Horbelt D, Boergermann J, Chaikuad A, Alfano I, Williams E, Lukonin I, et al
. Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem. 2015;290:3390-404 pubmed publisher
..We therefore suggest these inhibitors as suitable tools to promote functional myogenesis. ..
Paarmann P, Dörpholz G, Fiebig J, Amsalem A, Ehrlich M, Henis Y, et al
. Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling. Int J Biochem Cell Biol. 2016;76:51-63 pubmed publisher
..Our findings contribute to the understanding of fundamental mechanisms of BMP signaling and thus provide important information for future consideration in the context of therapeutic applications of BMPs. ..
SÃ¡nchez Duffhues G, Hiepen C, Knaus P, Ten Dijke P. Bone morphogenetic protein signaling in bone homeostasis. Bone. 2015;80:43-59 pubmed publisher
..This article is part of a Special Issue entitled "Muscle Bone Interactions". ..
Benn A, Bredow C, Casanova I, VukiÄeviÄ‡ S, Knaus P. VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling. J Cell Sci. 2016;129:206-18 pubmed publisher
Yadin D, Knaus P, Mueller T. Structural insights into BMP receptors: Specificity, activation and inhibition. Cytokine Growth Factor Rev. 2016;27:13-34 pubmed publisher
..Detailed knowledge about the receptors has enabled the development of BMP-specific type I receptor kinase inhibitors. In future these may help to treat human diseases such as fibrodysplasia ossificans progressiva. ..
Benn A, Hiepen C, Osterland M, SchÃ¼tte C, Zwijsen A, Knaus P. Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence. FASEB J. 2017;31:4720-4733 pubmed publisher
..Hiepen, C., Osterland, M., SchÃ¼tte, C., Zwijsen, A., Knaus, P. Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence. ..
Schreiber I, Dörpholz G, Ott C, Kragesteen B, Schanze N, Lee C, et al
. BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPAR? and GLUT4 upregulation. Sci Rep. 2017;7:17192 pubmed publisher
..Collectively, these findings suggest the BMP2 and BMP6 pathway(s) as promising new drug targets to treat insulin resistance. ..
Dörpholz G, Murgai A, Jatzlau J, Horbelt D, Belverdi M, Heroven C, et al
. IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation. Sci Rep. 2017;7:8778 pubmed publisher
..These findings provide profound understanding of the role of BMP signalling in early myogenic differentiation and open new ways for targeting the BMP pathway in muscle regeneration. ..
Kopf J, Petersen A, Duda G, Knaus P. BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway. BMC Biol. 2012;10:37 pubmed publisher
..Furthermore, the crosstalk of both pathways over longer time periods might occur on several signalling levels. ..