Holger M Koch

Summary

Country: Germany

Publications

  1. pmc Human body burdens of chemicals used in plastic manufacture
    Holger M Koch
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2063-78. 2009
  2. ncbi request reprint Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP
    Holger M Koch
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Institute of the Ruhr University Bochum, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Int J Hyg Environ Health 210:9-19. 2007
  3. ncbi request reprint Di-n-butylphthalate and butylbenzylphthalate - urinary metabolite levels and estimated daily intakes: pilot study for the German Environmental Survey on children
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Erlangen, Germany
    J Expo Sci Environ Epidemiol 17:378-87. 2007
  4. ncbi request reprint Determination of secondary, oxidised di-iso-nonylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers
    Holger M Koch
    Institut und Poliklinik für Arbeits, Sozial und Umweltmedizin, Schillerstrasse 25 29, 91054 Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 847:114-25. 2007
  5. doi request reprint Biomonitoring of exposure to N-methyl-2-pyrrolidone in workers of the automobile industry
    Swetlana Meier
    Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung, Institut der Ruhr Universität Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Ann Occup Hyg 57:766-73. 2013
  6. ncbi request reprint Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children -- A comparison of two estimation models based on urinary DEHP metabolite levels
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Enironmental Medicine, University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 210:35-42. 2007
  7. doi request reprint Exposure to phthalates in 5-6 years old primary school starters in Germany--a human biomonitoring study and a cumulative risk assessment
    Holger M Koch
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Int J Hyg Environ Health 214:188-95. 2011
  8. ncbi request reprint Exposure of nursery school children and their parents and teachers to di-n-butylphthalate and butylbenzylphthalate
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054, Erlangen, Germany
    Int Arch Occup Environ Health 78:223-9. 2005
  9. doi request reprint Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans after single oral doses
    Holger M Koch
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum IPA, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    Arch Toxicol 87:799-806. 2013
  10. ncbi request reprint New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054, Erlangen, Germany
    Arch Toxicol 79:367-76. 2005

Collaborators

Detail Information

Publications35

  1. pmc Human body burdens of chemicals used in plastic manufacture
    Holger M Koch
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2063-78. 2009
    ..We discuss several factors relevant for interpreting and understanding biomonitoring data, including selection of both biomarkers of exposure and human matrices, and toxicokinetic information...
  2. ncbi request reprint Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP
    Holger M Koch
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Institute of the Ruhr University Bochum, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Int J Hyg Environ Health 210:9-19. 2007
    ..After 24h, the carboxy-MINP metabolites replaced the OH-MINP metabolites as the major urinary metabolites. All oxidised DINP metabolites are suitable parameters for biomonitoring human DINP exposure...
  3. ncbi request reprint Di-n-butylphthalate and butylbenzylphthalate - urinary metabolite levels and estimated daily intakes: pilot study for the German Environmental Survey on children
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Erlangen, Germany
    J Expo Sci Environ Epidemiol 17:378-87. 2007
    ..For both phthalates and independent of the model, we found increasing daily intakes with decreasing age. Between 25% (creatinine model) and 50% (volume model) of the 2-4-year old children had daily intakes for DnBP above the TDI...
  4. ncbi request reprint Determination of secondary, oxidised di-iso-nonylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers
    Holger M Koch
    Institut und Poliklinik für Arbeits, Sozial und Umweltmedizin, Schillerstrasse 25 29, 91054 Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 847:114-25. 2007
    ..9microg/l OH-MINP, 8.9microg/l oxo-MINP and 16.4microg/l carboxy-MINP. Metabolites strongly correlated with each other over all samples analyzed (R>0.99, p<0.0001)...
  5. doi request reprint Biomonitoring of exposure to N-methyl-2-pyrrolidone in workers of the automobile industry
    Swetlana Meier
    Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung, Institut der Ruhr Universität Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Ann Occup Hyg 57:766-73. 2013
    ....
  6. ncbi request reprint Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children -- A comparison of two estimation models based on urinary DEHP metabolite levels
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Enironmental Medicine, University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 210:35-42. 2007
    ..Younger children seem to be more severely burdened, which may be due to a higher food consumption related to their bw, mouthing behaviour and/or playing near the ground...
  7. doi request reprint Exposure to phthalates in 5-6 years old primary school starters in Germany--a human biomonitoring study and a cumulative risk assessment
    Holger M Koch
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Int J Hyg Environ Health 214:188-95. 2011
    ..Therefore, the overall exposure to a number of phthalates, and the knowledge that these phthalates (and other anti-androgens) act in a dose-additive manner, urgently warrants a cumulative risk assessment approach...
  8. ncbi request reprint Exposure of nursery school children and their parents and teachers to di-n-butylphthalate and butylbenzylphthalate
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054, Erlangen, Germany
    Int Arch Occup Environ Health 78:223-9. 2005
    ..To obtain an estimate of internal exposure to DnBP and BBzP we compared the excretion of their metabolites in the urine of nursery school children with that of their teachers and parents...
  9. doi request reprint Metabolism of the plasticizer and phthalate substitute diisononyl-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans after single oral doses
    Holger M Koch
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum IPA, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    Arch Toxicol 87:799-806. 2013
    ..With this study, we provide reliable urinary excretion factors to calculate DINCH(®) intakes based on these metabolites in environmental and occupational studies...
  10. ncbi request reprint New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054, Erlangen, Germany
    Arch Toxicol 79:367-76. 2005
    ..All secondary metabolites are unsusceptible to contamination. Furthermore, there are strong hints that the secondary oxidised DEHP metabolites-not DEHP or MEHP-are the ultimate developmental toxicants...
  11. ncbi request reprint Determination of bisphenol a in urine from mother-child pairs-results from the duisburg birth cohort study, Germany
    Monika Kasper-Sonnenberg
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 75:429-37. 2012
    ..Only small amounts (less than 16%) were detectable as free (unconjugated) BPA. Analytical reliability is high even at such low levels, provided that external contamination is minimized...
  12. ncbi request reprint Di(2-ethylhexyl)phthalate (DEHP) exposure of voluntary plasma and platelet donors
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 208:489-98. 2005
    ..At present, discontinuous-flow devices should be preferred to avert conceivable health risks from plateletpheresis donors. Strategies to avoid DEHP exposure of donors during apheresis need to be developed...
  13. ncbi request reprint Internal exposure of the general population to DEHP and other phthalates--determination of secondary and primary phthalate monoester metabolites in urine
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, Erlangen D 91054, Germany
    Environ Res 93:177-85. 2003
    ..0 microg/L, for monoethylphthalate (MEP) 90.2 microg/L and for mono-n-octylphthalate (MOP)<1.0 microg/L (LOQ). These results will help to perform health risk assessments for the phthalate exposure of the general population...
  14. doi request reprint Bisphenol A in 24 h urine and plasma samples of the German Environmental Specimen Bank from 1995 to 2009: a retrospective exposure evaluation
    Holger M Koch
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance Institute of the Ruhr University Bochum, Burkle de la Camp Platz 1, Bochum, Germany
    J Expo Sci Environ Epidemiol 22:610-6. 2012
    ..Unconjugated BPA in urine and unconjugated or total BPA in plasma where contamination or breakdown of the glucuronide cannot be ruled out are of no value for human exposure assessment...
  15. doi request reprint Quantification of biomarkers of environmental exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) in urine via HPLC-MS/MS
    André Schütze
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 895:123-30. 2012
    ..With this analytical method we are able to perform human metabolism studies to provide metabolic conversion factors and to investigate the extent of DINCH exposure in the general population...
  16. ncbi request reprint Biological monitoring of the five major metabolites of di-(2-ethylhexyl)phthalate (DEHP) in human urine using column-switching liquid chromatography-tandem mass spectrometry
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25, D 91054 Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 816:269-80. 2005
    ..It will help to further explore the human metabolism of DEHP-an occupational and environmental toxicant of great concern...
  17. ncbi request reprint Penetration of beta-naphthylamine and o-toluidine through human skin in vitro
    Lars Lüersen
    Institute and Out Patient Clinic of Occupational, Social and Environmental Medicine, University Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 80:644-6. 2006
    ..2 vs. 0.8 h) and in high percentages (54 vs. 50%, respectively, of the applied dose within 24 h). A skin notation is therefore justified for these substances...
  18. doi request reprint Rapid determination of N-acetyl-4-aminophenol (paracetamol) in urine by tandem mass spectrometry coupled with on-line clean-up by two dimensional turbulent flow/reversed phase liquid chromatography
    Hendrik Modick
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr Universität Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 925:33-9. 2013
    ..Therefore, other routes of exposure than direct use of paracetamol, like aniline or paracetamol contaminated foodstuff, leading to the NAAP excretions have to be taken into account...
  19. doi request reprint Determination of 2,3-dihydroxypropionamide, an oxidative metabolite of acrylamide, in human urine by gas chromatography coupled with mass spectrometry
    Julia M Latzin
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr Universität Bochum IPA, Bochum, Germany
    Anal Bioanal Chem 402:2431-8. 2012
    ..Currently, we cannot confirm OH-PA to be a specific biomarker of the oxidative pathway of AA metabolism. Other sources than AA respectively GA might need to be considered for the formation of OH-PA...
  20. ncbi request reprint An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen, Erlangen, Germany
    Int J Hyg Environ Health 206:77-83. 2003
    ..The transgressions of the TDI and RfD for DEHP are accompanied by considerable ubiquitous exposures to DnBP and BbzP, two phthalates under scrutiny for similar toxicological mechanisms...
  21. ncbi request reprint Intravenous exposure to di(2-ethylhexyl)phthalate (DEHP): metabolites of DEHP in urine after a voluntary platelet donation
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 79:689-93. 2005
    ..Especially women in their reproductive age need to be protected from DEHP exposures exceeding the above mentioned preventive limit values...
  22. ncbi request reprint Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP)
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 207:15-22. 2004
    ..To date no information on the biological activity and toxicity of oxidative metabolites of DEHP is available. Since these are the major metabolites of DEHP toxicological data on these metabolites is urgently needed...
  23. ncbi request reprint N-Acetyl-4-aminophenol (paracetamol), N-acetyl-2-aminophenol and acetanilide in urine samples from the general population, individuals exposed to aniline and paracetamol users
    Georg Dierkes
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr Universität Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Int J Hyg Environ Health 217:592-9. 2014
    ....
  24. ncbi request reprint Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 78:123-30. 2004
    ..0 to 9.3. The excretion ratio of 5OH-MEHP to 5oxo-MEHP remained constant through time at 1.7 in the mean. After 44 h, 47% of the DEHP dose was excreted in urine, comprising MEHP (7.3%), 5OH-MEHP (24.7%) and 5oxo-MEHP (14.9%)...
  25. doi request reprint Ubiquitous presence of paracetamol in human urine: sources and implications
    Hendrik Modick
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr Universität Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Reproduction 147:R105-17. 2014
    ..Our findings indicate exposure to aniline (or aniline-releasing substances) as well as nutrition (next to the direct use of acetaminophen as medication) as possible sources of internal body burdens of NA4AP. ..
  26. ncbi request reprint Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll® DINCH® in 24 h urine samples from the German Environmental Specimen Bank
    André Schütze
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr Universität Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Int J Hyg Environ Health 217:421-6. 2014
    ....
  27. ncbi request reprint Quantification of four major metabolites of embryotoxic N-methyl- and N-ethyl-2-pyrrolidone in human urine by cooled-injection gas chromatography and isotope dilution mass spectrometry
    Birgit K Schindler
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr University Bochum IPA, Bochum, Germany
    Anal Chem 84:3787-94. 2012
    ..The high sensitivity of the method enables us to quantify NMP and NEP metabolites at current environmental exposures by human biomonitoring...
  28. ncbi request reprint Visible and subclinical skin changes in male and female dispatch department workers of newspaper printing plants
    Gintautas Korinth
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Skin Res Technol 11:132-9. 2005
    ..In contrast, physical irritation of the skin as another potential cause of occupational hand dermatitis has been investigated less...
  29. ncbi request reprint On-line clean-up by multidimensional liquid chromatography-electrospray ionization tandem mass spectrometry for high throughput quantification of primary and secondary phthalate metabolites in human urine
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, D 91054, Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 784:169-82. 2003
    ..Since secondary, functionalized metabolites of DEHP are included in the method an enduring problem of the past is excluded: sample contamination in the pre-analytical and analytical phase by both di- and monoesters...
  30. ncbi request reprint Impact of different welding techniques on biological effect markers in exhaled breath condensate of 58 mild steel welders
    Frank Hoffmeyer
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr Universität Bochum IPA, Bochum, Germany
    J Toxicol Environ Health A 75:525-32. 2012
    ..This study suggests an enhanced irritative effect in the lower airways of mild steel welders due to the application of FCAW compared to GMAW, most likely associated with a higher emission of welding fumes...
  31. doi request reprint Levels of phthalate metabolites in urine among mother-child-pairs - results from the Duisburg birth cohort study, Germany
    Monika Kasper-Sonnenberg
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 215:373-82. 2012
    ..Further analyses are ongoing to study long-term phthalate exposure and the associations with puberty outcome in these children...
  32. doi request reprint Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide
    Eva C Hartmann
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nurnberg, Schillerstr 25 29, 91054, Erlangen, Germany
    Arch Toxicol 85:601-6. 2011
    ....
  33. ncbi request reprint Occurrence and daily variation of phthalate metabolites in the urine of an adult population
    Hermann Fromme
    Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, D 85764 Oberschleissheim, Germany
    Int J Hyg Environ Health 210:21-33. 2007
    ..Our results of within-subject variability suggest that exposure assessment should not be based on a single urine measurement...
  34. ncbi request reprint DEHP metabolites in urine of children and DEHP in house dust
    Kerstin Becker
    Umweltbundesamt Federal Environmental Agency, Berlin, Germany
    Int J Hyg Environ Health 207:409-17. 2004
    ..The house dust analyses revealed DEHP contamination of all samples. The GM was 508 mg/kg dust. No correlation could be observed between the levels of any of the urinary DEHP metabolites and those of DEHP in house dust...
  35. ncbi request reprint NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps
    Holger M Koch
    Reprod Toxicol 18:759-60; author reply 761-4. 2004