J Kornhuber

Summary

Country: Germany

Publications

  1. ncbi request reprint Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Federal Republic of Germany
    J Neural Transm 106:857-67. 1999
  2. ncbi request reprint Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells
    J Wiltfang
    Department of Psychiatry, Molecular Neurobiology, and Department of Biochemistry II, University of Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 276:42645-57. 2001
  3. ncbi request reprint Lithium decreases secretion of Abeta1-42 and C-truncated species Abeta1-37/38/39/40 in chicken telencephalic cultures but specifically increases intracellular Abeta1-38
    H Esselmann
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    Neurodegener Dis 1:236-41. 2004
  4. ncbi request reprint Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Germany
    Electrophoresis 18:527-32. 1997
  5. ncbi request reprint The N-methyl-D-aspartate receptor channel blocker amantadine does not cause histopathological alterations in human brain tissue
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Germany
    Acta Neuropathol 98:85-90. 1999
  6. ncbi request reprint Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Germany
    J Neurochem 73:2485-90. 1999
  7. ncbi request reprint Persistence of haloperidol in human brain tissue
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Germany
    Am J Psychiatry 156:885-90. 1999
  8. ncbi request reprint In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression
    R Rupprecht
    Department of Psychiatry, , Federal Republic of Germany
    Eur Arch Psychiatry Clin Neurosci 241:35-40. 1991
  9. ncbi request reprint Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine
    E Savvateeva
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 107:581-601. 2000
  10. ncbi request reprint Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG
    L Frolich
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    Eur Arch Psychiatry Clin Neurosci 240:363-6. 1991

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Federal Republic of Germany
    J Neural Transm 106:857-67. 1999
    ..This makes flupirtine the prototype of a clinically applicable substance group with analgesic, muscle-relaxant and neuroprotective properties...
  2. ncbi request reprint Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells
    J Wiltfang
    Department of Psychiatry, Molecular Neurobiology, and Department of Biochemistry II, University of Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 276:42645-57. 2001
    ..Moreover, our results indicate that the latter Abeta peptide species could be generated by a beta(Asp/Ala)-secretase activity...
  3. ncbi request reprint Lithium decreases secretion of Abeta1-42 and C-truncated species Abeta1-37/38/39/40 in chicken telencephalic cultures but specifically increases intracellular Abeta1-38
    H Esselmann
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    Neurodegener Dis 1:236-41. 2004
    ..Therefore, we conclude that there are two independent mechanisms of lithium in intra- and extracellular Abeta peptide production...
  4. ncbi request reprint Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Germany
    Electrophoresis 18:527-32. 1997
    ..They may help to define the neurotoxic potential of the longer A beta peptides in relation to their aggregation state...
  5. ncbi request reprint The N-methyl-D-aspartate receptor channel blocker amantadine does not cause histopathological alterations in human brain tissue
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Germany
    Acta Neuropathol 98:85-90. 1999
    ..In conclusion, histopathological examination of the hippocampus, retrosplenial cortex, and cingulate gyrus of human brain did not reveal changes suggested to be specific for previous amantadine treatment...
  6. ncbi request reprint Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Germany
    J Neurochem 73:2485-90. 1999
    ..This study has determined that isoform-specific 14-3-3 antibodies against beta, gamma, and epsilon should be considered for the neurochemical differentiation of CJD from other neurodegenerative diseases...
  7. ncbi request reprint Persistence of haloperidol in human brain tissue
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Germany
    Am J Psychiatry 156:885-90. 1999
    ..The aim of this study was to directly examine haloperidol concentrations in human brain tissue in relation to drug-free time...
  8. ncbi request reprint In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression
    R Rupprecht
    Department of Psychiatry, , Federal Republic of Germany
    Eur Arch Psychiatry Clin Neurosci 241:35-40. 1991
    ..These data support the concept of a decreased functional plasticity of the glucocorticoid receptor in depression also at the cellular level...
  9. ncbi request reprint Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine
    E Savvateeva
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    J Neural Transm 107:581-601. 2000
    ..Memory decline was accompanied by a sharp decrease in immunoreactivity to the synaptic cysteine string protein, and alterations in volumetric parameters of the mushroom bodies, the brain structures implicated in memory...
  10. ncbi request reprint Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG
    L Frolich
    Department of Psychiatry, University of Wurzburg, Federal Republic of Germany
    Eur Arch Psychiatry Clin Neurosci 240:363-6. 1991
    ..The data do not support the hypothesis that a pathological leakage through the blood-CSF barrier facilitates the entry of extraneuronal proteins to the CNS, which might contribute to the pathophysiological process in DAT...
  11. ncbi request reprint Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder
    J Pauls
    Department of Psychiatry, University of Gottingen, Federal Republic of Germany
    J Neural Transm 107:1361-6. 2000
    ..A previously reported genetic association (Arinami et al., 1996) was not confirmed by the present study...
  12. ncbi request reprint Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    J Neurochem 81:481-96. 2002
    ..The severity of dementia was significantly correlated to the fractional Abeta peptide pattern but not to the absolute Abeta peptide concentrations...
  13. ncbi request reprint Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine levels in patients with alcoholism
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Neural Transm 113:357-63. 2006
    ..68, 95% CI=0.57-0.79, p=0.004). The present results show first evidence of an association between elevated plasma homocysteine levels in alcoholics and cognition deficits in patients undergoing alcohol withdrawal...
  14. ncbi request reprint [Neurochemical early and differential diagnostics for Alzheimer's disease]
    J Wiltfang
    Klinik mit Poliklinik für Psychiatrie und Psychotherapie Friedrich Alexander Universität Erlangen Nürnberg
    MMW Fortschr Med 146:38-40. 2004
    ..As a result, future preventive drug treatment strategies can be employed early and selectively...
  15. ncbi request reprint Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia
    J Wiltfang
    Molecular Neurobiology Lab, Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    World J Biol Psychiatry 6:69-84. 2005
    ..Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed...
  16. ncbi request reprint Reduced CSF carboxyterminally truncated Abeta peptides in frontotemporal lobe degenerations
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 114:621-8. 2007
    ..Moreover, independent methods of measurement should be applied to CSF Abeta1-38...
  17. ncbi request reprint Biological markers to predict previous alcohol withdrawal seizures: a risk assessment
    T Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm 114:151-4. 2007
    ..001, OR = 9.23, 95%CI = 2.36-36.05). A combination of both, homocysteine and prolactin, may help to assess the individual risk of alcohol withdrawal seizures in clinical practice...
  18. ncbi request reprint CSF diagnosis of Alzheimer's disease and dementia with Lewy bodies
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 113:1771-8. 2006
    ..Combined evaluation of these biomarkers provides a reasonable accuracy for differential diagnosis of AD and DLB...
  19. ncbi request reprint Immune complexes of auto-antibodies against A beta 1-42 peptides patrol cerebrospinal fluid of non-Alzheimer's patients
    A W Henkel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 12:601-10. 2007
    ..Our results assign a central role to the immune system in regulating A beta1-42 homeostasis by clustering this peptide in immunocomplexes...
  20. ncbi request reprint Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Mol Psychiatry 12:671-80. 2007
    ..CSF Abeta peptides may reflect disease-specific impact of distinct neurodegenerative processes on Abeta peptide metabolism and represent a potential diagnostic biomarker for AD, FTD and DLB...
  21. ncbi request reprint CPAP-therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome
    W Jordan
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    J Neural Transm 111:683-9. 2004
    ..005) and thus probably the (hyper)homocysteinemia-related cognitive dysfunction and the risk for cardio-/cerebrovascular diseases...
  22. ncbi request reprint Evaluation of oxidative stress measurements in obstructive sleep apnea syndrome
    W Jordan
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    J Neural Transm 113:239-54. 2006
    ..05). Gender effects in ROS generation also have to be considered. At present, we recommend the application of several oxidative stress measurements at different time points, preferably involving plasma MDA and urinary o,o'-dityrosine...
  23. ncbi request reprint [Excitatory neurotransmission in alcoholism]
    S Bleich
    Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Friedrich Alexander Universität zu Erlangen Nuremberg, Erlangen
    Fortschr Neurol Psychiatr 71:S36-44. 2003
    ..The role of alcoholism-associated hyperhomocysteinemia in respect to NMDA-receptor mediated neurotoxicity and excitotoxicity is discussed...
  24. ncbi request reprint Homocysteine and risk of open-angle glaucoma
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Schwabachanlage 6 10, D 91054 Erlangen Nuremberg, Federal Republic of Germany
    J Neural Transm 109:1499-504. 2002
    ..Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy...
  25. ncbi request reprint Spontaneous, slow and fast magnetoencephalographic activity in patients with schizophrenia
    W Sperling
    Department of Psychiatry and Psychotherapy of Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, 91054, Erlangen, Germany
    Schizophr Res 58:189-99. 2002
    ..Dipole localization (for both frequency ranges) showed a concentration effect (DCE) in the temporoparietal region in patients with schizophrenia...
  26. ncbi request reprint Potential genetic markers of sporadic Alzheimer's dementia
    W Retz
    Psychiatric Department, University of the Saarland, Hamburg Saar, Germany
    Psychiatr Genet 11:115-22. 2001
    ..We conclude that, apart from the ApoE allele 4, other genetically regulated factors like ApoCI and the LDL receptor modulate the individual risk for Alzheimer's disease...
  27. ncbi request reprint Moderate alcohol consumption in social drinkers raises plasma homocysteine levels: a contradiction to the 'French Paradox'?
    S Bleich
    Department of Psychiatry and Psychotherapy, Georg August University of Gottingen, Germany
    Alcohol Alcohol 36:189-92. 2001
    ....
  28. ncbi request reprint Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma
    J B Roedl
    Department of Ophthalmology and University Eye Hospital, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm 114:445-50. 2007
    ....
  29. ncbi request reprint Decreased circulating CD34+ stem cells in early Alzheimer's disease: Evidence for a deficient hematopoietic brain support?
    J M Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 11:1113-5. 2006
    ..467; P = 0.025) and most pronounced the Abeta42/40 ratio (r = -0.688; P = 0.005). Our data suggest a deficient regenerative hematopoietic support for the central nervous system in early AD...
  30. ncbi request reprint The German Competence Net Dementias: standard operating procedures for the neurochemical dementia diagnostics
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Neural Transm 113:1075-80. 2006
    ....
  31. ncbi request reprint Risk assessment of alcohol withdrawal seizures with a Kohonen feature map
    C Kurth
    Department of Clinical Neurophysiology, , Robert Koch Str. 40, , Germany
    Neuroreport 12:1235-8. 2001
    ..4% (one false positive prediction of 19 patients). We conclude that in patients with alcohol-induced hyperhomocysteinaemia the KFM is a useful tool to predict alcohol withdrawal seizures...
  32. ncbi request reprint A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Ann Neurol 47:399-403. 2000
    ..0 compared with subjects with neither of these two alleles. Our data confirm the results of a recently performed pilot study in an independent sample and suggest that the catD genotype is strongly associated with the risk for AD...
  33. ncbi request reprint Dopamine and N-methyl-D-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal
    T Biermann
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm 114:1081-4. 2007
    ..A significant difference in D1 receptor expression (T = 2.361; p = 0.035) in terms of up-regulation could be shown, though there were no significant changes concerning D2, NMDA1 or NMDA2B receptor expression...
  34. ncbi request reprint Apolipoprotein E polymorphism, homocysteine serum levels and hippocampal volume in patients with alcoholism: an investigation of a gene-environment interaction
    J Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenomics J 8:117-21. 2008
    ..We suggest that the disadvantageous effects of apolipoprotein E4 on alcohol-related brain volume loss are based on certain gene-environment interactions...
  35. doi request reprint Increased homocysteine levels in tear fluid of patients with primary open-angle glaucoma
    J B Roedl
    Department of Ophthalmology, University Eye Hospital, Erlangen Nuremberg, Germany
    Ophthalmic Res 40:249-56. 2008
    ..We assessed homocysteine (Hcy) levels in tear fluid and plasma of patients with primary open-angle glaucoma (POAG). We determined the association between Hcy levels, dry eye syndrome and B vitamin status...
  36. ncbi request reprint Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism
    D Bonsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    J Neural Transm 113:1299-304. 2006
    ..014). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control in these patients...
  37. ncbi request reprint Cognitive impairment and its association with homocysteine plasma levels in females with eating disorders - findings from the HEaD-study
    H Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Bad Oeynhausen, Germany
    J Neural Transm 112:1591-8. 2005
    ..566, OR=24.75, CI 2.89 - 212.23, P=0.003). These results indicate that under the special circumstances of eating disorders elevated homocysteine levels improve memory signaling possibly by facilitating long-term potentiation...
  38. pmc Prospective case control study on genetic assocation of apolipoprotein epsilon2 with intraocular pressure
    A Junemann
    Br J Ophthalmol 88:581-2. 2004
  39. ncbi request reprint Donepezil for Alzheimer's disease in clinical practice--The DONALD Study. A multicenter 24-week clinical trial in Germany
    L Froelich
    Division of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, University of Heidelberg, Heidelberg, Germany
    Dement Geriatr Cogn Disord 18:37-43. 2004
    ..There were only insignificant effects on ECG parameters. This study confirms the results obtained in previous double-blind trials, which showed that donepezil is effective and well tolerated in patients with mild-to-moderately severe AD...
  40. ncbi request reprint [Therapy and prophylaxis of Alzheimer's dementia]
    J Kornhuber
    Fortschr Neurol Psychiatr 72:183. 2004
  41. ncbi request reprint Homocysteine induces cell death of rat astrocytes in vitro
    J M Maler
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Neurosci Lett 347:85-8. 2003
    ..g. Alzheimer's disease, glaucomatous optic neuropathy). This is the first study to report that homocysteine induces cell death of astrocytes. The mechanisms by which homocysteine induces cell death of astrocytes warrant further study...
  42. ncbi request reprint [Limited efficacy of cholinesterase inhibitors in Alzheimer's dementia]
    J Kornhuber
    Fortschr Neurol Psychiatr 72:553-4. 2004
  43. ncbi request reprint Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism
    D Bonsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm 111:1611-6. 2004
    ..001). Since methylation of DNA is an important epigenetic factor in regulation of gene expression these findings may have important implications for a possible subsequent derangement of epigenetic control these patients...
  44. ncbi request reprint Homocysteine plasma levels are elevated in females with anorexia nervosa
    H Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm 112:979-85. 2005
    ....
  45. ncbi request reprint [Prevention of Alzheimer's disease]
    J Kornhuber
    Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen
    Fortschr Neurol Psychiatr 73:315-6. 2005
  46. ncbi request reprint Apolipoprotein E epsilon 4 is associated with hippocampal volume reduction in females with alcoholism
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm 110:401-11. 2003
    ..These findings indicate a genetic disposition for alcohol related brain atrophy in female carrying the ApoE4 genotype, which may also explain why female alcoholics are more susceptible to alcohol-induced brain damage...
  47. ncbi request reprint Lack of association between hippocampal volume reduction and first-onset alcohol withdrawal seizure. A volumetric MRI study
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Alcohol Alcohol 38:40-4. 2003
    ..Until recently, no data as to whether hippocampal volume reductions in alcoholics might serve as a predictor of withdrawal seizures were available...
  48. ncbi request reprint Advances in alcoholism research in Germany
    L G Schmidt
    Department of Psychiatry, Johannes Gutenberg University, Mainz, Germany
    Alcohol Clin Exp Res 29:1282-7. 2005
  49. ncbi request reprint Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism
    S Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    Neurosci Lett 335:179-82. 2003
    ..001, multiple regression analysis). Raised plasma levels of homocysteine are associated with hippocampal (brain) atrophy in alcoholism...
  50. doi request reprint [E-learning about dementia: a randomized study]
    M Weih
    Psychiatrische und Psychotherapeutische Klinik, Universitatsklinikum Erlangen, Schwabachanlage 6, Erlangen
    Fortschr Neurol Psychiatr 76:465-9. 2008
    ..This setting was compared with two different E-Learning formats using a randomized study design...