R Klopfleisch

Summary

Country: Germany

Publications

  1. doi Canine cutaneous peripheral nerve sheath tumours versus fibrosarcomas can be differentiated by neuroectodermal marker genes in their transcriptome
    R Klopfleisch
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    J Comp Pathol 148:197-205. 2013
  2. doi Tandem Duplication of KIT Exon 11 Influences the Proteome of Canine Mast Cell Tumours
    P Schlieben
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163, Berlin, Germany
    J Comp Pathol 148:318-22. 2013
  3. doi Identification of six potential markers for the detection of circulating canine mammary tumour cells in the peripheral blood identified by microarray analysis
    A Da Costa
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    J Comp Pathol 146:143-51. 2012
  4. doi The pathology of comparative animal models of human haemochromatosis
    R Klopfleisch
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Comp Pathol 147:460-78. 2012
  5. doi Multiple RT-PCR markers for the detection of circulating tumour cells of metastatic canine mammary tumours
    A Da Costa
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    Vet J 196:34-9. 2013
  6. doi All subunits of the interleukin-2 receptor are expressed by canine cutaneous mast cell tumours
    A Meyer
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Comp Pathol 149:19-29. 2013
  7. doi The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomas
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    Vet J 190:236-43. 2011
  8. doi Differences in the proteome of high-grade versus low-grade canine cutaneous mast cell tumours
    P Schlieben
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    Vet J 194:210-4. 2012
  9. doi CD25 Is Expressed by Canine Cutaneous Mast Cell Tumors but not by Cutaneous Connective Tissue Mast Cells
    A Meyer
    Department of Veterinary Pathology, College of Veterinary Medicine, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany email
    Vet Pathol 49:988-97. 2012
  10. doi Canine Cutaneous Histiocytomas are Clonal Lesions as Defined by X-linked Clonality Testing
    N M Delcour
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Str 15, 14163 Berlin, Germany
    J Comp Pathol 149:192-8. 2013

Collaborators

  • A D Gruber
  • A Meyer
  • A Th A Weiss
  • P Schlieben
  • A Da Costa
  • M C von Deetzen
  • N M Delcour
  • B Kohn
  • A Bondzio
  • C Weise
  • P Olias
  • B Schmeck
  • M Hummel
  • R Einspanier
  • A Ochs
  • D Lenze
  • M Bothe
  • L Mundhenk

Detail Information

Publications14

  1. doi Canine cutaneous peripheral nerve sheath tumours versus fibrosarcomas can be differentiated by neuroectodermal marker genes in their transcriptome
    R Klopfleisch
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    J Comp Pathol 148:197-205. 2013
    ..Furthermore, the genes associated with the fibrosarcoma phenotype may serve as markers to differentiate fibrosarcomas from other tumour types...
  2. doi Tandem Duplication of KIT Exon 11 Influences the Proteome of Canine Mast Cell Tumours
    P Schlieben
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163, Berlin, Germany
    J Comp Pathol 148:318-22. 2013
    ....
  3. doi Identification of six potential markers for the detection of circulating canine mammary tumour cells in the peripheral blood identified by microarray analysis
    A Da Costa
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    J Comp Pathol 146:143-51. 2012
    ..The six mRNA markers may be suitable for detection of canine mammary CTCs and allow the analysis of their spatiotemporal distribution in dogs with mammary tumours...
  4. doi The pathology of comparative animal models of human haemochromatosis
    R Klopfleisch
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Comp Pathol 147:460-78. 2012
    ....
  5. doi Multiple RT-PCR markers for the detection of circulating tumour cells of metastatic canine mammary tumours
    A Da Costa
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    Vet J 196:34-9. 2013
    ..However, a multimarker assay of four genes significantly enhanced the sensitivity of the assay and is therefore preferable for CTC detection...
  6. doi All subunits of the interleukin-2 receptor are expressed by canine cutaneous mast cell tumours
    A Meyer
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Comp Pathol 149:19-29. 2013
    ..The decrease in IL-2R expression with increasing histological evidence of malignancy suggests that the IL-2R may be more relevant for early MCT development and well-differentiated tumours...
  7. doi The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomas
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    Vet J 190:236-43. 2011
    ..Gene expression profiling of metastatic carcinomas, therefore, identified molecular pathways and functional gene families that are deregulated during malignant progression in canine mammary tumors...
  8. doi Differences in the proteome of high-grade versus low-grade canine cutaneous mast cell tumours
    P Schlieben
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    Vet J 194:210-4. 2012
    ..It is noteworthy that some of the proteins identified have been proposed as therapeutic targets for human oncology and it will be interesting to evaluate their therapeutic and diagnostic potential for canine MCTs...
  9. doi CD25 Is Expressed by Canine Cutaneous Mast Cell Tumors but not by Cutaneous Connective Tissue Mast Cells
    A Meyer
    Department of Veterinary Pathology, College of Veterinary Medicine, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany email
    Vet Pathol 49:988-97. 2012
    ..Because of the low number of CD25-positive tumor cells in high-grade tumors, the usefulness of CD25 as a tumor marker is, however, questionable...
  10. doi Canine Cutaneous Histiocytomas are Clonal Lesions as Defined by X-linked Clonality Testing
    N M Delcour
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Str 15, 14163 Berlin, Germany
    J Comp Pathol 149:192-8. 2013
    ..Analysis of 11 histiocytomas identified a non-random X chromosome inactivation of one androgen receptor allele. CCH may, therefore, be a clonal lesion and of neoplastic nature. ..
  11. doi Molecular quantification of canine specific microRNA species
    M C von Deetzen
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertagstraße 15, 14163 Berlin, Germany
    Res Vet Sci 95:562-8. 2013
    ..GeNorm and NormFinder analysis were used for the evaluation of potential housekeeping genes and identified miRNAs to be more stable housekeeping genes by trend. ..
  12. doi Weigners fixative-an alternative to formalin fixation for histology with improved preservation of nucleic acids
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Berlin, Germany
    Vet Pathol 50:191-9. 2013
    ..Weigners may therefore be a promising alternative to cryopreservation and may be embraced by people affected by formalin allergies...
  13. doi Iron overload syndrome in the black rhinoceros (Diceros bicornis): microscopical lesions and comparison with other rhinoceros species
    P Olias
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Comp Pathol 147:542-9. 2012
    ....
  14. doi Does the taking of biopsies affect the metastatic potential of tumours? A systematic review of reports on veterinary and human cases and animal models
    R Klopfleisch
    Freie Universitat Berlin, Institute of Veterinary Pathology, 14163 Berlin, Germany
    Vet J 190:e31-42. 2011
    ..The overall risk therefore appears to be negligible when compared to the valuable information obtained from biopsies in veterinary practice...