D Koesling

Summary

Country: Germany

Publications

  1. ncbi request reprint Negative feedback in NO/cGMP signalling
    D Koesling
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, Med Fak MA N1, Universitatsstrasse 150, 44780 Bochum, Germany
    Biochem Soc Trans 33:1119-22. 2005
  2. ncbi request reprint Nitric oxide-sensitive guanylyl cyclase: structure and regulation
    Doris Koesling
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Neurochem Int 45:813-9. 2004
  3. ncbi request reprint Regulation of nitric oxide-sensitive guanylyl cyclase
    Andreas Friebe
    Abteilung für Pharmakologie, Medizinische Fakultat, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Circ Res 93:96-105. 2003
  4. doi request reprint Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition
    O Dangel
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum, Germany
    J Thromb Haemost 8:1343-52. 2010
  5. ncbi request reprint Desensitization of NO/cGMP signaling in smooth muscle: blood vessels versus airways
    Florian Mullershausen
    Institut fur Pharmakologie und Toxikologie, Ruhr Universitat Bochum, Medizinische Fakultät MA N1, Universitatsstrasse 150, 44780 Bochum, Germany
    Mol Pharmacol 69:1969-74. 2006
  6. doi request reprint Exogenous nitric oxide donation causes desensitization of arteriolar relaxing activity in vivo: an intravital analysis in mice
    Andrej Ring
    Department of Surgery, Trauma Center, University Hospital Bergmannsheil, Bochum, Germany
    J Surg Res 164:169-74. 2010
  7. pmc Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system
    Evanthia Mergia
    Institut fur Pharmakologie und Toxikologie, Ruhr Universitat Bochum, Bochum, Germany
    J Clin Invest 116:1731-7. 2006
  8. pmc In vivo reconstitution of the negative feedback in nitric oxide/cGMP signaling: role of phosphodiesterase type 5 phosphorylation
    Florian Mullershausen
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum, Germany
    Mol Biol Cell 15:4023-30. 2004
  9. ncbi request reprint The enhanced NO-induced cGMP response induced by long-term L-NAME treatment is not due to enhanced expression of NO-sensitive guanylyl cyclase
    Florian Mullershausen
    Pharmakologie und Toxikologie, Medizinische Fakultät MA N1 39, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Vascul Pharmacol 40:161-5. 2003
  10. pmc Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling
    Florian Mullershausen
    Abteilung für Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, MA N1 43, Universitaetsstr 150, 44780 Bochum, Germany
    J Cell Biol 160:719-27. 2003

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Negative feedback in NO/cGMP signalling
    D Koesling
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, Med Fak MA N1, Universitatsstrasse 150, 44780 Bochum, Germany
    Biochem Soc Trans 33:1119-22. 2005
    ..As the cGMP-induced PDE5 activation turned out to be sustained, in the range of hours, it is probably responsible for the NO-induced desensitization observed within NO/cGMP signalling...
  2. ncbi request reprint Nitric oxide-sensitive guanylyl cyclase: structure and regulation
    Doris Koesling
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Neurochem Int 45:813-9. 2004
    ..In sum, the two known isoforms may stand for the neuronal and vascular form of NO-sensitive GC reflecting a possible association to the neuronal and endothelial NO-synthase, respectively...
  3. ncbi request reprint Regulation of nitric oxide-sensitive guanylyl cyclase
    Andreas Friebe
    Abteilung für Pharmakologie, Medizinische Fakultat, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Circ Res 93:96-105. 2003
    ..Finally, regulation of GC expression and a possible modulation of GC activity by other factors are discussed...
  4. doi request reprint Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition
    O Dangel
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum, Germany
    J Thromb Haemost 8:1343-52. 2010
    ..However, NO has been postulated to influence these platelet functions also via cGMP-independent mechanisms...
  5. ncbi request reprint Desensitization of NO/cGMP signaling in smooth muscle: blood vessels versus airways
    Florian Mullershausen
    Institut fur Pharmakologie und Toxikologie, Ruhr Universitat Bochum, Medizinische Fakultät MA N1, Universitatsstrasse 150, 44780 Bochum, Germany
    Mol Pharmacol 69:1969-74. 2006
    ..In summary, our results demonstrate the physiological impact of PDE5 activation on the control of smooth muscle tone and provide an explanation for the apparent impairment of NO-induced vasorelaxation...
  6. doi request reprint Exogenous nitric oxide donation causes desensitization of arteriolar relaxing activity in vivo: an intravital analysis in mice
    Andrej Ring
    Department of Surgery, Trauma Center, University Hospital Bergmannsheil, Bochum, Germany
    J Surg Res 164:169-74. 2010
    ..To examine whether a similar phenomenon can be detected in vivo, we analyzed relaxations of microvessels in response to repeated applications of NO...
  7. pmc Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system
    Evanthia Mergia
    Institut fur Pharmakologie und Toxikologie, Ruhr Universitat Bochum, Bochum, Germany
    J Clin Invest 116:1731-7. 2006
    ....
  8. pmc In vivo reconstitution of the negative feedback in nitric oxide/cGMP signaling: role of phosphodiesterase type 5 phosphorylation
    Florian Mullershausen
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum, Germany
    Mol Biol Cell 15:4023-30. 2004
    ..Phosphorylation of PDE5 seems to act as memory switch for activation leading to long-term desensitization of the signaling pathway...
  9. ncbi request reprint The enhanced NO-induced cGMP response induced by long-term L-NAME treatment is not due to enhanced expression of NO-sensitive guanylyl cyclase
    Florian Mullershausen
    Pharmakologie und Toxikologie, Medizinische Fakultät MA N1 39, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Vascul Pharmacol 40:161-5. 2003
    ..The results show that a reduction of the endogenous NO production induced by long-term L-NAME treatment does not lead to an up-regulation of NO-sensitive GC on the level of protein expression...
  10. pmc Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling
    Florian Mullershausen
    Abteilung für Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, MA N1 43, Universitaetsstr 150, 44780 Bochum, Germany
    J Cell Biol 160:719-27. 2003
    ..In sum, we suggest NO-induced activation and phosphorylation of PDE5 as the mechanism for a long-lasting negative feedback loop shaping the cGMP response in human platelets in order to adapt to the amount of NO available...
  11. doi request reprint More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation
    Feras Taqatqeh
    Department of Neurophysiology, Medical School, Ruhr University Bochum, 44780 Bochum, Germany
    J Neurosci 29:9344-50. 2009
    ..The unexpected role of cGMP at two sites of the synaptic cleft explains many of the controversial results in former NO research in LTP and demonstrates the necessity of presynaptic and postsynaptic changes for LTP expression...
  12. ncbi request reprint Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes
    M Russwurm
    Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Biol Chem 276:44647-52. 2001
    ....
  13. ncbi request reprint Isoforms of NO-sensitive guanylyl cyclase
    Michael Russwurm
    Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr Universitat Bochum, Germany
    Mol Cell Biochem 230:159-64. 2002
    ..The interaction with PSD-95 locates the alpha2beta1 isoform in close proximity to the NO-generating NO synthase thereby enabling the NO sensor to respond to locally raised NO concentrations...
  14. ncbi request reprint Inhibition of deactivation of NO-sensitive guanylyl cyclase accounts for the sensitizing effect of YC-1
    Michael Russwurm
    Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr Universitat Bochum, Germany
    J Biol Chem 277:24883-8. 2002
    ..In contrast to the wild type enzyme, YC-1 did not increase NO sensitivity of this mutant, clearly establishing inhibition of deactivation as the underlying mechanism of the NO sensitizer YC-1...
  15. pmc Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase
    Andreas Friebe
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Proc Natl Acad Sci U S A 104:7699-704. 2007
    ..Our knockout model completely disrupts the NO/cGMP signaling cascade and provides evidence for the unique role of NO-GC as NO receptor...
  16. ncbi request reprint Dimerization of nitric oxide-sensitive guanylyl cyclase requires the alpha 1 N terminus
    Corina Wagner
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, MA N1, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Biol Chem 280:17687-93. 2005
    ..Whereas beta(1) forms heme containing homodimers and is stable, alpha(1) appears to be prone to misfolding and degradation when heterodimerization is impaired by deletion of important sequences...
  17. ncbi request reprint Purification and characterization of NO-sensitive guanylyl cyclase
    Michael Russwurm
    Institut fur Pharmakologie und Toxikologie, Ruhr Universitat Bochum, Germany
    Methods Enzymol 396:492-501. 2005
    ..In this chapter, a fast method for purification of the enzyme from bovine lungs is described, and basic methods for characterization of the enzyme are summarized...
  18. pmc Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes
    Corina Russwurm
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum 44780, Germany
    J Biol Chem 284:25782-90. 2009
    ..In sum, these results demonstrate dual acylation as mechanism targeting neuronal PDE2A3 to synapses thereby ensuring local control of cyclic nucleotides...
  19. pmc Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach
    Michael Russwurm
    Institut fur Pharmakologie und Toxikologie, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Federal Republic of Germany
    Biochem J 407:69-77. 2007
    ..The in vivo performance of these new indicators is demonstrated in living cells and validated by comparison with cGMP dynamics as measured by radioimmunoassays...
  20. doi request reprint cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I
    Achim Schmidtko
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    J Neurosci 28:8568-76. 2008
    ..Together, our results provide evidence that NO-GC is crucially involved in the central sensitization of pain pathways during inflammatory and neuropathic pain...
  21. pmc Effects of nitroglycerin/L-cysteine on soluble guanylate cyclase: evidence for an activation/inactivation equilibrium controlled by nitric oxide binding and haem oxidation
    Antonius C F Gorren
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, A 8010 Graz, Austria
    Biochem J 390:625-31. 2005
    ..These results suggest that the effect of GTN/Cys is the result of an activation/inactivation equilibrium that is controlled by the rate of NO release and haem oxidation...
  22. ncbi request reprint Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases
    Arash Haghikia
    Faculty of Medicine, Institute of Physiology, Department of Neurophysiology, Ruhr University Bochum, D 44780 Bochum, Germany
    J Neurosci 27:818-23. 2007
    ..The requirement of both NO receptor GCs for LTP indicates the existence of two distinct NO/cGMP-mediated pathways, which have to work in concert for expression of LTP...
  23. ncbi request reprint Major occurrence of the new alpha2beta1 isoform of NO-sensitive guanylyl cyclase in brain
    Evanthia Mergia
    Pharmakologie und Toxikologie, Medizinische Fakultät MA N1 39, Ruhr Universitat Bochum, 44780, Bochum, Germany
    Cell Signal 15:189-95. 2003
    ..In sum, the major occurrence of the alpha(2)beta(1) heterodimer suggests a special role in synaptic transmission; whether this isoform outside the brain also occurs in neuronal networks has to be addressed in future studies...
  24. ncbi request reprint Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272
    Florian Mullershausen
    Insititut für Pharmakologie und Toxikologie, Ruhr Universitat Bochum, Bochum, Germany
    Circulation 109:1711-3. 2004
    ..We assessed a potential inhibition of PDE5 by the new GC activator BAY 41-2272...
  25. pmc Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide
    Alexander Kollau
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Universitatsplatz 2, A 8010 Graz, Austria
    Biochem J 385:769-77. 2005
    ..In addition, the previous conflicting notion of the existence of a high-affinity GTN-metabolizing pathway operating in intact blood vessels but not in tissue homogenates is explained...
  26. pmc NO activation of guanylyl cyclase
    Michael Russwurm
    Institute for Pharmacology und Toxicology, Medical Faculty, Ruhr University Bochum, Bochum, Germany
    EMBO J 23:4443-50. 2004
    ..The model not only covers the data reported here but also consolidates results from previous studies on NO-binding and dissociation/deactivation of GC...
  27. ncbi request reprint NO-sensitive guanylyl cyclase and NO-induced feedback inhibition in cGMP signaling
    Florian Mullershausen
    Institut fuer Pharmakologie und Toxikologie, Medizinische Fakultaet MA N1, Ruhr Universitaet Bochum, Universitaetsstr 150, 44789 Bochum, Germany
    Front Biosci 10:1269-78. 2005
    ..Moreover, tuning of PDE5 activity may also represent a regulatory link to mediate cross talk between NO-induced and natriuretic peptide-induced cGMP signaling in general...
  28. pmc Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases
    Matteo Beretta
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Graz, Austria
    J Biol Chem 283:17873-80. 2008
    ..Incubation of ALDH1 or ALDH2 with GTN resulted in sustained, chloral hydrate-sensitive formation of NO. These data may explain the coupling of ALDH2-catalyzed GTN metabolism to sGC activation in vascular smooth muscle...
  29. ncbi request reprint Bioactivation of nitroglycerin by ascorbate
    Alexander Kollau
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Universitatsplatz 2, A 8010 Graz, Austria
    Mol Pharmacol 72:191-6. 2007
    ..This reaction may contribute to GTN bioactivation in blood vessels under conditions of GTN tolerance and ascorbate supplementation...