Alfred Koenigsrainer

Summary

Country: Germany

Publications

  1. pmc MSH2 and CXCR4 involvement in malignant VIPoma
    Sven Muller
    Department of General, Visceral and Transplant Surgery, Tubingen, Germany
    World J Surg Oncol 10:264. 2012
  2. pmc Treatment with bevacizumab and FOLFOXIRI in patients with advanced colorectal cancer: presentation of two novel trials (CHARTA and PERIMAX) and review of the literature
    Alexander Stein
    University Cancer Center Hamburg, Germany
    BMC Cancer 12:356. 2012
  3. pmc Adenocarcinoma arising in a cystic duplication of the small bowel: case report and review of literature
    Gregor Blank
    Department of General, Visceral and Transplant Surgery, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    World J Surg Oncol 10:55. 2012
  4. pmc Simultaneous adrenal and extra-adrenal myelolipoma - an uncommon incident: case report and review of the literature
    Derek Zieker
    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, Tuebingen, Germany
    World J Surg Oncol 6:72. 2008
  5. pmc Laparoscopic resection of a lymphangiomatous cyst of the colon: a case report
    Jonas Hoffmann
    Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Med Case Reports 5:431. 2011
  6. pmc Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis
    Alexandra Heininger
    Klinik für Anaesthesiologie und Intensivmedizin, University Hospital of Tubingen, Hoppe Seyler Str 03, 72076 Tubingen, Germany
    Crit Care 15:R77. 2011
  7. pmc A simple dummy liver assist device prolongs anhepatic survival in a porcine model of total hepatectomy by slight hypothermia
    Karolin Thiel
    Department of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Hoppe Seyler Strasse 3, Tuebingen 72076, Germany
    BMC Gastroenterol 11:79. 2011
  8. pmc A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma
    Andreas A Schnitzbauer
    University Hospital Regensburg, Department of Surgery, Regensburg, Germany
    BMC Cancer 10:190. 2010
  9. ncbi request reprint [Klatskin tumor surgical treatment]
    A Konigsrainer
    Klinik für Allgemeine, Viszeral und Transplantationschirurgie, Tubingen
    Praxis (Bern 1994) 95:1643-4. 2006
  10. ncbi request reprint The 'Blind Innsbruck Ostomy', a cutaneous enterostomy for long-term histologic surveillance after small bowel transplantation
    Alfred Konigsrainer
    Department of General and Transplant Surgery, Innsbruck Medical University Hospital, Innsbruck, Austria
    Transpl Int 20:867-74. 2007

Detail Information

Publications83

  1. pmc MSH2 and CXCR4 involvement in malignant VIPoma
    Sven Muller
    Department of General, Visceral and Transplant Surgery, Tubingen, Germany
    World J Surg Oncol 10:264. 2012
    ..1 per million per year. The molecular mechanisms that mediate development of VIPomas are poorly investigated and require definition...
  2. pmc Treatment with bevacizumab and FOLFOXIRI in patients with advanced colorectal cancer: presentation of two novel trials (CHARTA and PERIMAX) and review of the literature
    Alexander Stein
    University Cancer Center Hamburg, Germany
    BMC Cancer 12:356. 2012
    ..Besides multidisciplinary management further treatment intensification is warranted to improve the still limited prognosis...
  3. pmc Adenocarcinoma arising in a cystic duplication of the small bowel: case report and review of literature
    Gregor Blank
    Department of General, Visceral and Transplant Surgery, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    World J Surg Oncol 10:55. 2012
    ..Here we report a unique case of an adenocarcinoma arising in a coincidentally found cystic duplication of the small bowel...
  4. pmc Simultaneous adrenal and extra-adrenal myelolipoma - an uncommon incident: case report and review of the literature
    Derek Zieker
    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, Tuebingen, Germany
    World J Surg Oncol 6:72. 2008
    ..Other soft tissue tumours such as well-differentiated liposarcomas appear morphological almost identical. Preoperative imaging and especially biopsy are important tools to diagnose these lesions...
  5. pmc Laparoscopic resection of a lymphangiomatous cyst of the colon: a case report
    Jonas Hoffmann
    Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Med Case Reports 5:431. 2011
    ..abstract:..
  6. pmc Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis
    Alexandra Heininger
    Klinik für Anaesthesiologie und Intensivmedizin, University Hospital of Tubingen, Hoppe Seyler Str 03, 72076 Tubingen, Germany
    Crit Care 15:R77. 2011
    ..However, the contribution of CMV reactivation on morbidity and mortality is still controversial. Therefore, we analyzed the incidence and impact of CMV reactivation on outcome in patients with severe sepsis...
  7. pmc A simple dummy liver assist device prolongs anhepatic survival in a porcine model of total hepatectomy by slight hypothermia
    Karolin Thiel
    Department of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Hoppe Seyler Strasse 3, Tuebingen 72076, Germany
    BMC Gastroenterol 11:79. 2011
    ..To address this issue, the present animal study was aimed to analyze the pure clinical effects of a simple extracorporeal dummy device in an anhepatic porcine model of acute liver failure...
  8. pmc A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma
    Andreas A Schnitzbauer
    University Hospital Regensburg, Department of Surgery, Regensburg, Germany
    BMC Cancer 10:190. 2010
    ..Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC...
  9. ncbi request reprint [Klatskin tumor surgical treatment]
    A Konigsrainer
    Klinik für Allgemeine, Viszeral und Transplantationschirurgie, Tubingen
    Praxis (Bern 1994) 95:1643-4. 2006
    ....
  10. ncbi request reprint The 'Blind Innsbruck Ostomy', a cutaneous enterostomy for long-term histologic surveillance after small bowel transplantation
    Alfred Konigsrainer
    Department of General and Transplant Surgery, Innsbruck Medical University Hospital, Innsbruck, Austria
    Transpl Int 20:867-74. 2007
    ..A long-term cutaneous enterostomy, even if disconnected from the intestinal continuity, enables simple long-term monitoring of small bowel allografts...
  11. ncbi request reprint Liver resection without hilus preparation and with selective intrahepatic hilus stapling for benign tumors and liver metastasis
    Ingmar Königsrainer
    Department of General, Visceral and Transplant Surgery, Tubingen University Hospital, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Langenbecks Arch Surg 392:485-8. 2007
    ..Our primary aim was to analyze the feasibility, blood loss, blood transfusion requirements, incidence of complications, and outcome using the approach for intrahepatic devascularization leaving the extrahepatic hilus untouched...
  12. doi request reprint [Peritoneal carcinomatosis of colorectal cancer: cytoreductive surgery and hyperthermic intraperitoneal chemotherapy]
    I Königsrainer
    Allgemein, Viszeral und Transplantationschiurgie, Universitätsklinik Tübingen
    Dtsch Med Wochenschr 136:1811-4. 2011
    ..This article addresses aspects of the disease, the rationale behind peritonectomy with HIPEC, and the surgical management of peritoneal carcinomatosis...
  13. doi request reprint Acute laparoscopic intervention for diverticular disease (AIDD): a feasible approach
    Marty Zdichavsky
    Division of General, Visceral and Transplant Surgery, University Hospital Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
    Langenbecks Arch Surg 395:41-8. 2010
    ..Benefits of elective surgical therapies could advance the early laparoscopic approach for acute sigmoid diverticulitis...
  14. doi request reprint Surgery of colorectal carcinoma in patients aged over 80
    Claudius Falch
    Department of Surgery, Comprehensive Cancer Center, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen, Germany
    Onkologie 32:10-6. 2009
    ..The incidence of colorectal carcinoma increases rapidly in aged patients. We investigated retrospectively the differences in treatment relative to the patients' age...
  15. doi request reprint Phosphoglycerate kinase 1 promoting tumor progression and metastasis in gastric cancer - detected in a tumor mouse model using positron emission tomography/magnetic resonance imaging
    Derek Zieker
    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 26:147-54. 2010
    ....
  16. ncbi request reprint Enteral immunonutrition during sepsis prevents pulmonary dysfunction in a rat model
    Joerg Glatzle
    Department of General and Transplantation Surgery, University Hospital of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    J Gastrointest Surg 11:719-24. 2007
    ..Sepsis often results in severe pulmonary dysfunction. Via the thoracic duct, the lung is the first organ exposed to gut-derived inflammatory mediators released into mesenteric lymph during sepsis...
  17. doi request reprint IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism
    Stefan Lob
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Tubingen, Germany
    Cancer Immunol Immunother 58:153-7. 2009
    ..The levo-isoform (L-1MT) blocks IDO1, whereas dextro-1MT (D-1MT), which is used in clinical trials, inhibits IDO2. Here we analyze IDO2 expression in human cancer cells and the impact of both 1-MT isoforms on IDO activity...
  18. ncbi request reprint Predictive value of routine transcutaneous tissue oxygen tension (tcpO2) measurement for the risk of non-healing and amputation in diabetic foot ulcer patients with non-palpable pedal pulses
    Ruth Ladurner
    Department of General and Transplant Surgery, University Hospital of Tubingen, Germany
    Med Sci Monit 16:CR273-7. 2010
    ..It was evaluated whether transcutaneous tissue oxygen tension (tcpO2) measurement, when assessed in daily routine, can be used to predict the risk of non-healing and amputation in diabetic foot ulcer patients with non-palpable pedal pulses...
  19. doi request reprint Lactate modulates gene expression in human mesenchymal stem cells
    Derek Zieker
    Department of General and Transplant Surgery, University of Tuebingen, Tuebingen, Germany
    Langenbecks Arch Surg 393:297-301. 2008
    ..Recently, it has been shown in vivo that lactate is also able to favour homing of stem cells. The aim of this investigation was to test the hypothesis that lactate has an impact on gene expression of mesenchymal stem cells (MSC)...
  20. doi request reprint Everolimus interferes with the inflammatory phase of healing in experimental colonic anastomoses
    Markus A Küper
    Department of General, Visceral and Transplant Surgery, University of Tubingen, Germany
    J Surg Res 167:158-65. 2011
    ..The aim of this study was to test the hypothesis that the mTOR inhibitor everolimus interferes with the inflammatory phase of healing in experimental colonic anastomoses...
  21. pmc Cellular liver regeneration after extended hepatic resection in pigs
    Ruth Ladurner
    Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Hoppe Seyler Street 3, D 72076 Tubingen, Germany
    HPB Surg 2009:306740. 2009
    ..The aim of this study was to evaluate whether the regeneration is due to hypertrophy or hyperplasia of the remnant liver after extended resection and whether a portosystemic shunt is beneficial...
  22. doi request reprint (18)F-FDG-PET/CT to select patients with peritoneal carcinomatosis for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
    Christina Pfannenberg
    Department of Radiology and Nuclear Medicine, University of Tuebingen, Tubingen, Germany
    Ann Surg Oncol 16:1295-303. 2009
    ..This study was designed to predict tumor load in patients with PC using dual-modality (18)FDG-PET/CT and to compare the results with those of PET and CT alone by correlating imaging findings with intraoperative staging...
  23. doi request reprint M.A.I.D.: a prognostic score estimating probability of healing in chronic lower extremity wounds
    Stefan Beckert
    Department of General and Transplant Surgery, University of Tubingen, Tubingen, Germany
    Ann Surg 249:677-81. 2009
    ..To evaluate a wound-based prognostic score for chronic lower extremity wounds suitable for daily routine use capable of predicting long-term healing...
  24. doi request reprint Morbid obesity and subsequent pancreatic cancer: pylorus-preserving pancreatoduodenectomy after laparoscopic sleeve gastrectomy
    Markus A Küper
    Department of General, Visceral, and Transplantation Surgery, Comprehensive Cancer Center, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Obes Surg 19:385-8. 2009
    ..In addition, there is a need for epidemiological studies of patients who undergo bariatric surgery and subsequently develop cancer...
  25. doi request reprint Local peritonectomy highly attracts free floating intraperitoneal colorectal tumour cells in a rat model
    Ingmar Königsrainer
    Department of General, Visceral and Transplant Surgery, University of Tubingen, Germany
    Cell Physiol Biochem 23:371-8. 2009
    ..Tumour recurrence may occur early after surgery. One potential mechanism is the ability of peritoneal lesions to attract tumour cells...
  26. doi request reprint Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, University of Tubingen, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 96:E1126-30. 2011
    ..Additionally, we investigated whether genetic variation in the liver specific GCK promoter determines liver fat content in humans...
  27. doi request reprint Transient lower esophageal sphincter relaxation and esophageal motor response
    Joachim H Schneider
    Department of General, Visceral, and Transplantation Surgery, University of Tubingen, Tubingen, Germany
    J Surg Res 159:714-9. 2010
    ..The aim of this study was to assess the frequency of EMRs after TLESR in healthy individuals and GERD patients and to develop an animal model for further investigation of EMRs...
  28. doi request reprint A pancreas-preserving technique for the management of symptomatic pancreatic anastomotic insufficiency refractory to conservative treatment after pancreas head resection
    Ingmar Königsrainer
    Department of General, Visceral, and Transplant Surgery, Tubingen University Hospital, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Langenbecks Arch Surg 395:693-6. 2010
    ..Management of symptomatic pancreatic anastomotic insufficiency after pancreas head resection remains controversial. Completion pancreatectomy as one frequently performed option is associated with poor prognosis...
  29. doi request reprint Fifty percent area reduction after 4 weeks of treatment is a reliable indicator for healing--analysis of a single-center cohort of 704 diabetic patients
    Stephan Coerper
    Department of General and Transplant Surgery, University Hospital Tubingen, Germany
    J Diabetes Complications 23:49-53. 2009
    ..The aim of the study was to investigate whether an area reduction greater than 50% within the first 4 weeks of treatment is associated with a higher long-term probability of healing...
  30. ncbi request reprint Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction?
    Stefan Lob
    Department of General, Visceral and Transplantsurgery, Eberhard Karls University, Tubingen, Germany
    Langenbecks Arch Surg 393:995-1003. 2008
    ..One mechanism possibly capable of achieving immunoregulation is based on indoleamine-2,3-dioxygenase (IDO)...
  31. ncbi request reprint Long-term outcome of endoscopic treatment of biliary strictures after liver transplantation
    Ivo W Graziadei
    Department of Gastroenterology and Hepatology, Medical University of Innsbruck, Innsbruck, Austria
    Liver Transpl 12:718-25. 2006
    ..Development of NAS reduces graft but not patient survival after endoscopic therapy...
  32. doi request reprint Preserving duodenal passage for bone mineralization: Billroth I versus Billroth II reconstruction after partial gastrectomy in growing minipigs
    Ingmar Königsrainer
    Department of General, Visceral, and Transplant Surgery, University Hospital Tubingen, Tubingen, Germany
    J Surg Res 155:321-9. 2009
    ..Therefore, we investigated the impact of duodenal exclusion on bone mineralization in respect to newer duodenal preserving operations in morbid obesity surgery...
  33. doi request reprint Multichannel intraluminal impedance measurement of gastroesophageal reflux in patients with different stages of morbid obesity
    Juliane M E Schneider
    Tübingen Comprehensive Cancer Center, Department of Surgery, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Obes Surg 19:1522-9. 2009
    ..Obesity is now one of the world's major chronic diseases. The etiology of the severe comorbid conditions associated with morbid obesity is not fully understood, and in particular the relationship between gastroesophageal reflux and obesity...
  34. doi request reprint The Over-The-Scope Clip (OTSC) for the treatment of gastrointestinal bleeding, perforations, and fistulas
    Andreas Kirschniak
    Department of General, Visceral and Transplantation Surgery, University of Tubingen, Hoppe Seyler Straße 3, 72072 Tubingen, Germany
    Surg Endosc 25:2901-5. 2011
    ..The aim of this retrospective study was to analyze the therapeutic results of the performed treatments...
  35. doi request reprint Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?
    Stefan Lob
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Hoppe Seyler Strasse 3, Tubingen, Germany
    Nat Rev Cancer 9:445-52. 2009
    ..A better understanding of IDO biology is needed to comprehend the effect of IDO inhibitors and to provide a rationale for their therapeutic application in cancer...
  36. doi request reprint Non-acid gastroesophageal reflux measured using multichannel intraluminal impedance in older patients
    Joachim H Schneider
    Department of General, Visceral, and Transplant Surgery, University of Tubingen, Tubingen, Germany
    J Gastrointest Surg 14:S17-23. 2010
    ..Diagnosing gastroesophageal reflux disease is challenging in the older population, as comorbid conditions can obscure the disease...
  37. pmc Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:2616-23. 2009
    ..We investigated whether the SNP determines liver fat independently of visceral adiposity and whether it may even play a role in protecting from insulin resistance...
  38. doi request reprint The impact of a micro-lightguide spectrophotometer on the intraoperative assessment of hepatic microcirculation: a pilot study
    Ruth Ladurner
    Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Microvasc Res 77:387-8. 2009
    ..The intraoperative measurement of the peripheral microperfusion after liver transplantation is connected with quite an effort and a continuous evaluation in the postoperative follow up is not possible till now...
  39. ncbi request reprint Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells
    Stefan Lob
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Tubingen, Germany
    Blood 111:2152-4. 2008
    ..Consequently, in humans any possible antitumor effects of D-1MT cannot be attributed to abrogation of IDO activity in DCs as described in this study...
  40. doi request reprint A prospective randomized multicenter trial comparing histidine-tryptophane-ketoglutarate versus University of Wisconsin perfusion solution in clinical pancreas transplantation
    Stefan Schneeberger
    Department of General and Transplant Surgery, Medical University Innsbruck, Innsbruck, Austria
    Transpl Int 22:217-24. 2009
    ..3% (HTK) vs. 100% (UW) (P = 0.397). With a mean cold ischemia time of 10 h in this study, HTK and UW solutions appear to be equally suitable for perfusion and organ preservation in clinical pancreas transplantation...
  41. ncbi request reprint Spectrum of surgical complications after simultaneous pancreas-kidney transplantation in a prospectively randomized study of two immunosuppressive protocols
    Wolfgang Steurer
    Department of General and Transplant Surgery, Medical University of Innsbruck, Austria
    Nephrol Dial Transplant 20:ii54-62. 2005
    ..This report analyses the spectrum of surgical complications among patients receiving tacrolimus and cyclosporin microemulsion (ME)-based therapy for SPK transplantation...
  42. doi request reprint Extracellular brain ammonia levels in association with arterial ammonia, intracranial pressure and the use of albumin dialysis devices in pigs with acute liver failure
    Kerstin Zwirner
    Department of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Tuebingen, Germany
    Metab Brain Dis 25:407-12. 2010
    ..It correlated strongly with the ICP and could serve as a sensitive marker for HE development. Albumin dialysis did not affect blood or brain ammonia levels...
  43. doi request reprint Effects of isoniazid and niacin on experimental wound-healing
    Jürgen Weinreich
    Department of General and Transplant Surgery, University of Tubingen, Tubingen, Germany
    Surgery 147:780-8. 2010
    ..There is a need for effective treatments of ischemic wounds. Our aim was to test the hypothesis that systemic administration of isoniazid or niacin can enhance wound healing in ischemic as well as nonischemic tissues...
  44. doi request reprint Role of IDO in organ transplantation: promises and difficulties
    Stefan Lob
    Department of General, Visceral, and Transplant Surgery, University Hospital of Tubingen, Tubingen, Germany
    Int Rev Immunol 28:185-206. 2009
    ..In this review article we will discuss the role of IDO in transplantation and take a critical look at IDO-based therapeutic strategies...
  45. doi request reprint Mechanical ileus induces surgical intervention due to gastric balloon: a case report and review of the literature
    Marty Zdichavsky
    Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Tubingen, Germany
    Obes Surg 20:1743-6. 2010
    ..The gastric balloon model can be associated with major complications and should be used critically. Removal of the balloon should be assured not later than 6 months when weight loss decreases...
  46. doi request reprint The enterohepatic circulation of amanitin: kinetics and therapeutical implications
    Christian Thiel
    Department of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Hoppe Seyler Strasse 3, Tuebingen 72076, Germany
    Toxicol Lett 203:142-6. 2011
    ..Aim of the study was to demonstrate amanitin kinetics in the enterohepatic circulation...
  47. doi request reprint Laparoscopic rectosigmoid resection for acute sigmoid diverticulitis
    Marty Zdichavsky
    Division of General, Visceral and Transplant Surgery, Department of Surgery, Eberhard Karls University Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    J Gastrointest Surg 13:804-5. 2009
    ..As more surgeons gain expertise in minimally invasive surgery of the rectosigmoid, this video highlights the main steps of a rectosigmoid resection for acute complicated diverticulitis...
  48. doi request reprint PGK1 a potential marker for peritoneal dissemination in gastric cancer
    Derek Zieker
    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, Tuebingen, Germany
    Cell Physiol Biochem 21:429-36. 2008
    ..The mechanisms that mediate peritoneal carcinomatosis in diffuse primary gastric tumours require definition...
  49. doi request reprint Long-term quality-of-life after open and laparoscopic sigmoid colectomy
    Guido Seitz
    Department of Pediatric Surgery, University Hospital, Tubingen, Germany
    Surg Laparosc Endosc Percutan Tech 18:162-7. 2008
    ..Laparoscopic sigmoid colectomy (LSC) is frequently performed for sigmoid diseases with excellent prognosis. We aimed to determine the long-term quality-of-life after open sigmoid colectomy (OSC) compared with LSC...
  50. doi request reprint Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans
    Andreas Peter
    Dept of Internal Medicine, University of Tubingen, German Center for Diabetes Research, Germany
    Am J Physiol Endocrinol Metab 300:E321-6. 2011
    ..We suggest that the FA composition of lipid subclasses, rather than of mixed lipids, should be analyzed to estimate SCD1 activity...
  51. pmc Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer
    Derek Zieker
    Department of General Visceral, Transplant Surgery Comprehensive Cancer Center, University of Tuebingen, D 72076 Tuebingen, Germany
    Int J Cancer 126:1513-20. 2010
    ..Thus, PGK1 may serve as prognostic marker and/or be a potential therapeutic target to prevent dissemination of gastric carcinoma cells into the peritoneum...
  52. ncbi request reprint Efficacy of topical pale sulfonated shale oil in the treatment of venous leg ulcers: a randomized, controlled, multicenter study
    Stefan Beckert
    Department of General and Transplantsurgery, University Hospital, Tubingen, Germany
    J Vasc Surg 43:94-100. 2006
    ..The aim of this study was to investigate whether PSSO is capable of enhancing venous ulcer healing beyond compression therapy alone...
  53. ncbi request reprint Stimulation of steroid-suppressed cutaneous healing by repeated topical application of IGF-I: different mechanisms of action based upon the mode of IGF-I delivery
    Stefan Beckert
    Department of General and Transplant Surgery, University of Tubingen, Tubingen, Germany
    J Surg Res 139:217-21. 2007
    ..The aim of this study was to show the effect of daily topical IGF-I therapy on cutaneous ulcer healing in a steroid-suppressed wound model...
  54. ncbi request reprint IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase
    Stefan Beckert
    Department of Surgery, School of Medicine, University of California, San Francisco, 94123, USA
    Biochem Biophys Res Commun 341:67-72. 2006
    ..The IGF-I-mediated phosphorylation and inhibition of PARP represent a novel mechanism of VEGF protein expression...
  55. doi request reprint Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation
    Sascha Venturelli
    Department of Internal Medicine I, Medical University Hospital, Otfried Mueller Str 10, D 72076 Tuebingen, Germany
    Gut 60:156-65. 2011
    ..Therefore, 5-aza-CR and 5-aza-dC were investigated in the context of TRAIL resistance...
  56. ncbi request reprint Lactate stimulates endothelial cell migration
    Stefan Beckert
    Department of Surgery, University of California, San Francisco, California, USA, and Department of General Surgery, University Hospital Tubingen, Germany
    Wound Repair Regen 14:321-4. 2006
    ..Lactate enhances VEGF production in endothelial cells, although lactate, itself, is not a chemoattractant. We conclude that the lactate-mediated increase in cellular migration is regulated by VEGF...
  57. ncbi request reprint The impact of the Micro-Lightguide O2C for the quantification of tissue ischemia in diabetic foot ulcers
    Stefan Beckert
    Department of General Surgery, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Diabetes Care 27:2863-7. 2004
    ..This study investigates the impact of the tissue O2 analysis system "O2C" for noninvasive quantification of tissue oxygenation in diabetic foot ulcer patients...
  58. doi request reprint Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen Germany
    Clin Chem 55:2113-20. 2009
    ..Additionally, we further evaluated commonly used fatty acid ratios [elongase, de novo lipogenesis, and Delta5 and Delta6 desaturase] in plasma VLDL and hepatic lipid fractions...
  59. ncbi request reprint A new wound-based severity score for diabetic foot ulcers: A prospective analysis of 1,000 patients
    Stefan Beckert
    Department of General and Transplant Surgery, University of Tubingen, Tubingen, Germany
    Diabetes Care 29:988-92. 2006
    ..The aim of this study was to establish a new wound-based clinical scoring system for diabetic foot ulcers suitable for daily clinical practice anticipating chances for healing and risk of amputation...
  60. ncbi request reprint Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells
    Gerald Brandacher
    Department of General and Transplant Surgery, Innsbruck Medical University, Austria
    Clin Cancer Res 12:1144-51. 2006
    ..In this study, we examined the contribution of the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) on this phenomenon...
  61. doi request reprint Cytostatic activity of the duplex drug linking 2'-deoxy-5-fluorouridine (5FdU) with 3'-C-ethynylcytidine (ECyd) against gastric adenocarcinoma cell lines
    Jürgen Weinreich
    Department of General, Visceral and Transplant Surgery, University of Tubingen, Tubingen, Germany
    Invest New Drugs 29:1294-302. 2011
    ..Due to its high cytostatic potential the duplex drug, which covalently links two active anticancer compounds, could be a new therapeutic alternative for chemotherapy in gastric cancer, currently treated with different combinations...
  62. doi request reprint Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learned
    Ingmar Königsrainer
    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Langenbecks Arch Surg 396:1077-81. 2011
    ..De novo cytoreductive surgery is crucial with the potential to improve prognosis, especially when combined with hyperthermic intraperitoneal chemotherapy (HIPEC)...
  63. ncbi request reprint Are indoleamine-2,3-dioxygenase producing human dendritic cells a tool for suppression of allogeneic T-cell responses?
    Stefan Lob
    Department of General, Visceral and Transplantation Surgery, Eberhard Karls University, Tubingen, Germany
    Transplantation 83:468-73. 2007
    ..This subset, characterized by nonadherence and CD123/CCR6 expression, exhibited sustained IDO production if exposed to interleukin (IL)-10. In the present work, we generated human nonadherent, CD123/CCR6 DCs secreting IL-10...
  64. doi request reprint Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized Wound Care Center
    Corinna Wicke
    Department of Surgery, University of Tubingen, Tubingen, Germany
    Wound Repair Regen 17:25-33. 2009
    ..Comorbidity was documented by the coprevalence of up to three underlying diseases related to impaired wound healing. The present study clearly showed that aging affects chronic wound healing negatively...
  65. ncbi request reprint Mitomycin C plus infusional 5-fluorouracil in platinum-refractory gastric adenocarcinoma: an extended multicenter phase II study
    Jorg Thomas Hartmann
    Abteilung Onkologie Hämatologie Immunologie Rheumatologie Pulmologie, Medizinische Klinik II, Eberhard Karls Universitat, Tubingen, Germany
    Onkologie 30:235-40. 2007
    ..To assess the toxicity and activity of bolus mitomycin C (MMC) in combination with a 24-hour continuous infusion of 5-fluorouracil (5-FU) in gastric cancer patients who had received at least one prior chemotherapy regimen...
  66. doi request reprint Sudden death after pancreatic head resection: rupture of hepatic artery caused by clostridial infection
    Ingmar Königsrainer
    Department of General, Visceral and Transplant Surgery, Tubingen University Hospital, Tubingen, Germany
    Surg Infect (Larchmt) 8:615-9. 2007
    ..Rupture of the hepatic artery caused by clostridial infection has not been reported before...
  67. ncbi request reprint Arginine vasopressin, but not epinephrine, improves survival in uncontrolled hemorrhagic shock after liver trauma in pigs
    Wolfgang G Voelckel
    Departments of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Crit Care Med 31:1160-5. 2003
    ..epinephrine vs. saline placebo on hemodynamic variables, regional blood flow, and short-term survival in an animal model of uncontrolled hemorrhagic shock and delayed fluid resuscitation...
  68. ncbi request reprint Alendronate in combination with calcium and vitamin D prevents bone loss after orthotopic liver transplantation: a prospective single-center study
    Gunda Millonig
    Department of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    Liver Transpl 11:960-6. 2005
    ..In conclusion, our study suggests that alendronate is efficacious in preventing the natural course of bone loss associated with LT...
  69. doi request reprint Response to preoperative therapy in upper gastrointestinal cancers
    Björn L D M Brücher
    Department of Surgery, Comprehensive Cancer Center, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen, Germany
    Ann Surg Oncol 16:878-86. 2009
    ..As patients with upper gastrointestinal cancers often undergo multimodal therapy, it is therefore imperative that new definitions for assessing the response to preoperative therapy be established...
  70. ncbi request reprint Left and right lobe split-liver transplantation for two paediatric recipients from a 9-year-old donor
    Hugo Bonatti
    Department of General and Transplant Surgery, University Hospital, Innsbruck, Austria
    Transpl Int 18:811-5. 2005
    ..These cases demonstrate the feasibility of splitting even paediatric grafts for two small children...
  71. ncbi request reprint Influence of negative expiratory pressure ventilation on hemodynamic variables during severe hemorrhagic shock
    Anette C Krismer
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Crit Care Med 34:2175-81. 2006
    ..Therefore, the purpose of our study was to evaluate the effects of negative expiratory pressure ventilation on mean arterial blood pressure, cardiac output, and short-term survival during severe hemorrhagic shock...
  72. ncbi request reprint Long-term efficacy and safety of mycophenolate mofetil in liver transplant recipients with calcineurin inhibitor-induced renal dysfunction
    Robert O Koch
    Department of Gastroenterology and Hepatology, University of Innsbruck, Innsbruck, Austria
    Transpl Int 17:518-24. 2004
    ..This study demonstrates the long-term efficacy and safety of MMF in OLT recipients with CI-induced nephropathy...
  73. ncbi request reprint Complete hepatic ischemia due to torsion of a large accessory liver lobe: first case to require transplantation
    Ruth Ladurner
    Department of General and Transplant Surgery, University Hospital Innsbruck, Austria
    Transpl Int 18:467-9. 2005
    ..Although rare, an accessory liver lobe may cause serious and life-threatening problems and should therefore be kept in mind in patients presenting with acute abdominal pain...
  74. doi request reprint Preoperative assessment of peritoneal carcinomatosis: intraindividual comparison of 18F-FDG PET/CT and MRI
    Bernhard Daniel Klumpp
    Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Abdom Imaging 38:64-71. 2013
    ..Our study compares dynamic contrast enhanced 3D MRI (T1wDCE) and 18F-FDG PET/CT regarding diagnostic accuracy in correlation with surgical exploration (SE) and histological (HI) results...
  75. pmc Standardized intensive care unit management in an anhepatic pig model: new standards for analyzing liver support systems
    Christian Thiel
    Department of General, Visceral and Transplant Surgery, Tubingen University Hospital, Hoppe Seyler Str, 3 Tübingen, D 72076, Germany
    Crit Care 14:R138. 2010
    ..The aim of this study was to analyze anhepatic survival time under standardized intensive care therapy in a pig model...
  76. ncbi request reprint Olive oil is more potent than fish oil to reduce septic pulmonary dysfunctions in rats
    Joerg Glatzle
    Department of General and Transplantation Surgery, University Hospital of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Langenbecks Arch Surg 392:323-9. 2007
    ..Abdominal sepsis is frequently the cause of severe pulmonary dysfunction. Via the thoracic duct, the lung is the first organ exposed to gut-derived mediators released into the mesenteric lymph...
  77. doi request reprint Laparoscopic sleeve gastrectomy: standardized technique of a potential stand-alone bariatric procedure in morbidly obese patients
    Markus A Kueper
    Department of General, Visceral and Transplant Surgery, University Hospital Tuebingen, Tuebingen, Germany
    World J Surg 32:1462-5. 2008
    ..The aim of this study was to define a standardized technique for laparoscopic sleeve gastrectomy in the morbidly obese patient...
  78. ncbi request reprint Influence of positive end-expiratory pressure ventilation on survival during severe hemorrhagic shock
    Anette C Krismer
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Ann Emerg Med 46:337-42. 2005
    ..Secondary study endpoints were hemodynamic variables and blood gases...
  79. ncbi request reprint A new endoscopic over-the-scope clip system for treatment of lesions and bleeding in the GI tract: first clinical experiences
    Andreas Kirschniak
    Clinic for General, Visceral and Transplantation Surgery, University Hospital of Tubingen, IHCI Institute, Steinbeis University Berlin, Ovesco Endoscopy GmbH, Tubingen, Germany
    Gastrointest Endosc 66:162-7. 2007
    ..We report on 11 patients with gastric or colonic bleeding or lesions who were treated with a new endoscopic over-the-scope clip (OTSC) system...
  80. ncbi request reprint Large proportion of low frequency microsatellite-instability and loss of heterozygosity in pheochromocytoma and endocrine tumors detected with an extended marker panel
    Susan Kupka
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Waldhornlestrasse 22, 72072 Tubingen, Germany
    J Cancer Res Clin Oncol 134:463-71. 2008
    ..Since microsatellite markers used for MSI detection have only been recommended for colorectal carcinoma (CRC), we established an extended marker set for MSI detection in PCC...
  81. ncbi request reprint Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs
    Karl H Stadlbauer
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesthesiology 98:699-704. 2003
    ..The authors compared the effects of vasopressin fluid resuscitation on survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs...
  82. ncbi request reprint Evaluation of mitochondrial respiratory function in small biopsies of liver
    Andrey V Kuznetsov
    Department of Transplant Surgery, D Swarovski Research Laboratory, University Hospital Innsbruck, Anichstrasse 35, Innsbruck, A 6020, Austria
    Anal Biochem 305:186-94. 2002
    ..This provides a basis for the analysis of mitochondrial function in human liver biopsies...
  83. ncbi request reprint Loss of intrahepatic bile ducts: an important feature of familial hemophagocytic lymphohistiocytosis
    Klaus Kapelari
    Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria
    Virchows Arch 446:619-25. 2005
    ..Consequently the patient underwent haploidentical peripheral stem cell transplantation. This patient is alive 5 years later. Loss of bile ducts may be an important feature of hepatic involvement by FHL...