Marcinkowski P, Hoyer I, Specker E, Furkert J, Rutz C, Neuenschwander M, et al
. A new highly thyrotropin receptor-selective small molecule antagonist with potential for the treatment of Graves' orbitopathy. Thyroid. 2018;: pubmed publisher
..In summary, we present a novel highly selective inhibitor for the TSHR, which has promising potential for further development for the treatment of GO. ..
Krause G, Protze J, Piontek J. Assembly and function of claudins: Structure-function relationships based on homology models and crystal structures. Semin Cell Dev Biol. 2015;42:3-12 pubmed publisher
..Detailed knowledge about structure-function relationships about claudins helps to reveal the molecular mechanisms of TJ assembly and regulation of paracellular permeability, which is yet not fully understood. ..
Neuhaus W, Piontek A, Protze J, Eichner M, Mahringer A, Subileau E, et al
. Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain. Biomaterials. 2018;161:129-143 pubmed publisher
..Using reliable in vitro BBB models, the results demonstrate that cCPE-based biologics designed to bind Cldn5 improve paracellular drug delivery across the BBB. ..
Krause G, Winkler L, Piehl C, Blasig I, Piontek J, Müller S. Structure and function of extracellular claudin domains. Ann N Y Acad Sci. 2009;1165:34-43 pubmed publisher
..These considerations may reveal the ECLs of claudins as decisive submolecular determinants that specify the function of a claudin. ..
Kleinau G, Hoyer I, Kreuchwig A, Haas A, Rutz C, Furkert J, et al
. From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs). J Biol Chem. 2011;286:25859-71 pubmed publisher
..Our findings might be relevant for all family A GPCRs as supported by a statistical analysis of residue properties between the TMHs of a vast number of GPCR sequences. ..
Protze J, Braun D, Hinz K, Bayer Kusch D, Schweizer U, Krause G. Membrane-traversing mechanism of thyroid hormone transport by monocarboxylate transporter 8. Cell Mol Life Sci. 2017;74:2299-2318 pubmed publisher
..Based on related sugar transporters, we suggest an alternating access mechanism for MCT8 involving a series of amino acid positions previously and newly identified as critical for transport. ..
Geithe C, Protze J, Kreuchwig F, Krause G, Krautwurst D. Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1. Cell Mol Life Sci. 2017;74:4209-4229 pubmed publisher
Hinz K, Neef D, Rutz C, Furkert J, Köhrle J, Schulein R, et al
. Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids. Mol Cell Endocrinol. 2017;443:163-174 pubmed publisher
..Thus, distinct molecular LAT2-features determine bidirectional AA transport but only an unidirectional 3,3'-T2 and T3 import. ..
Krause G, Hinz K. Thyroid hormone transport across L-type amino acid transporters: What can molecular modelling tell us?. Mol Cell Endocrinol. 2017;458:68-75 pubmed publisher
..Characterized substrate features that are needed for TH translocation and distinct LAT2 properties will be highlighted to understand the molecular import and export mechanisms of this transporter in more detail. ..