Harald Kogler

Summary

Country: Germany

Publications

  1. ncbi request reprint Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression
    Harald Kogler
    Abteilung fur Kardiologie, Georg August Universitat, Gottingen, Germany
    Circulation 113:2724-32. 2006
  2. ncbi request reprint Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat
    Harald Kogler
    Georg August Universitat Gottingen, Abteilung Kardiologie und Pneumologie, Robert Koch Str 40, D 37075 Gottingen, Germany
    Circ Res 93:230-7. 2003
  3. ncbi request reprint Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium
    Harald Kogler
    Institute of Molecular Cardiobiology, Johns Hopkins University, Baltimore, MD, USA
    Cardiovasc Res 59:582-92. 2003
  4. doi request reprint Elevated afterload, neuroendocrine stimulation, and human heart failure increase BNP levels and inhibit preload-dependent SERCA upregulation
    Karl Toischer
    Abteilung Kardiologie und Pneumologie, Georg August Universitat, Robert Koch Strasse 40, Gottingen, Germany
    Circ Heart Fail 1:265-71. 2008
  5. ncbi request reprint Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange
    Oliver Zeitz
    Georg August Universität Göttingen Universitätsklinik, Abteilung Kardiologie und Pneumologie, Gottingen, Germany
    Circ Res 90:988-95. 2002
  6. ncbi request reprint Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Gottingen, Germany
    Circulation 111:2588-95. 2005
  7. doi request reprint Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model
    Tobias Raupach
    Department of Cardiology and Pneumology, University Hospital Gottingen, Gottingen, Germany
    Pulm Pharmacol Ther 24:215-20. 2011
  8. ncbi request reprint Insulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Germany
    Circ Res 92:169-76. 2003
  9. ncbi request reprint Pressure overload and neurohumoral activation differentially affect the myocardial proteome
    Peter Schott
    Department of Cardiology and Respiratory Care, Georg August University, Gottingen, Germany
    Proteomics 5:1372-81. 2005
  10. pmc BNP controls early load-dependent regulation of SERCA through calcineurin
    Karl Toischer
    Abteilung Kardiologie und Pneumologie, Georg August Universitat, Robert Koch Str 40, 37075, Gottingen, Germany
    Basic Res Cardiol 105:795-804. 2010

Detail Information

Publications17

  1. ncbi request reprint Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression
    Harald Kogler
    Abteilung fur Kardiologie, Georg August Universitat, Gottingen, Germany
    Circulation 113:2724-32. 2006
    ..However, there is evidence that BNP-mediated signaling may adversely influence cardiac remodeling, with further impairment of calcium homeostasis...
  2. ncbi request reprint Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat
    Harald Kogler
    Georg August Universitat Gottingen, Abteilung Kardiologie und Pneumologie, Robert Koch Str 40, D 37075 Gottingen, Germany
    Circ Res 93:230-7. 2003
    ..Neuroendocrine factors, which equally affect both chambers, are not sufficient to alter the expression of Ca2+-cycling proteins...
  3. ncbi request reprint Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium
    Harald Kogler
    Institute of Molecular Cardiobiology, Johns Hopkins University, Baltimore, MD, USA
    Cardiovasc Res 59:582-92. 2003
    ..We examined whether this inotropic action is preserved or magnified in failing rat myocardium and whether the magnitude of this effect correlates with tissue xanthine-oxidoreductase (XOR) activity...
  4. doi request reprint Elevated afterload, neuroendocrine stimulation, and human heart failure increase BNP levels and inhibit preload-dependent SERCA upregulation
    Karl Toischer
    Abteilung Kardiologie und Pneumologie, Georg August Universitat, Robert Koch Strasse 40, Gottingen, Germany
    Circ Heart Fail 1:265-71. 2008
    ..In heart failure, brain-type natriuretic peptide (BNP) is elevated and the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) downregulated. We previously showed that preload-induced SERCA-upregulation is suppressed by exogenous BNP...
  5. ncbi request reprint Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange
    Oliver Zeitz
    Georg August Universität Göttingen Universitätsklinik, Abteilung Kardiologie und Pneumologie, Gottingen, Germany
    Circ Res 90:988-95. 2002
    ..Degradation of troponins appears to be species-dependent but does not contribute to the acute diastolic dysfunction...
  6. ncbi request reprint Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Gottingen, Germany
    Circulation 111:2588-95. 2005
    ..We examined inotropic responses and signal transduction mechanisms of insulin in human myocardium...
  7. doi request reprint Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model
    Tobias Raupach
    Department of Cardiology and Pneumology, University Hospital Gottingen, Gottingen, Germany
    Pulm Pharmacol Ther 24:215-20. 2011
    ..This study examined the effects of an angiotensin II receptor blocker (ARB) on pulmonary and systemic manifestations of emphysema in a mouse model...
  8. ncbi request reprint Insulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Germany
    Circ Res 92:169-76. 2003
    ..The increased [Ca2+]i with IGF-1 originates from both enhanced L-type Ca2+ currents and enhanced Na+-H+ exchange-dependent reverse-mode Na+-Ca2+ exchange. These nongenomic functional effects of IGF-1 may be of clinical relevance...
  9. ncbi request reprint Pressure overload and neurohumoral activation differentially affect the myocardial proteome
    Peter Schott
    Department of Cardiology and Respiratory Care, Georg August University, Gottingen, Germany
    Proteomics 5:1372-81. 2005
    ..This study represents the first in-depth analysis of global proteome alterations in a controlled animal model of pressure overload-induced myocardial hypertrophy...
  10. pmc BNP controls early load-dependent regulation of SERCA through calcineurin
    Karl Toischer
    Abteilung Kardiologie und Pneumologie, Georg August Universitat, Robert Koch Str 40, 37075, Gottingen, Germany
    Basic Res Cardiol 105:795-804. 2010
    ..This is followed by upregulation of natriuretic peptides with subsequent suppression of SERCA upregulation. Elevated natriuretic peptides may suppress SERCA expression by inhibition of calcineurin activity via activation of GC-A...
  11. doi request reprint Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction
    Claudius Jacobshagen
    Department of Cardiology, University of Gottingen, Gottingen, Germany
    Eur J Heart Fail 10:334-42. 2008
    ..It reduces load-induced LV dilation, contractile dysfunction and mortality in vivo. This may have clinical implications for the prevention and treatment of maladaptive hypertrophy and its progression to HF in humans...
  12. pmc Myocardial adaptation of energy metabolism to elevated preload depends on calcineurin activity : a proteomic approach
    Peter Schott
    Dept of Cardiology and Respiratory Care, Georg August University Gottingen, Gottingen, Germany
    Basic Res Cardiol 103:232-43. 2008
    ..This short-term adaptation to enhanced mechanical load appears to critically depend on calcineurin phosphatase activity...
  13. pmc Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model
    Lars Lüthje
    Kardiologie und Pneumologie, Georg August Universitat, Gottingen, Germany
    Respir Res 10:7. 2009
    ..Systemic effects of chronic obstructive pulmonary disease (COPD) significantly contribute to severity and mortality of the disease. We aimed to develop a COPD/emphysema model exhibiting systemic manifestations of the disease...
  14. ncbi request reprint Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms
    Wolfgang Schillinger
    Herzzentrum, Kardiologie und Pneumologie, Georg August Universitaet Goettingen, Robert Koch Strasse 40, 37099 Goettingen, Germany
    Circulation 116:57-66. 2007
    ..Proton pump inhibitors are used extensively for acid-related gastrointestinal diseases. Their effect on cardiac contractility has not been assessed directly...
  15. ncbi request reprint Alpha1-adrenergic stress induces downregulation of Na+/Ca2+ exchanger in myocardial preparations from rabbits at physiological preload
    Wolfgang Schillinger
    Universitaet Goettingen, Herzzentrum, Kardiologie und Pneumologie, Goettingen, Germany
    Eur J Heart Fail 9:329-35. 2007
    ..In hypertrophy and heart failure, distinct phenotypes with respect to NCX1 expression may result from the interaction between mechanical load and alpha1-adrenergic stimulation...
  16. ncbi request reprint Na(+)-Ca(2+) exchanger overexpression predisposes to reactive oxygen species-induced injury
    Stefan Wagner
    Department of Cardiology and Pneumology, , Robert Koch Str 40, , Germany
    Cardiovasc Res 60:404-12. 2003
    ..It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to increased expression of the sarcolemmal Na-Ca exchanger (NCX)...
  17. ncbi request reprint Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure
    Hans Peter Hermann
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Robert Koch Str 40, Göttingen D 37075, Germany
    Eur J Heart Fail 6:213-8. 2004
    ..Pyruvate increases myocardial performance in isolated myocardium and improves hemodynamics in patients with congestive heart failure...