P Kotsonis

Summary

Country: Germany

Publications

  1. pmc Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity
    P Kotsonis
    Department of Pharmacology and Toxicology, Julius Maximilians University, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Biochem J 340:745-52. 1999
  2. ncbi request reprint Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase
    A Reif
    Department of Pharmacology and Toxicology, Julius Maximilians University, Wurzburg, 97078 Germany
    J Biol Chem 274:24921-9. 1999
  3. pmc Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide
    P Kotsonis
    Department of Pharmacology, Julius Maximilians University, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Biochem J 346:767-76. 2000
  4. ncbi request reprint Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin
    P Kotsonis
    Department of Pharmacology and Toxicology, Julius Maximilians University, Versbacher Strasse 9, Würzburg 97078, Germany
    J Biol Chem 276:49133-41. 2001
  5. ncbi request reprint Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases
    E Butt
    Medical University Clinic, Institute of Clinical Biochemistry and Pathobiochemistry, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 275:5179-87. 2000

Collaborators

Detail Information

Publications5

  1. pmc Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity
    P Kotsonis
    Department of Pharmacology and Toxicology, Julius Maximilians University, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Biochem J 340:745-52. 1999
    ..Consistent with this, exogenous H2O2 also inhibited NOS activity during phase I. Thus during catalysis NOS is subject to complex autoinhibition by both enzyme-derived RNS and H2O2, differentially affecting enzyme activity...
  2. ncbi request reprint Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase
    A Reif
    Department of Pharmacology and Toxicology, Julius Maximilians University, Wurzburg, 97078 Germany
    J Biol Chem 274:24921-9. 1999
    ..In conclusion, we propose a role for H(4)Bip as a dimer-stabilizing factor of neuronal NOS during catalysis, possibly by interfering with enzyme destabilizing products...
  3. pmc Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide
    P Kotsonis
    Department of Pharmacology, Julius Maximilians University, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Biochem J 346:767-76. 2000
    ..generating conditions in the absence of substrate. These results suggest that H(4)Bip allosterically activates NOS-I and stabilizes quaternary structure by a novel mechanism involving the direct interception of auto-damaging O(2)(-.)...
  4. ncbi request reprint Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin
    P Kotsonis
    Department of Pharmacology and Toxicology, Julius Maximilians University, Versbacher Strasse 9, Würzburg 97078, Germany
    J Biol Chem 276:49133-41. 2001
    ....
  5. ncbi request reprint Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases
    E Butt
    Medical University Clinic, Institute of Clinical Biochemistry and Pathobiochemistry, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 275:5179-87. 2000
    ....