology, Neurodegeneration Laboratory, University of Tubingen, Hoppe Seyler Strasse 3, D 72076, Tubingen, Germany
    Neurosci Lett 351:125-9. 2003
    ..However, rare variants of the NF-M gene may act as susceptibility factors for PD and functional analyses of the identified variations are warranted to decipher possible mechanisms in neurodegeneration...
  23. pmc Effects of subthalamic nucleus stimulation on emotional prosody comprehension in Parkinson's disease
    Carolin Brück
    Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    PLoS ONE 6:e19140. 2011
    ..Accordingly, the objective of this study was to evaluate the effect of subthalamic nucleus (STN) stimulation on prosody processing...
  24. doi request reprint Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages
    Silke Nuber
    Department of Medical Genetics, University of Tuebingen, Germany
    Neurobiol Dis 44:192-204. 2011
    ..These modulations of neurotransmission may underlie in part some of the early neuropsychiatric symptoms in PD preceding dysfunction of the nigrostriatal dopaminergic system...
  25. doi request reprint Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease
    Anne S Soehn
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Neurogenetics 11:203-15. 2010
    ..Searching for mutations in the periphilin gene, we detected a K69E substitution in two patients of a PD family. Taken together, these findings support for the first time an involvement of periphilin in PD...
  26. ncbi request reprint Spectrum of phenotypes and genotypes in Parkinson's disease
    Olaf Riess
    Department of Medical Genetics, University Tübingen, Calwerstrasse 7, 72074 Tubingen, Germany
    J Neurol 249:III/15-20. 2002
    ..The recent identification of mutations in three genes involved in protein degradation and aggregation in familial PD does now facilitate the deciphering of other genes involved in the pathogenesis of the disease...
  27. ncbi request reprint Functional relevance of ceruloplasmin mutations in Parkinson's disease
    Helmine Hochstrasser
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    FASEB J 19:1851-3. 2005
    ..Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD...
  28. doi request reprint Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease
    Lena F Burbulla
    Laboratory of Functional Neurogenomics, Center of Neurology, Hertie Institute for Clinical Brain Research and German Research Center for Neurodegenerative Diseases DZNE, University of Tubingen, Tubingen, Germany
    J Neurol Sci 306:1-8. 2011
    ....
  29. doi request reprint Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice
    Silke Nuber
    Department of Medical Genetics, University of Tubingen, Calwerstr 7, 72076 Tubingen, Germany
    Neurogenetics 11:107-20. 2010
    ..These findings suggest a pathological role of overexpressed synphilin-1 in vivo and will help to further elucidate the mechanisms of protein aggregation and neuronal cell death...
  30. doi request reprint Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease
    Carola Schiesling
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 34:255-71. 2008
    ..Thus in the present review, we discuss clues from familial PD to our understanding of the molecular pathogenesis of neurodegeneration with special consideration of the variable clinical and neuropathological aspects...
  31. doi request reprint Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism
    Christian Plewnia
    Department of Psychiatry and Psychotherapy, Neurophysiology and Interventional Neuropsychiatry, University of Tubingen, Germany
    Cortex 49:1801-7. 2013
    ..In this study, we hypothesized that the COMT Met allele homozygosity, associated with higher levels of prefrontal dopamine, would influence the effect of tDCS on higher-level executive functions...
  32. ncbi request reprint Therapeutic strategies for Parkinson's disease based on data derived from genetic research
    Olaf Riess
    Department of Medical Genetics, University of Tubingen, Calwer Strasse 7, 72076 Tubingen, Germany
    J Neurol 250:I3-10. 2003
    ....
  33. ncbi request reprint Acute parkinsonism with corresponding lesions in the basal ganglia after heroin abuse
    Walter Mätzler
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Neurology 68:414. 2007
  34. doi request reprint Involuntary eyelid closure after STN-DBS: evidence for different pathophysiological entities
    Daniel Weiss
    Center of Neurology, Hertie Institute for Clinical Brain Research, and German Center for Neurodegenerative Diseases DZNE, University of Tubingen, Tubingen, Germany
    J Neurol Neurosurg Psychiatry 81:1002-7. 2010
    ..To gain insight into the hitherto undefined pathophysiology of IEC after STN-DBS, we performed a comprehensive clinical and electrophysiological characterisation of lid function in a total of six PD patients...