Robert Klopfleisch


Country: Germany


  1. Grassinger J, Merz S, Aupperle Lellbach H, Erhard H, Klopfleisch R. Correlation of BRAF Variant V595E, Breed, Histological Grade and Cyclooxygenase-2 Expression in Canine Transitional Cell Carcinomas. Vet Sci. 2019;6: pubmed publisher
    ..Further studies are necessary to clarify the clinical and prognostic relevance of the elevated intensity of COX-2 expression of TCC with BRAF mutation detected in non-terriers. ..
  2. Bertram C, Muller K, Klopfleisch R. Genital Tract Pathology in Female Pet Rabbits (Oryctolagus cuniculus): a Retrospective Study of 854 Necropsy Examinations and 152 Biopsy Samples. J Comp Pathol. 2018;164:17-26 pubmed publisher
    ..9% of biopsy samples. Of these, ovarian cysts, especially follicular cysts, and secondary tumours were found most frequently. Disorders of the Fallopian tube and the vagina were found in <1% of cases and should be considered rare. ..
  3. Bertram C, Muller K, Klopfleisch R. Genital Tract Pathology in Female Pet Guinea Pigs (Cavia porcellus): a Retrospective Study of 655 Post-mortem and 64 Biopsy Cases. J Comp Pathol. 2018;165:13-22 pubmed publisher
    ..9%) in animals aged 7-12 months. An association between ovarian cysts and uterine neoplasia or hyperplasia was not evident. Vaginal disorders were rare and included leiomyoma, polyps and vaginitis. ..
  4. Klopfleisch R. Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology--a systematic review. BMC Vet Res. 2013;9:123 pubmed publisher
  5. Koch A, Saran S, Tran D, Klebba Färber S, Thiesler H, Sewald K, et al. Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo. Cell Commun Signal. 2014;12:73 pubmed publisher
    ..This method may also prove useful for identification of genes in liver-resident cells that support cancer invasion by using PCLS from transgenic liver. ..
  6. Klopfleisch R. Personalised medicine in veterinary oncology: one to cure just one. Vet J. 2015;205:128-35 pubmed publisher
    ..These data may be the start point for personalised approaches in veterinary oncology leading to better efficacy and safety of therapeutic protocols. ..
  7. Bertram C, Firsching T, Klopfleisch R. Virtual Microscopy in Histopathology Training: Changing Student Attitudes in 3 Successive Academic Years. J Vet Med Educ. 2018;45:241-249 pubmed publisher
    ..Fifth-year students considered technical difficulties (i.e., insufficient transmission speed) to be the main disadvantage of this newer teaching modality. ..
  8. Klopfleisch R. Macrophage reaction against biomaterials in the mouse model - Phenotypes, functions and markers. Acta Biomater. 2016;43:3-13 pubmed publisher
    ..Their diverging functions, metabolism and markers are summarized and the relevance of this more diverse macrophage picture for the design of biomaterials is shortly discussed. ..
  9. Klopfleisch R, von Deetzen M, Weiss A, Weigner J, Weigner F, Plendl J, et al. Weigners fixative-an alternative to formalin fixation for histology with improved preservation of nucleic acids. Vet Pathol. 2013;50:191-9 pubmed publisher
    ..Weigners may therefore be a promising alternative to cryopreservation and may be embraced by people affected by formalin allergies. ..

More Information


  1. Klopfleisch R, Meyer A, Schlieben P, Bondzio A, Weise C, Lenze D, et al. Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes. BMC Vet Res. 2012;8:96 pubmed publisher
    ..These pathways may contain hypothetical targets for a combination therapy with masitinib to further improve its therapeutic effect. ..
  2. Klopfleisch R, Kohn B, Gruber A. Mechanisms of tumour resistance against chemotherapeutic agents in veterinary oncology. Vet J. 2016;207:63-72 pubmed publisher
    ..The known resistance mechanisms in animal tumours and the potential of these findings for improving treatment efficacy in veterinary oncology are also explored. ..
  3. Saran S, Tran D, Klebba Färber S, Morán Losada P, Wiehlmann L, Koch A, et al. THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier. BMC Cell Biol. 2013;14:51 pubmed publisher
    ..These data imply that THOC5 may be a useful tool for studying intestinal stem cells, for modifying the differentiation processes and for cancer therapy. ..
  4. Bulkowska M, Rybicka A, Senses K, Ulewicz K, Witt K, Szymańska J, et al. MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours. BMC Cancer. 2017;17:728 pubmed publisher
    ..However, validation of cfa-miR-144, cfa-miR-32 and cfa-miR-374a levels in blood samples did not follow changes observed in the non-metastatic and metastatic tumours. ..