Christoph Krafft

Summary

Country: Germany

Publications

  1. doi request reprint Disease recognition by infrared and Raman spectroscopy
    Christoph Krafft
    Bioanalytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    J Biophotonics 2:13-28. 2009
  2. doi request reprint Advances in optical biopsy - correlation of malignancy and cell density of primary brain tumors using Raman microspectroscopic imaging
    Christoph Krafft
    Institute of Photonic Technology, Albert Einstein Str 9, 07745 Jena, Germany
    Analyst 137:5533-7. 2012
  3. ncbi request reprint Distribution of amygdalin in apricot (Prunus armeniaca) seeds studied by Raman microscopic imaging
    Christoph Krafft
    Institute of Photonic Technology, Jena, Germany
    Appl Spectrosc 66:644-9. 2012
  4. doi request reprint Characterization of atherosclerotic plaque depositions by Raman and FTIR imaging
    Annika Lattermann
    University Hospital Friedrich Schiller University of Jena, Clinic for Internal Medicine I, Jena, Germany
    J Biophotonics 6:110-21. 2013
  5. doi request reprint Nonlinear microscopy, infrared, and Raman microspectroscopy for brain tumor analysis
    Tobias Meyer
    Institute of Photonic Technology e V, Albert Einstein Strasse 9, 07745 Jena, Germany
    J Biomed Opt 16:021113. 2011
  6. doi request reprint Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles
    Sebastian Dochow
    Institute of Photonic Technology IPHT, Albert Einstein Strasse 9, 07745 Jena, Germany
    Lab Chip 13:1109-13. 2013
  7. doi request reprint Unsupervised unmixing of Raman microspectroscopic images for morphochemical analysis of non-dried brain tumor specimens
    Norbert Bergner
    Institute of Photonic Technology, Albert Einstein Straße 9, 07745, Jena, Germany
    Anal Bioanal Chem 403:719-25. 2012
  8. doi request reprint Interpreting CARS images of tissue within the C-H-stretching region
    Tobias Meyer
    Institute of Photonic Technology e V, Albert Einstein Straße 9, 07745 Jena, Germany
    J Biophotonics 5:729-33. 2012
  9. doi request reprint Noninvasive imaging of intracellular lipid metabolism in macrophages by Raman microscopy in combination with stable isotopic labeling
    Christian Matthäus
    Institute of Photonic Technology, Albert Einstein Straße, 9, 07745 Jena, Germany
    Anal Chem 84:8549-56. 2012
  10. ncbi request reprint Classification of malignant gliomas by infrared spectroscopy and linear discriminant analysis
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Biopolymers 82:301-5. 2006

Collaborators

Detail Information

Publications41

  1. doi request reprint Disease recognition by infrared and Raman spectroscopy
    Christoph Krafft
    Bioanalytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    J Biophotonics 2:13-28. 2009
    ..The selected topics include tumors of epithelial tissue, brain tumors, prion diseases, bone diseases, atherosclerosis, kidney stones and gallstones, skin tumors, diabetes and osteoarthritis...
  2. doi request reprint Advances in optical biopsy - correlation of malignancy and cell density of primary brain tumors using Raman microspectroscopic imaging
    Christoph Krafft
    Institute of Photonic Technology, Albert Einstein Str 9, 07745 Jena, Germany
    Analyst 137:5533-7. 2012
    ..The results demonstrate how morphology and chemical composition obtained by Raman imaging correlate with histopathology and provide complementary, diagnostically relevant information at the cellular level...
  3. ncbi request reprint Distribution of amygdalin in apricot (Prunus armeniaca) seeds studied by Raman microscopic imaging
    Christoph Krafft
    Institute of Photonic Technology, Jena, Germany
    Appl Spectrosc 66:644-9. 2012
    ..The observed biological variability of the amygdalin distribution cannot yet be explained satisfactorily and requires further investigation...
  4. doi request reprint Characterization of atherosclerotic plaque depositions by Raman and FTIR imaging
    Annika Lattermann
    University Hospital Friedrich Schiller University of Jena, Clinic for Internal Medicine I, Jena, Germany
    J Biophotonics 6:110-21. 2013
    ..These results correlate well with histopathology. The described method is a promising tool for easy and fast molecular imaging of atherosclerosis...
  5. doi request reprint Nonlinear microscopy, infrared, and Raman microspectroscopy for brain tumor analysis
    Tobias Meyer
    Institute of Photonic Technology e V, Albert Einstein Strasse 9, 07745 Jena, Germany
    J Biomed Opt 16:021113. 2011
    ..Hence label-free vibrational microspectroscopic imaging is a promising tool for fast and precise in vivo diagnostics of brain tumors...
  6. doi request reprint Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles
    Sebastian Dochow
    Institute of Photonic Technology IPHT, Albert Einstein Strasse 9, 07745 Jena, Germany
    Lab Chip 13:1109-13. 2013
    ..Furthermore, our device was combined with optical traps to collect Raman-on-chip spectra of spherical polymer beads...
  7. doi request reprint Unsupervised unmixing of Raman microspectroscopic images for morphochemical analysis of non-dried brain tumor specimens
    Norbert Bergner
    Institute of Photonic Technology, Albert Einstein Straße 9, 07745, Jena, Germany
    Anal Bioanal Chem 403:719-25. 2012
    ..The results are compared for both unmixing algorithms and with previously reported supervised spectral decomposition techniques...
  8. doi request reprint Interpreting CARS images of tissue within the C-H-stretching region
    Tobias Meyer
    Institute of Photonic Technology e V, Albert Einstein Straße 9, 07745 Jena, Germany
    J Biophotonics 5:729-33. 2012
    ....
  9. doi request reprint Noninvasive imaging of intracellular lipid metabolism in macrophages by Raman microscopy in combination with stable isotopic labeling
    Christian Matthäus
    Institute of Photonic Technology, Albert Einstein Straße, 9, 07745 Jena, Germany
    Anal Chem 84:8549-56. 2012
    ..5, 1, 3, 6, 24, 30, and 36 h. This approach may also allow for investigating the cellular trafficking of other molecules, such as nutrients, metabolites, and drugs...
  10. ncbi request reprint Classification of malignant gliomas by infrared spectroscopy and linear discriminant analysis
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Biopolymers 82:301-5. 2006
    ..The high success rate demonstrates that IR spectroscopy can complement established methods such as histopathology or immunohistochemistry to characterize dried cryosections...
  11. ncbi request reprint Methodology for fiber-optic Raman mapping and FTIR imaging of metastases in mouse brains
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, 01062, Dresden, Germany
    Anal Bioanal Chem 389:1133-42. 2007
    ..Possible reasons why metastatic cells of malignant melanomas were not identified in FTIR images are discussed...
  12. ncbi request reprint Classification of malignant gliomas by infrared spectroscopic imaging and linear discriminant analysis
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Anal Bioanal Chem 387:1669-77. 2007
    ..Potential applications of IR spectroscopic imaging as a rapid tool to complement established diagnostic methods are discussed...
  13. doi request reprint Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps
    Sebastian Dochow
    Institute of Photonic Technology, Jena, Germany
    Anal Bioanal Chem 405:2743-6. 2013
    ..Mean sensitivity and specificity determined by iterated 10-fold cross validation were 96 and 99 %, respectively, for the distinction of leucocytes extracted from blood, breast cancer cells BT-20 and MCF-7, and leukaemia cells OCI-AML3...
  14. doi request reprint Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications
    Christoph Krafft
    Institute of Photonic Technology Jena, Albert Einstein Straße 9, 07745 Jena, Germany
    J Biomed Opt 17:040801. 2012
    ..Thereby, we aim at presenting a guide into one exciting branch of modern biophotonics research...
  15. doi request reprint Multimodal imaging to study the morphochemistry of basal cell carcinoma
    Nadine Vogler
    Institute of Photonic Technology Jena, Albert Einstein Straße 9, 07745 Jena, Germany
    J Biophotonics 3:728-36. 2010
    ..The joint information content obtained by such multimodal approach in studying various aspects of the malignant tissue alterations associated with basal cell carcinoma is discussed...
  16. ncbi request reprint Identification of primary tumors of brain metastases by infrared spectroscopic imaging and linear discriminant analysis
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Technol Cancer Res Treat 5:291-8. 2006
    ..These data trained a supervised classification model based on linear discriminant analysis that was used to identify the origin of 20 cryosections including one brain metastasis with an unknown primary tumor...
  17. ncbi request reprint Identification of primary tumors of brain metastases by SIMCA classification of IR spectroscopic images
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Biochim Biophys Acta 1758:883-91. 2006
    ..All specimens were assigned to the correct tissue class. This proof-of-concept study demonstrates that IR spectroscopy can complement established methods such as histopathology or immunohistochemistry for diagnosis...
  18. doi request reprint Suitability of infrared spectroscopic imaging as an intraoperative tool in cerebral glioma surgery
    Stephan B Sobottka
    Department of Neurosurgery, University Hospital, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
    Anal Bioanal Chem 393:187-95. 2009
    ..This retrospective study clearly demonstrates that infrared spectroscopic imaging may help to define tumor margins intraoperatively and to detect high-grade tumor residues for achieving more radical tumor resection...
  19. doi request reprint Raman spectroscopic imaging for in vivo detection of cerebral brain metastases
    Matthias Kirsch
    Department of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
    Anal Bioanal Chem 398:1707-13. 2010
    ..Future investigations aim to reduce the exposure time from minutes to seconds and improve the lateral resolution...
  20. doi request reprint Quantification of brain lipids by FTIR spectroscopy and partial least squares regression
    Isabell Dreissig
    Bioanalytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Spectrochim Acta A Mol Biomol Spectrosc 71:2069-75. 2009
    ..The composition of lipid extracts that were predicted by the PLS regression of IR spectra was compared with lipid quantification by thin layer chromatography...
  21. ncbi request reprint Near infrared Raman spectroscopic mapping of native brain tissue and intracranial tumors
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Analyst 130:1070-7. 2005
    ..The results constitute a basis for subsequent Raman studies to develop classification models for diagnosis of brain tissue...
  22. doi request reprint Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines
    Norbert Bergner
    Institute of Photonic Technology, Albert Einstein Strasse 9, D 07745 Jena, Germany
    Analyst 138:3983-90. 2013
    ..The results demonstrate the capability of FTIR imaging to complement histopathological tools for brain tissue diagnosis...
  23. doi request reprint In vivo characterization of atherosclerotic plaque depositions by Raman-probe spectroscopy and in vitro coherent anti-stokes Raman scattering microscopic imaging on a rabbit model
    Christian Matthäus
    Institute of Photonic Technology, Jena, Germany
    Anal Chem 84:7845-51. 2012
    ..In order to further characterize the plaque depositions visually, coherent anti-Stokes Raman scattering (CARS) microscopy images have been acquired and are compared with the Raman-probe results...
  24. doi request reprint Resonance Raman spectral imaging of intracellular uptake of β-carotene loaded poly(D,L-lactide-co-glycolide) nanoparticles
    Christian Matthäus
    Institute of Photonic Technology IPHT Jena, Albert Einstein Strasse 9, 07745 Jena, Germany
    Chemphyschem 14:155-61. 2013
    ..Carotene as a provitamin is not soluble in water and is thus usually of low bioavailability, which is enhanced by encapsulation into the nanoparticles...
  25. doi request reprint Multicore fiber with integrated fiber Bragg gratings for background-free Raman sensing
    Sebastian Dochow
    Institute of Photonic Technology Jena e V, Albert Einstein Str 9, 07745 Jena, Germany
    Opt Express 20:20156-69. 2012
    ..The probe was characterized regarding Raman background suppression, collection efficiency, and distance dependence. First Raman measurements on brain tissue are presented...
  26. doi request reprint Characterization of lipid extracts from brain tissue and tumors using Raman spectroscopy and mass spectrometry
    Milena Köhler
    Institute for Analytical Chemistry, Dresden University of Technology, 01062, Dresden, Germany
    Anal Bioanal Chem 393:1513-20. 2009
    ..This study demonstrates how to improve the analysis of brain tumors and to complement the diagnosis of brain pathologies using a multimodal approach...
  27. doi request reprint Sample size planning for classification models
    Claudia Beleites
    Department of Spectroscopy and Imaging, Institute of Photonic Technology, Jena, Germany
    Anal Chim Acta 760:25-33. 2013
    ....
  28. doi request reprint Identification and differentiation of single cells from peripheral blood by Raman spectroscopic imaging
    Ute Neugebauer
    Institute of Photonic Technology, Jena, Germany
    J Biophotonics 3:579-87. 2010
    ..The model was successfully applied to identify single cells from an independent mixture of cells based on their vibrational spectra. The classification was confirmed by fluorescence staining of the cells after the Raman measurement...
  29. doi request reprint Raman and CARS microspectroscopy of cells and tissues
    Christoph Krafft
    Institute of Photonic Technology, Albert Einstein Str 9, 07745 Jena, Germany
    Analyst 134:1046-57. 2009
    ....
  30. ncbi request reprint Differentiation of individual human mesenchymal stem cells probed by FTIR microscopic imaging
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, D 01062 Dresden, Germany
    Analyst 132:647-53. 2007
    ..This study demonstrated for the first time that FTIR microscopic imaging can probe stem cell differentiation at the single cell level rapidly, non-destructively and with minimal preparation...
  31. ncbi request reprint Classification of inflammatory bowel diseases by means of Raman spectroscopic imaging of epithelium cells
    Christiane Bielecki
    University Hospital Jena, Department of Internal Medicine II, Division of Gastroenterology, Hepatology, and Infectious Diseases, Jena, Germany
    J Biomed Opt 17:076030. 2012
    ....
  32. doi request reprint Spatially resolved determination of the structure and composition of diatom cell walls by Raman and FTIR imaging
    Martin Kammer
    Bioanalytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Anal Bioanal Chem 398:509-17. 2010
    ..The results reveal local differences in the cell wall composition of the honeycomb-like structures and the bottom layer...
  33. doi request reprint Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments
    Sebastian Dochow
    Institute of Photonic Technology, Jena, Germany
    Lab Chip 11:1484-90. 2011
    ..Implementation into microfluidic environments enables a high degree of automation that is required to improve the throughput of the approach for Raman activated cell sorting...
  34. doi request reprint A comparative Raman and CARS imaging study of colon tissue
    Christoph Krafft
    Institute of Photonic Technology, Germany, Albert Einstein Str 9, 07745 Jena, Germany
    J Biophotonics 2:303-12. 2009
    ..This first comparison establishes the foundation for further development of the CARS technology to assess tissue...
  35. doi request reprint Raman and FTIR microscopic imaging of colon tissue: a comparative study
    Christoph Krafft
    Dresden University of Technology, 01062 Dresden, Germany
    J Biophotonics 1:154-69. 2008
    ..5 microm from three ganglia that belong to the myenteric plexus. The results are discussed with respect to lateral resolution, spectral resolution, acquisition time and sensitivity of both modalities...
  36. ncbi request reprint Delimitation of squamous cell cervical carcinoma using infrared microspectroscopic imaging
    Wolfram Steller
    Institute for Analytical Chemistry, Dresden University of Technology, 01062, Dresden, Germany
    Anal Bioanal Chem 384:145-54. 2006
    ....
  37. ncbi request reprint Near infrared Raman spectra of human brain lipids
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Spectrochim Acta A Mol Biomol Spectrosc 61:1529-35. 2005
    ..We recorded Raman spectra of the 12 major and minor brain lipids with 785 nm excitation in order to identify their spectral fingerprints for qualitative and quantitative analyses...
  38. ncbi request reprint Studies on stress-induced changes at the subcellular level by Raman microspectroscopic mapping
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, D 01062 Dresden, Germany
    Anal Chem 78:4424-9. 2006
    ..The results demonstrate that Raman spectroscopic mapping might become a powerful tool in cell biology for single cell analysis...
  39. ncbi request reprint Identification of B and T cells in human spleen sections by infrared microspectroscopic imaging
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, Dresden, Germany
    Cytometry A 64:53-61. 2005
    ..We analyzed whether this method is competitive with classic immunohistochemical methods for immunologic tissue and cells...
  40. pmc Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis
    Peter Recknagel
    Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
    PLoS Med 9:e1001338. 2012
    ..We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass undetected by standard laboratory tests...
  41. ncbi request reprint Analysis of human brain tissue, brain tumors and tumor cells by infrared spectroscopic mapping
    Christoph Krafft
    Institute of Analytical Chemistry, Dresden University of Technology, 01062 Dresden, Germany
    Analyst 129:921-5. 2004
    ..As this parameter correlated with the grade of gliomas obtained from standard histopathological examination, it was applied to classify brain tissue sections based on IR spectroscopic mapping...