Research Topics
Species | Wolfgang KoppertSummaryCountry: Germany Publications
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Detail Information
Publications
The effect of intravenous infusion of adenosine on electrically evoked hyperalgesia in a healthy volunteer model of central sensitizationBoris A Chizh
GlaxoSmithKline, Addenbrooke s Centre for Clinical Investigation, Hills Road, Cambridge CB2 2GG, UK
Anesth Analg 99:816-22, table of contents. 2004..However, adenosine did not have the long-term effects seen in patients. The model can investigate mechanisms of drugs for the treatment of chronic pain...- The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humansWolfgang Koppert
Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Pain 108:148-53. 2004..Thus, besides its well-known effects on inflamed peripheral tissues, inhibition of central COX provides an important mechanism of NSAID-mediated antihyperalgesia in humans... - Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humansAndreas Tröster
Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
Anesthesiology 105:1016-23. 2006..The aim of the investigation was to determine analgesic and antihyperalgesic properties of the cyclooxygenase-2 inhibitor parecoxib on remifentanil-induced hypersensitivity in humans... - Supra-additive effects of tramadol and acetaminophen in a human pain modelJörg Filitz
Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Pain 136:262-70. 2008..The results might act as a rationale for combining both analgesics... 
Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesiaFrank Seifert
Department of Neurology, University Hospital Erlangen, 91054 Erlangen, Germany
J Neurosci 29:6167-75. 2009..We conclude that activity in mPFC correlates inversely with individual extent of central hyperalgesia and predicts individual pharmacological antihyperalgesic treatment response...- Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain modelWolfgang Koppert
Department of Anaesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Pain 118:15-22. 2005..It will be of major clinical interest whether this difference will translate into improved treatment of pain states dominated by central sensitization... - Activation of naloxone-sensitive and -insensitive inhibitory systems in a human pain modelWolfgang Koppert
Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
J Pain 6:757-64. 2005..Here we show activation of a naloxone-sensitive short-term and a naloxone-insensitive long-term inhibitory system in a new model of electrically induced pain and hyperalgesia... - Modulation of remifentanil-induced postinfusion hyperalgesia by propofolBoris Singler
Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
Anesth Analg 104:1397-403, table of contents. 2007..In this investigation we sought to determine the analgesic and antihyperalgesic properties of propofol in subhypnotic concentrations on remifentanil-induced postinfusion hypersensitivity in an experimental human pain model... - Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humansWolfgang Koppert
Department of Anesthesiology, University of Erlangen-Nuremberg, Krankenhausstrasse 12, D-91054 Erlangen, Germany
Pain 106:91-9. 2003.... - Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaineWolfgang Koppert
Department of Anesthesiology, University of Erlangen, Germany
Eur J Pain 8:237-44. 2004.... - Effects of intermittent hemodialysis on buprenorphine and norbuprenorphine plasma concentrations in chronic pain patients treated with transdermal buprenorphineJörg Filitz
Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Eur J Pain 10:743-8. 2006..Furthermore, hemodialysis did not affect buprenorphine plasma levels, leading to stable analgesic effects during the therapy... - Brain imaging of analgesic and antihyperalgesic effects of cyclooxygenase inhibition in an experimental human pain model: a functional MRI studyChristian Maihofner
Department of Neurology, Schwabachanlage 6, D91054 Erlangen, University Hospital Erlangen, Germany
Eur J Neurosci 26:1344-56. 2007..Therefore, the results of the present study suggest that there is a difference in the brain areas modulated by analgesia and antihyperalgesia... - Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humansWolfgang Koppert
Department of Anesthesiology, University Clinic of Erlangen, Germany
Anesthesiology 99:152-9. 2003.... - Differential effects on sensory functions and measures of epidermal nerve fiber density after application of a lidocaine patch (5%) on healthy human skinAndreas Wehrfritz
Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
Eur J Pain 15:907-12. 2011..These data warrant further studies on molecular mechanisms mediating a relief of neuropathic pain by topical lidocaine... - The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgeryWolfgang Koppert
Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Anesth Analg 103:1170-6. 2006..Further studies are warranted to determine adverse renal effects of longer-lasting therapy with these drugs, especially in patients with renal impairment or concomitant diseases... - Opioid-induced mast cell activation and vascular responses is not mediated by mu-opioid receptors: an in vivo microdialysis study in human skinJames A Blunk
Department of Anesthesiology, University Hospital, Erlangen, Germany
Anesth Analg 98:364-70, table of contents. 2004..Therefore, histamine release seen at large concentrations of potent micro agonists is caused by an unspecific effect rather than an activation of opioid receptors... - Interaction of fentanyl and buprenorphine in an experimental model of pain and central sensitization in human volunteersAndreas Tröster
Department of Anaesthesiology, University Hospital Erlangen, Erlangen, Germany
Clin J Pain 28:705-11. 2012..We assessed the analgesic and antihyperalgesic effects of the μ-agonist fentanyl and the partial μ-agonist/κ-antagonist buprenorphine in a human pain model, when given alone or in combination... - Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgeryWolfgang Koppert
Department of Anesthesiology, University of Erlangen, Erlangen, Germany
Anesth Analg 98:1050-5, table of contents. 2004.... - The first scintigraphic detection of tumor necrosis factor-alpha in patients with complex regional pain syndrome type 1Michael Bernateck
Department of Anesthesiology, Pain Clinic, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
Anesth Analg 110:211-5. 2010..Our findings support the growing evidence for neuroimmune disturbance in patients with CRPS and may have important further implications for specific anticytokine treatment in patients with CRPS... - Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawalMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Pain 106:49-57. 2003..This study also points to a differential susceptibility of different pain modalities for the expression of hyperalgesia associated with opioid administration... - The impact of opioid-induced hyperalgesia for postoperative painWolfgang Koppert
Klinik fur Anasthesiologie, Universitatsklinikum Erlangen, Krankenhousstrasse 12, D 91054 Erlongen, Germany
Best Pract Res Clin Anaesthesiol 21:65-83. 2007....