Wolfgang Koppert

Summary

Country: Germany

Publications

  1. ncbi request reprint The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitization
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge CB2 2GG, UK
    Anesth Analg 99:816-22, table of contents. 2004
  2. ncbi request reprint The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 108:148-53. 2004
  3. ncbi request reprint Supra-additive effects of tramadol and acetaminophen in a human pain model
    Jörg Filitz
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 136:262-70. 2008
  4. ncbi request reprint Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans
    Andreas Tröster
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    Anesthesiology 105:1016-23. 2006
  5. doi request reprint Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesia
    Frank Seifert
    Department of Neurology, University Hospital Erlangen, 91054 Erlangen, Germany
    J Neurosci 29:6167-75. 2009
  6. ncbi request reprint Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model
    Wolfgang Koppert
    Department of Anaesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 118:15-22. 2005
  7. ncbi request reprint Activation of naloxone-sensitive and -insensitive inhibitory systems in a human pain model
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    J Pain 6:757-64. 2005
  8. doi request reprint Interaction of fentanyl and buprenorphine in an experimental model of pain and central sensitization in human volunteers
    Andreas Tröster
    Department of Anaesthesiology, University Hospital Erlangen, Erlangen, Germany
    Clin J Pain 28:705-11. 2012
  9. ncbi request reprint Modulation of remifentanil-induced postinfusion hyperalgesia by propofol
    Boris Singler
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    Anesth Analg 104:1397-403, table of contents. 2007
  10. ncbi request reprint Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 106:91-9. 2003

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitization
    Boris A Chizh
    GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge CB2 2GG, UK
    Anesth Analg 99:816-22, table of contents. 2004
    ..However, adenosine did not have the long-term effects seen in patients. The model can investigate mechanisms of drugs for the treatment of chronic pain...
  2. ncbi request reprint The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 108:148-53. 2004
    ..Thus, besides its well-known effects on inflamed peripheral tissues, inhibition of central COX provides an important mechanism of NSAID-mediated antihyperalgesia in humans...
  3. ncbi request reprint Supra-additive effects of tramadol and acetaminophen in a human pain model
    Jörg Filitz
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 136:262-70. 2008
    ..The results might act as a rationale for combining both analgesics...
  4. ncbi request reprint Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans
    Andreas Tröster
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    Anesthesiology 105:1016-23. 2006
    ..The aim of the investigation was to determine analgesic and antihyperalgesic properties of the cyclooxygenase-2 inhibitor parecoxib on remifentanil-induced hypersensitivity in humans...
  5. doi request reprint Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesia
    Frank Seifert
    Department of Neurology, University Hospital Erlangen, 91054 Erlangen, Germany
    J Neurosci 29:6167-75. 2009
    ..We conclude that activity in mPFC correlates inversely with individual extent of central hyperalgesia and predicts individual pharmacological antihyperalgesic treatment response...
  6. ncbi request reprint Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model
    Wolfgang Koppert
    Department of Anaesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 118:15-22. 2005
    ..It will be of major clinical interest whether this difference will translate into improved treatment of pain states dominated by central sensitization...
  7. ncbi request reprint Activation of naloxone-sensitive and -insensitive inhibitory systems in a human pain model
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    J Pain 6:757-64. 2005
    ..The session effect was not reversed by naloxone. High-current-density electrical stimulation provokes central sensitization, but in addition inhibitory systems are activated that are only partly naloxone-sensitive...
  8. doi request reprint Interaction of fentanyl and buprenorphine in an experimental model of pain and central sensitization in human volunteers
    Andreas Tröster
    Department of Anaesthesiology, University Hospital Erlangen, Erlangen, Germany
    Clin J Pain 28:705-11. 2012
    ..We assessed the analgesic and antihyperalgesic effects of the μ-agonist fentanyl and the partial μ-agonist/κ-antagonist buprenorphine in a human pain model, when given alone or in combination...
  9. ncbi request reprint Modulation of remifentanil-induced postinfusion hyperalgesia by propofol
    Boris Singler
    Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
    Anesth Analg 104:1397-403, table of contents. 2007
    ..In this investigation we sought to determine the analgesic and antihyperalgesic properties of propofol in subhypnotic concentrations on remifentanil-induced postinfusion hypersensitivity in an experimental human pain model...
  10. ncbi request reprint Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 106:91-9. 2003
    ....
  11. ncbi request reprint Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen, Germany
    Eur J Pain 8:237-44. 2004
    ....
  12. ncbi request reprint Effects of intermittent hemodialysis on buprenorphine and norbuprenorphine plasma concentrations in chronic pain patients treated with transdermal buprenorphine
    Jörg Filitz
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Eur J Pain 10:743-8. 2006
    ..Furthermore, hemodialysis did not affect buprenorphine plasma levels, leading to stable analgesic effects during the therapy...
  13. ncbi request reprint Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Clinic of Erlangen, Germany
    Anesthesiology 99:152-9. 2003
    ....
  14. ncbi request reprint Brain imaging of analgesic and antihyperalgesic effects of cyclooxygenase inhibition in an experimental human pain model: a functional MRI study
    Christian Maihofner
    Department of Neurology, Schwabachanlage 6, D91054 Erlangen, University Hospital Erlangen, Germany
    Eur J Neurosci 26:1344-56. 2007
    ..Therefore, the results of the present study suggest that there is a difference in the brain areas modulated by analgesia and antihyperalgesia...
  15. doi request reprint Differential effects on sensory functions and measures of epidermal nerve fiber density after application of a lidocaine patch (5%) on healthy human skin
    Andreas Wehrfritz
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Eur J Pain 15:907-12. 2011
    ..These data warrant further studies on molecular mechanisms mediating a relief of neuropathic pain by topical lidocaine...
  16. ncbi request reprint Opioid-induced mast cell activation and vascular responses is not mediated by mu-opioid receptors: an in vivo microdialysis study in human skin
    James A Blunk
    Department of Anesthesiology, University Hospital, Erlangen, Germany
    Anesth Analg 98:364-70, table of contents. 2004
    ..Therefore, histamine release seen at large concentrations of potent micro agonists is caused by an unspecific effect rather than an activation of opioid receptors...
  17. ncbi request reprint The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery
    Wolfgang Koppert
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Anesth Analg 103:1170-6. 2006
    ..Further studies are warranted to determine adverse renal effects of longer-lasting therapy with these drugs, especially in patients with renal impairment or concomitant diseases...
  18. ncbi request reprint Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen, Erlangen, Germany
    Anesth Analg 98:1050-5, table of contents. 2004
    ....
  19. doi request reprint The first scintigraphic detection of tumor necrosis factor-alpha in patients with complex regional pain syndrome type 1
    Michael Bernateck
    Department of Anesthesiology, Pain Clinic, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    Anesth Analg 110:211-5. 2010
    ..Our findings support the growing evidence for neuroimmune disturbance in patients with CRPS and may have important further implications for specific anticytokine treatment in patients with CRPS...
  20. ncbi request reprint Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pain 106:49-57. 2003
    ..This study also points to a differential susceptibility of different pain modalities for the expression of hyperalgesia associated with opioid administration...
  21. ncbi request reprint The impact of opioid-induced hyperalgesia for postoperative pain
    Wolfgang Koppert
    Klinik fur Anasthesiologie, Universitatsklinikum Erlangen, Krankenhousstrasse 12, D 91054 Erlongen, Germany
    Best Pract Res Clin Anaesthesiol 21:65-83. 2007
    ....