Dietmar Krex

Summary

Country: Germany

Publications

  1. ncbi request reprint Long-term survival with glioblastoma multiforme
    Dietmar Krex
    Department of Neurosurgery, Carl Gustav Carus University Hospital, University of Technology, Dresden, Germany
    Brain 130:2596-606. 2007
  2. doi request reprint Is there pseudoprogression in secondary glioblastomas?
    Tareq A Juratli
    Department of Neurosurgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany Electronic address
    Int J Radiat Oncol Biol Phys 87:1094-9. 2013
  3. pmc Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas
    Tareq A Juratli
    Department of Neurosurgery, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    Neuro Oncol 15:682-90. 2013
  4. ncbi request reprint Extended single nucleotide polymorphism and haplotype analysis of the elastin gene in Caucasians with intracranial aneurysms provides evidence for racially/ethnically based differences
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Cerebrovasc Dis 18:104-10. 2004
  5. doi request reprint Current status of local therapy in malignant gliomas--a clinical review of three selected approaches
    Tareq A Juratli
    Department of Neurosurgery, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Pharmacol Ther 139:341-58. 2013
  6. doi request reprint IDH mutations as an early and consistent marker in low-grade astrocytomas WHO grade II and their consecutive secondary high-grade gliomas
    Tareq A Juratli
    University Hospital Dresden, Dresden, Germany
    J Neurooncol 108:403-10. 2012
  7. ncbi request reprint The role of endothelial nitric oxide synthase (eNOS) genetic variants in European patients with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, Carl Gustav Carus Hospital of University of Technology, Dresden, Germany
    J Cereb Blood Flow Metab 26:1250-5. 2006
  8. pmc Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing
    Sophie Eisenreich
    Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 8:e76623. 2013
  9. doi request reprint RET-protooncogene variants in patients with sporadic neoplasms of the digestive tract and the central nervous system
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr, Dresden, Germany
    Int J Colorectal Dis 26:835-40. 2011
  10. ncbi request reprint Tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphisms in a Caucasian population with abdominal aortic aneurysm
    Irene Hinterseher
    Department of Visceral, Thoracic and Vascular Surgery, Medical School of the Technical University of Dresden, Fetscherstr, 74 D 01307 Dresden, Germany
    World J Surg 31:2248-54. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Long-term survival with glioblastoma multiforme
    Dietmar Krex
    Department of Neurosurgery, Carl Gustav Carus University Hospital, University of Technology, Dresden, Germany
    Brain 130:2596-606. 2007
    ....
  2. doi request reprint Is there pseudoprogression in secondary glioblastomas?
    Tareq A Juratli
    Department of Neurosurgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany Electronic address
    Int J Radiat Oncol Biol Phys 87:1094-9. 2013
    ..Therefore, the goal of this study was to evaluate the frequency of PP in sGBM...
  3. pmc Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas
    Tareq A Juratli
    Department of Neurosurgery, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    Neuro Oncol 15:682-90. 2013
    ..To determine whether accumulation of 2-hydroxyglutarate in IDH-mutated low-grade gliomas (LGG; WHO grade II) correlates with their malignant transformation and to evaluate changes in metabolite levels during malignant progression...
  4. ncbi request reprint Extended single nucleotide polymorphism and haplotype analysis of the elastin gene in Caucasians with intracranial aneurysms provides evidence for racially/ethnically based differences
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Cerebrovasc Dis 18:104-10. 2004
    ..Recently, the genetic locus around the elastin gene (7q11) has been identified as linked to IA in a Japanese population. Our aim was to confirm these results in Caucasian populations...
  5. doi request reprint Current status of local therapy in malignant gliomas--a clinical review of three selected approaches
    Tareq A Juratli
    Department of Neurosurgery, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Pharmacol Ther 139:341-58. 2013
    ..Thus, we have to learn from our mistakes in the past and we strongly encourage future developments in this field. ..
  6. doi request reprint IDH mutations as an early and consistent marker in low-grade astrocytomas WHO grade II and their consecutive secondary high-grade gliomas
    Tareq A Juratli
    University Hospital Dresden, Dresden, Germany
    J Neurooncol 108:403-10. 2012
    ..The presence of IDH mutations fails to demonstrate a significant influence on survival in the multivariate analysis of LGA patients. Early RT appears to be beneficial only LGA patients with IDH-mutations...
  7. ncbi request reprint The role of endothelial nitric oxide synthase (eNOS) genetic variants in European patients with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, Carl Gustav Carus Hospital of University of Technology, Dresden, Germany
    J Cereb Blood Flow Metab 26:1250-5. 2006
    ..No single haplotype was significantly associated with the phenotype of an IA. The -786T>C, 894G>T, and 27-bp VNTR genetic variants of the eNOS gene are not associated with IA in the European population...
  8. pmc Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing
    Sophie Eisenreich
    Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 8:e76623. 2013
    ..In conclusion, the high frequency and the spectrum of CIC mutations in our 1p/19q-codeleted tumor cohort support the hypothesis that CIC acts as a tumor suppressor in these tumors, whereas FUBP1 might play only a minor role. ..
  9. doi request reprint RET-protooncogene variants in patients with sporadic neoplasms of the digestive tract and the central nervous system
    Felix Ruckert
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr, Dresden, Germany
    Int J Colorectal Dis 26:835-40. 2011
    ..The aim of this study was to evaluate if germline variants of the RET protooncogene are associated with GBM, pancreatic cancer and gastric cancer (GC)...
  10. ncbi request reprint Tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphisms in a Caucasian population with abdominal aortic aneurysm
    Irene Hinterseher
    Department of Visceral, Thoracic and Vascular Surgery, Medical School of the Technical University of Dresden, Fetscherstr, 74 D 01307 Dresden, Germany
    World J Surg 31:2248-54. 2007
    ..This case control study was designed to investigate the possible impact of genetic variants of the TIMP-1 gene in the etiology of AAA...
  11. pmc End-of-life caregivers' perception of medical and psychological support during the final weeks of glioma patients: a questionnaire-based survey
    Oliver Heese
    Department of Neurological Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuro Oncol 15:1251-6. 2013
    ..To obtain information about this period, we surveyed caregivers of patients who were registered in the German Glioma Network and who died from the disease...
  12. doi request reprint Favorable outcome in the elderly cohort treated by concomitant temozolomide radiochemotherapy in a multicentric phase II safety study of 5-ALA
    Walter Stummer
    Department of Neurosurgery, Westfalische Wilhelms Universitat, Albert Schweizer Street 33, Munster, Germany
    J Neurooncol 103:361-70. 2011
    ..Thus, older patients should not generally be excluded from accepted therapies (fluorescence-guided resection plus RT/TMZ)...
  13. ncbi request reprint Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Stroke 34:2817-21. 2003
    ..Their activity is controlled predominantly by tissue inhibitors of metalloproteinases (TIMPs). To investigate the possible impact of genetic variants within the genes encoding TIMP-1, -2, and -3, we conducted this case-control study...
  14. ncbi request reprint Matrix metalloproteinase-9 coding sequence single-nucleotide polymorphisms in caucasians with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Neurosurgery 55:207-12; discussion 212-3. 2004
    ..We performed a case-control study to investigate whether single-nucleotide polymorphisms (SNPs) within the coding region of the MMP-9 gene might affect the development of intracranial aneurysms...
  15. ncbi request reprint Genetic analysis of a multifocal glioblastoma multiforme: a suitable tool to gain new aspects in glioma development
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Neurosurgery 53:1377-84; discussion 1384. 2003
    ..The molecular background of these lesions is unknown. However, the ability to study multiple lesions of one patient simultaneously could provide new aspects in glioma development...
  16. doi request reprint Postoperative cerebellar mutism in adult patients with Lhermitte-Duclos disease
    Ali Afshar-Oromieh
    Department of Neurosurgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    Neurosurg Rev 33:401-8. 2010
    ....
  17. pmc 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations
    Seung Gi Jin
    Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cancer Res 71:7360-5. 2011
    ..In addition, a lack of 5hmC may become a useful biomarker for cancer diagnosis...
  18. ncbi request reprint Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Cerebrovasc Dis 16:363-8. 2003
    ..We conducted a case-control study to investigate the relationship of five polymorphisms of the P22PHOX gene and the occurrence of cerebral aneurysms...
  19. ncbi request reprint Physical and functional characterization of the human LGI1 gene and its possible role in glioma development
    Dietmar Krex
    Department of Neurosurgery, Universitatsklinikum Carl Gustav Carus, University of Technology, Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Acta Neuropathol 103:255-66. 2002
    ..In addition, that the effect is lacking after retroviral gene transfer in cell culture suggests that binding of some kind of a ligand is essential for its biological activity...
  20. ncbi request reprint The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease
    Hagen B Huttner
    Tissue Engineering Laboratories, Biotechnology Center BIOTEC, Technische Universitat Dresden, Tatzberg 47 51, 01307 Dresden, Germany
    Stem Cells 26:698-705. 2008
    ..Hence, analysis of CSF for membrane particles carrying the somatic stem cell marker prominin-1/CD133 offers a novel approach for studying human central nervous system disease...
  21. ncbi request reprint RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential
    Candice Elam
    Department of Cell and Cancer Biology, National Cancer Institute, 9610 Medical Center Drive, Rockville, MD 20820, USA
    Cancer Res 65:3117-25. 2005
    ..Thus, we identify a new member of the Ras superfamily that can serve as a potential tumor suppressor...
  22. ncbi request reprint Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas
    Luke Hesson
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, UK
    Oncogene 23:2408-19. 2004
    ..In addition, RASSF1A and BLU methylation appear to be independent and specific events and not due to region-wide changes in DNA methylation...
  23. ncbi request reprint Frequent epigenetic inactivation of the SLIT2 gene in gliomas
    Ashraf Dallol
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, UK
    Oncogene 22:4611-6. 2003
    ..2. Furthermore, our data suggest that a detailed analysis of both the cancer genome and epigenome will be required to identify key TSGs involved in glioma development...
  24. ncbi request reprint Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?
    Michael Weller
    Department of General Neurology, University of Tubingen, Tubingen, Germany
    Clin Cancer Res 13:6933-7. 2007
    ..Importantly, the possible effect of combined 1p/19q loss has not been studied in patients who were not treated with radiotherapy or chemotherapy...