Enno Klussmann


Country: Germany


  1. request reprint
    Deák V, Klussmann E. Pharmacological Interference With Protein-protein Interactions of Akinase Anchoring Proteins as a Strategy for the Treatment of Disease. Curr Drug Targets. 2016;17:1147-71 pubmed
    ..Targeting AKAP dependent protein-protein interactions for interference with local signal processing inside cells potentially allows for the development of therapeutics with high selectivity and fewer side effects. ..
  2. Ercu M, Klussmann E. Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System. J Cardiovasc Dev Dis. 2018;5: pubmed publisher
  3. Dema A, Perets E, Schulz M, Deák V, Klussmann E. Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling. Cell Signal. 2015;27:2474-87 pubmed publisher
  4. Klussmann E. Protein-protein interactions of PDE4 family members - Functions, interactions and therapeutic value. Cell Signal. 2016;28:713-8 pubmed publisher
    ..Houslay introduced into the PDE4 field for identifying interacting domains. The therapeutic potential of PDE4 interactions will also be discussed. ..
  5. Dema A, Schröter M, Perets E, Skroblin P, Moutty M, Deák V, et al. The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3? Interaction Protein (GSKIP) Regulates ?-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3?. J Biol Chem. 2016;291:19618-30 pubmed publisher
  6. Deák V, Skroblin P, Dittmayer C, Knobeloch K, Bachmann S, Klussmann E. The A-kinase Anchoring Protein GSKIP Regulates GSK3β Activity and Controls Palatal Shelf Fusion in Mice. J Biol Chem. 2016;291:681-90 pubmed publisher
    ..At embryonic day 18.5, GSK3β activity decreased to levels close to that of wild type. Our findings reveal a novel, crucial role for GSKIP in the coordination of GSK3β signaling in palatal shelf fusion. ..
  7. Götz F, Roske Y, Schulz M, Autenrieth K, Bertinetti D, Faelber K, et al. AKAP18:PKA-RII? structure reveals crucial anchor points for recognition of regulatory subunits of PKA. Biochem J. 2016;473:1881-94 pubmed publisher