Research Topics
| Christoph KrafftSummaryCountry: Germany Publications
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Detail Information
Publications
Disease recognition by infrared and Raman spectroscopyChristoph Krafft
Bioanalytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
J Biophotonics 2:13-28. 2009..The selected topics include tumors of epithelial tissue, brain tumors, prion diseases, bone diseases, atherosclerosis, kidney stones and gallstones, skin tumors, diabetes and osteoarthritis...- Advances in optical biopsy - correlation of malignancy and cell density of primary brain tumors using Raman microspectroscopic imagingChristoph Krafft
Institute of Photonic Technology, Albert Einstein Str 9, 07745 Jena, Germany
Analyst 137:5533-7. 2012..The results demonstrate how morphology and chemical composition obtained by Raman imaging correlate with histopathology and provide complementary, diagnostically relevant information at the cellular level... 
Distribution of amygdalin in apricot (Prunus armeniaca) seeds studied by Raman microscopic imagingChristoph Krafft
Institute of Photonic Technology, Jena, Germany
Appl Spectrosc 66:644-9. 2012..The observed biological variability of the amygdalin distribution cannot yet be explained satisfactorily and requires further investigation...- Nonlinear microscopy, infrared, and Raman microspectroscopy for brain tumor analysisTobias Meyer
Institute of Photonic Technology e V, Albert Einstein Strasse 9, 07745 Jena, Germany
J Biomed Opt 16:021113. 2011..Hence label-free vibrational microspectroscopic imaging is a promising tool for fast and precise in vivo diagnostics of brain tumors... - Unsupervised unmixing of Raman microspectroscopic images for morphochemical analysis of non-dried brain tumor specimensNorbert Bergner
Institute of Photonic Technology, Albert Einstein Straße 9, 07745, Jena, Germany
Anal Bioanal Chem 403:719-25. 2012..The results are compared for both unmixing algorithms and with previously reported supervised spectral decomposition techniques... - Methodology for fiber-optic Raman mapping and FTIR imaging of metastases in mouse brainsChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, 01062, Dresden, Germany
Anal Bioanal Chem 389:1133-42. 2007..Possible reasons why metastatic cells of malignant melanomas were not identified in FTIR images are discussed... - Classification of malignant gliomas by infrared spectroscopy and linear discriminant analysisChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Biopolymers 82:301-5. 2006..The high success rate demonstrates that IR spectroscopy can complement established methods such as histopathology or immunohistochemistry to characterize dried cryosections... - Classification of malignant gliomas by infrared spectroscopic imaging and linear discriminant analysisChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Anal Bioanal Chem 387:1669-77. 2007..Potential applications of IR spectroscopic imaging as a rapid tool to complement established diagnostic methods are discussed... - Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applicationsChristoph Krafft
Institute of Photonic Technology Jena, Albert Einstein Straße 9, 07745 Jena, Germany
J Biomed Opt 17:040801. 2012..Thereby, we aim at presenting a guide into one exciting branch of modern biophotonics research... - Multimodal imaging to study the morphochemistry of basal cell carcinomaNadine Vogler
Institute of Photonic Technology Jena, Albert Einstein Straße 9, 07745 Jena, Germany
J Biophotonics 3:728-36. 2010..The joint information content obtained by such multimodal approach in studying various aspects of the malignant tissue alterations associated with basal cell carcinoma is discussed... - Interpreting CARS images of tissue within the C-H-stretching regionTobias Meyer
Institute of Photonic Technology e V, Albert Einstein Straße 9, 07745 Jena, Germany
J Biophotonics 5:729-33. 2012.... - Identification of primary tumors of brain metastases by infrared spectroscopic imaging and linear discriminant analysisChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Technol Cancer Res Treat 5:291-8. 2006..These data trained a supervised classification model based on linear discriminant analysis that was used to identify the origin of 20 cryosections including one brain metastasis with an unknown primary tumor... - Suitability of infrared spectroscopic imaging as an intraoperative tool in cerebral glioma surgeryStephan B Sobottka
Department of Neurosurgery, University Hospital, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
Anal Bioanal Chem 393:187-95. 2009..This retrospective study clearly demonstrates that infrared spectroscopic imaging may help to define tumor margins intraoperatively and to detect high-grade tumor residues for achieving more radical tumor resection... - Identification of primary tumors of brain metastases by SIMCA classification of IR spectroscopic imagesChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Biochim Biophys Acta 1758:883-91. 2006..All specimens were assigned to the correct tissue class. This proof-of-concept study demonstrates that IR spectroscopy can complement established methods such as histopathology or immunohistochemistry for diagnosis... - Characterization of atherosclerotic plaque depositions by Raman and FTIR imagingAnnika Lattermann
University Hospital Friedrich Schiller University of Jena, Clinic for Internal Medicine I, Jena, Germany
J Biophotonics 6:110-21. 2013..These results correlate well with histopathology. The described method is a promising tool for easy and fast molecular imaging of atherosclerosis... - Quantification of brain lipids by FTIR spectroscopy and partial least squares regressionIsabell Dreissig
Bioanalytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Spectrochim Acta A Mol Biomol Spectrosc 71:2069-75. 2009..The composition of lipid extracts that were predicted by the PLS regression of IR spectra was compared with lipid quantification by thin layer chromatography... - Raman spectroscopic imaging for in vivo detection of cerebral brain metastasesMatthias Kirsch
Department of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
Anal Bioanal Chem 398:1707-13. 2010..Future investigations aim to reduce the exposure time from minutes to seconds and improve the lateral resolution... - Near infrared Raman spectroscopic mapping of native brain tissue and intracranial tumorsChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Analyst 130:1070-7. 2005..The results constitute a basis for subsequent Raman studies to develop classification models for diagnosis of brain tissue... - Characterization of lipid extracts from brain tissue and tumors using Raman spectroscopy and mass spectrometryMilena Köhler
Institute for Analytical Chemistry, Dresden University of Technology, 01062, Dresden, Germany
Anal Bioanal Chem 393:1513-20. 2009..This study demonstrates how to improve the analysis of brain tumors and to complement the diagnosis of brain pathologies using a multimodal approach... - Sample size planning for classification modelsClaudia Beleites
Department of Spectroscopy and Imaging, Institute of Photonic Technology, Jena, Germany
Anal Chim Acta 760:25-33. 2013.... - Noninvasive imaging of intracellular lipid metabolism in macrophages by Raman microscopy in combination with stable isotopic labelingChristian Matthäus
Institute of Photonic Technology, Albert Einstein Straße, 9, 07745 Jena, Germany
Anal Chem 84:8549-56. 2012..5, 1, 3, 6, 24, 30, and 36 h. This approach may also allow for investigating the cellular trafficking of other molecules, such as nutrients, metabolites, and drugs... - In vivo characterization of atherosclerotic plaque depositions by Raman-probe spectroscopy and in vitro coherent anti-stokes Raman scattering microscopic imaging on a rabbit modelChristian Matthäus
Institute of Photonic Technology, Jena, Germany
Anal Chem 84:7845-51. 2012..In order to further characterize the plaque depositions visually, coherent anti-Stokes Raman scattering (CARS) microscopy images have been acquired and are compared with the Raman-probe results... - Identification and differentiation of single cells from peripheral blood by Raman spectroscopic imagingUte Neugebauer
Institute of Photonic Technology, Jena, Germany
J Biophotonics 3:579-87. 2010..The model was successfully applied to identify single cells from an independent mixture of cells based on their vibrational spectra. The classification was confirmed by fluorescence staining of the cells after the Raman measurement... - Raman and CARS microspectroscopy of cells and tissuesChristoph Krafft
Institute of Photonic Technology, Albert Einstein Str 9, 07745 Jena, Germany
Analyst 134:1046-57. 2009.... - Differentiation of individual human mesenchymal stem cells probed by FTIR microscopic imagingChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, D 01062 Dresden, Germany
Analyst 132:647-53. 2007..This study demonstrated for the first time that FTIR microscopic imaging can probe stem cell differentiation at the single cell level rapidly, non-destructively and with minimal preparation... - Classification of inflammatory bowel diseases by means of Raman spectroscopic imaging of epithelium cellsChristiane Bielecki
University Hospital Jena, Department of Internal Medicine II, Division of Gastroenterology, Hepatology, and Infectious Diseases, Jena, Germany
J Biomed Opt 17:076030. 2012.... - Spatially resolved determination of the structure and composition of diatom cell walls by Raman and FTIR imagingMartin Kammer
Bioanalytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Anal Bioanal Chem 398:509-17. 2010..The results reveal local differences in the cell wall composition of the honeycomb-like structures and the bottom layer... - Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environmentsSebastian Dochow
Institute of Photonic Technology, Jena, Germany
Lab Chip 11:1484-90. 2011..Implementation into microfluidic environments enables a high degree of automation that is required to improve the throughput of the approach for Raman activated cell sorting... - Raman and FTIR microscopic imaging of colon tissue: a comparative studyChristoph Krafft
Dresden University of Technology, 01062 Dresden, Germany
J Biophotonics 1:154-69. 2008..5 microm from three ganglia that belong to the myenteric plexus. The results are discussed with respect to lateral resolution, spectral resolution, acquisition time and sensitivity of both modalities... - A comparative Raman and CARS imaging study of colon tissueChristoph Krafft
Institute of Photonic Technology, Germany, Albert Einstein Str 9, 07745 Jena, Germany
J Biophotonics 2:303-12. 2009..This first comparison establishes the foundation for further development of the CARS technology to assess tissue... - Delimitation of squamous cell cervical carcinoma using infrared microspectroscopic imagingWolfram Steller
Institute for Analytical Chemistry, Dresden University of Technology, 01062, Dresden, Germany
Anal Bioanal Chem 384:145-54. 2006.... - Near infrared Raman spectra of human brain lipidsChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Spectrochim Acta A Mol Biomol Spectrosc 61:1529-35. 2005..We recorded Raman spectra of the 12 major and minor brain lipids with 785 nm excitation in order to identify their spectral fingerprints for qualitative and quantitative analyses... - Studies on stress-induced changes at the subcellular level by Raman microspectroscopic mappingChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, D 01062 Dresden, Germany
Anal Chem 78:4424-9. 2006..The results demonstrate that Raman spectroscopic mapping might become a powerful tool in cell biology for single cell analysis... - Identification of B and T cells in human spleen sections by infrared microspectroscopic imagingChristoph Krafft
Institute for Analytical Chemistry, Dresden University of Technology, Dresden, Germany
Cytometry A 64:53-61. 2005..We analyzed whether this method is competitive with classic immunohistochemical methods for immunologic tissue and cells... - Multicore fiber with integrated fiber Bragg gratings for background-free Raman sensingSebastian Dochow
Institute of Photonic Technology Jena e V, Albert Einstein Str 9, 07745 Jena, Germany
Opt Express 20:20156-69. 2012..The probe was characterized regarding Raman background suppression, collection efficiency, and distance dependence. First Raman measurements on brain tissue are presented... - Analysis of human brain tissue, brain tumors and tumor cells by infrared spectroscopic mappingChristoph Krafft
Institute of Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
Analyst 129:921-5. 2004..As this parameter correlated with the grade of gliomas obtained from standard histopathological examination, it was applied to classify brain tissue sections based on IR spectroscopic mapping...