- Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulinC Krasel
Institut fur Pharmakologie und Toxikologie, Versbacher Str 9, D 97078 Wurzburg, Germany
J Biol Chem 276:1911-5. 2001..This inhibition was almost completely abolished in vitro when GRK2 was phosphorylated by PKC. These data suggest that calmodulin may be an inhibitor of GRK2 whose effects can be abolished with PKC-mediated phosphorylation of GRK2...
- Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related proteinJ P Vilardaga
Department of Pharmacology, Institute of Pharmacology and Toxicology, University of Wurzburg, D 97078 Wurzburg, Germany
J Biol Chem 276:33435-43. 2001..Furthermore, PTHR sequestration does not appear to require G protein activation...
- Kinetics of G-protein-coupled receptor signalling and desensitizationC Krasel
Institute for Pharmacology and Toxicology, Versbacher Str 9, D 97078 Wurzburg, Germany
Biochem Soc Trans 32:1029-31. 2004..Using these methods, we show that receptor activation by agonists and signalling to G-proteins occur on the subsecond time scale, whereas receptor desensitization is limited by receptor phosphorylation and proceeds more slowly...