Michael L Kramer

Summary

Country: Germany

Publications

  1. ncbi A new multiphasic buffer system for benzyldimethyl-n-hexadecylammonium chloride polyacrylamide gel electrophoresis of proteins providing efficient stacking
    Michael L Kramer
    Prion and Dementia Research Unit, University of Goettingen, Goettingen, Germany
    Electrophoresis 27:347-56. 2006
  2. ncbi Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    Michael L Kramer
    Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, 37075 Goettingen, Germany
    J Neurosci 27:1405-10. 2007
  3. ncbi Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay
    Michael L Kramer
    Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, Goettingen, Germany
    Biotechniques 44:403-11. 2008
  4. ncbi Prion protein binds copper within the physiological concentration range
    M L Kramer
    Department of Neuropathology, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    J Biol Chem 276:16711-9. 2001
  5. ncbi Prion protein helix1 promotes aggregation but is not converted into beta-sheet
    Jens Watzlawik
    Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, 37075 Goettingen, Germany
    J Biol Chem 281:30242-50. 2006
  6. ncbi Modulation of L-type voltage-gated calcium channels by recombinant prion protein
    Stefan Korte
    Department of Neuropathology, , , Germany
    J Neurochem 87:1037-42. 2003
  7. ncbi Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain
    Heike Siebert
    Institute of Neuropathology, University Medical Centre Goettingen, Goettingen, Germany
    J Neurochem 114:1007-18. 2010

Collaborators

Detail Information

Publications7

  1. ncbi A new multiphasic buffer system for benzyldimethyl-n-hexadecylammonium chloride polyacrylamide gel electrophoresis of proteins providing efficient stacking
    Michael L Kramer
    Prion and Dementia Research Unit, University of Goettingen, Goettingen, Germany
    Electrophoresis 27:347-56. 2006
    ..Due to efficient focusing of the introduced tracking dye, methyl green, termination of electrophoresis can now be more easily followed as compared to the Schlieren line...
  2. ncbi Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    Michael L Kramer
    Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, 37075 Goettingen, Germany
    J Neurosci 27:1405-10. 2007
    ..This concept may also be valid for Parkinson's disease...
  3. ncbi Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay
    Michael L Kramer
    Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, Goettingen, Germany
    Biotechniques 44:403-11. 2008
    ..Since it detects the pathological isoform instead of surrogate markers, the PAF assay may have also potential in diagnosis of PD and DLB...
  4. ncbi Prion protein binds copper within the physiological concentration range
    M L Kramer
    Department of Neuropathology, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    J Biol Chem 276:16711-9. 2001
    ..This argues strongly for a direct role of the prion protein in copper metabolism, since it is almost saturated at about 5 microm, and the exchangeable copper pool concentration in blood is about 8 microm...
  5. ncbi Prion protein helix1 promotes aggregation but is not converted into beta-sheet
    Jens Watzlawik
    Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, 37075 Goettingen, Germany
    J Biol Chem 281:30242-50. 2006
    ..In conclusion, we provide strong direct evidence that in contrast to earlier assumptions helix1 is not converted into beta-sheet during aggregation of PrP(C) to PrP(Sc)...
  6. ncbi Modulation of L-type voltage-gated calcium channels by recombinant prion protein
    Stefan Korte
    Department of Neuropathology, , , Germany
    J Neurochem 87:1037-42. 2003
    ..These data demonstrate that nanomolar concentrations of PrPC modulate L-type VGCCs in mouse cerebellar granule cells, an effect that is dependent upon the copper-binding amino-terminal domain of PrPC...
  7. ncbi Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain
    Heike Siebert
    Institute of Neuropathology, University Medical Centre Goettingen, Goettingen, Germany
    J Neurochem 114:1007-18. 2010
    ..alpha-Synuclein transgenic mice represent an appropriate model for investigations on axonal transport in neurodegenerative diseases...